Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamaseproducing Gram-negative bacteria: A pilot study, December 2014 to May 2015

Eurosurveillance

Volumn 21, Issue 25, 2016, Pages

  Timofte, Dorina ^a,b   Panzaru, C V ^c,e   Maciuca, I E ^a   Dan, M ^e   Mare, A D ^d   Man, A ^d   Toma, F ^d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE   (Romania)

^c GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^e Institute of Cardiovascular Diseases   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

CEFOTAXIME; STREPTOMYCIN; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIUM CONJUGATION; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CONTROLLED STUDY; DISEASE SURVEILLANCE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR BIOLOGY; MORGANELLA MORGANII; NONHUMAN; PILOT STUDY; POLYMERASE CHAIN REACTION; PREVALENCE; PSEUDOMONAS AERUGINOSA; REPLICON; CLASSIFICATION; CLINICAL TRIAL; CONTACT EXAMINATION; ENZYMOLOGY; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HEALTH PROMOTION; HEALTH SURVEY; HUMAN; ISOLATION AND PURIFICATION; MALE; MASS SCREENING; METABOLISM; MICROBIOLOGY; MULTICENTER STUDY; PROCEDURES; RISK FACTOR; ROMANIA; STATISTICS AND NUMERICAL DATA;

BACTERIAL PROTEINS; BETA-LACTAMASES; CONTACT TRACING; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HEALTH PROMOTION; HUMANS; MALE; MASS SCREENING; PILOT PROJECTS; POPULATION SURVEILLANCE; PREVALENCE; RISK FACTORS; ROMANIA;

EID: 85015352218     PISSN: 1025496X     EISSN: 15607917     Source Type: Journal    
DOI: 10.2807/1560-7917.ES.2016.21.25.30262     Document Type: Article

References (30)

1. Bakour S, Olaitan AO, Ammari H, Touati A, Saoudi S, Saoudi K, et al. Emergence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii ST2 Clinical Isolate in Algeria: First Case Report. Microb Drug Resist. 2015;21(3): 279-85. DOI: 10.1089/mdr.2014.0214 PMID: 25588125
2. Glasner C, Albiger B, Buist G, Tambić Andrasević A, Canton R, Carmeli Y, et al., European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group. Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries, February 2013.Euro Surveill. 2013;18(28): 20525. DOI: 10.2807/1560-7917.ES2013.18.28.20525 PMID: 23870096
3. European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance surveillance in Europe 2012. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2013. Available from: http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2012.pdf
4. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. Version 1.0. EUCAST. [Accessed 19 Jan 2016]. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Resistance_mechanisms/EUCAST_ detection_of_resistance_mechanisms_v1.0_20131211.pdf
5. Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae.J Antimicrob Chemother. 2010;65(3): 490-5. DOI: 10.1093/jac/dkp498 PMID: 20071363
6. Corvec S, Caroff N, Espaze E, Giraudeau C, Drugeon H, Reynaud A. AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains.J Antimicrob Chemother. 2003;52(4): 629-35. DOI: 10.1093/jac/dkg407 PMID: 12951337
7. Nordmann P, Poirel L, Carrër A, Toleman MA, Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011;49(2): 718-21. DOI: 10.1128/JCM.01773-10 PMID: 21123531
8. Woodford N, Ellington MJ, Coelho JM, Turton JF, Ward ME, Brown S, et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents. 2006;27(4): 351-3. DOI: 10.1016/j. ijantimicag.2006.01.004 PMID: 16564159
9. Antunes NT, Lamoureaux TL, Toth M, Stewart NK, Frase H, Vakulenko SB. Class D β-lactamases: are they all carbapenemases? Antimicrob Agents Chemother. 2014;58(4): 2119-25. DOI: 10.1128/AAC.02522-13 PMID: 24468778
10. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0, 2015. EUCAST; 2015. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_5.0_Breakpoint_Table_01. pdf
11. Clinical and Laboratory Standard Institute (CLSI). Performance standards for antimicrobial susceptibility testing. Twenty-first informational supplement. M100-S21. Vol. 31 No. 1. CLSI;2011.
12. Oliver A, Weigel LM, Rasheed JK, McGowan JE, Raney P, Tenover FC. Mechanisms of decreased susceptibility to cefpodoxime in Escherichia coli. Antimicrob Agents Chemother. 2002;46(12): 3829-36. DOI: 10.1128/AAC.46.12.3829-3836.2002 PMID: 12435684
13. McDaniels AE, Rice EW, Reyes AL, Johnson CH, Haugland RA, Stelma GN. Confirmational identification of Escherichia coli, a comparison of genotypic and phenotypic assays for glutamate decarboxylase and beta-D-glucuronidase. Appl Environ Microbiol. 1998;64(10): 4113.PMID: 16349569
14. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005;63(3): 219-28. DOI: 10.1016/j. mimet.2005.03.018 PMID: 15935499
15. Carattoli A, Seiffert SN, Schwendener S, Perreten V, Endimiani A. Differentiation of IncL and IncM Plasmids Associated with the Spread of Clinically Relevant Antimicrobial Resistance. PLoS One. 2015;10(5): e0123063. DOI: 10.1371/journal.pone.0123063 PMID: 25933288
16. Livermore DM, Walsh TR, Toleman M, Woodford N. Balkan NDM-1: escape or transplant? Lancet Infect Dis. 2011;11(3): 164. DOI: 10.1016/S1473-3099(11)70048-2 PMID: 21371654
17. Gruber TM, Göttig S, Mark L, Christ S, Kempf VAJ, Wichelhaus TA, et al. Pathogenicity of pan-drug-resistant Serratia marcescens harbouring blaNDM-1. J Antimicrob Chemother. 2015;70(4): 1026-30. PMID: 25468904
18. Voelz A, Müller A, Gillen J, Le C, Dresbach T, Engelhart S, et al. Outbreaks of Serratia marcescens in neonatal and pediatric intensive care units: clinical aspects, risk factors and management. Int J Hyg Environ Health. 2010;213(2): 79-87. DOI: 10.1016/j.ijheh.2009.09.003 PMID: 19783209
19. Yoon HJ, Choi JY, Park YS, Kim CO, Kim JM, Yong DE, et al. Outbreaks of Serratia marcescens bacteriuria in a neurosurgical intensive care unit of a tertiary care teaching hospital: a clinical, epidemiologic, and laboratory perspective. Am J Infect Control. 2005;33(10): 595-601. DOI: 10.1016/j. ajic.2005.01.010 PMID: 16330308
20. Poirel L, Bonnin RA, Nordmann P. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob Agents Chemother. 2012;56(1): 559-62. DOI: 10.1128/AAC.05289-11 PMID: 22083465
21. Kaase M, Pfennigwerth N, Lange F, Anders A, Gatermann SG. Molecular epidemiology of VIM-1 producing Escherichia coli from Germany referred to the National Reference Laboratory. Int J Med Microbiol. 2015;305(7): 784-9. DOI: 10.1016/j. ijmm.2015.08.032 PMID: 26321009
22. Jamal WY, Albert MJ, Khodakhast F, Poirel L, Rotimi VO. Emergence of New Sequence Type OXA-48 Carbapenemase-Producing Enterobacteriaceae in Kuwait. Microb Drug Resist. 2015;21(3): 329-34. DOI: 10.1089/mdr.2014.0123 PMID: 25551428
23. Hammoudi D, Ayoub Moubareck C, Aires J, Adaime A, Barakat A, Fayad N, et al. Countrywide spread of OXA-48 carbapenemase in Lebanon: surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period. Int J Infect Dis. 2014;29: 139-44. DOI: 10.1016/j.ijid.2014.07.017 PMID: 25449248
24. Towner KJ. Acinetobacter: an old friend, but a new enemy. J Hosp Infect. 2009;73(4): 355-63. DOI: 10.1016/j. jhin.2009.03.032 PMID: 19700220
25. Deshpande LM, Flonta M, Jones RN, Castanheira M. Detection of NDM-1-producing Enterobacteriaceae in Romania: report of the SENTRY Antimicrobial Surveillance Program. J Med Microbiol. 2014;63(Pt 3): 483-4. DOI: 10.1099/jmm.0.070334-0 PMID: 24346066
26. Gheorghe I, Novais Â, Grosso F, Rodrigues C, Chifiriuc MC, Lazar V, et al. Snapshot on carbapenemase-producing Pseudomonas aeruginosa and Acinetobacter baumannii in Bucharest hospitals reveals unusual clones and novel genetic surroundings for blaOXA-23. J Antimicrob Chemother. 2015;70(4): 1016-20.PMID: 25630639
27. Székely E, Damjanova I, Jánvári L, Vas KE, Molnár S, Bilca DV, et al. First description of bla(NDM-1), bla(OXA-48), bla(OXA-181) producing Enterobacteriaceae strains in Romania. Int J Med Microbiol. 2013;303(8): 697-700. DOI: 10.1016/j. ijmm.2013.10.001 PMID: 24183483
28. Bonnin RA, Poirel L, Licker M, Nordmann P. Genetic diversity of carbapenem-hydrolysing β-lactamases in Acinetobacter baumannii from Romanian hospitals. Clin Microbiol Infect. 2011;17(10): 1524-8. DOI: 10.1111/j.1469-0691.2011.03622.x PMID: 21883667
29. Mereuta AI, Badescu AC, Domeanu OS, Iancu LS, Tuchilus CG. Spread of VIM-2 metallo-beta-lactamase in Pseudomonas aeruginosa and Acinetobacter baumannii clinical isolates from Iasi, Romania. Rev Rom De Med De Laborator. 2013;21(4): 423-30. Available from: https://www.degruyter.com/dg/viewarticle.fullcontentlink: pdf eventlink/$002fj$002frrlm.2013.21.issue-4$002frrlm-2013-0035$002frrlm-2013-0035.pdf/rrlm-2013-0035. pdf?t: ac=j$002frrlm.2013.21.issue-4$002frrlm-2013-0035$002frrlm-2013-0035.xml
30. Albiger B, Glasner C, Struelens MJ, Grundmann H, Monnet DL, European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group. Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015. Euro Surveill. 2015;20(45): 30062. DOI: 10.2807/1560-7917. ES.2015.20.45.30062 PMID: 26675038