Polyphosphate strikes back

Blood

Volumn 128, Issue 24, 2016, Pages 2754-2756

  Maas, Coen ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 12A; COLLAGEN; PLASMIN; PLASMINOGEN; POLYMER; POLYPHOSPHATE; RNA; TISSUE PLASMINOGEN ACTIVATOR;

CYTOMETRY; ENDOTHELIUM CELL; ENZYME ACTIVITY; FIBRINOLYSIS; HUMAN; MICROSCOPY; NOTE; PLASMINOGEN ACTIVATION; POLYMERIZATION; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBUS;

HUMANS; POLYPHOSPHATES;

EID: 85014958869     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-10-743906     Document Type: Note

References (8)

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2. Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004;279(43):44250-44257.
3. Müller F, Mutch NJ, Schenk WA, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139(6):1143-1156.
4. Labberton L, Kenne E, Long AT, et al. Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection. Nat Commun. 2016;7:12616.
5. Morrissey JH, Smith SA. Polyphosphate as modulator of hemostasis, thrombosis, and inflammation. J Thromb Haemost. 2015;13(suppl 1):S92-S97.
6. Mutch NJ, Engel R, Uitte de Willige S, Philippou H, Ariëns RAS. Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin. Blood. 2010;115(19):3980-3988.
7. Konings J, Govers-Riemslag JWP, Philippou H, et al. Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood. 2011;118(14):3942-3951.
8. Levi M, Hack CE, de Boer JP, Brandjes DP, Büller HR, ten Cate JW. Reduction of contact activation related fibrinolytic activity in factor XII deficient patients. Further evidence for the role of the contact system in fibrinolysis in vivo. JClinInvest. 1991;88(4):1155-1160.