The Mosquito Repellent Citronellal Directly Potentiates Drosophila TRPA1, Facilitating Feeding Suppression

Molecules and Cells

Volumn 38, Issue 10, 2015, Pages 911-917

  Du, Eun Jo ^a   Ahn, Tae Jung ^a   Choi, Min Sung ^b   Kwon, Ilmin ^a   Kim, Hyung Wook ^c   Kwon, Jae Young ^b   Kang, Kyeong Jin ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Sejong University   (South Korea)

Author keywords

Anopheles gambiae; citronellal; Drosophila melanogaster; human TRPA1; insect repellent; TRPA1

Indexed keywords

ALDEHYDE; CALCIUM CHANNEL; CITRONELLAL; DROSOPHILA PROTEIN; INSECT REPELLENT; ISOPROTEIN; MALEIMIDE DERIVATIVE; N-METHYLMALEIMIDE; NERVE PROTEIN; TERPENE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPA1 PROTEIN, DROSOPHILA; TRPA1 PROTEIN, HUMAN;

ACTION POTENTIAL; AGONISTS; ANIMAL; ANOPHELES GAMBIAE; DROSOPHILA MELANOGASTER; DRUG EFFECTS; FEEDING BEHAVIOR; HUMAN; METABOLISM; OOCYTE; PHYSIOLOGY; XENOPUS LAEVIS;

ACTION POTENTIALS; ALDEHYDES; ANIMALS; ANOPHELES GAMBIAE; CALCIUM CHANNELS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEEDING BEHAVIOR; HUMANS; INSECT REPELLENTS; MALEIMIDES; MONOTERPENES; NERVE TISSUE PROTEINS; OOCYTES; PROTEIN ISOFORMS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS; XENOPUS LAEVIS;

EID: 85015565250     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/MOLCELLS.2015.0215     Document Type: Article

References (16)

1. Carlson, L.H.C., Machado, R.aF., Spricigo, C.B., Pereira, L.K., and Bolzan, A. (2001). Extraction of lemongrass essential oil with dense carbon dioxide. J. Supercrit. Fluids 21, 33-39.
2. 2+/calmodulin binding sites. Mol. Cells 37, 656-663.
3. Dunipace, L., Meister, S., McNealy, C., and Amrein, H. (2001). Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr. Biol. 11, 822-835.
4. Goldman-Huertas, B., Mitchell, R.F., Lapoint, R.T., Faucher, C.P., Hildebrand, J.G., and Whiteman, N.K. (2015). Evolution of herbivory in Drosophilidae linked to loss of behaviors, antennal responses, odorant receptors, and ancestral diet. Proc. Natl. Acad. Sci. USA 112, 201424656.
5. Hamada, F.N., Rosenzweig, M., Kang, K., Pulver, S.R., Ghezzi, A., Jegla, T.J., and Garrity, P.A. (2008). An internal thermal sensor controlling temperature preference in Drosophila. Nature 454, 217-220.
6. Ja, W.W., Carvalho, G.B., Mak, E.M., de la Rosa, N.N., Fang, A.Y., Liong, J.C., Brummel, T., and Benzer, S. (2007). Prandiology of Drosophila and the CAFE assay. Proc. Natl. Acad. Sci. USA 104, 8253-8256.
7. Kang, K., Pulver, S.R., Panzano, V.C., Chang, E.C., Griffith, L.C., Theobald, D.L., and Garrity, P.A. (2010). Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 464, 597-600.
8. Kang, K., Panzano, V.C., Chang, E.C., Ni, L., Dainis, A.M., Jenkins, A.M., Regna, K., Muskavitch, M.A.T., and Garrity, P.A. (2012). Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. Nature 481, 76-80.
9. Kwon, Y., Kim, S.H., Ronderos, D.S., Lee, Y., Akitake, B., Woodward, O.M., Guggino, W.B., Smith, D.P., and Montell, C. (2010). Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr. Biol. 20, 1672-1678.
10. Larsson, M.C., Domingos, A.I., Jones, W.D., Chiappe, M.E., Amrein, H., and Vosshall, L.B. (2004). Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron 43, 703-714.
11. Macpherson, L.J., Dubin, A.E., Evans, M.J., Marr, F., Schultz, P.G., Cravatt, B.F., and Patapoutian, A. (2007). Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445, 541-545.
12. Meunier, N., Rospars, J., Tanimura, T., and Marion-Poll, F. (2003). Peripheral coding of bitter taste in Drosophila. J. Neurobiol. 56, 139-152.
13. Ni, L., Bronk, P., Chang, E.C., Lowell, A.M., Flam, J.O., Panzano, V.C., Theobald, D.L., Griffith, L.C., and Garrity, P.A. (2013). A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila. Nature 500, 580-584.
14. Sakulku, U., Nuchuchua, O., Uawongyart, N., Puttipipatkhachorn, S., Soottitantawat, A., and Ruktanonchai, U. (2009). Characterization and mosquito repellent activity of citronella oil nanoemulsion. Int. J. Pharm. 372, 105-111.
15. Weiss, L.a, Dahanukar, A., Kwon, J.Y., Banerjee, D., and Carlson, J.R. (2011). The molecular and cellular basis of bitter taste in Drosophila. Neuron 69, 258-272.
16. Zhou, Y., Suzuki, Y., Uchida, K., and Tominaga, M. (2013). Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity. Nat. Commun. 4, 2399.