Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Cell Stem Cell

Volumn 20, Issue 4, 2017, Pages 547-557.e7

  Warren, Curtis R ^a   O'Sullivan, John F ^b   Friesen, Max ^a   Becker, Caroline E ^a   Zhang, Xiaoling ^f,g   Liu, Poching ^c   Wakabayashi, Yoshiyuki ^c   Morningstar, Jordan E ^b   Shi, Xu ^b   Choi, Jihoon ^a   Xia, Fang ^a   Peters, Derek T ^a   Florido, Mary H C ^a   Tsankov, Alexander M ^a,d   Duberow, Eilene ^a   Comisar, Lauren ^a   Shay, Jennifer ^a   Jiang, Xin ^a   Meissner, Alexander ^a,d   Musunuru, Kiran ^a   Kathiresan, Sekar ^b   Daheron, Laurence ^a   Zhu, Jun ^c   Gerszten, Robert E ^b   Deo, Rahul C ^e   Vasan, Ramachandran S ^f,g,h   O'Donnell, Christopher J ^f,i   Cowan, Chad A ^a,d,j   more..

^a Harvard University   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f FRAMINGHAM HEART STUDY   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h BOSTON UNIVERSITY   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

more..

Author keywords

adipocytes; cardiovascular disease; directed differentiation; expression quantitative trait locus; Framingham Heart Study; hepatocyte like cells; induced pluripotent stem cells; metabolomics; RNA sequencing; SORT1

Indexed keywords

ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CELL MARKER; CELSR2 PROTEIN; DNA METHYLTRANSFERASE 3B; ENG PROTEIN; HERMES ANTIGEN; NT5E PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROTEIN; PSMA5 PROTEIN; PSRC1 PROTEIN; REX1 PROTEIN; RNA; SARS PROTEIN; SORTILIN; SSEA3 PROTEIN; STAGE SPECIFIC EMBRYO ANTIGEN 4; TELOMERASE REVERSE TRANSCRIPTASE; TRA 1 60 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CARDIOMETABOLIC RISK; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; INDUCED PLURIPOTENT STEM CELL; LIPID STORAGE; LIVER CELL; METABOLIC DISORDER; METABOLOMICS; MOLECULAR PATHOLOGY; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; WHITE ADIPOCYTE; BIOLOGICAL MODEL; CHROMOSOME 1; COHORT ANALYSIS; CYTOLOGY; DONOR; GENETICS; GENOTYPE; LIPID METABOLISM; METABOLISM; MONONUCLEAR CELL; REPRODUCIBILITY; SEQUENCE ANALYSIS;

ADIPOCYTES, WHITE; CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; CHROMOSOMES, HUMAN, PAIR 1; COHORT STUDIES; DOWN-REGULATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEPATOCYTES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LEUKOCYTES, MONONUCLEAR; LIPID METABOLISM; METABOLIC DISEASES; METABOLOMICS; MODELS, GENETIC; PHENOTYPE; QUANTITATIVE TRAIT LOCI; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, RNA; TISSUE DONORS; TRANSCRIPTOME;

EID: 85017154259     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.01.010     Document Type: Article

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