메뉴 건너뛰기




Volumn 33, Issue 6, 2017, Pages 886-892

Exploring the predictive power of polygenic scores derived from genome-wide association studies: A study of 10 complex traits

Author keywords

[No Author keywords available]

Indexed keywords

BIPOLAR DISORDER; CORONARY ARTERY DISEASE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMAN; MAJOR DEPRESSION; MULTIFACTORIAL INHERITANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROCEDURES; RISK; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 85016902841     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/btw745     Document Type: Article
Times cited : (35)

References (34)
  • 1
    • 84937883029 scopus 로고    scopus 로고
    • Genomic risk prediction of complex human disease and its clinical application
    • Abraham, G. and Inouye, M. (2015) Genomic risk prediction of complex human disease and its clinical application. Curr. Opin. Genet. Dev., 33, 10-16.
    • (2015) Curr. Opin. Genet. Dev. , vol.33 , pp. 10-16
    • Abraham, G.1    Inouye, M.2
  • 2
    • 84943171338 scopus 로고    scopus 로고
    • A global reference for human genetic variation
    • Auton, A. et al. (2015) A global reference for human genetic variation. Nature, 526, 68-74.
    • (2015) Nature , vol.526 , pp. 68-74
    • Auton, A.1
  • 3
    • 84930213392 scopus 로고    scopus 로고
    • Second-generation PLINK: Rising to the challenge of larger and richer datasets
    • Chang, C.C. et al. (2015) Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience, 4, 7.
    • (2015) Gigascience , vol.4 , pp. 7
    • Chang, C.C.1
  • 4
    • 84875700256 scopus 로고    scopus 로고
    • Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
    • 405e401-403
    • Chatterjee, N. et al. (2013) Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat. Genet., 45, 400-405. 405e401-403.
    • (2013) Nat. Genet. , vol.45 , pp. 400-405
    • Chatterjee, N.1
  • 5
    • 84938379545 scopus 로고    scopus 로고
    • Sparse whole-genome sequencing identifies two loci for major depressive disorder
    • CONVERGE consortium (2015) Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature, 523, 588-591.
    • (2015) Nature , vol.523 , pp. 588-591
  • 6
    • 84871969762 scopus 로고    scopus 로고
    • Large-scale association analysis identifies new risk loci for coronary artery disease
    • CARDIoGRAMplusC4D Consortium. et al.
    • CARDIoGRAMplusC4D Consortium. et al. (2013) Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet., 45, 25-33.
    • (2013) Nat. Genet. , vol.45 , pp. 25-33
  • 7
    • 84876007072 scopus 로고    scopus 로고
    • Power and predictive accuracy of polygenic risk scores
    • Dudbridge, F. (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet., 9, e1003348.
    • (2013) PLoS Genet. , vol.9 , pp. e1003348
    • Dudbridge, F.1
  • 8
    • 2142732441 scopus 로고    scopus 로고
    • Large-scale simultaneous hypothesis testing: The choice of a null hypothesis
    • Efron, B. (2004) Large-scale simultaneous hypothesis testing: The choice of a null hypothesis. J. Am. Stat. Assoc., 99, 96-104.
    • (2004) J. Am. Stat. Assoc. , vol.99 , pp. 96-104
    • Efron, B.1
  • 9
    • 70349761735 scopus 로고    scopus 로고
    • Empirical bayes estimates for large-scale prediction problems
    • Efron, B. (2009) Empirical Bayes estimates for large-scale prediction problems. J. Am. Stat. Assoc., 104, 1015-1028.
    • (2009) J. Am. Stat. Assoc. , vol.104 , pp. 1015-1028
    • Efron, B.1
  • 11
    • 84856005992 scopus 로고    scopus 로고
    • Tweedie's formula and selection bias
    • Efron, B. (2011) Tweedie's formula and selection bias. J. Am. Stat. Assoc., 106, 1602-1614.
    • (2011) J. Am. Stat. Assoc. , vol.106 , pp. 1602-1614
    • Efron, B.1
  • 12
    • 1542784653 scopus 로고    scopus 로고
    • Empirical bayes analysis of a microarray experiment
    • Efron, B. et al. (2001) Empirical Bayes analysis of a microarray experiment. J. Am. Stat. Assoc., 96, 1151-1160.
    • (2001) J. Am. Stat. Assoc. , vol.96 , pp. 1151-1160
    • Efron, B.1
  • 13
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • et al.
    • Global Lipids Genetics Consortium. et al. (2013) Discovery and refinement of loci associated with lipid levels. Nat. Genet., 45, 1274-1283.
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
  • 14
    • 80155129902 scopus 로고    scopus 로고
    • The heterogeneity of "major depression"
    • Goldberg, D. (2011) The heterogeneity of "major depression". World Psychiatry, 10, 226-228.
    • (2011) World Psychiatry , vol.10 , pp. 226-228
    • Goldberg, D.1
  • 16
    • 33747881836 scopus 로고    scopus 로고
    • Predictive testing for complex diseases using multiple genes: Fact or fiction?
    • Janssens, A.C. et al. (2006) Predictive testing for complex diseases using multiple genes: fact or fiction?. Genet. Med., 8, 395-400.
    • (2006) Genet. Med. , vol.8 , pp. 395-400
    • Janssens, A.C.1
  • 17
    • 84879892380 scopus 로고    scopus 로고
    • A mega-analysis of genome-wide association studies for major depressive disorder
    • et al.
    • Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. et al. (2013) A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry, 18, 497-511.
    • (2013) Mol. Psychiatry , vol.18 , pp. 497-511
  • 18
    • 84953439419 scopus 로고    scopus 로고
    • Local true discovery rate weighted polygenic scores using GWAS summary data
    • Mak, T.S. et al. (2016) Local true discovery rate weighted polygenic scores using GWAS summary data. Behav. Genet., 46, 573-582.
    • (2016) Behav. Genet. , vol.46 , pp. 573-582
    • Mak, T.S.1
  • 19
    • 79960654629 scopus 로고    scopus 로고
    • Predictive genetic testing for the identification of high-risk groups: A simulation study on the impact of predictive ability
    • Mihaescu, R. et al. (2011) Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability. Genome Med., 3, 51.
    • (2011) Genome Med. , vol.3 , pp. 51
    • Mihaescu, R.1
  • 20
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris, A.P. et al. (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet., 44, 981-990.
    • (2012) Nat. Genet. , vol.44 , pp. 981-990
    • Morris, A.P.1
  • 21
    • 84954550234 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies of anxiety disorders
    • Otowa, T. et al. (2016) Meta-analysis of genome-wide association studies of anxiety disorders. Mol. Psychiatry, 21, 1391-1399.
    • (2016) Mol. Psychiatry , vol.21 , pp. 1391-1399
    • Otowa, T.1
  • 22
    • 38849091997 scopus 로고    scopus 로고
    • Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
    • discussion 207-112
    • Pencina, M.J. et al. (2008) Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat. Med., 27, 157-172. discussion 207-112
    • (2008) Stat. Med. , vol.27 , pp. 157-172
    • Pencina, M.J.1
  • 23
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Psychiatric GWAS Consortium Bipolar Disorder Working Group. (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet., 43, 977-983.
    • (2011) Nat. Genet. , vol.43 , pp. 977-983
  • 24
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • Purcell, S.M. et al. (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460, 748-752.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1
  • 25
    • 58149159573 scopus 로고    scopus 로고
    • Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    • Sabatti, C. et al. (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet., 41, 35-46.
    • (2009) Nat. Genet. , vol.41 , pp. 35-46
    • Sabatti, C.1
  • 26
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421-427.
    • (2014) Nature , vol.511 , pp. 421-427
  • 27
    • 79955824808 scopus 로고    scopus 로고
    • Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening
    • So, H.C. et al. (2011) Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am. J. Hum. Genet., 88, 548-565.
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 548-565
    • So, H.C.1
  • 28
    • 80051807776 scopus 로고    scopus 로고
    • Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study
    • So, H.C. et al. (2011) Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet. Epidemiol., 35, 447-456.
    • (2011) Genet. Epidemiol. , vol.35 , pp. 447-456
    • So, H.C.1
  • 29
    • 78650687187 scopus 로고    scopus 로고
    • A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained
    • So, H.C. and Sham, P.C. (2010) A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet., 6, e1001230.
    • (2010) PLoS Genet. , vol.6 , pp. e1001230
    • So, H.C.1    Sham, P.C.2
  • 30
    • 73849094087 scopus 로고    scopus 로고
    • Assessing the performance of prediction models: A framework for traditional and novel measures
    • Steyerberg, E.W. et al. (2010) Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology, 21, 128-138.
    • (2010) Epidemiology , vol.21 , pp. 128-138
    • Steyerberg, E.W.1
  • 31
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • Sullivan, P.F. et al. (2003) Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry, 60, 1187-1192.
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1
  • 32
    • 84952665106 scopus 로고    scopus 로고
    • Modeling linkage disequilibrium increases accuracy of polygenic risk scores
    • Vilhjalmsson, B.J. et al. (2015) Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am. J. Hum. Genet., 97, 576-592.
    • (2015) Am. J. Hum. Genet. , vol.97 , pp. 576-592
    • Vilhjalmsson, B.J.1
  • 33
    • 34948877698 scopus 로고    scopus 로고
    • Prediction of individual genetic risk to disease from genome-wide association studies
    • Wray, N.R. et al. (2007) Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res., 17, 1520-1528.
    • (2007) Genome Res. , vol.17 , pp. 1520-1528
    • Wray, N.R.1
  • 34
    • 84908121749 scopus 로고    scopus 로고
    • Research review: Polygenic methods and their application to psychiatric traits
    • Wray, N.R. et al. (2014) Research review: Polygenic methods and their application to psychiatric traits. J. Child Psychol. Psychiatry, 55, 1068-1087.
    • (2014) J. Child Psychol. Psychiatry , vol.55 , pp. 1068-1087
    • Wray, N.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.