Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells

Nature Microbiology

Volumn 2, Issue , 2017, Pages

  Wen, Jinsheng ^a,b   Tang, William Weihao ^a   Sheets, Nicholas ^a   Ellison, Julia ^a   Sette, Alessandro ^a   Kim, Kenneth ^a   Shresta, Sujan ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; HLA A ANTIGEN; HLA B ANTIGEN;

ANIMAL; CD8+ T LYMPHOCYTE; CROSS REACTION; DENGUE VIRUS; ENZYME LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; IMMUNOLOGY; METABOLISM; MOUSE; STAINING; ZIKA VIRUS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; DENGUE VIRUS; ENZYME-LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HLA-A ANTIGENS; HLA-B ANTIGENS; INTERFERON-GAMMA; MICE; STAINING AND LABELING; ZIKA VIRUS;

EID: 85015287311     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/nmicrobiol.2017.36     Document Type: Article

References (50)

1. Lazear, H. M., Diamond, M. S. Zika virus: new clinical syndromes and itsemergence in the western hemisphere. J. Virol. 90, 4864-4875 (2016).
2. Choumet, V., Despres, P. Dengue and other flavivirus infections. Rev. Sci. Tech. 34, 473-478, 467-472 (2015).
3. Faye, O., et al. Molecular evolution of Zika virus during its emergence in the 20thcentury. PLoS Negl. Trop. Dis. 8, e2636 (2014).
4. Cugola, F. R., et al. The Brazilian Zika virus strain causes birth defects inexperimental models. Nature 534, 267-271 (2016).
5. Miner, J. J., et al. Zika virus infection during pregnancy in mice causes placentaldamage and fetal demise. Cell 165, 1081-1091 (2016).
6. Li, C., et al. Zika virus disrupts neural progenitor development and leads tomicrocephaly in mice. Cell Stem Cell 19, 120-126 (2016).
7. Oehler, E., et al. Zika virus infection complicated by Guillain-Barre syndrome-case report, French Polynesia, December 2013. Euro Surveill. 19, 2 (2014).
8. D'Ortenzio, E., et al. Evidence of sexual transmission of Zika virus. N. Engl. J. Med. 374, 2195-2198 (2016).
9. Musso, D., et al. Potential sexual transmission of Zika virus. Emerg. Infect. Dis. 21, 359-361 (2015).
10. Dupont-Rouzeyrol, M., et al. Co-infection with Zika and dengue viruses in 2patients, New Caledonia, 2014. Emerg. Infect. Dis. 21, 381-382 (2015).
11. Screaton, G., Mongkolsapaya, J., Yacoub, S., Roberts, C. New insights into theimmunopathology and control of dengue virus infection. Nat. Rev. Immunol. 15, 745-759 (2015).
12. Rothman, A. L., Medin, C. L., Friberg, H., Currier, J. R. Immunopathogenesisversus protection in dengue virus infections. Curr. Trop. Med. Rep. 1, 13-20 (2014).
13. Weiskopf, D., Sette, A. T-cell immunity to infection with dengue virus inhumans. Front. Immunol. 5, 93 (2014).
14. Halstead, S. B. Dengue. Lancet 370, 1644-1652 (2007).
15. Huang, X., et al. Antibody-dependent enhancement of dengue virus infectioninhibits RLR-mediated type-I IFN-independent signalling through upregulationof cellular autophagy. Sci. Rep. 6, 22303 (2016).
16. Barba-Spaeth, G., et al. Structural basis of potent Zika-dengue virus antibodycross-neutralization. Nature 536, 48-53 (2016).
17. Dejnirattisai, W., et al. Dengue virus sero-cross-reactivity drives antibodydependentenhancement of infection with Zika virus. Nat. Immunol. 17, 1102-1108 (2016).
18. Swanstrom, J. A., et al. Dengue virus envelope dimer epitope monoclonalantibodies isolated from dengue patients are protective against Zika virus. mBio7, e01123-16 (2016).
19. Stettler, K., et al. Specificity, cross-reactivity, function of antibodies elicitedby Zika virus infection. Science 353, 823-826 (2016).
20. Elong Ngono, A., et al. Mapping and role of the CD8+ T cell response duringprimary Zika virus infection in mice. Cell Host Microbe 21, 35-46 (2017).
21. Weiskopf, D., et al. Insights into HLA-restricted T cell responses in a novelmouse model of dengue virus infection point toward new implications forvaccine design. J. Immunol. 187, 4268-4279 (2011).
22. Weiskopf, D., et al. Immunodominance changes as a function of the infectingdengue virus serotype and primary versus secondary infection. J. Virol. 88, 11383-11394 (2014).
23. Ashour, J., et al. Mouse STAT2 restricts early dengue virus replication. Cell HostMicrobe 8, 410-421 (2010).
24. Aguirre, S., et al. DENV inhibits type I IFN production in infected cells bycleaving human STING. PLoS Pathog. 8, e1002934 (2012).
25. Yu, C. Y., et al. Dengue virus targets the adaptor protein MITA to subvert hostinnate immunity. PLoS Pathog. 8, e1002780 (2012).
26. Weiskopf, D., et al. Comprehensive analysis of dengue virus-specific responsessupports an HLA-linked protective role for CD8+ T cells. Proc. Natl Acad. Sci. USA 110, E2046-E2053 (2013).
27. Weiskopf, D., et al. The human CD8+ T cell responses induced by a liveattenuated tetravalent dengue vaccine are directed against highly conservedepitopes. J. Virol. 89, 120-128 (2015).
28. Weiskopf, D., et al. Human CD8+ T-cell responses against the 4 dengue virusserotypes are associated with distinct patterns of protein targets. J. Infect. Dis. 212, 1743-1751 (2015).
29. Duangchinda, T., et al. Immunodominant T-cell responses to dengue virus NS3are associated with DHF. Proc. Natl Acad. Sci. USA 107, 16922-16927 (2010).
30. Rivino, L., et al. Differential targeting of viral components by CD4+ versus CD8+T lymphocytes in dengue virus infection. J. Virol. 87, 2693-2706 (2013).
31. Grant, A., et al. Zika virus targets human STAT2 to inhibit type I interferonsignaling. Cell Host Microbe 19, 882-890 (2016).
32. Dowall, S. D., et al. A susceptible mouse model for Zika virus infection. PLoSNegl. Trop. Dis. 10, e0004658 (2016).
33. Lazear, H. M., et al. A mouse model of Zika virus pathogenesis. Cell Host Microbe19, 720-730 (2016).
34. Teixeira, M. G., Siqueira, J. B. Jr, Ferreira, G. L., Bricks, L., Joint, G., UnnaschT. R. Epidemiological trends of dengue disease in Brazil (2000-2010): asystematic literature search and analysis. PLoS Negl. Trop. Dis. 7, e2520 (2013).
35. Prestwood, T. R., et al. Gamma interferon (IFN-') receptor restricts systemicdengue virus replication and prevents paralysis in IFN-'/' receptor-deficientmice. J. Virol. 86, 12561-12570 (2012).
36. Yauch, L. E., et al. A protective role for dengue virus-specific CD8+ T cells. J. Immunol. 182, 4865-4873 (2009).
37. Zellweger, R. M., et al. CD8+ T cells can mediate short-term protection againstheterotypic dengue virus reinfection in mice. J. Virol. 89, 6494-6505 (2015).
38. Elong Ngono, A., et al. Protective role of cross-reactive CD8 T cells againstdengue virus infection. EBioMedicine 13, 284-293 (2016).
39. Li, H., et al. Zika virus infects neural progenitors in the adult mouse brain andalters proliferation. Cell Stem Cell 19, 593-598 (2016).
40. Yockey, L. J., et al. Vaginal exposure to Zika virus during pregnancy leads to fetalbrain infection. Cell 166, 1247-1256 (2016).
41. Beckham, J. D., Pastula, D. M., Massey, A., Tyler, K. L. Zika virus as anemerging global pathogen: neurological complications of Zika virus. JAMANeurol. 73, 875-879 (2016).
42. Dowd, K. A., et al. Rapid development of a DNA vaccine for Zika virus. Science 354, 237-240 (2016).
43. Larocca, R. A., et al. Vaccine protection against Zika virus from Brazil. Nature 536, 474-478 (2016).
44. Hunter, P., Erasmus, B. J., Vorster, J. H. Teratogenicity of a mutagenised RiftValley fever virus (MVP 12) in sheep. Onderstepoort J. Vet. Res. 69, 95-98 (2002).
45. Adams Waldorf, K. M., McAdams, R. M. Influence of infection duringpregnancy on fetal development. Reproduction 146, R151-R162 (2013).
46. Yauch, L. E., et al. CD4+ T cells are not required for the induction of denguevirus-specific CD8+ T cell or antibody responses but contribute to protectionafter vaccination. J. Immunol. 185, 5405-5416 (2010).
47. Zellweger, R. M., et al. Role of humoral versus cellular responses induced by aprotective dengue vaccine candidate. PLoS Pathog. 9, e1003723 (2013).
48. Zellweger, R. M., Eddy, W. E., Tang, W. W., Miller, R., Shresta, S. CD8+ T cellsprevent antigen-induced antibody-dependent enhancement of dengue disease inmice. J. Immunol. 193, 4117-4124 (2014).
49. Weiskopf, D., et al. Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+ T cells associated with protective immunity. Proc. Natl Acad. Sci. USA 112, E4256-E4263 (2015).
50. Croft, M., Carter, L., Swain, S. L., Dutton, R. W. Generation of polarizedantigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180, 1715-1728 (1994).