-
1
-
-
84872379077
-
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
-
Jack, C.R. Jr., Knopman, D.S., Jagust, W.J., Petersen, R.C., Weiner, M.W., Aisen, P.S., et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12 (2013), 207–216.
-
(2013)
Lancet Neurol
, vol.12
, pp. 207-216
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Petersen, R.C.4
Weiner, M.W.5
Aisen, P.S.6
-
2
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroup
-
Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroup. Alzheimers Dement 7 (2011), 280–292.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
Bennett, D.A.4
Craft, S.5
Fagan, A.M.6
-
3
-
-
84871195205
-
Amyloid-beta assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study
-
Doraiswamy, P.M., Sperling, R.A., Coleman, R.E., Johnson, K.A., Reiman, E.M., Davis, M.D., et al. Amyloid-beta assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology 79 (2012), 1636–1644.
-
(2012)
Neurology
, vol.79
, pp. 1636-1644
-
-
Doraiswamy, P.M.1
Sperling, R.A.2
Coleman, R.E.3
Johnson, K.A.4
Reiman, E.M.5
Davis, M.D.6
-
4
-
-
84862735174
-
Amyloid deposition, hypometabolism, and longitudinal cognitive decline
-
Landau, S.M., Mintun, M.A., Joshi, A.D., Koeppe, R.A., Petersen, R.C., Aisen, P.S., et al. Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol 72 (2012), 578–586.
-
(2012)
Ann Neurol
, vol.72
, pp. 578-586
-
-
Landau, S.M.1
Mintun, M.A.2
Joshi, A.D.3
Koeppe, R.A.4
Petersen, R.C.5
Aisen, P.S.6
-
5
-
-
84892765470
-
Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
-
Lim, Y.Y., Maruff, P., Pietrzak, R.H., Ames, D., Ellis, K.A., Harrington, K., et al. Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease. Brain 137 (2013), 221–231.
-
(2013)
Brain
, vol.137
, pp. 221-231
-
-
Lim, Y.Y.1
Maruff, P.2
Pietrzak, R.H.3
Ames, D.4
Ellis, K.A.5
Harrington, K.6
-
6
-
-
84902162274
-
Amyloid and APOE epsilon4 interact to influence short-term decline in preclinical Alzheimer disease
-
Mormino, E.C., Betensky, R.A., Hedden, T., Schultz, A.P., Ward, A., Huijbers, W., et al. Amyloid and APOE epsilon4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82 (2014), 1760–1767.
-
(2014)
Neurology
, vol.82
, pp. 1760-1767
-
-
Mormino, E.C.1
Betensky, R.A.2
Hedden, T.3
Schultz, A.P.4
Ward, A.5
Huijbers, W.6
-
7
-
-
84954271511
-
Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community
-
Petersen, R.C., Wiste, H.J., Weigand, S.D., Rocca, W.A., Roberts, R.O., Mielke, M.M., et al. Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community. JAMA Neurol 73 (2016), 85–92.
-
(2016)
JAMA Neurol
, vol.73
, pp. 85-92
-
-
Petersen, R.C.1
Wiste, H.J.2
Weigand, S.D.3
Rocca, W.A.4
Roberts, R.O.5
Mielke, M.M.6
-
8
-
-
84876205585
-
Cognitive trajectories associated with beta-amyloid deposition in the oldest-old without dementia
-
Snitz, B.E., Weissfeld, L.A., Lopez, O.L., Kuller, L.H., Saxton, J., Singhabahu, D.M., et al. Cognitive trajectories associated with beta-amyloid deposition in the oldest-old without dementia. Neurology 80 (2013), 1378–1384.
-
(2013)
Neurology
, vol.80
, pp. 1378-1384
-
-
Snitz, B.E.1
Weissfeld, L.A.2
Lopez, O.L.3
Kuller, L.H.4
Saxton, J.5
Singhabahu, D.M.6
-
9
-
-
84884979769
-
Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial
-
Mills, S.M., Mallmann, J., Santacruz, A.M., Fuqua, A., Carril, M., Aisen, P.S., et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris) 169 (2013), 737–743.
-
(2013)
Rev Neurol (Paris)
, vol.169
, pp. 737-743
-
-
Mills, S.M.1
Mallmann, J.2
Santacruz, A.M.3
Fuqua, A.4
Carril, M.5
Aisen, P.S.6
-
10
-
-
80055034288
-
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments
-
Reiman, E.M., Langbaum, J.B., Fleisher, A.S., Caselli, R.J., Chen, K., Ayutyanont, N., et al. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alzheimers Dis 26 Suppl 3 (2011), 321–329.
-
(2011)
J Alzheimers Dis
, vol.26 Suppl 3
, pp. 321-329
-
-
Reiman, E.M.1
Langbaum, J.B.2
Fleisher, A.S.3
Caselli, R.J.4
Chen, K.5
Ayutyanont, N.6
-
11
-
-
84899047367
-
The A4 study: stopping AD before symptoms begin?
-
Sperling, R.A., Rentz, D.M., Johnson, K.A., Karlawish, J., Donohue, M., Salmon, D.P., et al. The A4 study: stopping AD before symptoms begin?. Sci Transl Med, 6, 2014, 228fs13.
-
(2014)
Sci Transl Med
, vol.6
, pp. 228fs13
-
-
Sperling, R.A.1
Rentz, D.M.2
Johnson, K.A.3
Karlawish, J.4
Donohue, M.5
Salmon, D.P.6
-
12
-
-
84875514732
-
Regulatory innovation and drug development for early-stage Alzheimer's disease
-
Kozauer, N., Katz, R., Regulatory innovation and drug development for early-stage Alzheimer's disease. N Engl J Med 368 (2013), 1169–1171.
-
(2013)
N Engl J Med
, vol.368
, pp. 1169-1171
-
-
Kozauer, N.1
Katz, R.2
-
13
-
-
84959233450
-
Beta-amyloid and cognitive decline in late middle age: findings from the Wisconsin Registry for Alzheimer's Prevention study
-
Clark, L.R., Racine, A.M., Koscik, R.L., Okonkwo, O.C., Engelman, C.D., Carlsson, C.M., et al. Beta-amyloid and cognitive decline in late middle age: findings from the Wisconsin Registry for Alzheimer's Prevention study. Alzheimers Dement 12 (2016), 805–814.
-
(2016)
Alzheimers Dement
, vol.12
, pp. 805-814
-
-
Clark, L.R.1
Racine, A.M.2
Koscik, R.L.3
Okonkwo, O.C.4
Engelman, C.D.5
Carlsson, C.M.6
-
14
-
-
73549106106
-
Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition
-
Storandt, M., Mintun, M.A., Head, D., Morris, J.C., Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol 66 (2009), 1476–1481.
-
(2009)
Arch Neurol
, vol.66
, pp. 1476-1481
-
-
Storandt, M.1
Mintun, M.A.2
Head, D.3
Morris, J.C.4
-
15
-
-
84927175617
-
An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease
-
Langbaum, J.B., Hendrix, S.B., Ayutyanont, N., Chen, K., Fleisher, A.S., Shah, R.C., et al. An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease. Alzheimers Dement 10 (2014), 666–674.
-
(2014)
Alzheimers Dement
, vol.10
, pp. 666-674
-
-
Langbaum, J.B.1
Hendrix, S.B.2
Ayutyanont, N.3
Chen, K.4
Fleisher, A.S.5
Shah, R.C.6
-
16
-
-
84970916692
-
Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: introducing the Z-scores of attention, verbal fluency, and episodic memory for nondemented older adults composite score
-
Lim, Y.Y., Snyder, P.J., Pietrzak, R.H., Ukiqi, A., Villemagne, V.L., Ames, D., et al. Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: introducing the Z-scores of attention, verbal fluency, and episodic memory for nondemented older adults composite score. Alzheimers Dement (Amst) 2 (2016), 19–26.
-
(2016)
Alzheimers Dement (Amst)
, vol.2
, pp. 19-26
-
-
Lim, Y.Y.1
Snyder, P.J.2
Pietrzak, R.H.3
Ukiqi, A.4
Villemagne, V.L.5
Ames, D.6
-
17
-
-
84905969638
-
The preclinical Alzheimer cognitive composite: measuring amyloid-related decline
-
Donohue, M.C., Sperling, R.A., Salmon, D.P., Rentz, D.M., Raman, R., Thomas, R.G., et al. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol 71 (2014), 961–970.
-
(2014)
JAMA Neurol
, vol.71
, pp. 961-970
-
-
Donohue, M.C.1
Sperling, R.A.2
Salmon, D.P.3
Rentz, D.M.4
Raman, R.5
Thomas, R.G.6
-
18
-
-
0033380443
-
Neuropsychological prediction of decline to dementia in nondemented elderly
-
Kluger, A., Ferris, S.H., Golomb, J., Mittelman, M.S., Reisberg, B., Neuropsychological prediction of decline to dementia in nondemented elderly. J Geriatr Psychiatry Neurol 12 (1999), 168–179.
-
(1999)
J Geriatr Psychiatry Neurol
, vol.12
, pp. 168-179
-
-
Kluger, A.1
Ferris, S.H.2
Golomb, J.3
Mittelman, M.S.4
Reisberg, B.5
-
19
-
-
0023194048
-
The Modified Mini-Mental State (3MS) examination
-
Teng, E.L., Chui, H.C., The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 48 (1987), 314–318.
-
(1987)
J Clin Psychiatry
, vol.48
, pp. 314-318
-
-
Teng, E.L.1
Chui, H.C.2
-
20
-
-
84956583549
-
Tau PET imaging in aging and early Alzheimer's disease
-
Johnson, K.A., Schultz, A., Betensky, R.A., Becker, J.A., Sepulcre, J., Rentz, D., et al. Tau PET imaging in aging and early Alzheimer's disease. Ann Neurol 79 (2016), 110–119.
-
(2016)
Ann Neurol
, vol.79
, pp. 110-119
-
-
Johnson, K.A.1
Schultz, A.2
Betensky, R.A.3
Becker, J.A.4
Sepulcre, J.5
Rentz, D.6
-
21
-
-
84912064760
-
Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals
-
Mormino, E.C., Betensky, R.A., Hedden, T., Schultz, A.P., Amariglio, R.E., Rentz, D.M., et al. Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol 71 (2014), 1379–1385.
-
(2014)
JAMA Neurol
, vol.71
, pp. 1379-1385
-
-
Mormino, E.C.1
Betensky, R.A.2
Hedden, T.3
Schultz, A.P.4
Amariglio, R.E.5
Rentz, D.M.6
-
22
-
-
0038218463
-
Wechsler Memory Scale-Revised
-
The Psychological Corporation San Antonio
-
Wechsler, D., Wechsler Memory Scale-Revised. 1987, The Psychological Corporation, San Antonio.
-
(1987)
-
-
Wechsler, D.1
-
23
-
-
0141687342
-
WAIS-R Manual: Wechsler Adult Intelligence Scale-Revised
-
The Psychological Corporation San Antonio
-
Wechsler, D., WAIS-R Manual: Wechsler Adult Intelligence Scale-Revised. 1981, The Psychological Corporation, San Antonio.
-
(1981)
-
-
Wechsler, D.1
-
24
-
-
0016823810
-
“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
-
Folstein, M.F., Folstein, S.E., McHugh, P.R., “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (1975), 189–198.
-
(1975)
J Psychiatr Res
, vol.12
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
25
-
-
0031452102
-
Free and cued selective reminding and selective reminding in the elderly
-
Grober, E., Merling, A., Heimlich, T., Lipton, R.B., Free and cued selective reminding and selective reminding in the elderly. J Clin Exp Neuropsychol 19 (1997), 643–654.
-
(1997)
J Clin Exp Neuropsychol
, vol.19
, pp. 643-654
-
-
Grober, E.1
Merling, A.2
Heimlich, T.3
Lipton, R.B.4
-
26
-
-
84943738470
-
Prediction of Alzheimer's disease dementia: data from the GuidAge Prevention Trial
-
Di Stefano, F., Epelbaum, S., Coley, N., Cantet, C., Ousset, P.J., Hampel, H., et al. Prediction of Alzheimer's disease dementia: data from the GuidAge Prevention Trial. J Alzheimers Dis 48 (2015), 793–804.
-
(2015)
J Alzheimers Dis
, vol.48
, pp. 793-804
-
-
Di Stefano, F.1
Epelbaum, S.2
Coley, N.3
Cantet, C.4
Ousset, P.J.5
Hampel, H.6
-
27
-
-
45749146772
-
Genuine memory deficits in dementia
-
Grober, E., Buschke, H., Genuine memory deficits in dementia. Dev Neuropsychol 3 (1987), 13–36.
-
(1987)
Dev Neuropsychol
, vol.3
, pp. 13-36
-
-
Grober, E.1
Buschke, H.2
-
28
-
-
77956398359
-
Free and cued selective reminding identifies very mild dementia in primary care
-
Grober, E., Sanders, A.E., Hall, C., Lipton, R.B., Free and cued selective reminding identifies very mild dementia in primary care. Alzheimer Dis Assoc Disord 24 (2010), 284–290.
-
(2010)
Alzheimer Dis Assoc Disord
, vol.24
, pp. 284-290
-
-
Grober, E.1
Sanders, A.E.2
Hall, C.3
Lipton, R.B.4
-
29
-
-
35948993429
-
Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study
-
Sarazin, M., Berr, C., De Rotrou, J., Fabrigoule, C., Pasquier, F., Legrain, S., et al. Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 69 (2007), 1859–1867.
-
(2007)
Neurology
, vol.69
, pp. 1859-1867
-
-
Sarazin, M.1
Berr, C.2
De Rotrou, J.3
Fabrigoule, C.4
Pasquier, F.5
Legrain, S.6
-
30
-
-
84858138385
-
Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
-
Wagner, M., Wolf, S., Reischies, F.M., Daerr, M., Wolfsgruber, S., Jessen, F., et al. Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease. Neurology 78 (2012), 379–386.
-
(2012)
Neurology
, vol.78
, pp. 379-386
-
-
Wagner, M.1
Wolf, S.2
Reischies, F.M.3
Daerr, M.4
Wolfsgruber, S.5
Jessen, F.6
-
31
-
-
0027425211
-
The Clinical Dementia Rating (CDR): current version and scoring rules
-
Morris, J.C., The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43 (1993), 2412–2414.
-
(1993)
Neurology
, vol.43
, pp. 2412-2414
-
-
Morris, J.C.1
-
32
-
-
84879122146
-
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
-
Roe, C.M., Fagan, A.M., Grant, E.A., Hassenstab, J., Moulder, K.L., Maue Dreyfus, D., et al. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 80 (2013), 1784–1791.
-
(2013)
Neurology
, vol.80
, pp. 1784-1791
-
-
Roe, C.M.1
Fagan, A.M.2
Grant, E.A.3
Hassenstab, J.4
Moulder, K.L.5
Maue Dreyfus, D.6
-
33
-
-
84876364640
-
Screening for predementia AD: time-dependent operating characteristics of episodic memory tests
-
Derby, C.A., Burns, L.C., Wang, C., Katz, M.J., Zimmerman, M.E., L'Italien, G., et al. Screening for predementia AD: time-dependent operating characteristics of episodic memory tests. Neurology 80 (2013), 1307–1314.
-
(2013)
Neurology
, vol.80
, pp. 1307-1314
-
-
Derby, C.A.1
Burns, L.C.2
Wang, C.3
Katz, M.J.4
Zimmerman, M.E.5
L'Italien, G.6
-
34
-
-
0034084815
-
The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort
-
Elias, M.F., Beiser, A., Wolf, P.A., Au, R., White, R.F., D'Agostino, R.B., The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol 57 (2000), 808–813.
-
(2000)
Arch Neurol
, vol.57
, pp. 808-813
-
-
Elias, M.F.1
Beiser, A.2
Wolf, P.A.3
Au, R.4
White, R.F.5
D'Agostino, R.B.6
-
35
-
-
39549112686
-
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
-
Grober, E., Hall, C.B., Lipton, R.B., Zonderman, A.B., Resnick, S.M., Kawas, C., Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J Int Neuropsychol Soc 14 (2008), 266–278.
-
(2008)
J Int Neuropsychol Soc
, vol.14
, pp. 266-278
-
-
Grober, E.1
Hall, C.B.2
Lipton, R.B.3
Zonderman, A.B.4
Resnick, S.M.5
Kawas, C.6
-
36
-
-
85002578779
-
The DIAN-TU Next Generation Alzheimer's prevention trial: adaptive design and disease progression model
-
Bateman, R.J., Benzinger, T.L., Berry, S., Clifford, D.B., Duggan, C., Fagan, A.M., et al. The DIAN-TU Next Generation Alzheimer's prevention trial: adaptive design and disease progression model. Alzheimers Dement 13 (2017), 8–19.
-
(2017)
Alzheimers Dement
, vol.13
, pp. 8-19
-
-
Bateman, R.J.1
Benzinger, T.L.2
Berry, S.3
Clifford, D.B.4
Duggan, C.5
Fagan, A.M.6
-
37
-
-
84952720498
-
CAP—advancing the evaluation of preclinical Alzheimer disease treatments
-
Reiman, E.M., Langbaum, J.B., Tariot, P.N., Lopera, F., Bateman, R.J., Morris, J.C., et al. CAP—advancing the evaluation of preclinical Alzheimer disease treatments. Nat Rev Neurol 12 (2016), 56–61.
-
(2016)
Nat Rev Neurol
, vol.12
, pp. 56-61
-
-
Reiman, E.M.1
Langbaum, J.B.2
Tariot, P.N.3
Lopera, F.4
Bateman, R.J.5
Morris, J.C.6
-
38
-
-
84947997387
-
Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease
-
Papp, K.V., Mormino, E.C., Amariglio, R.E., Munro, C., Dagley, A., Schultz, A.P., et al. Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease. Neuropsychology 30 (2015), 624–630.
-
(2015)
Neuropsychology
, vol.30
, pp. 624-630
-
-
Papp, K.V.1
Mormino, E.C.2
Amariglio, R.E.3
Munro, C.4
Dagley, A.5
Schultz, A.P.6
-
39
-
-
84984782703
-
Performance on the Cogstate Brief battery is related to amyloid levels and hippocampal volume in very mild dementia
-
Lim, Y.Y., Villemagne, V.L., Laws, S.M., Pietrzak, R.H., Ames, D., Fowler, C., et al. Performance on the Cogstate Brief battery is related to amyloid levels and hippocampal volume in very mild dementia. J Mol Neurosci 60 (2016), 362–370.
-
(2016)
J Mol Neurosci
, vol.60
, pp. 362-370
-
-
Lim, Y.Y.1
Villemagne, V.L.2
Laws, S.M.3
Pietrzak, R.H.4
Ames, D.5
Fowler, C.6
-
40
-
-
84979685822
-
The feasibility of At-Home iPad Cognitive Testing for use in clinical trials
-
Rentz, D.M., Dekhtyar, M., Sherman, J., Burnham, S., Blacker, D., Aghjayan, S.L., et al. The feasibility of At-Home iPad Cognitive Testing for use in clinical trials. J Prev Alzheimers Dis 3 (2016), 8–12.
-
(2016)
J Prev Alzheimers Dis
, vol.3
, pp. 8-12
-
-
Rentz, D.M.1
Dekhtyar, M.2
Sherman, J.3
Burnham, S.4
Blacker, D.5
Aghjayan, S.L.6
-
41
-
-
84979547145
-
Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study
-
Burnham, S.C., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., et al. Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurol 15 (2016), 1044–1053.
-
(2016)
Lancet Neurol
, vol.15
, pp. 1044-1053
-
-
Burnham, S.C.1
Bourgeat, P.2
Dore, V.3
Savage, G.4
Brown, B.5
Laws, S.6
-
42
-
-
84974602452
-
Hypothetical preclinical Alzheimer disease groups and longitudinal cognitive change
-
Soldan, A., Pettigrew, C., Cai, Q., Wang, M.C., Moghekar, A.R., O'Brien, R.J., et al. Hypothetical preclinical Alzheimer disease groups and longitudinal cognitive change. JAMA Neurol 73 (2016), 698–705.
-
(2016)
JAMA Neurol
, vol.73
, pp. 698-705
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Soldan, A.1
Pettigrew, C.2
Cai, Q.3
Wang, M.C.4
Moghekar, A.R.5
O'Brien, R.J.6
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