Frailty in Older Persons

Clinics in Geriatric Medicine

Volumn 33, Issue 3, 2017, Pages 293-303

  Cesari, Matteo ^a   Calvani, Riccardo ^b   Marzetti, Emanuele ^b  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Assessment; Disability; Elderly; Geriatrics; Prevention

Indexed keywords

AGING; DISABILITY; DISEASE ASSOCIATION; FRAIL ELDERLY; FRAILTY; FUNCTIONAL STATUS; GERIATRIC ASSESSMENT; GERIATRIC CARE; HUMAN; NONHUMAN; POPULATION RISK; REVIEW; AGED; ELDERLY CARE; ORGANIZATION AND MANAGEMENT; PHYSIOLOGY; PREVENTIVE HEALTH SERVICE; PROCEDURES; PUBLIC HEALTH;

AGED; AGING; FRAIL ELDERLY; FRAILTY; GERIATRIC ASSESSMENT; HEALTH SERVICES FOR THE AGED; HUMANS; PREVENTIVE HEALTH SERVICES; PUBLIC HEALTH;

EID: 85017168611     PISSN: 07490690     EISSN: 18798853     Source Type: Journal    
DOI: 10.1016/j.cger.2017.02.002     Document Type: Review

References (61)

1. Cherubini, A., Signore, S.D., Ouslander, J., et al. Fighting against age discrimination in clinical trials. J Am Geriatr Soc 58:9 (2010), 1791–1796.
2. World report on ageing and health, 2015, World Health Organization, Geneva (Switzerland).
3. Parfentjev, I.A., Frailty of old age and bacterial allergy. Geriatrics 11:6 (1956), 260–262.
4. Old and frail. Br Med J 1:5594 (1968), 723–724.
5. Cesari, M., Marzetti, E., Thiem, U., et al. The geriatric management of frailty as paradigm of “The end of the disease era”. Eur J Intern Med 31 (2016), 11–14.
6. Fried, L.P., Tangen, C.M., Walston, J., et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:3 (2001), M146–M156.
7. Morley, J.E., Vellas, B., Abellan van Kan, G., et al. Frailty consensus: a call to action. J Am Med Dir Assoc 14:6 (2013), 392–397.
8. Clegg, A., Young, J., Iliffe, S., et al. Frailty in elderly people. Lancet 381 (2013), 752–762.
9. Conti, A.A., Conti, A., Frailty and resilience from physics to medicine. Med Hypotheses, 74(6), 2010, 1090.
10. Rockwood, K., Song, X., MacKnight, C., et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 173:5 (2005), 489–495.
11. Mitnitski, A.B., Mogilner, A.J., Rockwood, K., Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal 1 (2001), 323–336.
12. De Lepeleire, J., Iliffe, S., Mann, E., et al. Frailty: an emerging concept for general practice. Br J Gen Pract 59:562 (2009), e177–e182.
13. Vellas, B., Cestac, P., Morley, J.E., Implementing frailty into clinical practice: we cannot wait. J Nutr Health Aging 16:7 (2012), 599–600.
14. Theou, O., Walston, J., Rockwood, K., Operationalizing frailty using the frailty phenotype and deficit accumulation approaches. Interdiscip Top Gerontol Geriatr 41 (2015), 66–73.
15. Hoogendijk, E.O., van der Horst, H.E., Deeg, D.J., et al. The identification of frail older adults in primary care: comparing the accuracy of five simple instruments. Age Ageing 42:2 (2013), 262–265.
16. Theou, O., Brothers, T.D., Mitnitski, A., et al. Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. J Am Geriatr Soc 61:9 (2013), 1537–1551.
17. Cesari, M., Gambassi, G., Abellan van Kan, G., et al. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing 43:1 (2014), 10–12.
18. Fried, L.P., Ferrucci, L., Darer, J., et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59:3 (2004), 255–263.
19. Theou, O., Cann, L., Blodgett, J., et al. Modifications to the frailty phenotype criteria: systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe. Ageing Res Rev 21 (2015), 78–94.
20. Rockwood, K., Mitnitski, A., How might deficit accumulation give rise to frailty?. J Frailty Aging 1:1 (2012), 8–12.
21. Guaraldi, G., Brothers, T.D., Zona, S., et al. A frailty index predicts survival and incident multimorbidity independent of markers of HIV disease severity. AIDS 29:13 (2015), 1633–1641.
22. Cesari, M., Costa, N., Hoogendijk, E.O., et al. How the frailty index may support the allocation of health care resources: an example from the INCUR study. J Am Med Dir Assoc 17:5 (2016), 448–450.
23. Kelaiditi, E., Canevelli, M., Andrieu, S., et al. Frailty index and cognitive decline in Alzheimer's Disease: data from the impact of cholinergic treatment use study. J Am Geriatr Soc 64:6 (2016), 1165–1170.
24. Feridooni, H.A., Sun, M.H., Rockwood, K., et al. Reliability of a frailty index based on the clinical assessment of health deficits in male C57BL/6J mice. J Gerontol A Biol Sci Med Sci 70:6 (2015), 686–693.
25. Mitnitski, A., Collerton, J., Martin-Ruiz, C., et al. Age-related frailty and its association with biological markers of ageing. BMC Med, 13, 2015, 161.
26. Gobbens, R.J., Luijkx, K.G., Wijnen-Sponselee, M.T., et al. In search of an integral conceptual definition of frailty: opinions of experts. J Am Med Dir Assoc 11:5 (2010), 338–343.
27. Gobbens, R.J., van Assen, M.A., Luijkx, K.G., et al. Testing an integral conceptual model of frailty. J Adv Nurs 68:9 (2012), 2047–2060.
28. Gobbens, R.J., van Assen, M.A., Luijkx, K.G., et al. The tilburg frailty indicator: psychometric properties. J Am Med Dir Assoc 11:5 (2010), 344–355.
29. Morley, J.E., Frailty: a time for action. Eur Geriatr Med 4 (2013), 215–216.
30. Morley, J.E., Malmstrom, T.K., Miller, D.K., A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging 16:7 (2012), 601–608.
31. Mossello, E., Profili, F., Di Bari, M., et al. Postal screening can identify frailty and predict poor outcomes in older adults: longitudinal data from INTER-FRAIL study. Age Ageing 45:4 (2016), 469–474.
32. Hebert, R., Bravo, G., Korner-Bitensky, N., et al. Predictive validity of a postal questionnaire for screening community-dwelling elderly individuals at risk of functional decline. Age Ageing 25:2 (1996), 159–167.
33. Ensrud, K., Ewing, S.K., Taylor, B.C., et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168:4 (2008), 382–389.
34. Romero-Ortuno, R., Walsh, C.D., Lawlor, B.A., et al. A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatr, 10, 2010, 57.
35. Studenski, S., Perera, S., Patel, K., et al. Gait speed and survival in older adults. JAMA 305:1 (2011), 50–58.
36. Studenski, S., Perera, S., Wallace, D., et al. Physical performance measures in the clinical setting. J Am Geriatr Soc 51:3 (2003), 314–322.
37. Guralnik, J.M., Simonsick, E.M., Ferrucci, L., et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:2 (1994), M85–M94.
38. Guralnik, J.M., Ferrucci, L., Simonsick, E.M., et al. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332:9 (1995), 556–561.
39. Cesari, M., Role of gait speed in the assessment of older patients. JAMA 305:1 (2011), 93–94.
40. Fit for Frailty - consensus best practice guidance for the care of older people living in community and outpatient settings - a report from the British Geriatrics Society, 2014, British Geriatrics Society.
41. Abellan van Kan, G., Rolland, Y.M., Andrieu, S., et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 13:10 (2009), 881–889.
42. Podsiadlo, D., Richardson, S., The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:2 (1991), 142–148.
43. Hébert, R., Durand, P.J., Dubuc, N., et al., PRISMA Group. Frail elderly patients. new model for integrated service delivery. Can Fam Physician 49 (2003), 992–997.
44. Turner, G., Clegg, A., Best practice guidelines for the management of frailty: a British Geriatrics Society, age UK and Royal College of general practitioners report. Age Ageing 43:6 (2014), 744–747.
45. Cesari, M., Prince, M., Thiyagarajan, J.A., et al. Frailty: an emerging public health priority. J Am Med Dir Assoc 17:3 (2016), 188–192.
46. Marzetti, E., Sanna, T., Calvani, R., et al. Brand new medicine for an older society. J Am Med Dir Assoc 17:6 (2016), 558–559.
47. Hadley, E.C., The science of the art of geriatric medicine. JAMA 273:17 (1995), 1381–1383.
48. Ellis, G., Whitehead, M.A., O'Neill, D., et al. Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev(7), 2011 CD006211.
49. Stuck, A.E., Aronow, H.U., Steiner, A., et al. A trial of annual in-home comprehensive geriatric assessments for elderly people living in the community. N Engl J Med 333:18 (1995), 1184–1189.
50. Stuck, A.E., Minder, C.E., Peter-Wüest, I., et al. A randomized trial of in-home visits for disability prevention in community-dwelling older people at low and high risk for nursing home admission. Arch Intern Med 160:7 (2000), 977–986.
51. Bernabei, R., Landi, F., Gambassi, G., et al. Randomised trial of impact of model of integrated care and case management for older people living in the community. BMJ 316:7141 (1998), 1348–1351.
52. Rubenstein, L.Z., Josephson, K.R., Wieland, G.D., et al. Effectiveness of a geriatric evaluation unit. A randomized clinical trial. N Engl J Med 311:26 (1984), 1664–1670.
53. Carfi, A., Antocicco, M., Brandi, V., et al. Characteristics of adults with down syndrome: prevalence of age-related conditions. Front Med (Lausanne), 1, 2014, 51.
54. Hermans, H., Evenhuis, H.M., Multimorbidity in older adults with intellectual disabilities. Res Dev Disabil 35:4 (2014), 776–783.
55. Kooij, K.W., Wit, F.W., Schouten, J., et al. HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls. AIDS 30:2 (2016), 241–250.
56. Pathai, S., Bajillan, H., Landay, A.L., et al. Is HIV a model of accelerated or accentuated aging?. J Gerontol A Biol Sci Med Sci 69:7 (2014), 833–842.
57. Cesari, M., Vellas, B., Frailty in clinical practice. Nestle Nutr Inst Workshop Ser 83 (2015), 93–98.
58. Harding, C., Pompei, F., Burmistrov, D., et al. Breast cancer screening, incidence, and mortality across US counties. JAMA Intern Med 175:9 (2015), 1483–1489.
59. Howrey, B.T., Kuo, Y.F., Lin, Y.L., et al. The impact of PSA screening on prostate cancer mortality and overdiagnosis of prostate cancer in the United States. J Gerontol A Biol Sci Med Sci 68:1 (2012), 56–61.
60. Antonelli-Incalzi, R., Gemma, A., Capparella, O., Orthogeriatric unit: a thinking process and a working model. Aging Clin Exp Res 20:2 (2008), 109–112.
61. Adunsky, A., Lerner-Geva, L., Blumstein, T., et al. Improved survival of hip fracture patients treated within a comprehensive geriatric hip fracture unit, compared with standard of care treatment. J Am Med Dir Assoc 12:6 (2011), 439–444.