-
3
-
-
84865492997
-
Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus
-
Patil HR, Al Badarin FJ, Al Shami HA, et al. Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus. Am J Cardiol. 2012;110(6):826–833.• This meta-analysis showed significant benefit in CV outcomes with DPP-4 inhibitors.
-
(2012)
Am J Cardiol
, vol.110
, Issue.6
, pp. 826-833
-
-
Patil, H.R.1
Al Badarin, F.J.2
Al Shami, H.A.3
-
4
-
-
84871936025
-
Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials
-
Monami M, Ahrén B, Dicembrini I, et al. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk:a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2013;15(2):112–120.• Another meta-analysis showed significant benefit in CV outcomes with DPP-4 inhibitors.
-
(2013)
Diabetes Obes Metab
, vol.15
, Issue.2
, pp. 112-120
-
-
Monami, M.1
Ahrén, B.2
Dicembrini, I.3
-
5
-
-
84871713043
-
Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus: a pooled analysis
-
Engel SS, Golm GT, Shapiro D, et al. Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus:a pooled analysis. Cardiovasc Diabetol. 2013;12:3.
-
(2013)
Cardiovasc Diabetol
, vol.12
, pp. 3
-
-
Engel, S.S.1
Golm, G.T.2
Shapiro, D.3
-
6
-
-
84945494524
-
Cardiovascular and heart failure safety profile of vildagliptin: a meta-analysis of 17 000 patients
-
McInnes G, Evans M, Del Prato S, et al. Cardiovascular and heart failure safety profile of vildagliptin:a meta-analysis of 17 000 patients. Diabetes Obes Metab. 2015;17(11):1085–1092.
-
(2015)
Diabetes Obes Metab
, vol.17
, Issue.11
, pp. 1085-1092
-
-
McInnes, G.1
Evans, M.2
Del Prato, S.3
-
7
-
-
84893200919
-
Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials
-
Iqbal N, Parker A, Frederich R, et al. Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus:pooled analysis of 20 clinical trials. Cardiovasc Diabetol. 2014;13:33.
-
(2014)
Cardiovasc Diabetol
, vol.13
, pp. 33
-
-
Iqbal, N.1
Parker, A.2
Frederich, R.3
-
8
-
-
84878939138
-
Cardiovascular safety of the dipetidyl peptidase-4 inhibitor alogliptin in type 2 diabetes mellitus
-
White WB, Pratley R, Fleck P, et al. Cardiovascular safety of the dipetidyl peptidase-4 inhibitor alogliptin in type 2 diabetes mellitus. Diabetes Obes Metab. 2013;15(7):668–673.
-
(2013)
Diabetes Obes Metab
, vol.15
, Issue.7
, pp. 668-673
-
-
White, W.B.1
Pratley, R.2
Fleck, P.3
-
9
-
-
84931264841
-
Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events
-
Rosenstock J, Marx N, Neubacher D, et al. Cardiovascular safety of linagliptin in type 2 diabetes:a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events. Cardiovasc Diabetol. 2015;14:57.
-
(2015)
Cardiovasc Diabetol
, vol.14
, pp. 57
-
-
Rosenstock, J.1
Marx, N.2
Neubacher, D.3
-
10
-
-
84883765959
-
Saxagliptin and cardiovascular outcomes in patientswith type 2 diabetes mellitus
-
Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patientswith type 2 diabetes mellitus. N Engl J Med. 2013;369:1317–1326.•• First CVOT to show CV neutrality with saxagliptin.
-
(2013)
N Engl J Med
, vol.369
, pp. 1317-1326
-
-
Scirica, B.M.1
Bhatt, D.L.2
Braunwald, E.3
-
11
-
-
84883745765
-
EXAMINE:alogliptinafter acute coronary syndrome in patients with type 2 diabetes
-
White WB, Cannon CP, Heller SR, et al. EXAMINE:alogliptinafter acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369:1327–1335.•• One of first CVOT to show CV neutrality with alogliptin in patients with acute coronary syndrome.
-
(2013)
N Engl J Med
, vol.369
, pp. 1327-1335
-
-
White, W.B.1
Cannon, C.P.2
Heller, S.R.3
-
12
-
-
84937053742
-
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
-
Green JB, Bethel MA, Armstrong PW, et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373:232–242.•• Sitagliptin CVOT suggesting CV neutrality and no signal of heart failure.
-
(2015)
N Engl J Med
, vol.373
, pp. 232-242
-
-
Green, J.B.1
Bethel, M.A.2
Armstrong, P.W.3
-
13
-
-
84901926135
-
Dipeptidyl peptidase-4 inhibitors and heart failure: a meta-analysis of randomized clinical trials
-
Monami M, Dicembrini I, Mannuci E., Dipeptidyl peptidase-4 inhibitors and heart failure:a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis. 2014;24(7):689–697.
-
(2014)
Nutr Metab Cardiovasc Dis
, vol.24
, Issue.7
, pp. 689-697
-
-
Monami, M.1
Dicembrini, I.2
Mannuci, E.3
-
14
-
-
84904007147
-
Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: meta-analysis of randomized clinical trials with 55,141 participants
-
Wu S, Hopper I, Skiba M, et al. Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes:meta-analysis of randomized clinical trials with 55,141 participants. Cardiovasc Ther. 2014;32(4):147–158.
-
(2014)
Cardiovasc Ther
, vol.32
, Issue.4
, pp. 147-158
-
-
Wu, S.1
Hopper, I.2
Skiba, M.3
-
15
-
-
84918561520
-
Sitagliptin use in patients with diabetes and heart failure: a population-based retrospective cohort study
-
Weir DL, McAlister FA, Senthilselvan A, et al. Sitagliptin use in patients with diabetes and heart failure:a population-based retrospective cohort study. JACC Heart Fail. 2014;2(6):573–582.
-
(2014)
JACC Heart Fail
, vol.2
, Issue.6
, pp. 573-582
-
-
Weir, D.L.1
McAlister, F.A.2
Senthilselvan, A.3
-
16
-
-
84919461875
-
Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in type 2 diabetes: a cohort study
-
Kim C, Glynn RJ, Liu J, et al. Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in type 2 diabetes:a cohort study. Acta Diabetol. 2014;51(6):1015–1023.
-
(2014)
Acta Diabetol
, vol.51
, Issue.6
, pp. 1015-1023
-
-
Kim, C.1
Glynn, R.J.2
Liu, J.3
-
17
-
-
84921933782
-
Incretin-based drugs and the risk of congestive heart failure
-
Yu OH, Filion KB, Azoulay L, et al. Incretin-based drugs and the risk of congestive heart failure. Diabetes Care. 2015;38(2):277–284.
-
(2015)
Diabetes Care
, vol.38
, Issue.2
, pp. 277-284
-
-
Yu, O.H.1
Filion, K.B.2
Azoulay, L.3
-
18
-
-
84917723836
-
Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial
-
Scirica BM, Braunwald E, Raz I, et al.; SAVOR-TIMI 53 Steering Committee and Investigators. Heart failure, saxagliptin, and diabetes mellitus:observations from the SAVOR-TIMI 53 randomized trial. Circulation. 2014; 130(18):1579–1588.•• Subgroup analysis of SAVOR TIMI found significantly increased heart failure in certain subgroups of patients.
-
(2014)
Circulation
, vol.130
, Issue.18
, pp. 1579-1588
-
-
Scirica, B.M.1
Braunwald, E.2
Raz, I.3
-
19
-
-
85007570554
-
-
Sep
-
Briefing Material. NDA 22350:saxagliptin (Onglyza). NDA 200678:saxagliptin/Metformin (Kombiglyze XR). April 2015; cited 2016 Sep30. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolic-DrugsAdvisoryCommittee/UCM442060.pdf• FDA analysis of SAVOR TIMI and vote regarding CV safety of saxagliptin.
-
(2015)
NDA 22350: saxagliptin (Onglyza). NDA 200678: saxagliptin/Metformin (Kombiglyze XR)
-
-
-
21
-
-
84930085787
-
Heart failure and mortality outcomes on alogliptin versus placebo from the EXAMINE trial
-
Zannad F, Cannon CP, Cushman WC, et al. Heart failure and mortality outcomes on alogliptin versus placebo from the EXAMINE trial. Lancet. 2015;385:2067–2076.• Post hoc subgroup analysis of alogliptin in EXAMINE.
-
(2015)
Lancet
, vol.385
, pp. 2067-2076
-
-
Zannad, F.1
Cannon, C.P.2
Cushman, W.C.3
-
22
-
-
85021438535
-
Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of arandomized clinical trial
-
McGuire DK, Van Dewerf F, Armstrong PW, et al.; Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS) Study Group. Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus:secondary analysis of arandomized clinical trial. JAMA Cardio. 2016; 1(2):126–135.• Post hoc subgroup analysis of sitagliptin in TECOS.
-
(2016)
JAMA Cardio
, vol.1
, Issue.2
, pp. 126-135
-
-
McGuire, D.K.1
Van Dewerf, F.2
Armstrong, P.W.3
-
23
-
-
85015830814
-
The safety of dipeptidyl peptidase 4 inhibitors and the risk for heart failure
-
Scirica BM. The safety of dipeptidyl peptidase 4 inhibitors and the risk for heart failure. JAMA Cardiol. 2016;1(2):123–125.
-
(2016)
JAMA Cardiol
, vol.1
, Issue.2
, pp. 123-125
-
-
Scirica, B.M.1
-
24
-
-
85015909360
-
-
cited, Sep
-
cited Sep 30, 2016. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM493965.pdf•• FDA put a labelling of heart failure risk with saxagliptin and alogliptin in patients with pre-existing heart or kidney disease.
-
(2016)
-
-
-
25
-
-
84903945830
-
Vildagliptin in Ventricular Dysfunction Diabetes Trial (VIVIDD)
-
McMurray JJ, Ponikowksi P, Bolli GB, et al. Vildagliptin in Ventricular Dysfunction Diabetes Trial (VIVIDD). Eur J Heart Fail. 2013;12(suppl):1.• Vildagliptin studied in patients with NYHA Class I-III heart failure and found no harm.
-
(2013)
Eur J Heart Fail
, vol.12
, pp. 1
-
-
McMurray, J.J.1
Ponikowksi, P.2
Bolli, G.B.3
-
26
-
-
85015900009
-
-
https://clinicaltrials.gov/ct2/show/NCT01897532
-
-
-
-
27
-
-
84926475145
-
Design and baseline characteristics of the CARdiovascular outcome trial of LINAgliptin versus glimepiride in type 2 diabetes (CAROLINA®)
-
Marx N, Rosenstock J, Kahn SE, et al. Design and baseline characteristics of the CARdiovascular outcome trial of LINAgliptin versus glimepiride in type 2 diabetes (CAROLINA®). Diab Vasc Dis Res. 2015;12(3):164–174.
-
(2015)
Diab Vasc Dis Res
, vol.12
, Issue.3
, pp. 164-174
-
-
Marx, N.1
Rosenstock, J.2
Kahn, S.E.3
-
28
-
-
84983422189
-
Cardiovascular safety of empagliflozin in patients with type 2 diabetes: a meta-analysis of data from randomized placebo-controlled trials
-
Salsali A, Kim G, Woerle HJ, et al. Cardiovascular safety of empagliflozin in patients with type 2 diabetes:a meta-analysis of data from randomized placebo-controlled trials. Diabetes Obes Metab. 2016;18(10):1034–1040.
-
(2016)
Diabetes Obes Metab
, vol.18
, Issue.10
, pp. 1034-1040
-
-
Salsali, A.1
Kim, G.2
Woerle, H.J.3
-
29
-
-
85015870271
-
-
cited, Sep
-
cited 2016 Sep 30. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM334550.pdf
-
(2016)
-
-
-
30
-
-
84958548824
-
Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
-
Sonesson C, Johansson PA, Johansson E, et al. Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories:a meta-analysis. Cardiovasc Diabetol. 2016;15:37.
-
(2016)
Cardiovasc Diabetol
, vol.15
, pp. 37
-
-
Sonesson, C.1
Johansson, P.A.2
Johansson, E.3
-
31
-
-
84944800184
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128.•• First antidiabetic agent empagliflozin to show robust reduction in CV endpoints.
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
-
32
-
-
79952694840
-
Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes
-
Ratner R, Han J, Nicewarner D, et al. Cardiovascular safety of exenatide BID:an integrated analysis from controlled clinical trials in participants with type 2 diabetes. Cardiovasc Diabetol. 2011;10:22.
-
(2011)
Cardiovasc Diabetol
, vol.10
, pp. 22
-
-
Ratner, R.1
Han, J.2
Nicewarner, D.3
-
33
-
-
84936943524
-
Safety and tolerability of exenatide once weekly in patients with type 2 diabetes: an integrated analysis of 4,328 patients
-
MacConell L, Gurney K, Malloy J, et al. Safety and tolerability of exenatide once weekly in patients with type 2 diabetes:an integrated analysis of 4,328 patients. Diabetes Metab Syndr Obes. 2015;18(8):241–253.
-
(2015)
Diabetes Metab Syndr Obes
, vol.18
, Issue.8
, pp. 241-253
-
-
MacConell, L.1
Gurney, K.2
Malloy, J.3
-
34
-
-
85015958677
-
-
cited, Sep
-
cited 2016 Sep 30 www.sanofi.co.uk/l/gb/en/download.jsp?file=1B4E8D41-8F6C-4399-8C64…pdf
-
(2016)
-
-
-
35
-
-
85015933671
-
Cardiovascular safety of liraglutide: pooled analysis of major adverse cardiovascular events across weight management and type 2 diabetes development programs
-
supplement _3/A12630
-
Caterson ID, Bain SC, Gross J, et al. Cardiovascular safety of liraglutide:pooled analysis of major adverse cardiovascular events across weight management and type 2 diabetes development programs. Circulation. 2015;132(Suppl_3/A12630).
-
(2015)
Circulation
, vol.132
-
-
Caterson, I.D.1
Bain, S.C.2
Gross, J.3
-
36
-
-
84959155948
-
Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events
-
Feb
-
Ferdinand KC, Botros FT, Atisso CM, et al. Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes:a pre-specified meta-analysis of prospectively adjudicated cardiovascular events. Cardiovasc Diabetol. 2016 Feb 24;15:38.
-
(2016)
Cardiovasc Diabetol
, vol.15
, pp. 38
-
-
Ferdinand, K.C.1
Botros, F.T.2
Atisso, C.M.3
-
37
-
-
84940747146
-
Cardiovascular safety of albiglutide in the Harmony programme: a meta-analysis
-
Fisher M, Petrie MC, Ambery PD, et al. Cardiovascular safety of albiglutide in the Harmony programme:a meta-analysis. Lancet Diabetes Endocrinol. 2015;3(9):697–703.
-
(2015)
Lancet Diabetes Endocrinol
, vol.3
, Issue.9
, pp. 697-703
-
-
Fisher, M.1
Petrie, M.C.2
Ambery, P.D.3
-
38
-
-
84948740668
-
Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
-
Pfeffer MA, Claggett B, Diaz R, et al. ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373(23):2247–2257.•• First CVOT trial with GLP-1RA published with lixisenatide and found to achieve CV neutrality.
-
(2015)
N Engl J Med
, vol.373
, Issue.23
, pp. 2247-2257
-
-
Pfeffer, M.A.1
Claggett, B.2
Diaz, R.3
-
39
-
-
84978839381
-
Liraglutide and cardiovascular outcomes in type 2 diabetes
-
Marso SP, Daniels GH, Brown-Frandsen K, et al. LEADER Investigators. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311–322.•• This trial of GLP-1RA liraglutide showing significant reduction on several CV end points.
-
(2016)
N Engl J Med
, vol.375
, Issue.4
, pp. 311-322
-
-
Marso, S.P.1
Daniels, G.H.2
Brown-Frandsen, K.3
-
40
-
-
84994813253
-
Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
-
Marso SP, Bain SC, Consoli A, et al.; SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375(19):1834–1844.•• Results with once-weekly GLP-1RA semaglutide showing significant reduction in 3P-MACE.
-
(2016)
N Engl J Med
, vol.375
, Issue.19
, pp. 1834-1844
-
-
Marso, S.P.1
Bain, S.C.2
Consoli, A.3
-
41
-
-
85015951327
-
-
Sep
-
2016 Sep 30. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM508422.pdf
-
(2016)
-
-
-
42
-
-
84982082404
-
Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial
-
Margulies KB, Hernandez AF, Redfield MM, et al. Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction:a randomized clinical trial. JAMA. 2016;316(5):500–508.• Liraglutide studied in patients with advanced heart failure.
-
(2016)
JAMA
, vol.316
, Issue.5
, pp. 500-508
-
-
Margulies, K.B.1
Hernandez, A.F.2
Redfield, M.M.3
-
43
-
-
85015936193
-
Effect of liraglutide, a glucagon-like peptide-I analogue, on left ventricular function in chronic heart failure patients with and without diabetes: the LIVE study
-
Florence, Italy, May
-
Jorsal A. Effect of liraglutide, a glucagon-like peptide-I analogue, on left ventricular function in chronic heart failure patients with and without diabetes:the LIVE study. Eur Soc Cardiol (ESC) Heart Fail. 2016;cited 2016 May22. Presentation 599. Florence, Italy
-
(2016)
Eur Soc Cardiol (ESC) Heart Fail
-
-
Jorsal, A.1
-
44
-
-
85015958162
-
-
https://clinicaltrials.gov/ct2/show/NCT02918591
-
-
-
-
45
-
-
85015845141
-
-
https://clinicaltrials.gov/ct2/show/NCT02862067
-
-
-
-
46
-
-
85015912646
-
-
https://clinicaltrials.gov/ct2/show/NCT02728453
-
-
-
-
47
-
-
85015859584
-
-
https://clinicaltrials.gov/ct2/show/NCT02653482
-
-
-
-
48
-
-
84997171051
-
Association of bile duct and gallbladder diseases with the use of incretin-based drugs in patients with type 2 diabetes mellitus
-
Faillie JL, Yu OH, Yin H, et al. Association of bile duct and gallbladder diseases with the use of incretin-based drugs in patients with type 2 diabetes mellitus. JAMA Intern Med. 2016;176(10):1474–1481.• This cross sectional study found increase in acute gall bladder disease with GLP-1RAs
-
(2016)
JAMA Intern Med
, vol.176
, Issue.10
, pp. 1474-1481
-
-
Faillie, J.L.1
Yu, O.H.2
Yin, H.3
-
49
-
-
0035405824
-
Risk of developing retinopathy in diabetes control and complications trial type 1 diabetic patients with good or poor metabolic control
-
Zhang L, Krzentowski G, Albert A, et al. Risk of developing retinopathy in diabetes control and complications trial type 1 diabetic patients with good or poor metabolic control. Diabetes Care. 2001;24(7):1275–1279.
-
(2001)
Diabetes Care
, vol.24
, Issue.7
, pp. 1275-1279
-
-
Zhang, L.1
Krzentowski, G.2
Albert, A.3
-
50
-
-
84951906012
-
Energy balance after sodium-glucose cotransporter 2 inhibition
-
Ferrannini G, Hach T, Crowe S, et al. Energy balance after sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015;38:1730–1735.
-
(2015)
Diabetes Care
, vol.38
, pp. 1730-1735
-
-
Ferrannini, G.1
Hach, T.2
Crowe, S.3
-
51
-
-
84994508611
-
Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial
-
Sep, Epub ahead of print
-
Frías JP, Guja C, Hardy E, et al. Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8):a 28 week, multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol. 2016 Sep 15; pii:S2213-8587(16)30267-4. Epub ahead of print. 10.1016/S2213-8587(16)30267-4• First RCT of combined GLP-1RA with SGLT-2I, showing incremental lowering of blood glucose.
-
(2016)
Lancet Diabetes Endocrinol
-
-
Frías, J.P.1
Guja, C.2
Hardy, E.3
|