Incidence and Outcomes of Central Nervous System Hemophagocytic Lymphohistiocytosis Relapse after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 23, Issue 5, 2017, Pages 857-860

  Lounder, Dana T ^a   Khandelwal, Pooja ^a   Chandra, Sharat ^a   Jordan, Michael B ^a   Kumar, Ashish R ^a   Grimley, Michael S ^a   Davies, Stella M ^a   Bleesing, Jack J ^a   Marsh, Rebecca A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Central nervous system disease; Hematopoietic stem cell transplantation; Hemophagocytic lymphohistiocytosis

Indexed keywords

ABATACEPT; ALEMTUZUMAB; CYCLOSPORIN; DEXAMETHASONE; ETOPOSIDE; FLUDARABINE; HYDROCORTISONE; MELPHALAN; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID ANALYSIS; CHILD; CHIMERA; CLINICAL OUTCOME; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOPHAGOCYTIC SYNDROME; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFANT; LEUKOCYTOSIS; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NEWBORN; OVERALL SURVIVAL; REDUCED INTENSITY CONDITIONING; RELAPSE; RETROSPECTIVE STUDY; RISK FACTOR; SYMPTOM; ADOLESCENT; CEREBROSPINAL FLUID; PATHOLOGY; PRESCHOOL CHILD; PROCEDURES; RECURRENT DISEASE; TRANSPLANTATION CONDITIONING; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; CENTRAL NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; CHIMERISM; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; RECURRENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SPINAL PUNCTURE; TRANSPLANTATION CONDITIONING; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85015761465     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2017.02.011     Document Type: Article

References (18)

1. 1 Jordan, M.B., Allen, C.E., Weitzman, S., Filipovich, A.H., McClain, K.L., How I treat hemophagocytic lymphohistiocytosis. Blood 118 (2011), 4041–4052.
2. 2 Kim, M.-M., Yum, M.-S., Choi, H.-W., et al. Central nervous system (CNS) involvement is a critical prognostic factor for hemophagocytic lymphohistiocytosis. Korean J Hematol, 47, 2012, 273.
3. 3 Haddad, E., Sulis, M.L., Jabado, N., Blanche, S., Fischer, A., Tardieu, M., Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis. Blood 89 (1997), 794–800.
4. 4 Goo, H.W., Weon, Y.C., A spectrum of neuroradiological findings in children with haemophagocytic lymphohistiocytosis. Pediatr Radiol 37 (2007), 1110–1117.
5. 5 Horne, A., Trottestam, H., Arico, M., et al. Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis. Br J Haematol 140 (2008), 327–335.
6. 6 Jordan, M.B., Filipovich, A.H., Hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis: a journey of a thousand miles begins with a single (big) step. Bone Marrow Transplant 42 (2008), 433–437.
7. 7 Henter, J.I., Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood 100 (2002), 2367–2373.
8. 8 Mahlaoui, N., Ouachee-Chardin, M., de Saint Basile, G., et al. Immunotherapy of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins: a single-center retrospective report of 38 patients. Pediatrics 120 (2007), e622–e628.
9. 9 Baker, K.S., Filipovich, A.H., Gross, T.G., et al. Unrelated donor hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis. Bone Marrow Transplant 42 (2008), 175–180.
10. 10 Ouachee-Chardin, M., Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: a single-center report of 48 patients. Pediatrics 117 (2006), e743–e750.
11. 11 Horne, A., Janka, G., Maarten Egeler, R., et al. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis. Br J Haematol 129 (2005), 622–630.
12. 12 Cooper, N., Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Blood 107 (2005), 1233–1236.
13. 13 Cooper, N., Rao, K., Goulden, N., Webb, D., Amrolia, P., Veys, P., The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis. Bone Marrow Transplant 42 (2008), S47–S50.
14. 14 Marsh, R.A., Vaughn, G., Kim, M.O., et al. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. Blood 116 (2010), 5824–5831.
15. 15 Marsh, R.A., Rao, M.B., Gefen, A., et al. Experience with alemtuzumab, fludarabine, and melphalan reduced-intensity conditioning hematopoietic cell transplantation in patients with nonmalignant diseases reveals good outcomes and that the risk of mixed chimerism depends on underlying disease, stem cell source, and alemtuzumab regimen. Biol Blood Marrow Transplant 21 (2015), 1460–1470.
16. 16 Marsh, R.A., Kim, M.-O., Liu, C., et al. An intermediate alemtuzumab schedule reduces the incidence of mixed chimerism following reduced-intensity conditioning hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis. Biol Blood Marrow Transplant 19 (2013), 1625–1631.
17. 17 Hartz, B., Marsh, R., Rao, K., et al. The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis. Blood 127 (2016), 3281–3290.
18. 18 Bock, A.M., LeVeque, M., Camitta, B., Talano, J.A., Successful treatment of recurrent CNS disease post-bone marrow transplant in children with familial hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 63 (2016), 2154–2158.