메뉴 건너뛰기




Volumn 122, Issue 4, 2017, Pages 795-808

Adenosine receptor-dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CARBON DIOXIDE; OXYGEN; THEOPHYLLINE;

EID: 85016967202     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00840.2016     Document Type: Article
Times cited : (23)

References (71)
  • 1
    • 0018235464 scopus 로고
    • Phosphorylation of smooth muscle myosin catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase
    • Adelstein R, Conti M. Phosphorylation of smooth muscle myosin catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase. J Biol Chem 253: 8347-8350, 1978.
    • (1978) J Biol Chem , vol.253 , pp. 8347-8350
    • Adelstein, R.1    Conti, M.2
  • 2
    • 84866985432 scopus 로고
    • Influence of sympathoexcitation at high altitude on cerebro-vascular function and ventilatory control in humans
    • Ainslie PN, Lucas SJE, Fan J-L, Thomas KN, Cotter JD, Tzeng YC, Burgess KR. Influence of sympathoexcitation at high altitude on cerebro-vascular function and ventilatory control in humans. J Appl Physiol (1985) 113: 1058-1067, 2012. doi:10.1152/japplphysiol.00463.2012.
    • (1985) J Appl Physiol , vol.113 , pp. 1058-1067
    • Ainslie, P.N.1    Lucas, S.J.E.2    Fan, J.-L.3    Thomas, K.N.4    Cotter, J.D.5    Tzeng, Y.C.6    Burgess, K.R.7
  • 3
    • 84893940541 scopus 로고    scopus 로고
    • Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
    • Ainslie PN, Shaw AD, Smith KJ, Willie CK, Ikeda K, Graham J, Macleod DB. Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia. Clin Sci (Lond) 126: 661-670, 2014. doi: 10.1042/CS20130343.
    • (2014) Clin Sci (Lond) , vol.126 , pp. 661-670
    • Ainslie, P.N.1    Shaw, A.D.2    Smith, K.J.3    Willie, C.K.4    Ikeda, K.5    Graham, J.6    Macleod, D.B.7
  • 4
    • 84903637736 scopus 로고    scopus 로고
    • Cerebral blood flow at high altitude
    • Ainslie PN, Subudhi AW. Cerebral blood flow at high altitude. High Alt Med Biol 15: 133-140, 2014. doi: 10.1089/ham.2013.1138.
    • (2014) High Alt Med Biol , vol.15 , pp. 133-140
    • Ainslie, P.N.1    Subudhi, A.W.2
  • 5
    • 0016224631 scopus 로고
    • Release of adenosine from ischemic brain: Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides
    • Berne RM, Rubio R, Curnish RR. Release of adenosine from ischemic brain: effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 35: 262-271, 1974. doi: 10.1161/01.RES.35.2.262.
    • (1974) Circ Res , vol.35 , pp. 262-271
    • Berne, R.M.1    Rubio, R.2    Curnish, R.R.3
  • 6
    • 38349008907 scopus 로고
    • Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans
    • Binks AP, Cunningham VJ, Adams L, Banzett RB. Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans. J Appl Physiol (1985) 104: 212-217, 2008. doi:10.1152/japplphysiol.00069.2007.
    • (1985) J Appl Physiol , vol.104 , pp. 212-217
    • Binks, A.P.1    Cunningham, V.J.2    Adams, L.3    Banzett, R.B.4
  • 7
    • 0023683618 scopus 로고
    • Theophylline effect on the cerebral blood flow response to hypoxemia
    • Bowton DL, Haddon WS, Prough DS, Adair N, Alford PT, Stump DA. Theophylline effect on the cerebral blood flow response to hypoxemia. Chest 94: 371-375, 1988. doi: 10.1378/chest.94.2.371.
    • (1988) Chest , vol.94 , pp. 371-375
    • Bowton, D.L.1    Haddon, W.S.2    Prough, D.S.3    Adair, N.4    Alford, P.T.5    Stump, D.A.6
  • 9
    • 0014116349 scopus 로고
    • Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man
    • Cohen PJ, Alexander SC, Smith TC, Reivich M, Wollman H. Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J Appl Physiol 23: 183-189, 1967.
    • (1967) J Appl Physiol , vol.23 , pp. 183-189
    • Cohen, P.J.1    Alexander, S.C.2    Smith, T.C.3    Reivich, M.4    Wollman, H.5
  • 10
    • 0019524369 scopus 로고
    • Intrasubject variation in sustained-release theophylline absorption
    • Dederich RA, Szefler SJ, Green ER. Intrasubject variation in sustained-release theophylline absorption. J Allergy Clin Immunol 67: 465-471, 1981. doi: 10.1016/0091-6749(81)90100-7.
    • (1981) J Allergy Clin Immunol , vol.67 , pp. 465-471
    • Dederich, R.A.1    Szefler, S.J.2    Green, E.R.3
  • 12
    • 0019603723 scopus 로고
    • Involvement of adenosine in cerebral hypoxic hyperemia in the dog
    • Emerson TE Jr, Raymond RM. Involvement of adenosine in cerebral hypoxic hyperemia in the dog. Am J Physiol Heart Circ Physiol 241: H134-H138, 1981.
    • (1981) Am J Physiol Heart Circ Physiol , vol.241 , pp. H134-H138
    • Emerson, T.E.1    Raymond, R.M.2
  • 13
    • 0022391705 scopus 로고
    • On the measurement of the mean velocity of blood flow over the cardiac cycle using doppler ultrasound
    • Evans DH. On the measurement of the mean velocity of blood flow over the cardiac cycle using Doppler ultrasound. Ultrasound Med Biol 11: 735-741, 1985. doi: 10.1016/0301-5629(85)90107-3.
    • (1985) Ultrasound Med Biol , vol.11 , pp. 735-741
    • Evans, D.H.1
  • 16
    • 0015394081 scopus 로고
    • The effect of intracarotid aminophylline infusion on the cerebral circulation
    • Gottstein U, Paulson OB. The effect of intracarotid aminophylline infusion on the cerebral circulation. Stroke 3: 560-565, 1972. doi: 10.1161/01.STR.3.5.560.
    • (1972) Stroke , vol.3 , pp. 560-565
    • Gottstein, U.1    Paulson, O.B.2
  • 17
    • 0019123056 scopus 로고
    • Indomethacin and inhibition of protein kinase reactions
    • Goueli SA, Ahmed K. Indomethacin and inhibition of protein kinase reactions. Nature 287: 171-172, 1980. doi: 10.1038/287171a0.
    • (1980) Nature , vol.287 , pp. 171-172
    • Goueli, S.A.1    Ahmed, K.2
  • 18
    • 0013804409 scopus 로고
    • Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures
    • Harper AM, Glass HI. Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures. J Neurol Neurosurg Psychiatry 28: 449-452, 1965. doi: 10.1136/jnnp.28.5.449.
    • (1965) J Neurol Neurosurg Psychiatry , vol.28 , pp. 449-452
    • Harper, A.M.1    Glass, H.I.2
  • 19
    • 84892605970 scopus 로고    scopus 로고
    • Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated cerebral vasodilation in young adults with metabolic syndrome
    • Harrell JW, Schrage WG. Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated cerebral vasodilation in young adults with metabolic syndrome. Am J Physiol Heart Circ Physiol 306: H261-H269, 2014. doi: 10.1152/ajpheart.00709.2013.
    • (2014) Am J Physiol Heart Circ Physiol , vol.306 , pp. H261-H269
    • Harrell, J.W.1    Schrage, W.G.2
  • 21
    • 0021321684 scopus 로고
    • The role of adenosine in CBF increases during hypoxia in young vs aged rats
    • Hoffman WE, Albrecht RF, Miletich DJ. The role of adenosine in CBF increases during hypoxia in young vs aged rats. Stroke 15: 124-129, 1984. doi: 10.1161/01.STR.15.1.124.
    • (1984) Stroke , vol.15 , pp. 124-129
    • Hoffman, W.E.1    Albrecht, R.F.2    Miletich, D.J.3
  • 22
    • 84979895552 scopus 로고    scopus 로고
    • CrossTalk opposing view: The MCA diameter does change during alterations in arterial blood gases and blood pressure
    • Hoiland RL, Ainslie PN. CrossTalk opposing view: The MCA diameter does change during alterations in arterial blood gases and blood pressure. J Physiol 594: 4073-4075, 2016. doi: 10.1113/JP271981.
    • (2016) J Physiol , vol.594 , pp. 4073-4075
    • Hoiland, R.L.1    Ainslie, P.N.2
  • 25
    • 84974712299 scopus 로고    scopus 로고
    • Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: A role for prostaglandins?
    • Hoiland RL, Tymko MM, Bain AR, Wildfong KW, Monteleone B, Ainslie PN. Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins? J Physiol 594: 3463-3481, 2016. doi: 10.1113/JP272012.
    • (2016) J Physiol , vol.594 , pp. 3463-3481
    • Hoiland, R.L.1    Tymko, M.M.2    Bain, A.R.3    Wildfong, K.W.4    Monteleone, B.5    Ainslie, P.N.6
  • 26
    • 84897129339 scopus 로고    scopus 로고
    • Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude
    • Imray C, Chan C, Stubbings A, Rhodes H, Patey S, Wilson MH, Bailey DM, Wright AD; Birmingham Medical Research Expeditionary Society. Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude. High Alt Med Biol 15: 21-27, 2014. doi: 10.1089/ham.2013.1079.
    • (2014) High Alt Med Biol , vol.15 , pp. 21-27
    • Imray, C.1    Chan, C.2    Stubbings, A.3    Rhodes, H.4    Patey, S.5    Wilson, M.H.6    Bailey, D.M.7    Wright, A.D.8
  • 27
    • 0029875840 scopus 로고    scopus 로고
    • S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
    • Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380: 221-226, 1996. doi: 10.1038/380221a0.
    • (1996) Nature , vol.380 , pp. 221-226
    • Jia, L.1    Bonaventura, C.2    Bonaventura, J.3    Stamler, J.S.4
  • 28
    • 0018164636 scopus 로고
    • Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase
    • Kantor HS, Hampton M. Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase. Nature 276: 841-842, 1978. doi: 10.1038/276841a0.
    • (1978) Nature , vol.276 , pp. 841-842
    • Kantor, H.S.1    Hampton, M.2
  • 29
    • 0019726296 scopus 로고
    • Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase
    • Kerrick WG, Hoar PE. Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase. Nature 292: 253-255, 1981. doi: 10.1038/292253a0.
    • (1981) Nature , vol.292 , pp. 253-255
    • Kerrick, W.G.1    Hoar, P.E.2
  • 30
    • 84957352638 scopus 로고
    • The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men
    • Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27: 484-492, 1948. doi: 10.1172/JCI101995.
    • (1948) J Clin Invest , vol.27 , pp. 484-492
    • Kety, S.S.1    Schmidt, C.F.2
  • 31
    • 77956520929 scopus 로고    scopus 로고
    • The relationship between oxygen and adenosine in astrocytic cultures
    • Kulik TB, Aronhime SN, Echeverry G, Beylin A, Winn HR. The relationship between oxygen and adenosine in astrocytic cultures. Glia 58: 1335-1344, 2010.10.1002/glia.21011.
    • (2010) Glia , vol.58 , pp. 1335-1344
    • Kulik, T.B.1    Aronhime, S.N.2    Echeverry, G.3    Beylin, A.4    Winn, H.R.5
  • 33
    • 84901207743 scopus 로고
    • Effect of acute hypoxia on regional cerebral blood flow: Effect of sympathetic nerve activity
    • Lewis NCS, Messinger L, Monteleone B, Ainslie PN. Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity. J Appl Physiol (1985) 116: 1189-1196, 2014. doi:10.1152/japplphysiol.00114.2014.
    • (1985) J Appl Physiol , vol.116 , pp. 1189-1196
    • Lewis, N.C.S.1    Messinger, L.2    Monteleone, B.3    Ainslie, P.N.4
  • 34
    • 84947289919 scopus 로고
    • Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia
    • Liu X, Gebremedhin D, Harder DR, Koehler RC. Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia. J Appl Physiol (1985) 119: 1202-1209, 2015. doi:10.1152/japplphysiol.01043.2014.
    • (1985) J Appl Physiol , vol.119 , pp. 1202-1209
    • Liu, X.1    Gebremedhin, D.2    Harder, D.R.3    Koehler, R.C.4
  • 35
    • 77149177664 scopus 로고    scopus 로고
    • Influence of changes in blood pressure on cerebral perfusion and oxygenation
    • Lucas SJE, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55: 698-705, 2010. doi: 10.1161/HYPERTENSIONAHA.109.146290.
    • (2010) Hypertension , vol.55 , pp. 698-705
    • Lucas, S.J.E.1    Tzeng, Y.C.2    Galvin, S.D.3    Thomas, K.N.4    Ogoh, S.5    Ainslie, P.N.6
  • 36
    • 0017352925 scopus 로고
    • The effect of intraarterial administered aminophylline on cerebral hemodynamics in man
    • Magnussen I, Hoedt-Rasmussen K. The effect of intraarterial administered aminophylline on cerebral hemodynamics in man. Acta Neurol Scand 55: 131-136, 1977. doi: 10.1111/j.1600-0404.1977.tb05633.x.
    • (1977) Acta Neurol Scand , vol.55 , pp. 131-136
    • Magnussen, I.1    Hoedt-Rasmussen, K.2
  • 38
    • 52549112109 scopus 로고    scopus 로고
    • Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia
    • Miekisiak G, Kulik T, Kusano Y, Kung D, Chen J-F, Winn HR. Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia. J Cereb Blood Flow Metab 28: 1656-1664, 2008. doi: 10.1038/jcbfm.2008.57.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1656-1664
    • Miekisiak, G.1    Kulik, T.2    Kusano, Y.3    Kung, D.4    Chen, J.-F.5    Winn, H.R.6
  • 40
    • 0023224814 scopus 로고
    • Role of adenosine in regulation of cerebral blood flow: Effects of theophylline during normoxia and hypoxia
    • Morii S, Ngai AC, Ko KR, Winn HR. Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. Am J Physiol Heart Circ Physiol 253: H165-H175, 1987.
    • (1987) Am J Physiol Heart Circ Physiol , vol.253 , pp. H165-H175
    • Morii, S.1    Ngai, A.C.2    Ko, K.R.3    Winn, H.R.4
  • 41
  • 42
    • 0017729772 scopus 로고
    • Adenosine in rat cerebral cortex: Its determination, normal values, and correlation to AMP and cyclic AMP during shortlasting ischemia
    • Nordström CH, Rehncrona S, Siesjö BK, Westerberg E. Adenosine in rat cerebral cortex: its determination, normal values, and correlation to AMP and cyclic AMP during shortlasting ischemia. Acta Physiol Scand 101: 63-71, 1977. doi: 10.1111/j.1748-1716.1977.tb05984.x.
    • (1977) Acta Physiol Scand , vol.101 , pp. 63-71
    • Nordström, C.H.1    Rehncrona, S.2    Siesjö, B.K.3    Westerberg, E.4
  • 44
    • 0016687061 scopus 로고
    • Regional cerebral blood flow estimated by 133-xenon inhalation
    • Obrist WD, Thompson HK Jr, Wang HS, Wilkinson WE. Regional cerebral blood flow estimated by 133-xenon inhalation. Stroke 6: 245-256, 1975. doi: 10.1161/01.STR.6.3.245.
    • (1975) Stroke , vol.6 , pp. 245-256
    • Obrist, W.D.1    Thompson, H.K.2    Wang, H.S.3    Wilkinson, W.E.4
  • 45
    • 84874098503 scopus 로고    scopus 로고
    • Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries
    • Ogoh S, Sato K, Nakahara H, Okazaki K, Subudhi AW, Miyamoto T. Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries. Exp Physiol 98: 692-698, 2013. doi: 10.1113/expphysiol.2012.068015.
    • (2013) Exp Physiol , vol.98 , pp. 692-698
    • Ogoh, S.1    Sato, K.2    Nakahara, H.3    Okazaki, K.4    Subudhi, A.W.5    Miyamoto, T.6
  • 46
    • 84865703594 scopus 로고
    • Sympathetic regulation of the human cerebrovascular response to carbon dioxide
    • Peebles KC, Ball OG, MacRae BA, Horsman HM, Tzeng YC. Sympathetic regulation of the human cerebrovascular response to carbon dioxide. J Appl Physiol (1985) 113: 700-706, 2012. doi:10.1152/japplphysiol.00614.2012.
    • (1985) J Appl Physiol , vol.113 , pp. 700-706
    • Peebles, K.C.1    Ball, O.G.2    MacRae, B.A.3    Horsman, H.M.4    Tzeng, Y.C.5
  • 48
    • 0027212086 scopus 로고
    • Adenosine 5=-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex
    • Phillis JW, O'Regan MH, Perkins LM. Adenosine 5=-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex. Neurosci Lett 151: 94-96, 1993. doi: 10.1016/0304-3940(93)90054-O.
    • (1993) Neurosci Lett , vol.151 , pp. 94-96
    • Phillis, J.W.1    O'Regan, M.H.2    Perkins, L.M.3
  • 49
    • 84910038303 scopus 로고    scopus 로고
    • Factors affecting the determination of cerebrovascular reactivity
    • Regan RE, Fisher JA, Duffin J. Factors affecting the determination of cerebrovascular reactivity. Brain Behav 4: 775-788, 2014. doi: 10.1002/brb3.275.
    • (2014) Brain Behav , vol.4 , pp. 775-788
    • Regan, R.E.1    Fisher, J.A.2    Duffin, J.3
  • 50
    • 0002905048 scopus 로고
    • The lake louise scute mountain sickness scoring system
    • edited by Sutton JR, Houston CS, Coates G. Burlington, VT: Queen City Press
    • Roach RC, Bartsch P, Oelz O, Hackett PH. The Lake Louise scute mountain sickness scoring system, in Hypoxia and Molecular Medicine, edited by Sutton JR, Houston CS, Coates G. Burlington, VT: Queen City Press, 1993, p. 272-274.
    • (1993) Hypoxia and Molecular Medicine , pp. 272-274
    • Roach, R.C.1    Bartsch, P.2    Oelz, O.3    Hackett, P.H.4
  • 52
    • 0014699031 scopus 로고
    • The effect of adenosine and adenine nucleotides on the cyclic adenosine 3=, 5=-phosphate content of Guinea pig cerebral cortex slices
    • Sattin A, Rall TW. The effect of adenosine and adenine nucleotides on the cyclic adenosine 3=, 5=-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol 6: 13-23, 1970.
    • (1970) Mol Pharmacol , vol.6 , pp. 13-23
    • Sattin, A.1    Rall, T.W.2
  • 53
    • 85015586916 scopus 로고    scopus 로고
    • Hemodynamics
    • Secomb TW. Hemodynamics. Compr Physiol 6: 975-1003, 2016. doi: 10.1002/cphy.c150038.
    • (2016) Compr Physiol , vol.6 , pp. 975-1003
    • Secomb, T.W.1
  • 56
    • 0014900277 scopus 로고
    • Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man
    • Shapiro W, Wasserman AJ, Baker JP, Patterson JL Jr. Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man. J Clin Invest 49: 2362-2368, 1970. doi: 10.1172/JCI106455.
    • (1970) J Clin Invest , vol.49 , pp. 2362-2368
    • Shapiro, W.1    Wasserman, A.J.2    Baker, J.P.3    Patterson, J.L.4
  • 59
    • 84943178731 scopus 로고    scopus 로고
    • Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow
    • Thomas KN, Lewis NCS, Hill BG, Ainslie PN. Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow. Am J Physiol Regul Integr Comp Physiol 309: R707-R720, 2015. doi: 10.1152/ajpregu.00211.2015.
    • (2015) Am J Physiol Regul Integr Comp Physiol , vol.309 , pp. R707-R720
    • Thomas, K.N.1    Lewis, N.C.S.2    Hill, B.G.3    Ainslie, P.N.4
  • 60
    • 44449093677 scopus 로고    scopus 로고
    • Comparative bioavailability and in vitro in vivo correlation of two sustained release brands of theophylline: Tablets and pellets
    • Tulain U, Ur-Rahman N. Comparative bioavailability and in vitro in vivo correlation of two sustained release brands of theophylline: tablets and pellets. Pak J Pharm Sci 21: 131-138, 2008.
    • (2008) Pak J Pharm Sci , vol.21 , pp. 131-138
    • Tulain, U.1    Ur-Rahman, N.2
  • 63
    • 0017294784 scopus 로고
    • The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline
    • Wahl M, Kuschinsky W. The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline. Pflugers Arch 362: 55-59, 1976. doi: 10.1007/BF00588681.
    • (1976) Pflugers Arch , vol.362 , pp. 55-59
    • Wahl, M.1    Kuschinsky, W.2
  • 64
    • 0002696406 scopus 로고
    • The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man
    • Wechsler RL, Kleiss LM, Kety SS. The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man. J Clin Invest 29: 28-30, 1950. doi: 10.1172/JCI102230.
    • (1950) J Clin Invest , vol.29 , pp. 28-30
    • Wechsler, R.L.1    Kleiss, L.M.2    Kety, S.S.3
  • 68
    • 0018729531 scopus 로고
    • Brain adenosine production in the rat during 60 seconds of ischemia
    • Winn HR, Rubio R, Berne RM. Brain adenosine production in the rat during 60 seconds of ischemia. Circ Res 45: 486-492, 1979. doi: 10.1161/01.RES.45.4.486.
    • (1979) Circ Res , vol.45 , pp. 486-492
    • Winn, H.R.1    Rubio, R.2    Berne, R.M.3
  • 70
    • 0019790855 scopus 로고
    • The role of adenosine in the regulation of cerebral blood flow
    • Winn HR, Rubio GR, Berne RM. The role of adenosine in the regulation of cerebral blood flow. J Cereb Blood Flow Metab 1: 239-244, 1981. doi: 10.1038/jcbfm.1981.29.
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 239-244
    • Winn, H.R.1    Rubio, G.R.2    Berne, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.