Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

Cell Stem Cell

Volumn 20, Issue 6, 2017, Pages 771-784.e6

  Ambrosi, Thomas H ^a   Scialdone, Antonio ^b,c   Graja, Antonia ^a   Gohlke, Sabrina ^a   Jank, Anne Marie ^a   Bocian, Carla ^a   Woelk, Lena ^a   Fan, Hua ^d   Logan, Darren W ^b,e   Schürmann, Annette ^a,g   Saraiva, Luis R ^f   Schulz, Tim J ^a,g  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e MONELL CHEMICAL SENSES CENTER   (United States)

^f SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^g GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

adipogenesis; adipogenic progenitors; aging; bone healing; bone marrow adipose tissue; DPP4; hematopoiesis; mesenchymal stem cells; obesity; regeneration

Indexed keywords

DIPEPTIDYL PEPTIDASE IV;

ADIPOCYTE; ADIPOGENESIS; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL SUBPOPULATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME RELEASE; FRACTURE HEALING; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LIPID DIET; MALE; MESENCHYMAL STEM CELL; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; STEM CELL EXPANSION; ANIMAL; ENZYMOLOGY; GENETICS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ADIPOCYTES; AGING; ANIMALS; BONE MARROW; BONE REGENERATION; DIPEPTIDYL PEPTIDASE 4; HEMATOPOIESIS; MICE; MICE, TRANSGENIC; OBESITY;

EID: 85015335169     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.02.009     Document Type: Article

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