An evaluation of the effect of an angiotensinconverting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: A randomized placebo-controlled trial (AARDVARK)

European Heart Journal

Volumn 37, Issue 42, 2016, Pages 3213-3221

  Bicknell, Colin D ^a   Kiru, Gaia ^b   Falaschetti, Emanuela ^b   Powell, Janet T ^d   Poulter, Neil R ^b   Ashby, Deborah ^q   Brown, Louise ^q   Dhanjil, Surinder ^q   Davies, Meryl ^q   Earnshaw, Jonothan ^q   Shearman, Cliff ^q   Newton, Barrie ^q   Thompson, Simon ^q   Beevers, Gareth ^q   Wilmink, Teun ^q   Allen, Louise ^c   Scriven, Jennifer ^c   Rolls, Alex ^c   Coghlan, Candice ^c   James, Rebecca ^c   Whitehouse, Andrew ^c   Williams, Angela ^d   Modarai, Bijan ^e   Waltham, Matthew ^e   Clark, Susan ^e   Davis, Meryl ^f   Imray, Christopher ^g   Kite, Alison ^g   Chetter, Ian ^h   Clarke, Emma ^h   Firth, Anna ^h   Rittoo, Dynesh ⁱ   Baker, Sara ⁱ   Choksy, Sohail ^j   Morgan, Marianne ^j   Townsend, Trevor ^j   Lees, Tim ^k   Wilson, Lesley ^k   Wealleans, Vera ^k   Parr, Noala ^k   Brown, Andrew ^l   Mowatt, Florrie ^l   Chipp, Ruth ^l   Thompson, Andrew ^m   Gibson, Andy ^m   Coleman, Zoe ^m   Smith, Thomas ^m   Meyer, Felicity ⁿ   Burrows, Mandy ⁿ   Smyth, Vince ^o   Schirro, Andrew ^o   Edlin, Helena ^o   Nawaz, Shah ^p   Warren, Rebecca ^p   King, Craig ^p   Swift, Diane ^p   Okhuoya, Faith ^p   Bailey, Cheryl ^p   more..

^a ST MARY S HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d CHARING CROSS HOSPITAL   (United Kingdom)

^e ST THOMAS HOSPITAL   (United Kingdom)

^f ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^g UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

^h HULL AND EAST YORKSHIRE HOSPITALS NHS TRUST   (United Kingdom)

ⁱ ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^j East Suffolk and North Essex Foundation Trust   (United Kingdom)

^k NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^l CITY HOSPITALS SUNDERLAND NHS FOUNDATION TRUST   (United Kingdom)

^m YORK TEACHING HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

ⁿ NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^o MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^p SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^q NONE

more..

Author keywords

Abdominal aortic aneurysm; ACE inhibition; Blood pressure lowering; Calcium channel blocker; Perindopril; Placebo controlled

Indexed keywords

AMLODIPINE; CREATININE; LOSARTAN; PERINDOPRIL; PLACEBO; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ABDOMINAL AORTA ANEURYSM; AGED; ARTERY DIAMETER; ARTICLE; CONTROLLED STUDY; COUGHING; CREATININE BLOOD LEVEL; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ECHOGRAPHY; ELECTIVE SURGERY; ENGLAND; ENZYME INHIBITION; FEMALE; GROWTH RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARALLEL DESIGN; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE; ABDOMINAL AORTIC ANEURYSM; BLOOD PRESSURE; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; HYPERTENSION; MIDDLE AGED; STATISTICAL MODEL;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; AORTIC ANEURYSM, ABDOMINAL; BLOOD PRESSURE; DOUBLE-BLIND METHOD; ENGLAND; HUMANS; HYPERTENSION; LIKELIHOOD FUNCTIONS; MIDDLE AGED; SINGLE-BLIND METHOD;

EID: 85015792770     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehw257     Document Type: Article

References (24)

1. Davis M, Harris M, Earnshaw JJ. Implementation of the National Health Service Abdominal Aortic Aneurysm Screening Program in England. J Vasc Surg 2013;57: 1440-1445.
2. Reimerink JJ, van der Laan MJ, Koelemay MJ, Balm R, Legemate DA. Systematic review and meta-analysis of population-based mortality from ruptured abdominal aortic aneurysm. Br J Surg 2013;100:1405-1413.
3. GrantSW, Grayson AD, Mitchell DC, McCollum CN. Evaluation of five risk prediction models for elective abdominal aortic aneurysm repair using the UK National Vascular Database. Br J Surg 2012;99:673-679.
4. Malas M, Arhuidese I, Qazi U, Black J, Perler B, Freischlag JA. Perioperative mortality following repair of abdominal aortic aneurysms: application of a randomized clinical trial to real-world practice using a validated nationwide data set. JAMA Surg 2014; 149:1260-1265.
5. Filardo G, Powell JT, Martinez MA, Ballard DJ. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev 2015;2:CD001835.
6. Brady AR, Thompson SG, Fowkes FG, Greenhalgh RM, Powell JT. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation 2004;110:16-21.
7. Ashton HA, Buxton MJ, Day NE, Kim LG, Marteau TM, Scott RA, Thompson SG, Walker NM, Multicentre Aneurysm Screening Study Group. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet 2002;360: 1531-1539.
8. Cosford PA, Leng GC. Screening for abdominal aortic aneurysm. Cochrane Database Syst Rev 2007;CD002945.
9. Inoue N, Muramatsu M, Jin D, Takai S, Hayashi T, Katayama H, Kitaura Y, Tamai H, Miyazaki M. Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II-infused ApoE-deficient mice. J Atheroscler Thromb 2009;16:164-171.
10. Xiong F, Zhao J, Zeng G, Huang B, Yuan D, Yang Y. Inhibition of AAA in a rat model by treatment with ACEI perindopril. J Surg Res 2014;189:166-173.
11. Liao S, Miralles M, Kelley BJ, Curci JA, Borhani M, Thompson RW. Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensinconverting enzyme inhibitors. J Vasc Surg 2001;33:1057-1064.
12. Hackam DG, Thiruchelvam D, Redelmeier DA. Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet 2006; 368:659-665.
13. Thompson A, Cooper JA, Fabricius M, Humphries SE, Ashton HA, Hafez H. An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance. J Vasc Surg 2010;52:55-61e2.
14. Sweeting MJ, Thompson SG, Brown LC, Greenhalgh RM, Powell JT. Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms. J Vasc Surg 2010;52:1-4.
15. Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH. ACE inhibitors potently reduce vascular inflammation, results of an open proof-ofconcept study in the abdominal aortic aneurysm. PLoS ONE 2014;9:e111952.
16. National Institute of Health Research. Clinical study protocol. http://www.nets. nihr.ac.uk/-data/assets/pdf-file/0003/51987/PRO-08-109-02.pdf (12 October 2015).
17. Mehta JL, Lopez LM, Vlachakis ND, Gradman AH, Nash DT, O'Connell MT, Garland WT, Pickering BI. Double-blind evaluation of the dose-response relationship of amlodipine in essential hypertension. Am Heart J 1993;125:1704-1710.
18. Myers MG. A dose-response study of perindopril in hypertension: effects on BP 6 and 24 h after dosing. Perindopril Multicentre Dose-Response Study Group. Can J Cardiol 1996;12:1191-1196.
19. Chrysant SG, McDonald RH, Wright JT, Barden PL, Weiss RJ. Perindopril as monotherapy in hypertension: a multicenter comparison of two dosing regimens. The Perindopril Study Group. Clin Pharmacol Ther 1993;53:479-484.
20. National Institute of Clinical Excellence. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. http://www.nice.org.uk/guidance/cg181 (12 October 2015).
21. Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H. BP and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet 2014;383:1899-1911.
22. Norman PE, Jamrozik K, Lawrence-Brown MM, Le MT, Spencer CA, Tuohy RJ, Parsons RW, Dickinson JA. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. Br Med J 2004; 329:1259.
23. Propranolol Trial Investigators. Propranolol for small abdominal aortic aneurysms: results of a randomized trial. J Vasc Surg 2002;35:72-79.
24. Schlosser FJ, Tangelder MJ, Verhagen HJ, van der Heijden GJ, Muhs BE, van der Graaf Y, Moll FL, SMART study group. Growth predictors and prognosis of small abdominal aortic aneurysms. J Vasc Surg 2008;47:1127-1133.