Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity

Journal of Dentistry

Volumn 60, Issue , 2017, Pages 36-43

  Hall, Claire ^a   Mason, Stephen ^a   Cooke, Jonathan ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Calcium sodium phosphosilicate; Dentine hypersensitivity; Occlusion; Toothpaste

Indexed keywords

ARGININE; CALCIUM CARBONATE; CALCIUM PHOSPHATE; DESENSITIZING AGENT; FLUORIDE; RHENANITE; SILICATE; SODIUM FLUORIDE; TOOTHPASTE;

ADOLESCENT; ADULT; CHEMISTRY; CHINA; CONTROLLED STUDY; DENTIN SENSITIVITY; FEMALE; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR; TOOTH BRUSHING; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ARGININE; CALCIUM CARBONATE; CALCIUM PHOSPHATES; CHINA; DENTIN DESENSITIZING AGENTS; DENTIN SENSITIVITY; FEMALE; FLUORIDES; HUMANS; MALE; MIDDLE AGED; SILICATES; SODIUM FLUORIDE; TIME FACTORS; TOOTHBRUSHING; TOOTHPASTES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85016394866     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdent.2017.02.009     Document Type: Article

References (53)

1. [1] Addy, M., Smith, S.R., Dentin hypersensitivity: an overview on which to base tubule occlusion as a management concept. J. Clin. Dent. 21 (2010), 25–30.
2. [2] Addy, M., Mostafa, P., Absi, E.G., Adams, D., Cervical dentine hypersensitivity. Etiology and management with particular reference to dentifrices. Rowe, N.H., (eds.) Proceedings of Symposium on Hypersensitive Dentin. Origin and Management, 1985, University of Michigan, Ann Arbor, MI, 147–167.
3. [3] Holland, G.R., Narhi, M.N., Addy, M., Gangarosa, L., Orchardson, R., Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J. Clin. Periodontol. 24 (1997), 808–813.
4. [4] Canadian Advisory Board on Dentin Hypersensitivity, Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J. Can. Dent. Assoc. 69 (2003), 221–226.
5. [5] Brännström, M., A hydrodynamic mechanism in the transmission of pain producing stimuli through dentine. Anderson, D.J., (eds.) Sensory Mechanisms in Dentine. Proceedings of a Symposium Held at the Royal Society of Medicine, London, September 24th, 1962, 1963, Pergamon Press Oxford, 73–79.
6. [6] Hall, R.C., Embery, G., Shellis, R.P., Biological and structural features of enamel and dentine: current concepts relevant to erosion and dentine hypersensitivity. Addy, M., Embery, G., Edgar, W.M., Orchardson, R., (eds.) Tooth Wear and Sensitivity, 2000, Martin Dunitz Ltd, London, 3–19.
7. [7] Ling, T.Y., Gillam, D.G., The effectiveness of desensitizing agents for the treatment of cervical dentine sensitivity (CDS) –a review. J. West Soc. Periodontol. Periodontal Abstr. 44 (1996), 5–12.
8. [8] Markowitz, K., Pashley, D.H., Discovering new treatments for sensitive teeth: the long path from biology to therapy. J. Oral Rehabil. 35 (2008), 300–315.
9. [9] Bamise, C.T., Esan, T.A., Mechanisms and treatment approaches of dentine hypersensitivity: a literature review. Oral Health Prev. Dent. 9 (2011), 353–367.
10. [10] Greenspan, D.C., NovaMin and tooth sensitivity –an overview. J. Clin. Dent. 21 (2010), 61–65.
11. [11] West, N., Seong, J., Davies, M., Dentine hypersensitivity. Monogr. Oral Sci. 25 (2014), 108–122.
12. [12] Zaidel, L., Patel, R., Mello, S., Heu, R., Stranick, M., Chopra, S., Prencipe, M., Anti-hypersensitivity mechanism of action for a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica. Am. J. Dent., 2011, 6A–13A 24 Spec. No. A.
13. [13] Gendreau, L., Barlow, A.P., Mason, S.C., Overview of the clinical evidence for the use of NovaMin in providing relief from the pain of dentin hypersensitivity. J. Clin. Dent. 22 (2011), 90–95.
14. [14] Earl, J.S., Leary, R.K., Muller, K.H., Langford, R.M., Greenspan, D.C., Physical and chemical characterization of dentin surface following treatment with NovaMin technology. J. Clin. Dent. 22 (2011), 62–67.
15. [15] Earl, J.S., Topping, N., Elle, J., Langford, R.M., Greenspan, D.C., Physical and chemical characterization of the surface layers formed on dentin following treatment with a fluoridated toothpaste containing NovaMin. J. Clin. Dent. 22 (2011), 68–73.
16. [16] Jones, S.B., Parkinson, C.R., Jeffery, P., Davies, M., Macdonald, E.L., Seong, J., West, N.X., A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment. J. Dent. 43 (2015), 757–764.
17. [17] Parkinson, C.R., Willson, R.J., A comparative in vitro study investigating the occlusion and mineralization properties of commercial toothpastes in a four-day dentin disc model. J. Clin. Dent. 22 (2011), 74–81.
18. [18] West, N.X., Macdonald, E.L., Jones, S.B., Claydon, N.C., Hughes, N., Jeffery, P., Randomized in situ clinical study comparing the ability of two new desensitizing toothpaste technologies to occlude patent dentin tubules. J. Clin. Dent. 22 (2011), 82–89.
19. [19] LaTorre, G., Greenspan, D.C., The role of ionic release from NovaMin (calcium sodium phosphosilicate) in tubule occlusion: an exploratory in vitro study using radio-labeled isotopes. J. Clin. Dent. 21 (2010), 72–76.
20. [20] Acharya, A.B., Surve, S.M., Thakur, S.L., A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity. J. Clin. Exp. Dent. 5 (2013), e18–e22.
21. [21] Ananthakrishna, S., Raghu, T., Koshy, S., Kumar, N., Clinical evaluation of the efficacy of bioactive glass and strontium chloride for treatment of dentinal hypersensitivity. J. Interdiscip. Dent. 2 (2012), 92–97.
22. [22] Du, M.Q., Bian, Z., Jiang, H., Greenspan, D.C., Burwell, A.K., Zhong, J., Tai, B.J., Clinical evaluation of a dentifrice containing calcium sodium phosphosilicate (NovaMin) for the treatment of dentin hypersensitivity. Am. J. Dent. 21 (2008), 210–214.
23. [23] Li, C., Huang, J., Liang, H., Toothpaste containing NovaMin is applied to treat dentine hypersensitivity. Chin. J. Tissue Eng. Res. 17 (2013), 6846–6852.
24. [24] Litkowski, L., Greenspan, D.C., A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity –proof of principle. J. Clin. Dent. 21 (2010), 77–81.
25. [25] Pradeep, A.R., Sharma, A., Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. J. Periodontol. 81 (2010), 1167–1173.
26. [26] Pradeep, A.R., Agarwal, E., Naik, S.B., Bajaj, P., Kalra, N., Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity: a randomized clinical trial. Aust. Dent. J. 57 (2012), 429–434.
27. [27] Rajesh, K.S., Hedge, S., Arun Kumar, M.S., Shetty, D.G., Evaluation of the efficacy of a 5% calcium sodium phosphosilicate (Novamin) containing dentifrice for the relief of dentinal hypersensitivity: a clinical study. Indian J. Dent. Res. 23 (2012), 363–367.
28. [28] Salian, S., Thakur, S., Kulkarni, S., LaTorre, G., A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. J. Clin. Dent. 21 (2010), 82–87.
29. [29] Satyapal, T., Mali, R., Mali, A., Patil, V., Comparative evaluation of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate for dentinal hypersensitivity: a clinical study. J. Indian Soc. Periodontol. 18 (2014), 581–585.
30. [30] Sharma, N., Roy, S., Kakar, A., Greenspan, D.C., Scott, R., A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin) 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. J. Clin. Dent. 21 (2010), 88–92.
31. [31] Surve, S.M., Acharya, A.B., Shetty, A., Thakur, S.L., Efficacy of calcium sodium phosphosilicate in managing dentinal hypersensitivity. Gen. Dent. 60 (2012), e308–e311.
32. [32] Ayad, F., Ayad, N., Delgado, E., Zhang, Y.P., DeVizio, W., Cummins, D., Mateo, L.R., Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in Mississauga Canada. J. Clin. Dent 20 (2009), 115–122.
33. [33] Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., DeVizio, W., Zhang, Y.P., Cummins, D., Dibart, S., Mateo, L.R., Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome Italy. J. Clin. Dent. 20 (2009), 17–22.
34. [34] Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., Zhang, Y.P., DeVizio, W., Delgado, E., Cummins, D., Dibart, S., Mateo, L.R., Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study in Rome Italy. J. Clin. Dent. 20 (2009), 137–143.
35. [35] Docimo, R., Perugia, C., Bartolino, M., Maturo, P., Montesani, L., Zhang, Y.P., DeVizio, W., Mateo, L.R., Dibart, S., Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an eight-week clinical study. J. Clin. Dent. 22 (2011), 121–127.
36. [36] Kakar, A., Kakar, K., Sreenivasan, P.K., DeVizio, W., Kohli, R., Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial. J. Clin. Dent. 23 (2012), 40–47.
37. [37] Kakar, A., Kakar, K., Sreenivasan, P.K., DeVizio, W., Kohli, R., Comparison of the clinical efficacy in reducing dentin hypersensitivity of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm sodium monofluorophosphate to a commercially available toothpaste containing 1000 ppm sodium monofluorophosphate: an eight-week clinical trial on adults in New Delhi India. J. Clin. Dent. 23 (2012), 33–39.
38. [38] Que, K., Fu, Y., Lin, L., Hu, D., Zhang, Y.P., Panagakos, F.S., DeVizio, W., Mateo, L.R., Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginineand 1450 ppm fluoride: an 8-week clinical study on Chinese adults. Am. J. Dent., 2010, 28A–35A 23 Spec. No. A.
39. [39] Cummins, D., The efficacy of a new dentifrice containing 8.0% arginine calcium carbonate, and 1450 ppm fluoride in delivering instant and lasting relief of dentin hypersensitivity. J. Clin. Dent. 20 (2009), 109–114.
40. [40] Cummins, D., Recent advances in dentin hypersensitivity: clinically proven treatments for instant and lasting sensitivity relief. Am. J. Dent., 2010, 3A–13A 23 Spec. No. A.
41. [41] Lavender, S.A., Petrou, I., Heu, R., Stranick, M.A., Cummins, D., Kilpatrick-Liverman, L., Sullivan, R.J., Santarpia, R.P., 3rd, Mode of action studies on a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate systemand 1450 ppm fluoride. Am. J. Dent., 2010, 14A–19A 23 Spec. No. A.
42. [42] Bae, J.A., Myung, S.K., Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. J. Clin. Periodontol. 42 (2015), 131–141.
43. [43] Nagata, T., Ishida, H., Shinohara, H., Nishikawa, S., Kasahara, S., Wakano, Y., Daigen, S., Troullos, E.S., Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. J. Clin. Periodontol. 21 (1994), 217–221.
44. [44] Schiff, T., Dotson, M., Cohen, S., De Vizio, W., McCool, J., Volpe, A., Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. J. Clin. Dent., 1994, 87–92 5 Spec. No.
45. [45] Wara-aswapati, N., Krongnawakul, D., Jiraviboon, D., Adulyanon, S., Karimbux, N., Pitiphat, W., The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health: plaque formation and dentine hypersensitivity. J. Clin. Periodontol. 32 (2005), 53–58.
46. [46] Schiff, T., Dotson, M., Cohen, S., De Vizio, W., McCool, J., Volpe, A., Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. J. Clin. Dent., 1994, 87–92 5 (Spec. No.).
47. [47] Polson, A.M., Caton, J.G., Yeaple, R.N., Zander, H.A., Histological determination of probe tip penetration into gingival sulcus of humans using an electronic pressure-sensitive probe. J. Clin. Periodontol. 7 (1980), 479–488.
48. [48] Löe, H., Silness, J., Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol. Scand. 21 (1963), 533–551.
49. [49] Laster, L., Laudenbach, K.W., Stoller, N.H., An evaluation of clinical tooth mobility measurements. J. Periodontol. 46 (1975), 603–607.
50. [50] Orchardson, R., Collins, W.J.N., Thresholds of hypersensitive teeth to 2 forms of controlled stimulation. J. Clin. Periodontol. 14 (1987), 68–73.
51. [51] Addy, M., West, N.X., Barlow, A., Smith, S., Dentine hypersensitivity: is there both stimulus and placebo responses in clinical trials?. Int. J. Dent. Hygiene 5 (2007), 53–59.
52. [52] West, N.X., Addy, M., Jackson, R.J., Ridge, D.B., Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. J. Clin. Periodontol. 24 (1997), 209–215.
53. [53] Feil, P.H., Grauer, J.S., Gadbury-Amyot, C.C., Kula, K., McCunniff, M.D., Intentional use of the Hawthorne effect to improve oral hygiene compliance in orthodontic patients. J. Dent. Educ. 66 (2002), 1129–1135.