[10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells

Experimental and Molecular Pathology

Volumn 102, Issue 2, 2017, Pages 370-376

  Bernard, Megan M ^a   McConnery, Jason R ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Gingerol

Indexed keywords

(10) GINGEROL; (6) GINGEROL; (8) GINGEROL; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; ACETYLCYSTEINE; ANTIOXIDANT; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CARRIER PROTEIN; CASP3 PROTEIN, MOUSE; CASPASE 3; CATECHOL DERIVATIVE; DIABLO PROTEIN, MOUSE; FATTY ALCOHOL; GINGEROL; MITOCHONDRIAL PROTEIN; PEPTIDE CHLOROMETHYL KETONE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; CYTOPLASM; GINGER; HUMAN; HUMAN CELL; IN VITRO STUDY; MDA-MB-231 CELL LINE; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PLANT ROOT; S PHASE CELL CYCLE CHECKPOINT; TRIPLE NEGATIVE BREAST CANCER; ANIMAL; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PATHOLOGY; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

ACETYLCYSTEINE; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CATECHOLS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FATTY ALCOHOLS; FEMALE; GINGER; HUMANS; MICE; MITOCHONDRIAL PROTEINS; PLANT ROOTS; REACTIVE OXYGEN SPECIES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 85015302819     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2017.03.006     Document Type: Article

References (21)

1. Andreopoulou, E., Schweber, S.J., Sparano, J.A., McDaid, H.M., Therapies for triple negative breast cancer. Expert Opin. Pharmacother. 16 (2015), 1–16.
2. Cadoo, K.A., Fornier, M.N., Morris, P.G., Biological subtypes of breast cancer: current concepts and implications for recurrence patterns. Q. J. Nucl. Med. Mol. Imaging 57 (2013), 312–321.
3. Comelli, M., Genero, N., Mavelli, I., Caspase-independent apoptosis in Friend's erythroleukemia cells: role of mitochondrial ATP synthesis impairment in relocation of apoptosis-inducing factor and endonuclease G. J. Bioenerg. Biomembr. 41 (2009), 49–59.
4. da Silva, J.A., Becceneri, A.B., Mutti, H.S., Martin, A.C.B.M., da Silva, M.F., Fernandes, J.B., Vieira, P.C., Cominetti, M.R., Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 903 (2012), 157–162.
5. Delbridge, A.R., Valente, L.J., Strasser, A., The role of the apoptotic machinery in tumor suppression. Cold Spring Harb. Perspect. Biol., 4, 2012, a008789.
6. Hansch, C., Fujita, T., ρ-σ-π analysis. A method for the correlation of biological activity and chemical structure. J. Am. Chem. Soc. 86 (1964), 1616–1626.
7. Kandoth, C., McLellan, M.D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J.F., Wyczalkowski, M.A., Leiserson, M.D., Miller, C.A., Welch, J.S., Walter, M.J., Wendl, M.C., Ley, T.J., Wilson, R.K., Raphael, B.J., Ding, L., Mutational landscape and significance across 12 major cancer types. Nature 502 (2013), 333–339.
8. Kubra, I.R., Rao, L.J., An impression of current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale roscoe). Crit. Rev. Food Sci. Nutr. 52 (2012), 651–688.
9. Lee, H.S., Seo, E.Y., Kang, N.E., Kim, W.K., [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J. Nutr. Biochem. 19 (2008), 313–331.
10. Radhakrishnan, E.K., Bava, S.V., Narayanan, S.S., Nath, L.R., Thulasidasan, A.K., Soniya, E.V., Anto, R.J., [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One, 9, 2014, e104401.
11. Ryu, M.J., Chung, H.S., [10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells. In Vitro Cell. Dev. Biol. Anim. 51 (2015), 92–101.
12. Sang, S., Hong, J., Wu, H., Liu, J., Yang, C.S., Pan, M.H., Badmaev, V., Ho, C.T., Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J. Agric. Food Chem. 57 (2009), 10645–10650.
13. Semwal, R.B., Semwal, D.K., Combrinck, S., Viljoen, A.M., Gingerols and shogaols: important nutraceutical principles from ginger. Phytochemistry 117 (2015), 554–568.
14. Shao, X., Lv, L., Parks, T., Wou, H., Ho, C.T., Sang, S., Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. J. Agric. Food Chem. 58 (2010), 12608–12614.
15. Siddiqui, J.A., Singh, A., Chaqtoo, M., Singh, N., Godbole, M.M., Chakravarti, B., Phytochemicals for breast cancer therapy: current status and future implications. Curr. Cancer Drug Targets 15 (2015), 116–135.
16. Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2017. CA Cancer J. Clin. 67 (2017), 7–30.
17. Vakifahmetoglu-Norberg, H., Ouchida, A.T., Norberg, E., The role of mitochondria in metabolism and cell death. Biochem. Biophys. Res. Commun. 482 (2017), 426–431.
18. Wang, C.C., Chen, L.G., Lee, L.T., Yang, L.L., Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In Vivo 17 (2003), 641–645.
19. Wang, C.Z., Qi, L.W., Yuan, C.S., Cancer chemoprevention effects of ginger and its active constituents: potential for new drug discovery. Am. J. Chin. Med. 43 (2015), 1351–1363.
20. Yang, G., Wang, S., Zhong, L., Dong, X., Zhang, W., Jiang, L., Geng, C., Sun, X., Liu, X., Chen, M., Ma, Y., 6-Gingerol induces apoptosis through lysosomal–mitochondrial axis in human hepatoma G2 cells. Phytother. Res. 26 (2012), 1667–1673.
21. Yoon, M.K., Ha, J.H., Lee, M.S., Chi, S.W., Structure and apoptotic function of p73. BMB Rep. 48 (2015), 81–90.