Performance and economic evaluation of the molecular detection of pathogens for patients with severe infections: the EVAMICA open-label, cluster-randomised, interventional crossover trial

Intensive Care Medicine

Volumn 43, Issue 11, 2017, Pages 1613-1625

  Cambau, Emmanuelle ^a,b   Durand Zaleski, Isabelle ^c,d   Bretagne, Stéphane ^a,b,e,f   Brun Buisson, Christian ^e   Cordonnier, Catherine ^e   Duval, Xavier ^a   Herwegh, Stéphanie ^g   Pottecher, Julien ^h   Courcol, René ^g   Bastuji Garin, Sylvie ^e,i   Lefort, Agnès ^j   Mantz, Jean ^j   Pease, Sébastien ^j   Lavagna, Leïla ^j   Nicolas Chanoine, Marie Hélène ^j   Leflon, Véronique ^j   Marcon, Estelle ^j   Ruimy, Raymond ^j   Andremont, Antoine ^j   Lebras, Jacques ^j   Iung, Bernard ^j   Regnier, Bernard ^j   Yeni, Patrick ^j   Montravers, Philippe ^j   Mourvillier, Bruno ^j   Ilic Habensus, Emila ^j   Talbi, Nadia El Alami ^j   Lasocki, Sigismond ^j   Bouscary, Didier ^j   Mira, Jean Paul ^j   Grimaldi, David ^j   Marin, Nathalie ^j   Doloy, Alexandra ^j   Poyart, Claire ^j   Scherrer, Emmanuel ^j   Chambon Pautas, Cecile ^j   Cook, Fabrice ^j   Mekontso Dessap, Armand ^j   Schortgen, Frédérique ^j   Chedevergne, Karine ^j   Vernant, Jean Paul ^j   Gauvin Bodin, Liliane ^j   Trouillet, Jean Louis ^j   Chastre, Jean ^j   Bricaire, François ^j   Brossier, Florence ^j   Jarlier, Vincent ^j   Dheder, Nathalie ^j   Nieszkowska, Ania ^j   Datry, Annick ^j   Fekkar, Arnaud ^j   Buffet, Pierre ^j   Mazier, Rommy ^j   Brun, Sophie ^j   Meyssonnier, Vanina ^j   Isnard, Françoise ^j   Baudel, Jean Luc ^j   Meynard, Jean Luc ^j   Petit, Jean Claude ^j   Lalande, Valérie ^j   Roux, Patricia ^j   Raffoux, Emmanuel ^j   Ribaud, Patricia ^j   Das, Vincent ^j   Schlemmer, Benoit ^j   Azoulay, Elie ^j   Chimot, Loic ^j   Molina, Jean Michel ^j   Ponscarme, Diane ^j   Pavie, Juliette ^j   Simon, François ^j   Casin, Isabelle ^j   Menotti, Jean ^j   Gruson, Didier ^j   Bessède, Emilie ^j   Guilhon, Emmanuelle ^j   Accoceberry, Isabelle ^j   Millet, Pascal ^j   Bébéar, Cécile ^j   Berthoux, Christian ^j   Tonnelier, Jean Marie ^j   Garre, Michel ^j   Hery Arnaud, Geneviève ^j   Payan, Christopher ^j   Nevez, Gilles ^j   Timsit, Jean Francois ^j   Cahn, Jean Yves ^j   Brion, Jean Paul ^j   Le beau, Bernard ^j   Courby, Stephane ^j   Pelloux, Hervé ^j   Maurin, Max ^j   Epaulard, Olivier ^j   Hamidfar, Rebecca ^j   Berthon, Céline ^j   Coiteux, Valérie ^j   Terriou, Louis ^j   Nseir, Saadalla ^j   Auffray, Jean Luc ^j   Jouet, Jean Pierre ^j   Durocher, Alain ^j   Faure, Karine ^j   Clavel, Marc ^j   Camus, Daniel ^j   Dugard, Anthony ^j   Tisseuil, Chantal ^j   Duchiron, Cécile ^j   Ajzenberg, Daniel ^j   Bordessoule, Dominique ^j   Garnier, Fabien ^j   François, Bruno ^j   Ploy, Marie Cécile ^j   Darde, Marie Laure ^j   Chaury, Marie Pierre ^j   Giraud, Stephane ^j   Jaccard, Arnaud ^j   Moreau, Stéphane ^j   Réménieras, Liliane ^j   Touati, Mohamed ^j   Turlure, Pascal ^j   Amiel, Jean Bernard ^j   Pichon, Nicolas ^j   Postil, Déborah ^j   Vignon, Philippe ^j   Espinouse, Daniel ^j   Jacques, Didier ^j   De Monbrison, Frédérique ^j   Grozel, Jean Michel ^j   Chomarat, Monique ^j   Gueugniaud, Pierre Yves ^j   Sanogo, Rokiatou ^j   Drancourt, Michel ^j   Fournier, Pierre Edouard ^j   Roux, Véronique ^j   Delmer, Alain ^j   Himberlin, Chantal ^j   Kolb, Brigitte ^j   Lé, Quoc Hung ^j   Appriou, Morgane ^j   Cousson, Joël ^j   Nazeyrollas, Pierre ^j   Strady, Christophe ^j   Dechamps, Christophe ^j   Vernet, Véronique ^j   Toubas, Dominique ^j   Guyotat, Denis ^j   Auboyer, Christian ^j   Zeni, Fabrice ^j   Alamartine, Eric ^j   Cathebras, Pascal ^j   Lucht, Frédéric ^j   Viallon, Alain ^j   Melis, Adrien ^j   Ros, Alain ^j   Carricajo, Anne ^j   Devanlay, Camille ^j   Labruyere, Carine ^j   Vautrin, Catherine ^j   Cazorla, Céline ^j   Tavernier, Emmanuelle ^j   Grattard, Florence ^j   Aubert, Gérald ^j   Morel, Jerome ^j   Cornillon, Jérome ^j   Abba, Karima ^j   Flori, Pierre ^j   Sung, Roger Tran Manh ^j   Pozzetto, Bruno ^j   Schneider, Francis ^j   Hansmann, Yves ^j   Herbrecht, Raoul ^j   Jaulhac, Benoit ^j   Piémont, Yves ^j   Lestcher, Valérie ^j   Colombat, Philippe ^j   Senecal, Delphine ^j   Garot, Denis ^j   Perrottin, Dominique ^j   Besnier, Jean Marc ^j   Goudeau, Alain ^j   Lanotte, Philippe ^j   Chandenier, Jacques ^j   Baloul, Samia ^j   Corbel, Céline ^j   Dabbech, Moufida ^j   Gaba, Mabel ^j   Jozefowicz, Elsa ^j   Lafaye, Magali ^j   Maugard, Fabien ^j   Rabeuf, Remi ^j   Rabetrano, Hasina ^j   Veerabudun, Kalaivani ^j   Viallette, Cédric ^j   Stahl, Jean Paul ^j   Delhaes, Laurence ^j   more..

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c APHP URC ECO   (France)

^d FACULTÉ DE MÉDECINE   (France)

^e HENRI MONDOR HOSPITAL   (France)

^f INSTITUT PASTEUR   (France)

^g LILLE UNIVERSITY HOSPITAL   (France)

^h HÔPITAL DE HAUTEPIERRE   (France)

ⁱ UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^j Microbiology Institute ^*

more..

Author keywords

Aetiological source; Bacteremia; PCR; Sepsis

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; BETA LACTAM ANTIBIOTIC; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; ANTIFUNGAL THERAPY; ARTICLE; ASPERGILLUS; BACTERIAL ENDOCARDITIS; CANDIDA; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CROSSOVER PROCEDURE; FEBRILE NEUTROPENIA; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOSPITAL COST; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROORGANISM DETECTION; MULTICENTER STUDY; NONHUMAN; OPEN STUDY; RANDOMIZED CONTROLLED TRIAL; SEPSIS; BLOOD; CLINICAL TRIAL; COST BENEFIT ANALYSIS; ECONOMICS; ENDOCARDITIS; HOSPITAL MORTALITY; INTENSIVE CARE UNIT; INTENTION TO TREAT ANALYSIS; MIDDLE AGED; MOLECULAR DIAGNOSIS; MORTALITY; RETROSPECTIVE STUDY; RISK FACTOR; STATISTICS AND NUMERICAL DATA; TIME FACTOR; TIME TO TREATMENT; TOTAL QUALITY MANAGEMENT;

AGED; ANTI-BACTERIAL AGENTS; COST-BENEFIT ANALYSIS; CROSS-OVER STUDIES; ENDOCARDITIS; FEBRILE NEUTROPENIA; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; QUALITY IMPROVEMENT; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; TIME FACTORS; TIME-TO-TREATMENT;

EID: 85016969127     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-017-4766-4     Document Type: Article

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