The phenotypic spectrum of congenital Zika syndrome

American Journal of Medical Genetics, Part A

Volumn 173, Issue 4, 2017, Pages 841-857

  del Campo, Miguel ^a   Feitosa, Ian M L ^b,c   Ribeiro, Erlane M ^d   Horovitz, Dafne D G ^e   Pessoa, André L S ^d   França, Giovanny V A ^f   García Alix, Alfredo ^g   Doriqui, Maria J R ^h   Wanderley, Hector Y C ⁱ   Sanseverino, Maria V T ^j   Neri, João I C F ^k   Pina Neto, João M ^l   Santos, Emerson S ^m   Verçosa, Islane ⁿ   Cernach, Mirlene C S P ^o   Medeiros, Paula F V ^p   Kerbage, Saile C ^d   Silva, André A ^b,j,q   van der Linden, Vanessa ^r   Martelli, Celina M T ^e   Cordeiro, Marli T ^e   Dhalia, Rafael ^e   Vianna, Fernanda S L ^b,j   Victora, Cesar G ^s   Cavalcanti, Denise P ^t   Schuler Faccini, Lavinia ^b,k   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^d Hospital Infantil Albert Sabin   (Brazil)

^e INSTITUTO OSWALDO CRUZ   (Brazil)

^f MINISTÉRIO DA SAÚDE   (Brazil)

^g UNIVERSITY OF BARCELONA   (Spain)

^h Juvêncio Mattos Children's Hospital   (Brazil)

ⁱ Centro de Referências Para Imunobiológicos Especiais CRIE da Secretaria de Saúde Do Estado Do Espírito Santo   (Brazil)

^j HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^k POTIGUAR UNIVERSITY   (Brazil)

^l UNIVERSITY OF SÃO PAULO   (Brazil)

^m FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

ⁿ Centro de Aperfeiçoamento Visual Ver a Esperança Renascer CAVIVER   (Brazil)

^o FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^p FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

^q UNIVATES University   (Brazil)

^r AACD   (Brazil)

^s FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^t UNIVERSITY OF CAMPINAS   (Brazil)

more..

Author keywords

congenital Zika infection; congenital Zika sequence; congenital Zika syndrome; disruption; disruptive sequence; dysmorphology; fetal brain disruption sequence; teratogen; teratology; Zika virus

Indexed keywords

IMMUNOGLOBULIN M; IMMUNOGLOBULIN G; VIRUS ANTIBODY;

ADOLESCENT; ADULT; ARTHROGRYPOSIS; ARTICLE; CEREBROSPINAL FLUID; CONGENITAL INFECTION; DISEASE SEVERITY; FEMALE; FOOT MALFORMATION; HEAD CIRCUMFERENCE; HUMAN; IMMOBILITY; INFANT; JOINT CONTRACTURE; MAJOR CLINICAL STUDY; MALE; MICROCEPHALY; NEUROIMAGING; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; ZIKA FEVER; ZIKA VIRUS; ABNORMALITIES; BRAIN; BRAZIL; COMPLICATION; DIAGNOSTIC IMAGING; EPIDEMIC; FETAL DISEASES; FETUS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; PATHOGENICITY; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SYNDROME; VIROLOGY; ZIKA VIRUS INFECTION;

ANTIBODIES, VIRAL; BRAIN; BRAZIL; DISEASE OUTBREAKS; FEMALE; FETAL DISEASES; FETUS; HUMANS; IMMUNOGLOBULIN G; INFANT; MICROCEPHALY; NEUROIMAGING; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SYNDROME; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85015890304     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.38170     Document Type: Article

References (90)

1. Abdel-Salam, G. M., Zaki, M. S., Saleem, S. N., & Gaber, K. R. (2008). Microcephaly, malformation of brain development and intracranial calcification in sibs: Pseudo-torch or a new syndrome. American Journal of Medical Genetics Part A, 146A, 2929–2936.
2. Abdel-Salam, G. M., Abdel-Hamid, M. S., El-Khayat, H. A., Eid, O. M., Saba, S., Farag, M. K., … Gaber, K. R. (2015). Fetal brain disruption sequence versus fetal brain arrest: A distinct autosomal recessive developmental brain malformation phenotype. American Journal of Medical Genetics Part A, 167A, 1089–1099.
3. Alarcon, A., Martinez-Biarge, M., Cabañas, F., Hernanz, A., Quero, J., & Garcia-Alix, A. (2013). Clinical, biochemical, and neuroimaging findings predict long-term neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. Jornal de Pediatria, 163, 828–834.e1.
4. Alexander, I. E., Tauro, G. P., & Bankier, A. (1995). Fetal brain disruption sequence in sisters. European Journal of Pediatrics, 154, 654–657.
5. Anbeek, P., Išgum, I., Van Kooij, B. J., Mol, C. P., Kersbergen, K. J., Groenendaal, F., … Benders, M. J. (2013). Automatic segmentation of eight tissue classes in neonatal brain MRI. PLoS ONE, 8, e81895.
6. Averill, L. W., Kandula, V. V., Akyol, Y., & Epelman, M. (2015). Fetal brain magnetic resonance imaging findings In congenital cytomegalovirus infection with postnatal imaging correlation. Seminars in Ultrasound, CT, and MR, 36, 476–486.
7. Bell, T. M., Field, E. J., & Narang, H. K. (1971). Zika virus infection of the central nervous system of mice. Archiv für die gesamte Virusforschung, 35, 183–193.
8. Besnard, M., Eyrolle-Guignot, D., Guillemette-Artur, P., Lastère, S., Bost-Bezeaud, F., Marcelis, L., … Mallet, H.-P. (2016). Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013–2014 Zika virus epidemic in French Polynesia. Euro Surveillance, 21, 13.
9. Bonnemann, C. G., & Meinecke, P. (2000). Dysmorphology fetal brain disruption. Journal of Medical Genetics, 27, 273–274.
10. Brasil, P., Calvet, G. A., Siqueira, A. M., Wakimoto, M., de Sequeira, P. C., Nobre, A., … Jaenisch, T. (2016). Zika virus outbreak in rio de janeiro, Brazil: Clinical characterization, epidemiological and virological aspects. PLOS Neglected Tropical Diseases, 10, 1–13.
11. Brasil, P., Pereira, J. P., Jr., Raja Gabaglia, C., Damasceno, L., Wakimoto, M., Ribeiro Nogueira, R. M., … Nielsen-Saines, K. (2016). Zika virus infection in pregnant women in rio de janeiro — preliminary report. New England Journal of Medicine, NEJMoa1602412.
12. Brasil, P., Pereira, J. P., Jr, Moreira, M. E., Ribeiro Nogueira, R. M., Damasceno, L., Wakimoto, M., … Nielsen-Saines, K. (2016). Zika virus infection in pregnant women in rio de janeiro. New England Journal of Medicine, 375, 2321–2334.
13. Calvet, G., Aguiar, R. S., Melo, A. S., Sampaio, S. A., de Filippis, I., Fabri, A., … de Filippis, A. M. (2016). Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: A case study. Lancet Infectious Diseases, 16, 653–660.
14. Campos, G. S., Bandeira, A. C., & Sardi, S. I. (2015). Zika virus outbreak, bahia. Brazil Emerging Infectious Diseases, 21, 1885–1886.
15. Capretti, M. G., Lanari, M., Tani, G., Ancora, G., Sciutti, R., Marsico, C., … Faldella, G. (2014). Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain and Development, 36, 203–211.
16. Carvalho, F. H., Cordeiro, K. M., Peixoto, A. B., Tonni, G., Moron, A. F., Feitosa, F. E., … Araujo Júnior, E. (2016). Associated ultrasonographic findings in fetuses with microcephaly due to suspected Zika virus (ZIKV) infection during pregnancy. Prenatal Diagnosis, 36, 882–887.
17. Carvalho, M. D., Ferreira, L., Caldas, S., Linden, V. V. D., Coeli, R., & Ramos, F. (2016). Sensorineural hearing loss in a case of congenital Zika virus. Brazilian Journal of Otorhinolaryngology, pii: S1808-8694(16)30127-6. doi: 10.1016/j.bjorl.2016.06.001. [Epub ahead of print].
18. Carvalho, M. D., Miranda-Filho, D. B., van der Linden, V., Sobral, P. F., Ramos, R. C., Rocha, M., … Nunes, M. L. (2017). Sleep EEG patterns in infants with congenital Zika virus syndrome. Clinical Neurophysiology, 128, 204–214.
19. Cavalheiro, S., Lopez, A., Serra, S., Da Cunha, A., da Costa, M. D., Moron, A., & Lederman, H. M. (2016). Microcephaly and Zika virus: Neonatal neuroradiological aspects. Child's Nervous System, 32, 1057–1060.
20. Chang, C., Ortiz, K., Ansari, A., & Gershwin, M. E. (2016). The Zika outbreak of the 21st century. Journal of Autoimmunity, 68, 1–13.
21. Cordeiro, M. T., Pena, L. J., Brito, C. A., Gil, L. H., & Marques, E. T. (2016). Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil. The Lancet, 387, 1811–1812.
22. Corona-Rivera, J. R., Corona-Rivera, E., Romero-Velarde, E., Hernández-Rocha, J., Bobadilla-Morales, L., & Corona-Rivera, A. (2001). Report and review of the fetal brain disruption sequence. European Journal of Pediatrics, 160, 664–667.
23. Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L., Guimarães, K. P., … Beltrão-Braga, P. C. (2016). The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534, 267–271.
24. Culjat, M., Darling, S. E., Nerurkar, V. R., Ching, N., Kumar, M., Min, S. K., … Melish, M. E. (2016). Clinical and imaging findings in an infant with zika embryopathy. Clinical Infectious Diseases, 1–7.
25. Dang, J., Tiwari, S. K., Lichinchi, G., Qin, Y., Patil, V. S., Eroshkin, A. M., & Rana, T. M. (2016). Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell, 19, 258–265.
26. de Araújo, T. V., Rodrigues, L. C., de Alencar Ximenes, R. A., de Barros Miranda-Filho, D., Montarroyos, U. R., de Melo, A. P., … Martelli, C. M. (2016). Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: Preliminary report of a case-control study. Lancet Infect. Lancet Infectious Diseases, 3099, 1–8.
27. De Barros Miranda-Filho, D., Martelli, C. M., Ximenes, R. A., Araújo, T. V., Rocha, M. A., Ramos, R. C., … Rodrigues, L. C. (2016). Initial description of the presumed congenital Zika syndrome. American Journal of Public Health, 106, 598–600.
28. de Fatima Vasco Aragao, M., van der Linden, V., Brainer-Lima, A. M., Coeli, R. R., Rocha, M. A., Sobral da Silva, P., … Valenca, M. M. (2016). Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: Retrospective case series study. BMJ, 353, i1901.
29. De Felice, C., Toti, P., Di Maggio, G., Parrini, S., & Bagnoli, F. (2001). Absence of the inferior labial and lingual frenula in Ehlers-Danlos syndrome. The Lancet, 357, 1500–1502.
30. de Paula Freitas, B., de Oliveira Dias, J. R., Prazeres, J., Sacramento, G. A., Ko, A. I., Maia, M., & Belfort, R., Jr (2016). Ocular findings in infants with microcephaly associated with presumed zika virus congenital. JAMA Ophthalmology, 134, 529–535.
31. Dick, G. W. A. (1952). Zika virus (I). Isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46, 509–520.
32. Driggers, R. W., Ho, C.-Y., Korhonen, E. M., Kuivanen, S., Jääskeläinen, A. J., Smura, T., … Vapalahti, O. (2016). Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. New England Journal of Medicine, 374, 2142–2151.
33. Dudley, D. M., Aliota, M. T., Mohr, E. L., Weiler, A. M., Lehrer-Brey, G., Weisgrau, K. L., … O'Connor, D. H. (2016). A rhesus macaque model of Asian-lineage Zika virus infection. Nature Communications, 7, 12204.
34. Fauci, A. S., & Morens, D. M. (2016). Zika virus in the americas — yet another arbovirus threat. New England Journal of Medicine, 374, 601–604.
35. França, G. V., Schuler-Faccini, L., Oliveira, W. K., Henriques, C. M., Carmo, E. H., Pedi, V. D., & Victora, C. G. (2016). Congenital Zika virus syndrome in Brazil: A case series of the first 1501 Livebirths with complete investigation. The Lancet, 388, 891–897.
36. Furdon, S. A., & Clark, D. A. (2003). Scalp hair characteristics in the newborn infant. Advances in Neonatal Care, 3, 286–296.
37. Goodfellow, F. T., Tesla, B., Simchick, G., Zhao, Q., Hodge, T., Brindley, M. A., & Stice, S. L. (2016). Zika virus induced mortality and microcephaly in chicken embryos. Stem Cells and Development, 25, 1691–1697.
38. Guillemette-Artur, P., Besnard, M., Eyrolle-Guignot, D., Jouannic, J. M., & Garel, C. (2016). Prenatal brain MRI of fetuses with Zika virus infection. Pediatric Radiology, 46, 1032–1039.
39. Hanson, J., Smith, D., & Cohen, M. J. (1976). Prominent lateral palatine ridges: Developmental and clinical relevance. Jornal de Pediatria, 89, 54–58.
40. Hazin, A. N., Poretti, A., Di Cavalcanti Souza Cruz, D., Tenorio, M., van der Linden, A., & Huisman, T. A. (2016). Computed tomographic findings in microcephaly associated with zika virus. New England Journal of Medicine, 374, 2193–2195.
41. Honein, M. A., Dawson, A. L., Petersen, E. E., Jones, A. M., Lee, E. H., … Yazdy, M. M. (2017). Birth defects among fetuses and infants of US women with evidence of possible zika virus infection during pregnancy. JAMA, 317, 59–68.
42. Huang, W.-C., Abraham, R., Shim, B.-S., Choe, H., & Page, D. T. (2016). Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild-type mice. Scientific Reports, 6, 34793.
43. Hughes, E. (1986). Congenital disruption: Microcephaly due to vascular In utero documentation. Pediatrics, 78, 85.
44. Illingworth, R. (1965). Head circumference of infants related to body weight. Archives of Disease in Childhood, 40, 672–676.
45. Jones, K. L. (1980). The Miller-Dieker syndrome. Journal of pediatrics, 66, 277–281.
46. Jones, K. L., Jones, M. C., Del Campo, M. (Eds.), (2013). Smith's recognizable patterns of human malformation (7th ed.). Philadelphia, PA: Elsevier.
47. Kimura, S., & Kitagawa, T. (1986). Embryological development of human palmar, plantar, and digital flexion creases. Anatomical Record, 216, 191–197.
48. Kumar, A., Kanojia, R. K., & Saili, A. (2014). Skin dimples. International Journal of Dermatology, 53, 789–797.
49. Kurjak, A., Tikvica, A., Stanojevic, M., Miskovic, B., Ahmed, B., Azumendi, G., & Di Renzo, G. C. (2008). The assessment of fetal neurobehavior by three- dimensional and four-dimensional ultrasound. journal of Maternal-Fetal and Neonatal Medicine, 21, 675–684.
50. Leal, C., Esteves-pereira, A. P., Nakamura-pereira, M., Torres, J. A., Theme-filha, M., Maria, R., … Gama, S. G. (2016). Prevalence and risk factors related to preterm birth in Brazil. Reproductive Health, 13.
51. Li, H., Saucedo-Cuevas, L., Regla-Nava, J. A., Terskikh, A. V., Shresta, S., Gleeson, J. G., … Tang, W. (2016). Zika virus infects neural progenitors in the adult mouse brain and alters proliferation. Stem Cell, 19, 1–6.
52. MacHet, L., Hüttenberger, B., Georgesco, G., Doré, C., Jamet, F., Bonnin-Goga, B., … Vaillant, L. (2010). Absence of inferior labial and lingual frenula in ehlers-danlos syndrome: A minor diagnostic criterion in french patients. American Journal of Clinical Dermatology, 11, 269–273.
53. Martines, R. B., Bhatnagar, J., de Oliveira Ramos, A. M., Davi, H. P., Iglezias, S. D., Kanamura, C. T., … Zaki, S. R. (2016). Pathology of congenital Zika syndrome in Brazil: A case series. The Lancet, 388, 898–904.
54. Melo, A. S., Aguiar, R. S., Amorim, M. M., Arruda, M. B., Melo, F. O., Ribeiro, S. T., … Tanuri, A. (2016). Congenital zika virus infection: Beyond neonatal microcephaly. JAMA Neurology, 73, 1407–1416.
55. Microcephaly Epidemic Research Group (2016). Microcephaly epidemic research group. microcephaly in infants, pernambuco state, Brazil, 2015. Emerging Infectious Diseases, 22, 1090–1093.
56. Miranda, H. A., 2nd, Costa, M. C., Frazão, M. A., Simão, N., Franchischini, S., & Moshfeghi, D. M. (2016). Expanded spectrum of congenital ocular findings in microcephaly with presumed zika infection. Ophthalmology, 123, 1788–1794.
57. Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., … Avšič, T. (2016). Zika virus associated with microcephaly. New England Journal of Medicine, 374, 951–958.
58. Mochida, G. H., Ganesh, V. S., Felie, J. M., Gleason, D., Hill, R. S., Clapham, K. R., … Walsh, C. A. (2010). A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. American Journal of Human Genetics, 87, 882–889.
59. Moore, C., Weaver, D., & Bull, M. (1990). Fetal brain disruption sequence. Jornal de Pediatria, 116, 383–386.
60. Moore, C. A., Staples, J. E., Dobyns, W. B., Pessoa, A., Ventura, C. V., Fonseca, E. B., … Rasmussen, S. A. (2016). Characterizing the pattern of anomalies in congenital zika syndrome for pediatric clinicians. JAMA Pediatrics, [Epub ahead of print].
61. Moura da Silva, A. A., Ganz, J. S., Sousa, P. D., Doriqui, M. J., Ribeiro, M. R., Branco, M. D., Queiroz, R. C., … Soares de Britto E Alves, M. T. (2016). Early growth and neurologic outcomes of infants with probable congenital zika virus syndrome. Emerging Infectious Diseases, 22, 1953–1956.
62. Nishi, M., Miyake, H., Akashi, H., Shimizu, H., Tateyama, H., Chaki, R., & Nishi, M. … (1992). An index for proportion of head size to body mass during infancy. Journal of Child Neurology, 7, 400–403.
63. Paciorkowski, A. R., Keppler-Noreuil, K., Robinson, L., Sullivan, C., Sajan, S., Christian, S. L., & Dobyns, W. B. (2013). Deletion 16p13.11 uncovers NDE1 mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption. American Journal of Medical Genetics Part A, 161, 1523–1530.
64. PAHO. (2015). Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas. Pan American Health Organization, 1–11.
65. Rasmussen, S. A., Jamieson, D. J., Honein, M. A., & Petersen, L. R. (2016). Zika virus and birth defects — reviewing the evidence for causality. New England Journal of Medicine, 384, 1981–1987.
66. Rochelson, B., Vohra, N., Krantz, D., & Macri, V. J. (2006). Geometric morphometric analysis of shape outlines of the normal and abnormal fetal skull using three-dimensional sonographic multiplanar display. Ultrasound in Obstetrics and Gynecology, 27, 167–172.
67. Russell, K., Oliver, S. E., Lewis, L., Barfield, W. D., Cragan, J., Meaney-Delman, D., … Rasmussen, S. A. (2016). Update: Interim guidance for the evaluation and management of infants with possible congenital zika virus infection—United States, August 2016. MMWR Morbidity and Mortality Weekly Report, 65, 870–878.
68. Russell, L., Weaver, D., Bull, M., & Weinbaum, M. (1984). In utero brain destruction resulting in collapse of the fetal skull, microcephaly, scalp rugae, and neurologic impairment: The fetal brain disruption sequence. American Journal of Medical Genetics, 17, 509–521.
69. Sadler, T. W. (2015). Langman's medical embryology (13th ed.). China: Wolters Kluwer Health.
70. Sarno, M., Sacramento, G. A., Khouri, R., do Rosário, M. S., Costa, F., Archanjo, G., … de Almeida, A. R. P. (2016). Zika virus infection and stillbirths: A case of hydrops fetalis, hydranencephaly and fetal demise. PLOS Neglected Tropical Diseases, 10, 5–9.
71. Schram, A., Kroes, H. Y., Sollie, K., Timmer, B., Barth, P., & Essen, T. V. (2004). Clinical report hereditary fetal brain degeneration resembling fetal brain disruption sequence in two sibships. American Journal of Medical Genetics Part A, 182A, 172–182.
72. Schuler-Faccini, L., Ribeiro, E. M., Feitosa, I. M., Horovitz, D. D., Cavalcanti, D. P., … Pessoa, A. (2016). Possible association between zika virus infection and microcephaly—Brazil, 2015. MMWR Morbidity and Mortality Weekly Report, 65, 59–62.
73. Schuler-Faccini, L., Sanseverino, M., Vianna, F., da Silva, A. A., Larrandaburu, M., Marcolongo-Pereira, C., & Abeche, A. M. (2016). Zika virus: A new human teratogen? Implications for women reproductive age. Clinical Pharmacology and Therapeutics, 100, 28–30.
74. Smith, D. W., & Gong, B. T. (1973). Scalp hair patterning as a clue to early fetal brain development. Jornal de Pediatria, 83, 374–380.
75. Soares de Oliveira-Szejnfeld, P., Levine, D., Melo, A. S., Amorim, M. M., Batista, A. G., Chimelli, L., … Tovar-Moll, F. (2016). Congenital brain abnormalities and zika virus: What the radiologist can expect to see prenatally and postnatally. Radiology, 281, 161584.
76. Soares de Souza, A., Moraes Dias, C., Braga, F. D., Terzian, A. C., Estofolete, C. F., Oliani, A. H., … Vaz-Oliani, D. C. (2016). Fetal infection by Zika virus in the third trimester—report of 2 cases. Clinical Infectious Diseases, 15, 1622–1625.
77. Stevens, C. A., Carey, J. C., Shah, M., & Bagley, G. P. (1988). Development of human palmar and digital flexion creases. Jornal de Pediatria, 113, 128–132.
78. Stratton, R. F., Dobyns, W. B., Airhart, S. D., & Ledbetter, D. H. (1984). New chromosomal syndrome: Miller-Dieker syndrome and monosomy 17p13. Human Genetics, 67, 193–200.
79. Suy, A., Sulleiro, E., Rodó, C., Vázquez,, Bocanegra, C., Molina, I., … Carreras, E. (2016). Prolonged zika virus viremia during pregnancy. The New England Journal of Medicine, 375, 2611–2613.
80. Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., … Ming, G. L. (2016). Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell, 18, 587–590.
81. van der Eijk, A. A., van Genderen, P. J., Verdijk, R. M., Reusken, C. B., Mögling, R., van Kampen, J. J., … Koopmans, M. P. (2016). Miscarriage associated with zika virus infection. New England Journal of Medicine, 375, 1002–1004.
82. van der Linden, V., Filho, E. L., Lins, O. G., van der Linden, A., Aragão Mde, F., Brainer-Lima, A. M., … Ramos, R. C. (2016). Congenital Zika syndrome with arthrogryposis: Retrospective case series study. BMJ, 354, i3899.
83. Van der Linden, V., Pessoa, A., Dobyns, W., Barkovich, A. J., & Júnior, H. V. D. L. (2016). Description of 13 infants born during October 2015-January 2016 with congenital Zika virus infection without microcephaly at birth—Brazil. MMWR Morbidity and Mortality Weekly Report.
84. Ventura, C. V., Maia, M., Bravo-Filho, V., Góis, A. L., & Belfort, R. (2016). Zika virus in Brazil and macular atrophy in a child with microcephaly. The Lancet, 387, 228.
85. Ventura, C. V., Maia, M., Travassos, S. B., Martins, T. T., Patriota, F., Nunes, M. E., … Belfort, R. (2016). Risk factors associated with the ophthalmoscopic findings identified in infants with presumed zika virus congenital infection. JAMA Ophthalmology, 134, 912–918.
86. Ventura, C. V., Maia, M., Ventura, B. V., Van Der Linden, V., Araújo, E. B., Ramos, R. C., … Ventura, L. O. (2016). Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arquivos Brasileiros de Oftalmologia, 79, 1–3.
87. Verloes, A., Drunat, S., Gressens, P., & Passemard, S. (1993). Primary autosomal recessive microcephalies and Seckel syndrome spectrum disorders. In: R. A. Pagon, M. P. Adam, H. H. Ardinger, S. E. Wallace, A. Amemiya, L. J. H. Bean, T. D. Bird, N. Ledbetter, H. C. Mefford, R. J. H. Smith, & K. Stephens (Eds.). GeneReviews® [Internet] (pp. 1993–2017). Seattle, WA: University of Washington, Seattle.
88. Villar, J., Cheikh Ismail, L., Victora, C. G., Ohuma, E. O., Bertino, E., Altman, D. G., … Kennedy, S. H. (2014). International standards for newborn weight, length, and head circumference by gestational age and sex: The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. The Lancet, 384, 857–868.
89. Villó, N., Beceiro, J., Cebrero, M., & de Frias, E. G. (2001). Fetal brain disruption sequence in a newborn infant with a history of cordocentesis at 21 weeks gestation. Archives of Disease in Childhood Fetal and Neonatal Edition, 84, 63–64.
90. Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., … Jin, P. (2016). Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Research, 44, gkw765.