The effects of growing up on a farm on adult lung function and allergic phenotypes: An international population-based study

Thorax

Volumn 72, Issue 3, 2017, Pages 236-244

  Campbell, B ^a   Raherison, C ^b   Lodge, C J ^a,c   Lowe, A J ^a,c   Gislason, T ^d,e   Heinrich, J ^f,g   Sunyer, J ^h,i,j   Gomez Real F ^k,l   Norback D ^m   Matheson, M C ^a   Wjst, M ^f   Dratva, J ^n,o   De Marco, R ^p   Jarvis, D ^q   Schlunssen V ^r   Janson, C ^k   Leynaert, B ^s   Svanes, C ^k   Dharmage, S C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^e UNIVERSITY OF ICELAND   (Iceland)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

ⁱ CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^j UNIVERSITAT POMPEU FABRA   (Spain)

^k HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^l UNIVERSITY OF BERGEN   (Norway)

^m UPPSALA UNIVERSITY   (Sweden)

ⁿ SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^o UNIVERSITY OF BASEL   (Switzerland)

^p UNIVERSITY OF VERONA   (Italy)

^q NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^r AARHUS UNIVERSITY   (Denmark)

^s Centre de Recherche Albert Bonniot   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADULTHOOD; AGRICULTURAL LAND; ALLERGIC ASTHMA; ALLERGIC SENSITIZATION; ALLERGY; ARTICLE; ASTHMA; ATOPIC RHINITIS; ATOPY; BIODIVERSITY; BIRTHPLACE; BRONCHUS HYPERREACTIVITY; CAT; CHILDHOOD; CITY; CONTROLLED STUDY; DAY CARE; DEMOGRAPHY; DISEASE ASSOCIATION; DOG; ENVIRONMENTAL EXPOSURE; FEMALE; HOME ENVIRONMENT; HUMAN; LUNG FUNCTION; MALE; PHENOTYPE; POPULATION RESEARCH; PROTECTION; RHINITIS; RURAL AREA; SENSITIZATION; SMOKING; URBAN AREA; ANIMAL; CHILD; CHILD CARE; HYPERSENSITIVITY; INTERNATIONAL COOPERATION; LUNG FUNCTION TEST; MIDDLE AGED; SIBLING;

ADULT; ANIMALS; ASTHMA; BIODIVERSITY; CATS; CHILD; CHILD CARE; DOGS; ENVIRONMENTAL EXPOSURE; FARMS; FEMALE; HUMANS; HYPERSENSITIVITY; INTERNATIONALITY; MALE; MIDDLE AGED; PHENOTYPE; RESIDENCE CHARACTERISTICS; RESPIRATORY FUNCTION TESTS; RHINITIS; SIBLINGS;

EID: 85014607030     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-208154     Document Type: Article

References (40)

1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-60.
2. von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 2010;10:861-8.
3. Genuneit J. Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta-analysis. Pediatr Allergy Immunol 2012;23:509-18.
4. Braun-Fahrländer C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869-77.
5. Schram-Bijkerk D, Doekes G, Douwes J, et al. Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. Clin Exp Allergy 2005;35:1272-8.
6. Thorne PS, Kulhánková K, Yin M, et al. Endotoxin exposure is a risk factor for asthma: The National survey of endotoxin in United States housing. Am J Respir Crit Care Med 2005;172:1371-7.
7. van Strien RT, Engel R, Holst O, et al. Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health. J Allergy Clin Immunol 2004;113:860-7.
8. von Mutius E, Braun-Fahrländer C, Schierl R, et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30:1230-4.
9. Campbell BE, Lodge CJ, Lowe AJ, et al. Exposure to "farming" and objective markers of atopy: a systematic review and meta-analysis. Clin Exp Allergy 2015;45:744-57.
10. Portengen L, Sigsgaard T, Omland Ø, et al. Low prevalence of atopy in young danish farmers and farming students born and raised on a farm. Clin Exp Allergy 2002;32:247-53.
11. Schulze A, van Strien RT, Praml G, et al. Characterization of asthma among adults with and without childhood farm contact. Eur Respir J 2007;29:1169-73.
12. Fuchs O, Genuneit J, Latzin P, et al. Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide. J Allergy Clin Immunol 2012;130:382-8.e6.
13. Ernst P, Cormier Y. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care Med 2000;161:1563-6.
14. Merchant JA, Naleway AL, Svendsen ER, et al. Asthma and farm exposures in a cohort of rural Iowa children. Environ Health Perspect 2005;113:350-6.
15. Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005;60:1357-60.
16. Vargas C, Bustos P, Diaz PV, et al. Childhood environment and atopic conditions, with emphasis on asthma in a Chilean agricultural area. J Asthma 2008;45:73-8.
17. Azad MB, Konya T, Maughan H, et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol 2013;9:15.
18. Calvani M Jr, Alessandri C, Bonci E. Fever episodes in early life and the development of atopy in children with asthma. Eur Respir J 2002;20:391-6.
19. Burney PG, Luczynska C, Chinn S, et al. The European Community Respiratory Health Survey. Eur Respir J 1994;7:954-60.
20. European Community Respiratory Health Survey II Steering Committee. The European Community Respiratory Health Survey II. Eur Respir J 2002;20:1071-9.
21. Dharmage S, Bailey M, Raven J, et al. Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure. Am J Respir Crit Care Med 2001;164:65-71.
22. Leynaert B, Neukirch C, Jarvis D, et al. Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood? Am J Respir Crit Care Med 2001;164Pt 1):1829-34.
23. Lluis A, Depner M, Gaugler B, et al. Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood. J Allergy Clin Immunol 2014;133:551-9.
24. Naleway AL. Asthma and atopy in rural children: is farming protective? Clin Med Res 2004;2:5-12.
25. Downs SH, Marks GB, Mitakakis TZ, et al. Having lived on a farm and protection against allergic diseases in Australia. Clin Exp Allergy 2001;31:570-5.
26. Illi S, Depner M, Genuneit J, et al. Protection from childhood asthma and allergy in Alpine farm environments-the GABRIEL Advanced Studies. J Allergy Clin Immunol 2012;129:1470-7.e6.
27. Riedler J, Braun-Fahrländer C, Eder W, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001;358:1129-33.
28. Svanes C, Zock JP, Antó J, et al. Do asthma and allergy influence subsequent pet keeping? An analysis of childhood and adulthood. J Allergy Clin Immunol 2006;118:691-8.
29. Genuneit J. Sex-Specific Development of Asthma Differs between Farm and Nonfarm Children: A Cohort Study. Am J Respir Crit Care Med 2014;190:588-90.
30. Clough S. Gender and the hygiene hypothesis. Soc Sci Med 2011;72:486-93.
31. Rennie DC, Karunanayake CP, Chen Y, et al. Early farm residency and prevalence of asthma and hay fever in adults. J Asthma 2016;53:2-10.
32. Rennie DC, Lawson JA, Karunanayake CP, et al. Farm Exposure and Atopy in Men and Women: The Saskatchewan Rural Health Study. J Agromedicine 2015;20:302-9.
33. Mészáros D, Burgess J, Walters EH, et al. Domestic airborne pollutants and asthma and respiratory symptoms in middle age. Respirology 2014;19:411-18.
34. Mann JK, Balmes JR, Bruckner TA, et al. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environ Health Perspect 2010;118:1497-502.
35. Oosterlee A, Drijver M, Lebret E, et al. Chronic respiratory symptoms in children and adults living along streets with high traffic density. Occup Environ Med 1996;53:241-7.
36. de Jong K, Boezen HM, Hacken NH, et al., Life Lines cohort study. GST-omega genes interact with environmental tobacco smoke on adult level of lung function. Respir Res 2013;14:83.
37. Lau MYZ, Dharmage SC, Burgess JA, et al. CD14 polymorphisms, microbial exposure and allergic diseases: a systematic review of gene-environment interactions. Allergy 2014;69:1440-53.
38. Lauener RP, Birchler T, Adamski J, et al. Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children. Lancet 2002;360:465-6.
39. Klaassen EM, Thönissen BE, van Eys G, et al. A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children. Allergy Asthma Clin Immunol 2013;9:10.
40. Minelli C, Wei I, Sagoo G, et al. Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review. Am J Epidemiol 2011;173:603-20.