Evaluation of Genotoxicity and Efficacy of At-home Bleaching in Smokers: A Single-blind Controlled Clinical Trial

Operative Dentistry

Volumn 40, Issue 2, 2015, Pages E47-E55

  De Geus, Juliana L ^a   Rezende, Márcia ^a   Margraf, Letícia S ^a   Bortoluzzi, Marcelo C ^a   Fernández, Eduardo ^b   Loguercio, Alessandro D ^a   Reis, Alessandra ^a   Kossatz, Stella ^a  

^a STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIDE PEROXIDE; PEROXIDE; TOOTH BLEACHING AGENT; UREA;

ADOLESCENT; ADULT; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL PROCEDURE; DNA DAMAGE; DRUG EFFECTS; FEMALE; GINGIVA; HUMAN; MALE; MUTAGEN TESTING; PROCEDURES; SELF CARE; SINGLE BLIND PROCEDURE; SMOKING; TOOTH DISCOLORATION; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; DNA DAMAGE; FEMALE; GINGIVA; HUMANS; MALE; MUTAGENICITY TESTS; PEROXIDES; SELF CARE; SINGLE-BLIND METHOD; SMOKING; TOOTH BLEACHING; TOOTH BLEACHING AGENTS; TOOTH DISCOLORATION; TREATMENT OUTCOME; UREA; YOUNG ADULT;

EID: 85016649900     PISSN: 03617734     EISSN: 15592863     Source Type: Journal    
DOI: 10.2341/14-121-C     Document Type: Article

References (70)

1. de Almeida LCAG, Costa CAS, Riehl H, dos Santos PH, Sundfeld R, & Briso ALF (2012) Occurrence of sensitivity during at-home and in-office tooth bleaching therapies with or without use of light sources Acta Odontológica Latinoamericana 25(1) 3-8.
2. Ogura K, Tanaka R, Shibata Y, Miyazaki T, & Hisamitsu H (2013) In vitro demineralization of tooth enamel subjected to two whitening regimens Journal of the American Dental Association 144(7) 799-807.
3. Haywood VB, & Heymann HO (1989) Nightguard vital bleaching Quintessence International 20(3) 173-175.
4. Meireles SS, Heckmann SS, Leida FL, Santos IS, Della Bona Á, & Demarco FF (2008) Efficacy and safety of 10% and 16% carbamide peroxide tooth-whitening gels: A randomized clinical trial Operative Dentistry 33(6) 606-612.
5. Basting LB, Amaral FLB, França FMG, & Flório FM (2012) Clinical comparative study of the effectiveness of and tooth sensitivity to10% and 20% carbamide peroxide home-use and 35% and 38% hydrogen peroxide in-office bleaching materials containing desensitizing agents Operative Dentistry 37(5) 464-473.
6. Reis A, Kossatz S, Martins GC, & Loguercio AD (2013) Efficacy of and effects on tooth sensitivity of in-office bleaching gel concentrations: A randomized clinical trial Operative Dentistry 38(4) 386-393.
7. Krause F, Jepsen S, & Braun A (2008) Subjective intensities of pain and contentment with treatment outcomes during tray bleaching of vital teeth employing different carbamide peroxide concentrations Quintessence International 39(3) 203-209.
8. Grobler SR, Hayward R, Wiese S, Moola MH, & van W Kotze TJ (2010) Spectrophotometric assessment of the effectiveness of Opalescence PF 10%: A 14-month clinical study Journal of Dentistry 38(2) 113-117.
9. Türkün M, Celik EU, Aladaǧ A, & Gökay N (2010) Oneyear clinical evaluation of the efficacy of a new daytime at-home bleaching technique Journal of Esthetic and Restorative Dentistry 22(2) 139-146.
10. Jadad E, Montoya J, Arana G, Gordillo LAA, Palo RM, & LoguercioAD(2011) Spectrophotometric evaluation of color alterations with a new dental bleaching product in patients wearing orthodontic appliances American Journal of Orthodontics and Dentofacial Orthopedics 140(1) e43-e47.
11. Rezende M, Loguercio AD, Reis A, & Kossatz S (2013) Clinical effects of exposure to coffee during at-home vital bleaching Operative Dentistry 38(6) E229-E36.
12. de la Peña VA, & Ratón ML (2014) Randomized clinical trial on the efficacy and safety of four professional at-home tooth whitening gels Operative Dentistry 39(2) 136-143.
13. Bernardon JK, Sartori N, Ballarin A, Perdigão J, Lopes GC, & Baratieri LN (2010) Clinical performance of vital bleaching techniques Operative Dentistry 35(1) 3-10.
14. BonaféE, Bacovis CL, Iensen S, Loguercio AD, Reis A, & Kossatz S (2013) Tooth sensitivity and efficacy of in-office bleaching in restored teeth Journal of Dentistry 41(4) 363-369.
15. Wasilewski MS, Takahashi MK, Kirsten GA, & de Souza EM (2010) Effect of cigarette smoke and whiskey on the color stability of dental composites American Journal of Dentistry 2(1) 4-8.
16. Bazzi JZ, Bindo MJF, Rached RN, Mazur RF, Vieira S, & de Souza EM (2012) The effect of at-home bleaching and toothbrushing on removal of coffee and cigarette smoke stains and color stability of enamel Journal of the American Dental Association 143(5) e1-e7.
17. Devita VT Jr, Lawrence TS, & Rosberg AS (2011) Cancer Principles & Practice of Oncology: Tobacco 9th ed Lippincott Williams & Wilkins, Philadelphia 150-156.
18. Alkhatib MN, Holt RD, & Bedi R (2005) Smoking and tooth discolouration: Findings from a national crosssectional study BMC Public Health 5 27.
19. Beliën JA, Copper MP, Braakhuis BJ, Snow GB, & Baak JP (1995) Standardization of counting micronuclei: Definition of a protocol to measure genotoxic damage in human exfoliated cells Carcinogenesis 16(10) 2395-2400.
20. Sivasankari NP, Kaur S, Reddy KS, Rao KR, & Kumar SJM (2012) Micronucleus assay-Screening tool in the diagnosis of oral carcinoma in tobacco users International Journal of Pharma and Bio Sciences 3(4) 646-651.
21. Stich HF, & Rosin M (1983) Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells International Journal of Cancer 31(3) 305-308.
22. Stich HF, Rosin M, & Vallejera MO (1984) Reduction with vitamin A and beta-carotene administration of proportion of micronucleated buccal mucosa cells in Asian betel nut and tobacco chewers Lancet 1(8388) 1204-1206.
23. Cairns J (1975) Mutation selection and the natural history of cancer Nature 255(5505) 197-200.
24. Nerseyan A, Muradyan R, Kundi M, & Schulte-Hermann R (2011) Impact of smoking on the frequencies of micronuclei and other nuclear abnormalities in exfoliated oral cells: A comparative study with different cigarette types Mutagenesis 26(2) 295-301.
25. Bansal H, Sandhu VS, Bhandari R, & Sharma D (2012) Evaluation of micronuclei in tabacco users: A study in Punjabi population Contemporary Clinical Dentistry 3(2) 184-187.
26. Attin T, Schmidlin PR, Wegehaupt F, & Wiegand A (2009) Influence of study design on the impact of bleaching agents on dental enamel microhardness: A review Dental Materials 25(2) 143-157
27. Minoux M, & Serfaty R (2008) Vital tooth bleaching: Biologic adverse effects-A review Quintessence International 39(8) 645-659.
28. Weitzman SA, Weitberg AB, Stossel TP, Schwartz J, & Shklar G (1986) Effects of hydrogen peroxide on oral carcinogenesis in hamsters Journal of Periodontology 57(11) 685-688.
29. de Castro Albuquerque R, Gomez RS, Dutra RA, Vasconcellos WA, Gomez RS, & Gomez MV (2002) Effects of a 10% carbamide peroxide bleaching agent on rat oral epithelium proliferation Brazilian Dental Journal 13(3) 162-165.
30. Oya Y, Yamamoto K, & Tonomura A (1986) The biological activity of hydrogen peroxide I. Induction of chromosometype aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts Mutation Research 172(3) 245-253.
31. Ziegler-Skylakakis K, & Andrae U (1987) Mutagenicity of hydrogen peroxide in V79 Chinese hamster cells Mutation Research 192(1) 65-67.
32. Kleiman NJ, Wang R, & Spector A (1990) Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells Mutation Research 240(1) 35-45.
33. Fenech M, Crott J, Turner J, & Brown S (1999) Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesisblock micronucleus assay: Description of the method and results for hydrogen peroxide Mutagenesis 14(6) 605-612.
34. Ribeiro DA, Marques MEA, & Salvatori DMF (2005) Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay Journal of Oral Rehabilitation 32(10) 766-771.
35. Fernández MR, Carvalho RV, Ogliari FA, Beira FA, Etges A, & Bueno M (2010) Cytotoxicity and genotoxicity of sodium percarbonate: A comparison with bleaching agents commonly used in discoloured pulpless teeth International Endodontic Journal 43(2) 102-108.
36. Lucier RN, Etienne O, Ferreira S, Garlick JA, Kugel G, & Egles C (2013) Soft-tissue alterations following exposure to tooth-whitening agents Journal of Periodontology 84(4) 513-519.
37. da Costa Filho LC, da Costa CC, Sória ML, & Taga R (2002) Effect of home bleaching and smoking on marginal gingival epithelium proliferation: A histologic study in women Journal of Oral Pathology & Medicine 31(8) 473-480.
38. Klaric E, Par M, Profeta I, Kopjar N, Rozgaj R, Kasuba V, Zeljezic D, & Tarle Z (2013) Genotoxic effect of two bleaching agents on oral mucosa Cancer Genomics Proteomics 10(5) 209-215.
39. IARC (1986) Tobacco smoking IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 38 35-394.
40. Taybos G (2003) Oral changes associated with tobacco use American Journal of the Medical Sciences 326(4) 179-182.
41. IARC (2004) Tobacco smoke and involuntary smoking IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 83 1-1438.
42. Thylstrup A, & Fejerskov O (1978) Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes Community Dentistry and Oral Epidemiology 6(6) 315-328.
43. Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, & Zeiger E, Knasmueller S, Fenech M (2008) The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps Mutation Research 659(1-2) 93-108.
44. Angelieri F, Moleirinho TCG, Carlin V, Oshima CTF, & Ribeiro DA (2010) Biomonitoring of oral epitelial cells in smokers and nonsmokers submitted to panoramic Xray: Comparison between buccal mucosa and lateral border of the tongue Clinical Oral Investigation 14(6) 669-674.
45. Naderi NJ, Farhadi S, & Sarshar S (2012) Micronucleus assay of buccal mucosa cells in smokers with the history of smoking less and more than 10 years Indian Journal of Pathology and Microbiology 55(4) 433-438.
46. Matis BA, Hamdan YS, Cochran MA, & Eckert GJ (2002) A clinical evaluation of a bleaching agent used with and without reservoirs Operative Dentistry 27(1) 5-11.
47. American Dental Association (2006) ADA Acceptance Program Guidelines Dentist-dispensed home-use tooth bleaching products. Retrieved online February 13, 2014 from: http://www.ada.org/ada/seal/
48. Bortoluzzi MC, Campagnoli EB, Milan JR, Reinheimer A, Masson M, & Capella DL (2014) Frequency of micronucleus in oral epithelial cells after exposure to mate-tea in healthy humans Medicina Oral Patologia Oral y Cirugia Bucal 19(4) e345-349.
49. Tolbert PE, Shy CM, & Allen JW (1992) Micronuclei and other nuclear anomalies in buccal smears: Methods development Mutation Research 271(1) 69-77.
50. Paravina RD, Johnston WM, & Powers JM (2007) New shade guide for evaluation of tooth whitening-Colorimetric study Journal of Esthetic and Restorative Dentistry 9(5) 276-283.
51. Matis BA, Mousa HN, Cochran MA, & Eckert GJ (2000) Clinical evaluation of bleaching agents of different concentrations Quintessence International 31(5) 303-310.
52. Maggio B, Gallagher A, Bowman J, Barrett K, Borden L, Mason S, & Felix H (2003) Evaluation of a whitening gel designed to accelerate whitening Compendium of Continuing Education in Dentistry 24(7) 519-520.
53. Matis BA, Cochran MA, & Eckert G (2009) Review of the effectiveness of various tooth whitening systems Operative Dentistry 34(2) 230-235.
54. Paravina RD (2008) New shade guide for tooth whitening monitoring: Visual assessment Journal of Prosthetic Dentistry 99(3) 178-184.
55. Braun A, Jepsen S, & Krause F (2007) Spectrophotometric and visual evaluation of vital tooth bleaching employing different carbamide peroxide concentrations Dental Materials 23(2) 165-169.
56. Kalyana P, Shashidhar A, Meghashyam B, Sreevidya KR, & Sweta S (2011) Stain removal efficacy of a novel dentifrice containing papain and Bromelain extracts-An in vitro study International Journal of Dental Hygiene 9(3) 229-233.
57. Kurokawa Y, Takamura N, Matsushima Y, Imazawa T, & Hayashi Y (1984) Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis Cancer Letters 24(3) 299-304.
58. Takahashi M, Hasegawa R, Furukawa F, Toyoda K, Sato H, & Hayashi Y (1986) Effects of ethanol, potassium metabisulfite, formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with Nmethyl-N-nitro-N-nitrosoguanidine Japanese Journal of Cancer Research 77(2) 118-124.
59. Marshall MV, Kuhn JO, Torrey CF, Fischman SL, & Cancro LP (1996) Hamster cheek pouch bioassay of dentifrices containing hydrogen peroxide and baking soda Journal of the American College of Toxicology 15(1) 45-61.
60. Collet AM, Palmieri M, Molinari B, Schwint AE, & Itoiz ME (2001) Experimental study to test the potential tumor promotion effect of a tooth bleaching agent Acta Odontológica Latinoamericana 14(1-2) 30-34.
61. Hagmar L, Bonassi S, Strömberg U, Brøgger A, Knudsen LE, Norppa H, & Reuterwall C (1998) Chromosomal aberrations in lymphocytes predict human cancer: A report from the European Study Group on cytogenetic biomarkers and health (ESCH) Cancer Research 58(18) 4117-4121.
62. Bonassi S, Hagmar L, Strömberg U, Huici Montagud A, Tinnerberg H, Forni A, HeikkiläP, Wanders S, Wilhardt P, IHansteen IL, Knudsen LE, & Norppa H (2000) Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens Cancer Research 60(6) 1619-1625.
63. Bhattathiri VN, Bindu L, Remani P, Chandralekha B, Davis CA, & Nair MK (1996) Serial cytological assay of micronucleus induction: A new tool to predict human cancer radiosensitivity Radiotherapy & Oncology 41(2) 139-142.
64. Basu A, Ghosh P, Das JK, Banerjee A, Ray K, & Giri AK (2004) Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: A comparative study in three cell types Cancer Epidemiology, Biomarkers & Prevention 13(5) 820-827.
65. Suhas S, Ganapathy KS, Gayatri Devi M, & Ramesh C (2004) Application of the micronucleus test to exfoliated epithelial cells from the oral cavity of beedi smokers, a high-risk group for oral cancer Mutation Research 561(1-2) 15-21.
66. Nerseyan A, Kundi M, Atefie K, Schulte-Hermann R, & Knasmüller, S (2006) Effect of staining procedures on the results of micronucleus assays with exfoliated oral mucosa cells Cancer Epidemiology, Biomarkers & Prevention 15(10) 1835-1840.
67. Kausar A, Giri S, Mazumdar M, Giri A, Roy P, & Dhar P (2009) Micronucleus and other nuclear abnormalities among betel quid chewers with or without sadagura, a unique smokeless tobacco preparation, in a population from North-East India Mutation Research 677(1-2) 72-75.
68. Valavanidis A, Vlachogianni T, & Fiotakis K (2009) Tobacco smoke: Involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles International Journal of Environmental Research and Public Health 6(2) 445-462.
69. Newman MG, Takei HH, & Klokkevold PR, Carranza FA (2012) Carranza's Clinical Periodontology 11th ed Elsevier, St. Louis 21.
70. Thomas P, Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, Knasmueller S & Fenech M.. (2009) Buccal micronucleus cytome assay Nature Protocols 4(6) 825-837.