Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR+/- Rhesus Macaques

Human Gene Therapy Clinical Development

Volumn 28, Issue 1, 2017, Pages 39-50

  Greig, Jenny A ^a   Limberis, Maria P ^b   Bell, Peter ^a   Chen, Shu Jen ^a   Calcedo, Roberto ^a   Rader, Daniel J ^b   Wilson, James M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

AAV; familial hypercholesterolemia; gene therapy; LDLR; low density lipoprotein receptor; toxicology

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LOW DENSITY LIPOPROTEIN RECEPTOR; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; CHOLESTEROL;

ADAPTIVE IMMUNITY; ADENO ASSOCIATED VIRUS 8; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; MALE; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; RHESUS MONKEY; TRANSGENE; VIRUS CAPSID; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; DEFICIENCY; DEPENDOPARVOVIRUS; DISEASE MODEL; GENE THERAPY; GENE VECTOR; GENETICS; HYPERLIPOPROTEINEMIA TYPE II; LIVER; METABOLISM; MUTATION; PATHOLOGY; TOXICITY;

ANIMALS; APOBEC-1 DEAMINASE; CHOLESTEROL; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC THERAPY; GENETIC VECTORS; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIVER; MACACA MULATTA; MALE; MUTATION; RECEPTORS, LDL;

EID: 85016108471     PISSN: 23248637     EISSN: 23248645     Source Type: Journal    
DOI: 10.1089/humc.2017.014     Document Type: Article

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