Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells

Blood

Volumn 128, Issue 23, 2016, Pages 2655-2665

  Vardaki, Ioulia ^a   Sanchez, Claire ^a   Fonseca, Pedro ^a   Olsson, Magnus ^b   Chioureas, Dimitrios ^a   Rassidakis, George ^a   Ullén, Anders ^a   Zhivotovsky, Boris ^b   Bjorkhölm, Magnus ^c   Panaretakis, Theocharis ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Department of Environmental Medicine ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 9; PROTEIN BCL XL; BCL2L1 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; PROTEIN BCL X;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; BONE MARROW STROMA CELL; CANCER STAGING; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ECTOPIC EXPRESSION; EXOSOME; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; IMMUNOELECTRON MICROSCOPY; LYMPHOMA CELL; MALE; MCF-7 CELL LINE; MIDDLE AGED; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CANCER STEM CELL; GENETICS; HEMATOPOIETIC STEM CELL; JURKAT CELL LINE; LYMPHOMA; METABOLISM; MISSENSE MUTATION; PATHOLOGY; STROMA CELL;

AMINO ACID SUBSTITUTION; BCL-X PROTEIN; CASPASE 3; EXOSOMES; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; JURKAT CELLS; LYMPHOMA; MALE; MCF-7 CELLS; MULTIPLE MYELOMA; MUTATION, MISSENSE; NEOPLASTIC STEM CELLS; STROMAL CELLS;

EID: 85015614722     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-05-715961     Document Type: Article

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