Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients

Clinical Microbiology and Infection

Volumn 15, Issue 6, 2009, Pages 592-595

  Zaragoza, Raf ^a   Peman J ^b   Quindos G ^c   Iruretagoyena, J R ^d   Cuetara M S ^e   Ramirez P ^b   Gomez M D ^b   Camarena, J J ^a   Viudes, A ^b   Ponton J ^c   Sancho, S ^a   Gonzalez R ^a   Gimenez M J ^b   Alkorta, M ^d   Suarez J ^e   Martin Mazuelos E ^f   Linares Sicilia, M J ^g  

^a HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d HOSPITAL DE CRUCES   (Spain)

^e HOSPITAL SEVERO OCHOA   (Spain)

^f Valme Hospital   (Spain)

^g HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Antibodies; Candida germ tube; Critically ill patients; ICU; Invasive candidiasis; Mortality; Pre emptive antifungal therapy

Indexed keywords

ANTIBODY; ANTIFUNGAL AGENT;

ADULT; AGED; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BLOOD CULTURE; CANDIDA ALBICANS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; FUNGAL DETECTION; HUMAN; INTENSIVE CARE UNIT; INVASIVE CANDIDIASIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROLOGY; SPAIN; TERTIARY HEALTH CARE; TUBE;

CANDIDA; CANDIDA ALBICANS;

EID: 67651040720     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2009.02794.x     Document Type: Article

References (19)

1. Zaragoza R, Peman J. Invasive fungal infections in critically ill patients: Different therapeutic options and a uniform strategy. Rev Iberoam Micol 2006; 23: 59-63.
2. Zaragoza R, Peman J. Diagnostic and therapeutic approach to fungal infections in critical care settings: Different options but the same strategy. J Invasive Fungal Infect 2007; 1: 50-58.
3. Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality. Antimicrob Agents Chemother 2005; 49: 3640-3645.
4. Garey KW, Rege M, Pai MP et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional study. Clin Infect Dis 2006; 43: 25-31.
5. Quindos G, Moragues MD, Ponton J. Is there a role for antibody testing in the diagnosis of invasive candidiasis? Rev Iberoam Micol 2004; 21: 10-14.
6. Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg 1994; 220: 751-758.
7. Ponton J, Jones JM. Identification of two germ tube specific cell wall antigens of Candida albicans. Infect Immun 1986; 54: 864-868.
8. Quindos G, Ponton J, Cisterna R. Detection of antibodies to Candida albicans germ-tubes in the serodiagnosis of systemic candidosis. Eur J Clin Microbiol Infect Dis 1987; 6: 142-146.
9. Ponton J, Quindos G, Arilla MC, Mackenzie DW. Simplified adsorption method for detection of antibodies to Candida albicans germ tubes. J Clin Microbiol 1994; 32: 217-219.
10. Quindos G, Alvarez M, Regulez P, Ponton J, Cisterna R. Diagnosis of systemic candidiasis in parenteral drug addicts by detection of antimycelial antibodies. Med Clin (Barc) 1988; 90: 451-455.
11. Garcia-Ruiz JC, del Carmen AM, Regulez P, Quindos G, Alvarez A, Ponton J. Detection of antibodies to Candida albicans germ tubes for diagnosis and therapeutic monitoring of invasive candidiasis in patients with hematologic malignancies. J Clin Microbiol 1997; 35: 3284-3287.
12. Iruretagoyena JR, Regulez P, Quindos G, Ponton J. Antibodies to Candida albicans germ tubes in two intensive care patients with invasive candidiasis. Rev Iberoam Micol 2000; 17: 93-96.
13. Moragues MD, Ortiz N, Iruretagoyena JR et al. Evaluation of a new commercial test (Candida albicans IFA IgG) for the serodiagnosis of invasive candidiasis. Enferm Infecc Microbiol Clin 2004; 22: 83-88.
14. Quindos G, Ponton J, Cisterna R, Mackenzie DW. Value of detection of antibodies to Candida albicans germ tube in the diagnosis of systemic candidosis. Eur J Clin Microbiol Infect Dis 1990; 9: 178-183.
15. Salesa R, Moragues MD, Sota R, Peman J, Quindos G, Ponton J. Specific antibody response in a patient with Candida dubliniensis fungemia. Rev Iberoam Micol 2001; 18: 42-44.
16. Berenguer J, Buck M, Witebsky F, Stock F, Pizzo PA, Walsh TJ. Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis. Disseminated versus single-organ infection. Diagn Microbiol Infect Dis 1993; 17: 103-109.
17. Leon C, Ruiz-Santana S, Saavedra P et al. A bedside scoring system ('Candida score') for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med 2006; 34: 730-737.
18. Montagnoli C, Sandini S, Bacci A, Romani L, La VR. Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis. Med Mycol 2004; 42: 319-324.
19. Bromuro C, La VR, Sandini S, Urbani F, Ausiello CM, Morelli L, Fe d'Ostiani C, Romani L, Cassone A. A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis. Infect Immun 1998; 66: 2154-2162.