Desensitizing toothpaste versus placebo for dentin hypersensitivity: A systematic review and meta-analysis

Journal of Clinical Periodontology

Volumn 42, Issue 2, 2015, Pages 131-141

  Bae, Ji Hyun ^a   Kim, Young Kyun ^a   Myung, Seung Kwon ^b  

^a Seoul National University Bundang Hospital   (South Korea)

^b National Cancer Center   (South Korea)

Author keywords

air blast test; dentin hypersensitivity; desensitizing toothpaste; meta analysis; placebo; randomized controlled clinical trial

Indexed keywords

ARGININE; CALCIUM CARBONATE; DESENSITIZING AGENT; FLUORIDE; NITRIC ACID DERIVATIVE; PHOSPHATE; PLACEBO; POTASSIUM DERIVATIVE; POTASSIUM NITRATE; PRO-ARGIN; SILICATE; STRONTIUM; TIN FLUORIDE; TOOTHPASTE;

DENTIN SENSITIVITY; HUMAN; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ARGININE; CALCIUM CARBONATE; DENTIN DESENSITIZING AGENTS; DENTIN SENSITIVITY; FLUORIDES; HUMANS; NITRATES; PHOSPHATES; PLACEBOS; POTASSIUM COMPOUNDS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SILICATES; STRONTIUM; TIN FLUORIDES; TOOTHPASTES;

EID: 84922815158     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/jcpe.12347     Document Type: Review

References (60)

1. Addy, M., Mostafa, P., &, Newcombe, R. G., (1987) Dentine hypersensitivity: the distribution of recession, sensitivity and plaque. Journal of Dentistry 15, 242-248.
2. Ayad, F., Ayad, N., Delgado, E., Zhang, Y. P., DeVizio, W., Cummins, D., &, Mateo, L. R., (2009) Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: A three-day clinical study in mississauga, Canada. The Journal of Clinical Dentistry 20, 115-122.
3. Brannstrom, M., (1963) Dentin sensitivity and aspiration of odontoblasts. Journal of the American Dental Association 66, 366-370.
4. Chaknis, P., Panagakos, F. S., DeVizio, W., Sowinski, J., Petrone, D., &, Proskin, H,. (2011) Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study. American Journal of Dentistry 24 Spec No 14A-20A.
5. Chesters, R., Kaufman, H. W., Wolff, M. S., Huntington, E., &, Kleinberg, I., (1992) Use of multiple sensitivity measurements and logit statistical analysis to assess the effectiveness of a potassium-citrate-containing dentifrice in reducing dentinal hypersensitivity. Journal of Clinical Periodontology 19, 256-261.
6. Cohen, J., (1977) Statistical power analysis for the behavioral sciences, revised edition. New York: Academic Press.
7. Collins, J. F., &, Perkins, L., (1984) Clinical evaluation of the effectiveness of three dentifrices in relieving dentine sensitivity. Journal of Periodontology 55, 720-725.
8. Conforti, N., Battista, G. W., Petrone, D. M., Petrone, M. E., Chaknis, P., Zhang, Y. P., DeVizio, W., Volpe, A. R., &, Proskin, H. M., (2000) Comparative investigation of the desensitizing efficacy of a new dentifrice: a 14-day clinical study. Compendium of Continuing Education in Dentistry. Supplement 27, 17-22; quiz 28.
9. Cummins, D., (2009) Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. The Journal of Clinical Dentistry 20, 1-9.
10. Cummins, D,. (2010) Recent advances in dentin hypersensitivity: clinically proven treatments for instant and lasting sensitivity relief. American Journal of Dentistry 23, Spec No A, 3A-13A.
11. Davies, R., Scully, C., &, Preston, A. J., (2010) Dentifrices-an update. Medicina Oral, Patología Oral y Cirugía Bucal 15, e976-e982.
12. Day, T., Einwag, J., Hermann, J. S., He, T., Anastasia, M. K., Barker, M., &, Zhang, Y., (2010) A clinical assessment of the efficacy of a stannous-containing sodium fluoride dentifrice on dentinal hypersensitivity. The Journal of Contemporary Dental Practice 11, e001-e008.
13. Docimo, R., Perugia, C., Bartolino, M., Maturo, P., Montesani, L., Zhang, Y. P., DeVizio, W., Mateo, L. R., &, Dibart, S., (2011) Comparative evaluation of the efficacy of three commercially available. Toothpastes on dentin hypersensitivity reduction: an eight-week clinical study. The Journal of Clinical Dentistry 22, 121-127.
14. Du Min, Q., Bian, Z., Jiang, H., Greenspan, D. C., Burwell, A. K., Zhong, J., &, Tai, B. J., (2008) Clinical evaluation of a dentifrice containing calcium sodium phosphosilicate (novamin) for the treatment of dentin hypersensitivity. American Journal of Dentistry 21, 210-214.
15. Fu, Y., Li, X., Que, K., Wang, M., Hu, D., Mateo, L. R., DeVizio, W., &, Zhang, Y. P,. (2010) Instant dentin hypersensitivity relief of a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate system and 1450 ppm fluoride: a 3-day clinical study in Chengdu, China. American Journal of Dentistry 23, Spec No A, 20A-27A.
16. Gendreau, L., Barlow, A. P., &, Mason, S. C., (2011) Overview of the clinical evidence for the use of NovaMin in providing relief from the pain of dentin hypersensitivity. The Journal of Clinical Dentistry 22, 90-95.
17. Gillam, D. G., Bulman, J. S., Jackson, R. J., &, Newman, H. N., (1996) Comparison of 2 desensitizing dentifrices with a commercially available fluoride dentifrice in alleviating cervical dentine sensitivity. Journal of Periodontology 67, 737-742.
18. Gillam, D. G., Seo, H. S., Bulman, J. S., &, Newman, H. N., (1999) Perceptions of dentine hypersensitivity in a general practice population. Journal of Oral Rehabilitation 26, 710-714.
19. Glass, G. V., (1976) Primary, secondary, and meta-analysis of reasearch. Educational Researcher 5, 3-8.
20. He, T., Barker, M. L., Qaqish, J., &, Sharma, N., (2011) Fast onset sensitivity relief of a 0.454% stannous fluoride dentifrice. The Journal of Clinical Dentistry 22, 46-50.
21. Hegde, S., Rao, B. H., Kakar, R. C., &, Kakar, A,. (2013) A comparison of dentifrices for clinical relief from dentin hypersensitivity using the Jay Sensitivity Sensor Probe. American Journal of Dentistry 26, Spec No B, 29B-36B.
22. Higgins, J., &, Green, S,. (2011). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, Available from www.cochrane-handbook.org.
23. Holland, G. R., Narhi, M. N., Addy, M., Gangarosa, L., &, Orchardson, R., (1997) Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Journal of Clinical Periodontology 24, 808-813.
24. Ide, M., Wilson, R. F., &, Ashley, F. P., (2001) The reproducibility of methods of assessment for cervical dentine hypersensitivity. Journal of Clinical Periodontology 28, 16-22.
25. Kakar, A., Dibart, S., &, Kakar, K,. (2013) Clinical assessment of a new dentifrice with 8% arginine and calcium carbonate on dentin hypersensitivity in an Indian population using a new measuring device: the Jay Sensitivity Sensor Probe. American Journal of Dentistry 26, Spec No B, 13B-20B.
26. Kakar, A., &, Kakar, K,. (2013) Measurement of dentin hypersensitivity with the Jay Sensitivity Sensor Probe and the Yeaple probe to compare relief from dentin hypersensitivity by dentifrices. American Journal of Dentistry 26, Spec No B, 21B-28B.
27. Kakar, A., Kakar, K., Sreenivasan, P. K., DeVizio, W., &, Kohli, R., (2012) Comparison of the clinical efficacy in reducing dentin hypersensitivity of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm sodium monofluorophosphate to a commercially available toothpaste containing 1000 ppm sodium monofluorophosphate: an eight-week clinical trial on adults in New Delhi, India. The Journal of Clinical Dentistry 23, 33-39.
28. Li, Y., Lee, S., Zhang, Y. P., Delgado, E., Devizio, W., &, Mateo, L. R., (2011) Comparison of clinical efficacy of three toothpastes in reducing dentin hypersensitivity. The Journal of Clinical Dentistry 22, 113-120.
29. Lin, P. Y., Cheng, Y. W., Chu, C. Y., Chien, K. L., Lin, C. P., &, Tu, Y. K., (2013) In-office treatment for dentin hypersensitivity: a systematic review and network meta-analysis. Journal of Clinical Periodontology 40, 53-64.
30. Litkowski, L., &, Greenspan, D. C., (2010) A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity-proof of principle. The Journal of Clinical Dentistry 21, 77-81.
31. Liu, H., &, Hu, D., (2012) Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. Clinical Therapeutics 34, 614-622.
32. Mason, S., Hughes, N., Sufi, F., Bannon, L., Maggio, B., North, M., &, Holt, J., (2010) A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. The Journal of Clinical Dentistry 21, 42-48.
33. Nagata, T., Ishida, H., Shinohara, H., Nishikawa, S., Kasahara, S., Wakano, Y., Daigen, S., &, Troullos, E. S., (1994) Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Journal of Clinical Periodontology 21, 217-221.
34. Nathoo, S., Delgado, E., Zhang, Y. P., DeVizio, W., Cummins, D., &, Mateo, L. R., (2009) Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in New Jersey, USA. The Journal of Clinical Dentistry 20, 123-130.
35. Parkinson, C., Hughes, N., Jeffery, P., Jain, R., Kennedy, L., Qaqish, J., Gallob, J. T., &, Mason, S,. (2013) The efficacy of an experimental dentifrice containing 0.454% w/w stannous fluoride in providing relief from the pain of dentin hypersensitivity: an 8-week clinical study. American Journal of Dentistry 26, Spec No A, 25A-31A.
36. Pearce, N. X., Addy, M., &, Newcombe, R. G., (1994) Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. Journal of Periodontology 65, 113-119.
37. Poulsen, S., Errboe, M., Lescay Mevil, Y., &, Glenny, A. M,. (2006) Potassium containing toothpaste for dentine hypersensitivity. Cochrane Database Systematic Review CD0-01476.
38. Pradeep, A. R., Agarwal, E., Naik, S. B., Bajaj, P., &, Kalra, N., (2012) Comparison of efficacy of three commercially available dentifrices [corrected] on dentinal hypersensitivity: a randomized clinical trial. Australian Dental Journal 57, 429-434.
39. Pradeep, A. R., &, Sharma, A., (2010) Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of Periodontology 81, 1167-1173.
40. Prasad, K. V., Sohoni, R., Tikare, S., Yalamalli, M., Rajesh, G., &, Javali, S. B., (2010) Efficacy of two commercially available dentifrices in reducing dentinal hypersensitivity. Indian Journal of Dental Research 21, 224-230.
41. Que, K., Fu, Y., Lin, L., Hu, D., Zhang, Y. P., Panagakos, F. S., DeVizio, W., &, Mateo, L. R,. (2010) Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults. American Journal of Dentistry 23, Spec No A, 28A-35A.
42. Rajesh, K. S., Hedge, S., Arun Kumar, M. S., &, Shetty, D. G., (2012) Evaluation of the efficacy of a 5% calcium sodium phosphosilicate (Novamin) containing dentifrice for the relief of dentinal hypersensitivity: a clinical study. Indian Journal of Dental Research 23, 363-367.
43. Salian, S., Thakur, S., Kulkarni, S., &, Latorre, G., (2010) A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. The Journal of Clinical Dentistry 21, 82-87.
44. Salvato, A. R., Clark, G. E., Gingold, J., &, Curro, F. A., (1992) Clinical effectiveness of a dentifrice containing potassium chloride as a desensitizing agent. American Journal of Dentistry 5, 303-306.
45. Schiff, T., Dos Santos, M., Laffi, S., Yoshioka, M., Baines, E., Brasil, K. D., McCool, J. J., &, De Vizio, W., (1998) Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity. The Journal of Clinical Dentistry 9, 22-25.
46. Schiff, T., Dotson, M., Cohen, S., De Vizio, W., McCool, J., &, Volpe, A,. (1994) Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of Clinical Dentistry 5, Spce No: 87-92.
47. Schiff, T., He, T., Sagel, L., &, Baker, R., (2006) Efficacy and safety of a novel stabilized stannous fluoride and sodium hexametaphosphate dentifrice for dentinal hypersensitivity. The Journal of Contemporary Dental Practice 7, 1-8.
48. Schiff, T., Saletta, L., Baker, R. A., Winston, J. L., &, He, T., (2005) Desensitizing effect of a stabilized stannous fluoride/Sodium hexametaphosphate dentifrice. Compendium of Continuing Education in Dentistry. Supplement 26, 35-40.
49. Schiff, T., Zhang, Y. P., DeVizio, W., Stewart, B., Chaknis, P., Petrone, M. E., Volpe, A. R., &, Proskin, H. M,. (2000) A randomized clinical trial of the desensitizing efficacy of three dentifrices. Compendium of Continuing Education in Dentistry. Supplement 27, 4-10; quiz 28.
50. Scott, J., &, Huskisson, E. C., (1976) Graphic representation of pain. Pain 2, 175-184.
51. Sgolastra, F., Petrucci, A., Severino, M., Gatto, R., &, Monaco, A., (2013) Lasers for the treatment of dentin hypersensitivity: a meta-analysis. Journal of Dental Research 92, 492-499.
52. Shiau, H. J., (2012) Dentin hypersensitivity. The Journal of Evidence-Based Dental Practice 12 (3 Suppl.), 220-228.
53. Silverman, G., Berman, E., Hanna, C. B., Salvato, A., Fratarcangelo, P., Bartizek, R. D., Bollmer, B. W., Campbell, S. L., Lanzalaco, A. C., Mackay, B. J., McClanahan, S. F., Perlich, M. A., &, Shaffer, J. B., (1996) Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity. Journal of the American Dental Association 127, 191-201.
54. Silverman, G., Gingold, J., &, Curro, F. A., (1994) Desensitizing effect of a potassium chloride dentifrice. American Journal of Dentistry 7, 9-12.
55. Sowinski, J. A., Battista, G. W., Petrone, M. E., Chaknis, P., Zhang, Y. P., DeVizio, W., Volpe, A. R., &, Proskin, H. M,. (2000) A new desensitizing dentifrice-an 8-week clinical investigation. Compendium of Continuing Education in Dentistry. Supplement 27, 11-16; quiz 28.
56. Sowinski, J., Ayad, F., Petrone, M., DeVizio, W., Volpe, A., Ellwood, R., &, Davies, R., (2001) Comparative investigations of the desensitising efficacy of a new dentifrice. Journal of Clinical Periodontology 28, 1032-1036.
57. Wara-aswapati, N., Krongnawakul, D., Jiraviboon, D., Adulyanon, S., Karimbux, N., &, Pitiphat, W., (2005) The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. Journal of Clinical Periodontology 32, 53-58.
58. West, N., Addy, M., &, Hughes, J., (1997) Dentine hypersensitivity: the effects of brushing desensitizing toothpastes, their solid and liquid phases, and detergents on dentine and acrylic: studies in vitro. Journal of Oral Rehabilitation 25, 885-895.
59. White, D. J., Lawless, M. A., Fatade, A., Baig, A., von Koppenfels, R., Duschner, H., &, Götz, H., (2007) Stannous fluoride/sodium hexametaphosphate dentifrice increases dentin resistance to tubule exposure in vitro. The Journal of Clinical Dentistry 18, 55-59.
60. Yan, B., Yi, J., Li, Y., Chen, Y., &, Shi, Z., (2013) Arginine-containing toothpastes for dentin hypersensitivity: systematic review and meta-analysis. Quintessence International 44, 709-723.