PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases

Oncotarget

Volumn 8, Issue 14, 2017, Pages 23529-23538

  Ziv, Etay ^a   Bergen, Michael ^b   Yarmohammadi, Hooman ^a   Boas, F Ed ^a   Petre, E Nadia ^a   Sofocleous, Constantinos T ^a   Yaeger, Rona ^a   Solit, David B ^a   Solomon, Stephen B ^a   Erinjeri, Joseph P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b MOUNT SINAI HOSPITAL   (United States)

Author keywords

Biomarkers; Colorectal; MAPK; PI3K; Radioembolization

Indexed keywords

ANALGESIC AGENT; ANTIBIOTIC AGENT; B RAF KINASE; BEVACIZUMAB; CETUXIMAB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; OMEPRAZOLE; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; SUCRALFATE;

ADULT; AGED; AKT1 GENE; ARTICLE; BRAF GENE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER MORTALITY; CANCER PATIENT; CANCER RADIOTHERAPY; CHOLANGITIS; COHORT ANALYSIS; COLORECTAL LIVER METASTASIS; FEMALE; GENE; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN TISSUE; INCIDENCE; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MEK1 GENE; MUTATIONAL ANALYSIS; ONCOGENE K RAS; ONCOGENE N RAS; OUTCOME ASSESSMENT; PAIN; PIK3CA GENE; PREDICTION; RADIOEMBOLIZATION; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; ARTIFICIAL EMBOLIZATION; COLORECTAL NEOPLASMS; DISEASE COURSE; GENETICS; LIVER NEOPLASMS; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; PATHOLOGY; PROCEDURES; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RADIOTHERAPY; SECONDARY; STATISTICS AND NUMERICAL DATA; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; EMBOLIZATION, THERAPEUTIC; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; OUTCOME ASSESSMENT (HEALTH CARE); PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY; RETROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 85017035090     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15278     Document Type: Article

References (39)

1. Siegel RL, Miller KD and Jemal A. Cancer statistics, 2016. CA: a cancer journal for clinicians. 2016; 66:7-30.
2. Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I and Van Cutsem E. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. The New England journal of medicine. 2004; 351:337-345.
3. De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, Penault-Llorca F, Rougier P, Vincenzi B, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. The Lancet Oncology. 2010; 11:753-762.
4. Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, et al. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer. 2014; 120:1482-1490.
5. Barault L, Veyrie N, Jooste V, Lecorre D, Chapusot C, Ferraz JM, Lievre A, Cortet M, Bouvier AM, Rat P, Roignot P, Faivre J, Laurent-Puig P, et al. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. International journal of cancer. 2008; 122:2255-2259.
6. Fumagalli D, Gavin PG, Taniyama Y, Kim SI, Choi HJ, Paik S and Pogue-Geile KL. A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes. BMC cancer. 2010; 10:101.
7. Therkildsen C, Bergmann TK, Henrichsen-Schnack T, Ladelund S and Nilbert M. The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis. Acta oncologica (Stockholm, Sweden). 2014; 53:852-864.
8. Kato S, Iida S, Higuchi T, Ishikawa T, Takagi Y, Yasuno M, Enomoto M, Uetake H and Sugihara K. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer. 2007; 121:1771-1778.
9. Phipps AI, Buchanan DD, Makar KW, Win AK, Baron JA, Lindor NM, Potter JD and Newcomb PA. KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers. British journal of cancer. 2013; 108:1757-1764.
10. Lewandowski RJ, Memon K, Mulcahy MF, Hickey R, Marshall K, Williams M, Salzig K, Gates VL, Atassi B, Vouche M, Atassi R, Desai K, Hohlastos E, et al. Twelveyear experience of radioembolization for colorectal hepatic metastases in 214 patients: survival by era and chemotherapy. European journal of nuclear medicine and molecular imaging. 2014; 41:1861-1869.
11. Hickey R, Lewandowski RJ, Prudhomme T, Ehrenwald E, Baigorri B, Critchfield J, Kallini J, Gabr A, Gorodetski B, Geschwind JF, Abbott A, Shridhar R, White SB, et al. 90Y Radioembolization of Colorectal Hepatic Metastases Using Glass Microspheres: Safety and Survival Outcomes from a 531-Patient Multicenter Study. Journal of nuclear medicine. 2016; 57:665-671.
12. Sofocleous CT, Violari EG, Sotirchos VS, Shady W, Gonen M, Pandit-Taskar N, Petre EN, Brody LA, Alago W, Do RK, D'Angelica MI, Osborne JR, Segal NH, et al. Radioembolization as a Salvage Therapy for Heavily Pretreated Patients With Colorectal Cancer Liver Metastases: Factors That Affect Outcomes. Clinical colorectal cancer. 2015; 14:296-305.
13. Cosimelli M, Golfieri R, Cagol PP, Carpanese L, Sciuto R, Maini CL, Mancini R, Sperduti I, Pizzi G, Diodoro MG, Perrone M, Giampalma E, Angelelli B, et al. Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastases. British journal of cancer. 2010; 103:324-331.
14. Kennedy AS, Ball DS, Cohen SJ, Cohn M, Coldwell DM, Drooz A, Ehrenwald E, Kanani S, Nutting CW, Moeslein FM, Putnam SG, 3rd, Rose SC, Savin MA, et al. Hepatic imaging response to radioembolization with yttrium-90-labeled resin microspheres for tumor progression during systemic chemotherapy in patients with colorectal liver metastases. Journal of gastrointestinal oncology. 2015; 6:594-604.
15. Boas FE, Brody LA, Erinjeri JP, Yarmohammadi H, Shady W, Kishore S and Sofocleous CT. Quantitative Measurements of Enhancement on Preprocedure Triphasic CT Can Predict Response of Colorectal Liver Metastases to Radioembolization. AJR Am J Roentgenol. 2016:1-5.
16. Narsinh KH, Van Buskirk M, Kennedy AS, Suhail M, Alsaikhan N, Hoh CK, Thurston K, Minocha J, Ball DS, Cohen SJ, Cohn M, Coldwell DM, Drooz A, et al. Hepatopulmonary Shunting: A Prognostic Indicator of Survival in Patients with Metastatic Colorectal Adenocarcinoma Treated with 90Y Radioembolization. Radiology. 2016:152100.
17. Lahti SJ, Xing M, Zhang D, Lee JJ, Magnetta MJ and Kim HS. KRAS Status as an Independent Prognostic Factor for Survival after Yttrium-90 Radioembolization Therapy for Unresectable Colorectal Cancer Liver Metastases. Journal of vascular and interventional radiology. 2015; 26:1102-1111.
18. Lipsyc M and Yaeger R. Impact of somatic mutations on patterns of metastasis in colorectal cancer. Journal of gastrointestinal oncology. 2015; 6:645-649.
19. Yaeger R, Cowell E, Chou JF, Gewirtz AN, Borsu L, Vakiani E, Solit DB, Rosen N, Capanu M, Ladanyi M and Kemeny N. RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer. Cancer. 2015; 121:1195-1203.
20. Duldulao MP, W. L, Nelson RA, Li W, Chen Z, Kim J and Garcia-Aguilar J. Mutations in specific codons of the KRAS oncogene are associated with variable resistance to neoadjuvant chemoradiation therapy in patients with rectal adenocarcinoma. Annals of surgical oncology. 2013; 20:2166-2171.
21. Kim IA, S.S. B, Fernandes A, Wu J, Muschel RJ, McKenna WG, Birnbaum MJ and Bernhard EJ. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer research. 2005; 65:7902-7910.
22. Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C and Schultz N. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Science signaling. 2013; 6:pl1.
23. He Y, Van't Veer LJ, Mikolajewska-Hanclich I, van Velthuysen ML, Zeestraten EC, Nagtegaal ID, van de Velde CJ and Marijnen CA. PIK3CA mutations predict local recurrences in rectal cancer patients. Clinical cancer research. 2009; 15:6956-6962.
24. He Y, Van't Veer LJ, Lopez-Yurda M, van de Velde CJ and Marijnen CA. Do rectal cancer patients with PIK3CA mutations benefit from preoperative radiotherapy with regard to local recurrences? Clinical cancer research. 2010; 16:6179.
25. Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nature communications. 2016; 7:11428.
26. Krasilnikov M, Adler V, Fuchs SY, Dong Z, Haimovitz-Friedman A, Herlyn M and Ronai Z. Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells. Molecular carcinogenesis. 1999; 24:64-69.
27. Jiang Z, Pore N, Cerniglia GJ, Mick R, Georgescu MM, Bernhard EJ, Hahn SM, Gupta AK and Maity A. Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. Cancer research. 2007; 67:4467-4473.
28. Mendoza MC, Er EE and Blenis J. The Ras-ERK and PI3KmTOR pathways: cross-talk and compensation. Trends Biochem Sci. 2011; 36:320-328.
29. Chen YH, Wei MF, Wang CW, Lee HW, Pan SL, Gao M, Kuo SH, Cheng AL and Teng CM. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. Cancer Lett. 2015; 357:582-590.
30. Normanno N, Rachiglio AM, Lambiase M, Martinelli E, Fenizia F, Esposito C, Roma C, Troiani T, Rizzi D, Tatangelo F, Botti G, Maiello E, Colucci G, et al. Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial. Annals of oncology. 2015; 26:1710-1714.
31. Sylvester BE and Vakiani E. Tumor evolution and intratumor heterogeneity in colorectal carcinoma: insights from comparative genomic profiling of primary tumors and matched metastases. Journal of gastrointestinal oncology. 2015; 6:668-675.
32. Yueh AE, Payne SN, Leystra AA, Van De Hey DR, Foley TM, Pasch CA, Clipson L, Matkowskyj KA and Deming DA. Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. PloS one. 2016; 11.
33. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C and Seruca R. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC cancer. 2008; 8:255.
34. Whitehall VL, Rickman C, Bond CE, Ramsnes I, Greco SA, Umapathy A, McKeone D, Faleiro RJ, Buttenshaw RL, Worthley DL, Nayler S, Zhao ZZ, Montgomery GW, et al. Oncogenic PIK3CA mutations in colorectal cancers and polyps. International journal of cancer. 2012; 131:813-820.
35. Brannon AR, Vakiani E, Sylvester BE, Scott SN, McDermott G, Shah RH, Kania K, Viale A, Oschwald DM, Vacic V, Emde AK, Cercek A, Yaeger R, et al. Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. Genome Biol. 2014; 15:454.
36. Rekhtman N, Paik P, Arcila ME, Tafe LJ, Oxnard GR, Moreira AL, Travis WD, Zakowski MF, Kris MG and Ladanyi M. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clinical cancer research. 2012; 18:1167-1176.
37. Cheng DT, Mitchell TN, Zehir A, Shah RH, Benayed R, Syed A, Chandramohan R, Liu ZY, Won HH, Scott SN, Brannon AR, O'Reilly C, Sadowska J, et al. Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. The Journal of molecular diagnostics. 2015; 17:251-264.
38. Omary RA, Bettmann MA, Cardella JF, Bakal CW, Schwartzberg MS, Sacks D, Rholl KS, Meranze SG and Lewis CA. Quality improvement guidelines for the reporting and archiving of interventional radiology procedures. Journal of vascular and interventional radiology. 2003; 14:S293-295.
39. Fine J and Gray R. A proportional hazards model for the subdistribution of a competing risk. Journal of the American Statistical Association. 1999; 94:496-509.