Thyroid hormone therapy for older adults with subclinical hypothyroidism

New England Journal of Medicine

Volumn 376, Issue 26, 2017, Pages 2534-2544

  Stott, D J ^a   Rodondi, N ^d,e   Kearney, P M ^g   Ford, I ^b   Westendorp, R G J ⁱ   Mooijaart, S P ^l,m   Sattar, N ^b   Aubert, C E ^d   Aujesky, D ^d   Bauer, D C ^o   Baumgartner, C ^d   Blum, M R ^d   Browne, J P ^g   Byrne, S ^g   Collet, T H ^f   Dekkers, O M ^l   Den Elzen, W P J ^l   Du Puy, R S ^l   Ellis, G ^c   Feller, M ^d,e   Floriani, C ^d   Hendry, K ^a   Hurley, C ^g   Jukema, J W ^l   Kean, S ^b   Kelly, M ^g,h   Krebs, D ^d   Langhorne, P ^a   McCarthy, G ^g   McCarthy, V ^g   McConnachie, A ^b   McDade, M ^a   Messow, M ^b   O'Flynn, A ^g   O'Riordan, D ^g   Poortvliet, R K E ^l   Quinn, T J ^a   Russell, A ^g   Sinnott, C ^g   Smit, J W A ⁿ   Van Dorland, H A ^d   Walsh, K A ^g   Walsh, E K ^g   Watt, T ^j,k   Wilson, R ^b   Gussekloo, J ^l   more..

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c MONKLANDS HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

^f LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^g UNIVERSITY COLLEGE CORK   (Ireland)

^h MERCY UNIVERSITY HOSPITAL   (Ireland)

ⁱ UNIVERSITY OF COPENHAGEN   (Denmark)

^j University of Copenhagen   (Denmark)

^k GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^l LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^m Institute for Evidence Based Medicine in Old Age   (Netherlands)

ⁿ RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^o UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; PLACEBO; THYROTROPIN; THYROXINE;

AGED; ARTICLE; ATRIAL FIBRILLATION; BODY WEIGHT; CLINICAL OUTCOME; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FRACTURE; HEART FAILURE; HORMONAL THERAPY; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SUBCLINICAL HYPOTHYROIDISM; BLOOD; CLINICAL TRIAL; COMPLICATION; FATIGUE; HYPOTHYROIDISM; INTENTION TO TREAT ANALYSIS; MULTICENTER STUDY; TREATMENT FAILURE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FATIGUE; FEMALE; HUMANS; HYPOTHYROIDISM; INTENTION TO TREAT ANALYSIS; MALE; QUALITY OF LIFE; THYROTROPIN; THYROXINE; TREATMENT FAILURE;

EID: 85017137004     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1603825     Document Type: Article

References (29)

1. Rugge JB, Bougatsos C, Chou R. Screening for and treatment of thyroid dysfunction: an evidence review for the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality, 2014.
2. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado Thyroid Disease Prevalence Study. Arch Intern Med 2000; 160: 526-34.
3. Monzani F, Di Bello V, Caraccio N, et al. Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study. J Clin Endocrinol Metab 2001; 86: 1110-5.
4. Parle J, Roberts L, Wilson S, et al. A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. J Clin Endocrinol Metab 2010; 95: 3623-32.
5. Baumgartner C, den Elzen WP, Blum MR, et al. Variation in treatment strategies of Swiss general practitioners for subclinical hypothyroidism in older adults. Swiss Med Wkly 2015; 145: w14156.
6. Carle A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Laurberg P. Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case-control study. Eur J Endocrinol 2014; 171: 593-602.
7. Javed Z, Sathyapalan T. Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther Adv Endocrinol Metab 2016; 7: 12-23.
8. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010; 304: 1365-74.
9. Villar HC, Saconato H, Valente O, Atallah AN. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev 2007; 3: CD003419.
10. Mikhail GS, Alshammari SM, Alenezi MY, Mansour M, Khalil NA. Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism. Endocr Pract 2008; 14: 570-5.
11. Stott DJ, Gussekloo J, Kearney PM, et al. Study protocol: Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). BMC Endocr Disord 2017; 17: 6.
12. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2013; 310: 2191-4.
13. MRC guidelines for good clinical practice in clinical trials. London: Medical Research Council, 1998.
14. Watt T, Hegedus L, Groenvold M, et al. Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO. Eur J Endocrinol 2010; 162: 161-7.
15. Wong CK, Lang BH, Lam CL. A systematic review of quality of thyroid-specific health-related quality-of-life instruments recommends ThyPRO for patients with benign thyroid diseases. J Clin Epidemiol 2016; 78: 63-72.
16. EuroQol Group. EuroQol - a new facility for the measurement of healthrelated quality of life. Health Policy 1990; 16: 199-208.
17. Watt T, Bjorner JB, Groenvold M, et al. Development of a short version of the Thyroid-Related Patient-Reported Outcome ThyPRO. Thyroid 2015; 25: 1069-79.
18. Gunther CM, Burger A, Rickert M, Crispin A, Schulz CU. Grip strength in healthy caucasian adults: reference values. J Hand Surg Am 2008; 33: 558-65.
19. Houx PJ, Shepherd J, Blauw GJ, et al. Testing cognitive function in elderly populations: the PROSPER study: PROspective Study of Pravastatin in the Elderly at Risk. J Neurol Neurosurg Psychiatry 2002; 73: 385-9.
20. Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J 1965; 14: 61-5.
21. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged - the Index of ADL: a standardised measure of biological and psychosocial function. JAMA 1963; 185: 914-9.
22. Winther KH, Cramon P, Watt T, et al. Disease-specific as well as generic quality of life is widely impacted in autoimmune hypothyroidism and improves during the first six months of levothyroxine therapy. PLoS One 2016; 11(6): e0156925.
23. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 2007; 92: 1715-23.
24. McClure NS, Xie F, Luo N, Johnson JA. Instrument-defined estimates of the minimally important difference for EQ-5D-5L index scores. Value Health (in press).
25. Reuters VS, Teixeira PdeF, Vigario PS, et al. Functional capacity and muscular abnormalities in subclinical hypothyroidism. Am J Med Sci 2009; 338: 259-63.
26. Razvi S, Weaver JU, Butler TJ, Pearce SH. Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality. Arch Intern Med 2012; 172: 811-7.
27. Diez JJ, Iglesias P, Burman KD. Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 2005; 90: 4124-7.
28. Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf) 1991; 34: 77-83.
29. Pearce SH, Brabant G, Duntas LH, et al. 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J 2013; 2: 215-28.