Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity

Cell Metabolism

Volumn 25, Issue 3, 2017, Pages 635-646

  Ahuja, Malini ^a   Schwartz, Daniella M ^b   Tandon, Mayank ^a   Son, Aran ^a   Zeng, Mei ^a   Swaim, William ^a   Eckhaus, Michael ^c   Hoffman, Victoria ^c   Cui, Yiyuan ^d   Xiao, Bo ^d   Worley, Paul F ^e   Muallem, Shmuel ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d SICHUAN UNIVERSITY   (China)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; AUTACOID; ORAI1 PROTEIN, MOUSE;

ACINAR CELL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BACTERIAL LOAD; BACTERIAL OVERGROWTH; BACTERIAL TRANSLOCATION; CELL DEATH; CONTROLLED STUDY; DIGESTIVE SYSTEM INFLAMMATION; DYSBIOSIS; FEEDING; GENE DELETION; HOMEOSTASIS; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; INTESTINAL BARRIER FUNCTION; INTESTINAL SECRETION; INTESTINE FLORA; INTESTINE FUNCTION; INTESTINE INFECTION; MORTALITY; MOUSE; NONHUMAN; PANCREAS INJURY; PANCREAS SECRETION; PRIORITY JOURNAL; SURVIVAL; WEIGHT GAIN; ANIMAL; CALCIUM SIGNALING; CYTOLOGY; DEFICIENCY; EXOCYTOSIS; GASTROINTESTINAL TRACT; IMMUNOLOGY; INTESTINE; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; PANCREAS; PATHOLOGY; PROTEIN SYNTHESIS; SECRETION (PROCESS);

ACINAR CELLS; ANIMALS; ANTI-INFECTIVE AGENTS; CALCIUM SIGNALING; CELL DEATH; EXOCYTOSIS; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; GENE DELETION; HOMEOSTASIS; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATION MEDIATORS; INTESTINES; MICE; MICROBIAL VIABILITY; ORAI1 PROTEIN; PANCREAS; PROTEIN BIOSYNTHESIS;

EID: 85014571306     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.02.007     Document Type: Article

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