Daily fatigue-reducing effect of astaxanthin - A randomized, placebo-controlled, double-blind, parallel-group study

Japanese Pharmacology and Therapeutics

Volumn 45, Issue 1, 2017, Pages 61-72

  Hongo, Nobuko ^a   Fujishita, Mayuko ^a   Takahashi, Yu ^a   Adachi, Yuki ^a   Takahashi, Jiro ^a   Tominaga, Kumi ^a   Miura, Naoki ^b  

^a AstaReal Co   (Japan)

^b Miura Clinic   (Japan)

Author keywords

Astaxanthin; Biological antioxidant potential; Fatigue; Randomized controlled study; Tocotrienol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA TOCOTRIENOL; AMYLASE; ASPARTATE AMINOTRANSFERASE; ASTAXANTHIN; BILIRUBIN; CALCIUM; CHLORIDE; CREATINE KINASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IRON; KETONE BODY; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; NITROGEN; PLACEBO; POTASSIUM; PROTEIN; SODIUM; UREA; URIC ACID; UROBILINOGEN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; AMYLASE BLOOD LEVEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BICYCLE ERGOMETRY; BILIRUBIN BLOOD LEVEL; CALCIUM BLOOD LEVEL; CHLORIDE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FATIGUE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INTENTION TO TREAT ANALYSIS; IRON BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; MAGNESIUM BLOOD LEVEL; MALE; MENTAL PERFORMANCE; OCCULT BLOOD; PARALLEL DESIGN; POTASSIUM BLOOD LEVEL; PROFILE OF MOOD STATES; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; SODIUM BLOOD LEVEL; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; VISUAL ANALOG SCALE;

EID: 85014820786     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Di Mascio P, Devasagayam TP, Kaiser S, Sies H. Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. Biochem Soc Trans 1990; 18: 1054-6.
2. Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N, et al. Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors 2004; 20: 49-59.
3. Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis 2010; 209: 520-3.
4. Nakagawa K, Kiko T, Miyazawa T, Burdeos GC, Kimura F, Satoh A, et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Br J Nutr 2011; 105: 1563-71.
5. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochim Pol 2012; 59: 43-7.
6. Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, et al. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal 2003; 5: 139-44.
7. Aoi W, Naito Y, Takanami Y, Ishii T, Kawai Y, Akagiri S, et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun 2008; 366: 892-7.
8. Nagaki Y, Tsukahara H, Yoshimoto T, Masuda K. Effect of astaxanthin on accommodation and asthenopia. Folia Japonica de Ophthalmologica Clinica 2010; 3: 461-8.
9. Nagaki Y, Mihara M, Tsukahara H, Ohno S. The supplementation effect of astaxanthin on accommodation and asthenopia. J Clin Therap Med 2006; 22: 41-54.
10. Shiratori K, Ohgami K, Nitta T, Shinmei Y, Chin S, Yoshida K, et al. Effect of astaxanthin on accommodation and asthenopia: efficacy-identification study in healthy volunteers. J Clin Therap Med 2005; 21: 637-50.
11. Nitta T, Ohgami K, Shiratori K, Shinmei K, Chin S, Yoshida K, et al. Effects of astaxanthin on accommodation and asthenopia: dose finding study in healthy volunteers. J Clin Therap Med 2005; 21: 543-56.
12. Watanabe Y, Hashimoto S, Kuratsune H, Kondo K, Kawahara T, Kubo C, et al. Guideline of clinical evaluation of anti-fatigue. Nipponhirougakkaishi 2012; 7: 1-13.
13. Watanabe Y. What is fatigue?: statistics of fatigue in Japan and what are the problems to be solved by fatigue science? J Clin Exp Med 2009; 228: 593-7.
14. Malmsten CL, Lignell Å. Dietary supplementation with astaxanthin-rich algal meal improves strength endurance: a double blind placebo controlled study on male students. Carotenoid Science 2008; 13: 20-2.
15. Earnest CP, Lupo M, White KM, Church TS. Effect of astaxanthin on cycling time trial performance. Int J Sports Med 2011; 32: 882-8.
16. Hongo N, Fujishita M, Takahashi J, Tominaga K, Miura N. Randomized controlled trial of the anti-fatigue effects of astaxanthin on mental and physical loads simulating daily life. J Clin Therap Med 2016; 32: 577-91.
17. Dohi K, Satoh K, Ohtaki H, Shioda S, Miyake Y, Shindo M, et al. Elevated plasma levels of bilirubin in patients with neurotrauma reflect its pathophysiological role in free radical scavenging. In Vivo 2005; 19: 855-60.
18. Fukuda S, Nojima J, Motoki Y, Yamaguti K, Nakatomi Y, Okawa N, et al. A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. Biol Physchol 2016; 118: 88-93.
19. Iwabayashi M, Fujioka N, Nomoto K, Miyazaki R, Takahashi H, Hibino S, et al. Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. Anti-Aging Med 2009; 6: 15-21.
20. Wu H, Niu H, Shao A, Wu C, Dixon BJ, Zhang J, et al. Astaxanthin as a potential neuroprotective agent for neurological diseases. Mar Drugs 2015; 13: 5750-66.
21. Nagata A, Tajima T, Hamamatsu H. Effect of astaxanthin on recovery from whole fatigue with three stepwise exercises. Hirou-To-Kyuyou-No-Kagaku 2003; 18: 35-46.
22. Yook JS, Okamoto M, Rakwal R, Shibato J, Lee MC, Matsui T, et al. Astaxanthin supplementation enhances adult hippocampal neurogenesis and spatial memory in mice. Mol Nutr Food Res 2016; 60: 589-99.