Disease-specific as well as generic quality of life is widely impacted in autoimmune hypothyroidism and improves during the first six months of levothyroxine therapy

PLoS ONE

Volumn 11, Issue 6, 2016, Pages

  Winther, Kristian Hillert ^a,b   Cramon, Per ^c   Watt, Torquil ^c,d   Bjorner, Jakob Bue ^e,f   Ekholm, Ola ^g   Feldt Rasmussen, Ulla ^c   Groenvold, Mogens ^e,h   Rasmussen, Åse Krogh ^c   Hegedüs, Laszlo ^a,b   Joop Bonnema, Steen ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c University of Copenhagen   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f OPTUM   (United States)

^g UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^h BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; HORMONE; THYROXINE;

ADULT; AGED; ARTICLE; AUTOIMMUNE THYROIDITIS; BODILY PAIN; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DANISH CITIZEN; DISEASE SPECIFIC QUALITY OF LIFE; ENERGY; FATIGUE; FEMALE; FOLLOW UP; HEALTH STATUS; HEALTH SURVEY; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MULTICENTER STUDY; PAIN; PROSPECTIVE STUDY; QUALITY OF LIFE; SEXUAL BEHAVIOR; SHORT FORM 36; SOCIAL STATUS; SYMPTOM; TREATMENT DURATION; ADOLESCENT; HASHIMOTO DISEASE; MIDDLE AGED; PATHOPHYSIOLOGY; PSYCHOMETRY; QUESTIONNAIRE; THYROIDITIS, AUTOIMMUNE; TIME FACTOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HASHIMOTO DISEASE; HORMONES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PSYCHOMETRICS; QUALITY OF LIFE; SURVEYS AND QUESTIONNAIRES; THYROIDITIS, AUTOIMMUNE; THYROXINE; TIME FACTORS; YOUNG ADULT;

EID: 84973379928     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0156925     Document Type: Article

References (39)

1. Pedersen IB, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, et al. An increased incidence of overt hypothyroidism after iodine fortification of salt in Denmark: a prospective population study. J Clin Endocrinol Metab 2007; 92:3122-3127. PMID: 17504896
2. Carle A, Laurberg P, Pedersen IB, Knudsen N, Perrild H, Ovesen L, el al. Epidemiology of subtypes of hypothyroidism in Denmark. Eur J Endocrinol 2006; 154:21-28. PMID: 16381987
3. Wiersinga WM. Paradigm shifts in thyroid hormone replacement therapies for hypothyroidism. Nat Rev Endocrinol 2014; 10:164-174. doi: 10.1038/nrendo.2013.258 PMID: 24419358
4. Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, Dayan CM. Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf) 2002; 57:577-585.
5. Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JG, et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol 2005; 153:747-753. PMID: 16322379
6. Quinque EM, Villringer A, Kratzsch J, Karger S. Patient-reported outcomes in adequately treated hypothyroidism-insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ. Health Qual Life Outcomes 2013; 11:68. doi: 10.1186/1477-7525-11-68 PMID: 23618009
7. Kelderman-Bolk N, Visser TJ, Tijssen JG, Berghout A. Quality of life in patients with primary hypothyroidism is related to BMI. Eur J Endocrinol 2015; 173: 507-515. doi: 10.1530/EJE-15-0395 PMID: 26169304
8. Black N. Patient reported outcome measures could help transform healthcare. BMJ 2013; 346:f167 doi: 10.1136/bmj.f167 PMID: 23358487
9. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med 1993; 118:622-629. PMID: 8452328
10. Hays RD. Generic versus disease-targeted instruments. In: Fayers P, Hays RD (eds). Assessing quality of life in clinical trials. 2nd edition. Oxford University Press, Oxford, 2005; 3-8.
11. Ware JE Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30:473-483. PMID: 1593914
12. Contopoulos-Ioannidis DG, Karvouni A, Kouri I, Ioannidis JP. Reporting and interpretation of SF-36 outcomes in randomised trials: systematic review. BMJ 2009; 338:a3006. doi: 10.1136/bmj.a3006 PMID: 19139138
13. McMillan CV, Bradley C, Woodcock A, Razvi S, Weaver JU. Design of new questionnaires to measure quality of life and treatment satisfaction in hypothyroidism. Thyroid 2004; 14:916-25. PMID: 15671770
14. McMillan CV, Bradley C, Razvi S, Weaver JU. Evaluation of new measures of the impact of hypothyroidism on quality of life and symptoms: the ThyDQoL and ThySRQ. Value Health 2008; 11:285-294. doi: 10.1111/j.1524-4733.2007.00232.x PMID: 18380641
15. Watt T, Hegedus L, Rasmussen AK, Groenvold M, Bonnema SJ, Bjorner JB, et al. Which domains of thyroid-related quality of life are most relevant? Patients and clinicians provide com-plementary perspectives. Thyroid 2007; 17:647-54. PMID: 17696835
16. Watt T, Rasmussen AK, Groenvold M, Bjorner JB, Watt SH, Bonnema SJ, et al. Improving a newly developed patient-reported outcome for thyroid patients, using cognitive interviewing. Qual Life Res 2008; 17:1009-17. doi: 10.1007/s11136-008-9364-z PMID: 18584308
17. Watt T, Bjorner JB, Groenvold M, Rasmussen AK, Bonnema SJ, Hegedüs L, et al. Establishing construct validity for the thyroid-related patient reported outcome measure (ThyPRO): an initial examination. Qual Life Res 2009; 18:483-96. doi: 10.1007/s11136-009-9460-8 PMID: 19288224
18. Watt T, Hegedus L, Groenvold M, Bjorner JB, Rasmussen AK, Bonnema SJ, et al. Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO. Eur J Endocrinol 2010; 162:161-167 doi: 10.1530/EJE-09-0521 PMID: 19797502
19. Watt T, Groenvold M, Hegedus L, Bonnema SJ, Rasmussen AK, Feldt-Rasmussen U, et al. Few items in the thyroid-related quality of life instrument ThyPRO exhibited differential item functioning. Qual Life Res 2014; 23: 327-338. doi: 10.1007/s11136-013-0462-1 PMID: 23812962
20. Watt T, Groenvold M, Deng N, Gandek B, Feldt-Rasmussen U, Rasmussen AK, et al. Confirmatory factor analysis of the thyroid-related quality of life questionnaire ThyPRO. Health Qual Life Outcomes 2014; 12:126. doi: 10.1186/s12955-014-0126-z PMID: 25213857
21. Watt T, Cramon P, Hegedus L, Bjorner JB, Bonnema SJ, Rasmussen AR, et al. The thyroid-related quality of life measure ThyPRO has good responsiveness and ability to detect relevant treatment effects. J Clin Endocrinol Metab 2014; 99:3708-3717. doi: 10.1210/jc.2014-1322 PMID: 25004246
22. Ware JE Jr., Kosinski M, Bjorner JB, Maruish M. 2007 SF-36 Health Survey. Manual and Interpretation Guide. 2nd edition, QualityMetric Incorporated, Lincoln, RI.
23. Cramon P, Bonnema SJ, Bjorner JB, Ekholm O, Feldt-Rasmussen U, Frendl DM, et al. Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. Thyroid 2015; 25:284-91. doi: 10.1089/thy.2014.0433 PMID: 25602312
24. Ekholm O, Hesse U, Davidsen M, Kjoller M. The study design and characteristics of the Danish national health interview surveys. Scand J Public Health 2009; 37:758-765. doi: 10.1177/1403494809341095 PMID: 19622549
25. Cohen J. A power primer. Psychol Bull 1992; 112:155-159. PMID: 19565683
26. Carle A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Laurberg P. Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case-control study. Eur J Endocrinol 2014; 171:593-602. doi: 10.1530/EJE-14-0481 PMID: 25305308
27. Samuels MH. Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes 2014; 21:377-83. doi: 10.1097/MED.0000000000000089 PMID: 25122491
28. Dayan CM, Panicker V. Hypothyroidism and depression. Eur Thyroid J 2013; 2:168-79. doi: 10.1159/000353777 PMID: 24847450
29. Krysiak R, Drosdzol-Cop A, Skrzypulec-Plinta V, Okopien B. Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism. Clin Endocrinol 2015; [Epub ahead of print]
30. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000; 160:526-34. PMID: 10695693
31. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr., Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. New Engl J Med 2008; 359:2195-2207. doi: 10.1056/NEJMoa0807646 PMID: 18997196
32. Thvilum M, Brandt F, Almind D, Christensen K, Hegedus L, Brix TH. Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins. J Clin Endocrinol Metab 2013; 98:1069-1075. doi: 10.1210/jc.2012-3375 PMID: 23365121
33. Thvilum M, Brandt F, Almind D, Christensen K, Brix TH, Hegedus L. Type and Extent of Somatic Morbidity before and after the Diagnosis of Hypothyroidism. A Nationwide Register Study. PloS One 2013; 8:e75789. doi: 10.1371/journal.pone.0075789 PMID: 24066186
34. Thvilum M, Brandt F, Almind D, Christensen K, Brix TH, Hegedüs L. Increased Psychiatric Morbidity Before and After the Diagnosis of Hypothyroidism: A Nationwide Register Study. Thyroid 2014; 24:802-808. doi: 10.1089/thy.2013.0555 PMID: 24383722
35. Stewart M, Brown JB, Donner A, McWhinney IR, Oates J, Weston WW, et al. The impact of patient-centered care on outcomes. J Fam Pract 2000; 49:796-804. PMID: 11032203
36. Tzelepis F, Sanson-Fisher RW, Zucca AC, Fradgley EA. Measuring the quality of patient-centered care: why patient-reported measures are critical to reliable assessment. Patient Prefer Adherence 2015; 9:831-835. doi: 10.2147/PPA.S81975 PMID: 26150703
37. Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet 2010; 375:686-95. doi: 10.1016/S0140-6736(09)61706-2 PMID: 20171404
38. Watt T, Bjorner JB, Groenvold M, Cramon P, Winther KH, Hegedus L, et al. Development of a short version of the thyroid-related patient-reported outcome ThyPRO. Thyroid 2015; 25:1069-1079. doi: 10.1089/thy.2015.0209 PMID: 26214034
39. Winther KH, Watt T, Bjorner JB, Cramon P, Feldt-Rasmussen U, Gluud C, et al. The chronic autoimmune thyroiditis quality of life selenium trial (CATALYST): study protocol for a randomized controlled trial. Trials 2014; 15:115. doi: 10.1186/1745-6215-15-115 PMID: 24716668