Multiclonal expansion of klebsiella pneumoniae isolates producing NDM-1 in Rio de Janeiro, Brazil

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 4, 2017, Pages

  Aires, Caio Augusto Martins ^a   Pereira, Polyana Silva ^a   De Araujo, Carlos Felipe Machado ^a   Chagas, Thiago Pavoni Gomes ^a   Oliveira, Jane Cleide Ribeiro ^b   Buonora, Sibelle Nogueira ^c   Albano, Rodolpho Mattos ^d   Carvalho Assef, Ana Paula D'Alincourt ^a   Asensi, Marise Dutra ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Laboratório Central de Saúde Pública Noel Nutels LACEN RJ   (Brazil)

^c Secretaria Estadual de Saúde ^*  (Brazil)

^d STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Klebsiella pneumoniae; MLST; Molecular typing; NDM carbapenemase; New Delhi metallo lactamase

Indexed keywords

AMIKACIN; AZTREONAM; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COTRIMOXAZOLE; ERTAPENEM; FOSFOMYCIN TROMETAMOL; GENTAMICIN; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; NUCLEASE S1; PIPERACILLIN PLUS TAZOBACTAM; POLYMYXIN B; TIGECYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE NDM-1; FOSFOMYCIN; MINOCYCLINE; TRANSPOSON;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENETICS; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; BRAZIL; GENOTYPE; HUMAN; KLEBSIELLA PNEUMONIAE; MOLECULAR CLONING; MOLECULAR HYBRIDIZATION; MULTILOCUS SEQUENCE TYPING; NEW DELHI METALLO BETA LACTAMASE 1 PRODUCING KLEBSIELLA PNEUMONIAE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; ANALOGS AND DERIVATIVES; BACTERIUM IDENTIFICATION; CELL CLONE; CHEMISTRY; CLASSIFICATION; DRUG EFFECTS; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; METABOLISM; MICROBIOLOGY; MULTIDRUG RESISTANCE; PHYLOGENY; PLASMID; TRANSMISSION; TRANSPOSON;

AMIKACIN; ANTI-BACTERIAL AGENTS; BACTERIAL TYPING TECHNIQUES; BETA-LACTAMASES; BRAZIL; CLONE CELLS; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; FOSFOMYCIN; GENE EXPRESSION; GENOTYPE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MINOCYCLINE; MULTILOCUS SEQUENCE TYPING; PHYLOGENY; PLASMIDS; POLYMYXIN B;

EID: 85017010227     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01048-16     Document Type: Article

References (39)

1. NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53:5046-5054. https://doi.org/10.1128/AAC.00774-09.
2. Nordmann P, Poirel L, Mark AT, Timothy RW. 2011. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? J Antimicrob Chemother 66:689-692. https://doi.org/10.1093/jac/dkq520.
3. Nordmann P, Poirel L. 2014. The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. Clin Microbiol Infect 20:821-830. https://doi.org/10.1111/1469-0691.12719.
4. Carvalho-Assef APD, Pereira PS, Albano RM, Berião GC, Chagas TPG, Timm LN, Da Silva RCF, Falci DR, Asensi MD. 2013. Isolation of NDM-producing Providencia rettgeri in Brazil. J Antimicrob Chemother 68:2956-2957. https://doi.org/10.1093/jac/dkt298.
5. Carvalho-Assef APD, Pereira PS, Albano RM, Berião GC, Tavares CP, Chagas TPG, Marques EA, Timm LN, Da Silva RCF, Falci DR, Asensi MD. 2014. Detection of NDM-1-, CTX-M-15-, and qnrB4-producing Enterobacter hormaechei isolates in Brazil. Antimicrob Agents Chemother 58:2475-2476. https://doi.org/10.1128/AAC.02804-13.
6. Rozales FP, Ribeiro VB, Magagnin CM, Pagano M, Lutz L, Falci DR, Machado A, Barth AL, Zavascki AP. 2014. Emergence of NDM-1-producing Enterobacteriaceae in Porto Alegre, Brazil. Int J Infect Dis 25:79-81. https://doi.org/10.1016/j.ijid.2014.01.005.
7. Carneiro M, Gonçalves RA, de Souza JG, Teixeira CB, Krummenauer EC, Machado JAA, Waib LF, Pina Trench FJ. 2014. New carbapenases in Brazil. Expert Rev Anti Infect Ther 12:155-156. https://doi.org/10.1586/14787210.2014.867804.
8. Pereira PS, Albano RM, Asensi MD, Carvalho-Assef APD. 2015. Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil. Mem Inst Oswaldo Cruz 110:580-582.
9. Brisse S, Passet V, Grimont PA. 2014. Description of Klebsiella quasipneumoniae sp. nov., isolated from human infections, with two subspecies, Klebsiella quasipneumoniae subsp. quasipneumoniae subsp. nov. and Klebsiella quasipneumoniae subsp. similipneumoniae subsp. nov., and demonstration that Klebsiella singaporensis is a junior heterotypic synonym of Klebsiella variicola. Int J Syst Evol Microbiol 64:3146-3152. https://doi.org/10.1099/ijs.0.062737-0.
10. Agência Nacional de Vigilância Sanitária (ANVISA). 2013. Medidas de prevenção e controle de infecções por enterobactérias multiresistentes. Nota Técnica 01/2013. ANVISA. Brasília, Brazil.
11. Clinical and Laboratory Standards Institute. 2015. Performance standards for antimicrobial susceptibility testing; 25th informational supplement. Document M100-S25. Clinical and Laboratory Standards Institute, Wayne, PA.
12. NDM-1-positive Enterobacteriaceae. Antimicrob Agents Chemother 55:5403-5407. https://doi.org/10.1128/AAC.00585-11.
13. Monteiro J, Widen RH, Pignatari ACC, Kubasek C, Silbert S. 2012. Rapid detection of carbapenemase genes by multiplex real-time PCR. J Antimicrob Chemother 67:906-909. https://doi.org/10.1093/jac/dkr563.
14. Mulvey MR, Soule G, Boyd D, Demczuk W, Ahmed R. 2003. Characterization of the first extended-spectrum β-lactamase-producing Salmonella isolate identified in Canada. J Clin Microbiol 41:460-462. https://doi.org/10.1128/JCM.41.1.460-462.2003.
15. Hasman H, Mevius D, Veldman K, Olesen I, Aarestrup FM. 2005. β-Lactamases among extended-spectrum β-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in the Netherlands. J Antimicrob Chemother 56:115-121. https://doi.org/10.1093/jac/dki190.
16. Cattoir V, Poirel L, Rotimi V, Soussy CJ, Nordmann P. 2007. Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 60:394-397. https://doi.org/10.1093/jac/dkm204.
17. Enne VI, Delsol AA, Roe JM, Bennett PM. 2006. Evidence of antibiotic resistance gene silencing in Escherichia coli. Antimicrob Agents Chemother 50:3003-3010. https://doi.org/10.1128/AAC.00137-06.
18. Díaz P, Bello H, Domínguez M, Trabal N, Mella S, Zemelman R, González G. 2004. Resistance to gentamicin, amikacin and ciprofloxacin among nosocomial isolates of Klebsiella pneumoniae subspecie pneumoniae producing extended spectrum β-lactamases. Rev Med Chile 132:1173-1178. (In Spanish.)
19. Melano R, Corso A, Petroni A, Centrón D, Orman B, Pereyra A, Moreno N, Galas M. 2003. Multiple antibiotic-resistance mechanisms including a novel combination of extended-spectrum β-lactamases in a Klebsiella pneumoniae clinical strain isolated in Argentina. J Antimicrob Chemother 52:36-42. https://doi.org/10.1093/jac/dkg281.
20. Warburg G, Hidalgo-Grass C, Partridge SR, Tolmasky ME, Temper V, Moses AE, Block C, Strahilevitz J. 2012. A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6′)-Ib. J Antimicrob Chemother 67:898-901. https://doi.org/10.1093/jac/dkr552.
21. Fritsche TR, Castanheira M, Miller GH, Jones RN, Armstrong ES. 2008. Detection of methyltransferases conferring high-level resistance to aminoglycosides in enterobacteriaceae from Europe, North America, and Latin America. Antimicrob Agents Chemother 52:1843-1845. https://doi.org/10.1128/AAC.01477-07.
22. Castanheira M, Fritsche TR, Sader HS, Jones RN. 2008. RmtD 16S RNA methylase in epidemiologically unrelated SPM-1-producing Pseudomonas aeruginosa isolates from Brazil. Antimicrob Agents Chemother 52:1587-1588. https://doi.org/10.1128/AAC.01502-07.
23. Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P. 2009. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 4(3):e4982. https://doi.org/10.1371/journal.pone.0004982.
24. Lafeuille E, Decré D, Mahjoub-Messai F, Bidet P, Arlet G, Bingen E. 2013. OXA-48 carbapenemase-producing Klebsiella pneumoniae isolated from Libyan patients. Microb Drug Resist 19:491-497. https://doi.org/10.1089/mdr.2012.0219.
25. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. 2008. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis 62:1-6. https://doi.org/10.1016/j.diagmicrobio.2008.04.007.
26. Ma L-C, Fang C-T, Lee C-Z, Shun C-T, Wang J-T. 2005. Genomic heterogeneity in Klebsiella pneumoniae strains is associated with primary pyogenic liver abscess and metastatic infection. J Infect Dis 192:117-128. https://doi.org/10.1086/430619.
27. Fang C-T, Chuang Y-P, Shun C-T, Chang S-C, Wang J-T. 2004. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 199:697-705. https://doi.org/10.1084/jem.20030857.
28. Chou H, Lee C, Ma L, Fang C, Chang S, Wang J. 2004. Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection. Infect Immun 72:3783-3792.
29. Bachman MA, Oyler JE, Burns SH, Caza M, Lépine F, Dozois CM, Weiser JN. 2011. Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2. Infect Immun 79:3309-3316. https://doi.org/10.1128/IAI.05114-11.
30. Shon AS, Bajwa RP, Russo TA. 2013. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4:107-118. https://doi.org/10.4161/viru.22718.
31. European Committee on Antimicrobial Susceptibility Testing. 2015. Breakpoint tables for interpretation of MICs and zone diameters, version 5.0. European Committee on Antimicrobial Susceptibility Testing, Växjö, Sweden. http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST-files/Breakpoint-tables/v-5.0-Breakpoint-Table-01.pdf.
32. Nordmann P, Naas T, Poirel L. 2011. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17:1791-1798. https://doi.org/10.3201/eid1710.110655.
33. Pereira PS, Borghi M, Albano RM, Lopes JCO, Silveira MC, Marques EA, Oliveira JCR, Asensi MD, Carvalho-Assef APD. 2015. Coproduction of NDM-1 and KPC-2 in Enterobacter hormaechei from Brazil. Microb Drug Resist 21:234-236. https://doi.org/10.1089/mdr.2014.0171.
34. Pereira PS, de Araujo CFM, Seki LM, Zahner V, Carvalho-Assef APD, Asensi MD. 2013. Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother 68:312-316. https://doi.org/10.1093/jac/dks396.
35. Pitout JDD, Nordmann P, Poirel L. 2015. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob Agents Chemother 59:5873-5884. https://doi.org/10.1128/AAC.01019-15.
36. Jin Y, Shao C, Li J, Fan H, Bai Y, Wang Y. 2015. Outbreak of multidrug resistant NDM-1-producing Klebsiella pneumoniae from a neonatal unit in Shandong Province, China. PLoS One 10:e0119571. https://doi.org/10.1371/journal.pone.0119571.
37. Baraniak A, Izdebski R, Fiett J, Gawryszewska I, Bojarska K, Herda M, Literacka E, Zabicka D, Tomczak H, Pewiñska N, Szarata M, Ozorowski T, Milner A, Hryniewicz W, Gniadkowski M. 2016. NDM-producing Enterobacteriaceae in Poland, 2012-14: inter-regional outbreak of Klebsiella pneumoniae ST11 and sporadic cases. J Antimicrob Chemother 71:85-91. https://doi.org/10.1093/jac/dkv282.
38. Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, Chaudhary U, Doumith M, Giske CG, Irfan S, Krishnan P, Kumar AV, Maharjan S, Mushtaq S, Noorie T, Paterson DL, Pearson A, Perry C, Pike R, Rao B, Ray U, Sarma JB, Sharma M, Sheridan E, Thirunarayan MA, Turton J, Upadhyay S, Warner M, Welfare W, Livermore DM, Woodford N. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597-602. https://doi.org/10.1016/S1473-3099(10)70143-2.
39. Campos JC, da Silva MJF, dos Santos PRN, Barros EM, Pereira MDO, Seco BMS, Magagnin CM, Leiroz LK, de Oliveira TGM, de Faria C, Cerdeira LT, Barth AL, Sampaio SCF, Zavascki AP, Poirel L, Sampaio JLM. 2015. Characterization of Tn3000, a transposon responsible for blaNDM-1 dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco and India. Antimicrob Agents Chemother 59:7387-7395. https://doi.org/10.1128/AAC.01458-15.