Pharmacogenomic study in patients with multiple sclerosis Responders and nonresponders to IFN-β

Neurology: Neuroimmunology and NeuroInflammation

Volumn 2, Issue 5, 2015, Pages e154-

  Bustamante, Marta F ^a   Morcillo Suárez, Carlos ^b,s   Malhotra, Sunny ^d   Rio, Jordi ^j   Leyva, Laura ^a   Fernández, Oscar ^c   Zettl, Uwe K ^d,p   Killestein, Joep ^b,r   Brassat, David ^d,q   García Merino, Juan Antonio ^e   Sánchez, Antonio J ^f   Urcelay, Elena ^g   Alvarez Lafuente, Roberto ^c   Villar, Lusia M ^c,s   Alvarez Cermeño, Jose Carlos ^e,t   Farré, Xavier ^f   Lechner Scott, Jeannette ^h,u   Vandenbroeck, Koen ^i,v   Rodríguez Antigüedad, Alfredo ^j   Drulovic, Jelena S ^a   Boneschi, Filippo Martinelli ^k   Chan, Andrew ^l   Oksenberg, Jorge ^m   Navarro, Arcadi ⁿ   Montalban, Xavier ^o   Comabella, Manuel ^a   more..

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b Barcelona Biomedical Research Park   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^e UNIVERSITY OF ROSTOCK   (Germany)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^g INSERM   (France)

^h HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

ⁱ INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^j HOSPITAL RAMÓN Y CAJAL   (Spain)

^k JOHN HUNTER HOSPITAL   (Australia)

^l HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^m UNIVERSITY OF NEWCASTLE   (Australia)

ⁿ UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^o BASQUE FOUNDATION FOR SCIENCE   (Spain)

^p ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE   (Spain)

^q HOSPITAL DE BASURTO   (Spain)

^r UNIVERSITY OF BELGRADE   (Serbia)

^s SAN RAFFAELE HOSPITAL   (Italy)

^t ST JOSEF HOSPITAL   (Germany)

^u UNIVERSITY OF CALIFORNIA   (United States)

^v INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BETA INTERFERON; CXCL1 CHEMOKINE; GAMMA AMINOBUTYRIC ACID A RECEPTOR RHO 3; INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS KINASE BETA; INTERFERON; INTERFERON ALPHA BETA AND OMEGA RECEPTOR 1; INTERFERON INDUCED WITH HELICASE C DOMAIN 1; NEUROTRANSMITTER RECEPTOR; PELLINO E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER 3; STIP1 HOMOLOGY AND U BOX CONTAINING PROTEIN 1 E3 UBIQUITIN PROTEIN LIGASE; TOLL LIKE RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SCREENING; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PHARMACOGENOMICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

EID: 85015273760     PISSN: None     EISSN: 23327812     Source Type: Journal    
DOI: 10.1212/NXI.0000000000000154     Document Type: Article

References (11)

1. Jacobs LD, Cookfair DL, Rudick RA, et al. Intramus cular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Col laborative Research Group (MSCRG). Ann Neurol 1996;39:285-294.
2. Río J, Nos C, Tintoré M, et al. Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with inter-feron beta: implications for clinical trials. Ann Neurol 2002;52:400-406.
3. Mahurkar S, Suppiah V, O'Doherty C. Pharmacoge-nomics of interferon beta and glatiramer acetate response: a review of the literature. Autoimmun Rev 2014;13:178-186.
4. Comabella M, Lünemann JD, Río J, et al. A type I inter-feron signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain 2009;132:3353-3365.
5. Comabella M, Craig DW, Morcillo-Suárez C, et al. Genome-wide scan of 500, 000 single-nucleotide polymor phisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. Arch Neurol 2009;66: 972-978.
6. Byun E, Caillier SJ, Montalban X, et al. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol 2008;65: 337-344.
7. Río J, Nos C, Tintoré M, et al. Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients. Ann Neurol 2006;59:344-352.
8. Lorente-Galdos B, Medina I, Morcillo-Suarez R, et al. SYSNPs (Select Your SNPs): a web tool for automatic and massive selection of SNPs. Int J Data Min Bioinform 2012;6:324-334.
9. Morcillo-Suarez C, Alegre J, Sangros R, et al. SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data. Bioinfor-matics 2008;24:1643-1644.
10. Siednienko J, Jackson R, Mellett M, et al. Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3-and viral-induced expression of type I interferons. Nat Immunol 2012;13:1055-1062.
11. Bustamante MF, Fissolo N, Río J, et al. Implication of the Toll-like receptor 4 pathway in the response to interferon-b in multiple sclerosis. Ann Neurol 2011;70:634-645.