Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

Annals of Neurology

Volumn 81, Issue 4, 2017, Pages 549-559

  Abner, Erin L ^a   Kryscio, Richard J ^a   Schmitt, Frederick A ^b   Fardo, David W ^a   Moga, Daniela C ^a   Ighodaro, Eseosa T ^b   Jicha, Gregory A ^b   Yu, Lei ^c   Dodge, Hiroko H ^d   Xiong, Chengjie ^e   Woltjer, Randall L ^d   Schneider, Julie A ^c   Cairns, Nigel J ^f   Bennett, David A ^c   Nelson, Peter T ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AMYLOID PLAQUE; ARTERIOLOSCLEROSIS; ARTICLE; AUTOPSY; BRAIN HEMORRHAGE; BRAIN INFARCTION; COGNITION; COHORT ANALYSIS; COMORBIDITY; DIFFUSE LEWY BODY DISEASE; FEMALE; FOLLOW UP; HIPPOCAMPAL SCLEROSIS; HUMAN; LONGITUDINAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SENILE PLAQUE; TAUOPATHY; UNITED STATES; VASCULAR AMYLOIDOSIS; VERY ELDERLY; ALZHEIMER DISEASE; BRAIN ATHEROSCLEROSIS; CLASSIFICATION; CLINICAL TRIAL; COGNITIVE DEFECT; DEMENTIA; MULTICENTER STUDY; PATHOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ARTERIOLOSCLEROSIS; AUTOPSY; COGNITIVE DYSFUNCTION; DEMENTIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRACRANIAL ARTERIOSCLEROSIS; MALE; TAUOPATHIES;

EID: 85016009213     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24903     Document Type: Article

References (41)

1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Int Med 2004;256:183–194.
2. Roberts R, Knopman DS. Classification and epidemiology of MCI. Clin Geriatr Med 2013;29:753–772.
3. Mitchell AJ, Shiri-Feski M. Rate of progression of mild cognitive impairment to dementia—meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 2009;119:252–265.
4. Abner EL, Kryscio RJ, Cooper GE, et al. Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimer Dis 2012;2012:291920.
5. Kryscio RJ, Abner EL, Lin Y, et al. Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia. J Alzheimers Dis 2013;35:823–832.
6. Knopman DS, Jack DR Jr, Wiste HJ, et al. Brain injury biomarkers are not dependent on β-amyloid in normal elderly. Ann Neurol 2013;73:472–480.
7. Jicha GA, Abner E, Schmitt FA, et al. Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings. Dement Geriatr Cogn Disord 2008;26:187–192.
8. Jicha GA, Parisi JE, Dickson DW, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol 2006;63:674–681.
9. Petersen RC, Aisen P, Boeve BF, et al. Criteria for mild cognitive impairment due to Alzheimer's disease in the community. Ann Neurol 2013;74:199–208.
10. Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 2009;66:200–208.
11. Nelson PT, Schmitt FA, Lin Y, et al. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain 2011;134:1506–1518.
12. Crary JF, Trojanowski JQ, Schneider JA, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 2014;128:755–766.
13. Ighodaro ET, Abner EL, Fardo DW, et al. Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. J Cereb Blood Flow Metab 2017;37:201–216.
14. Abner EL, Schmitt FA, Nelson PT, et al. The Statistical Modeling of Aging and Risk of Transition Project: data collection and harmonization across 11 longitudinal cohort studies of aging, cognition, and dementia. Obs Stud 2015;1:56–73.
15. Green MS, Kaye JA, Ball MJ. The Oregon Brain Aging Study: neuropathology accompanying healthy aging in the oldest old. Neurology 2000;54:105–113.
16. Kaye J, Michael Y, Calvert J, et al. Exceptional brain aging in a rural population-based cohort. J Rural Health 2009;25:320–325.
17. Bennett DA, Wilson RS, Schneider JA, et al. Natural history of mild cognitive impairment in older persons. Neurology 2002;59:198–205.
18. Bennett DA, Schneider JA, Buchman AS, et al. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 2005;25:163–175.
19. Berg L, McKeel DW, Miller JP, et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease. Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 1998;55:326–335.
20. Schmitt FA, Nelson PT, Abner E, et al. University of Kentucky Sanders-Brown Health Brain Aging Volunteers: donor characteristics, procedures, and neuropathology. Curr Alzheimer Res 2012;9:724–733.
21. Morris JC, Storandt M, Milller JP, et al. Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001;58:397–405.
22. Morris JC, Fulling K. Early Alzheimer's disease. Diagnostic considerations. Arch Neurol 1988;45:345–349.
23. Stern Y. The concept of cognitive reserve: a catalyst for research. J Clin Exp Neuropsychol 2003;25:589–593.
24. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994.
25. McKhann G, Drachman D, Folstin M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939–944.
26. Schneider JA, Wilson RS, Bienias JL, et al. Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 2004;62:1148–1155.
27. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239–259.
28. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479–486.
29. McKeith LG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies. Third report of the DLB consortium. Neurology 2005;65:1863–1872.
30. Brenowitz WD, Nelson PT, Besser LM, et al. Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes. Neurobiol Aging 2015;36:2702–2708.
31. Montine TJ, Phelps CH, Beach TG, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathological assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 2012;123:1–11.
32. Jack CR, Knopman DS, Chételat G, et al. Suspected non-Alzheimer disease pathophysiology—concept and controversy. Nat Rev Neurol 2016;12:117–124.
33. Markesbery WR, Schmitt FA, Kryscio RJ, et al. Neuropathologic substrate of mild cognitive impairment. Arch Neurol 2006;63:38–46.
34. Storandt M, Grant EA, Miller JP, Morric JC. Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology 2006;67:467–473.
35. Dugger BN, Davis K, Malek-Ahmadi M, et al. Neuropathological comparisons of amnestic and nonamnestic mild cognitive impairment. BMC Neurol 2015;15:146.
36. Vos SJ, Xiong C, Visser PJ, et al. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol 2013;12:957–965.
37. Arvanitakis Z, Capuano AW, Leurgans SE, et al. Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study. Lancet Neurol 2016;15:934–943.
38. Haneuse S, Schildcrout J, Crane P, et al. Adjustment for selection bias in observational studies with application to the analysis of autopsy data. Neuroepidemiology 2009;32:229–239.
39. Nelson PT, Abner EL, Schmitt FA, et al. Modelling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 2010;10:66–79.
40. Nag S, Yu L, Capuano AW, et al. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol 2015;77:942–952.
41. Jicha GA, Petersen RC, Knopman DS, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol 2006;65:602–609.