A review from patents inspired by two plant genera: Uncaria and Hamelia

Phytochemistry Reviews

Volumn 16, Issue 4, 2017, Pages 693-723

  Flores Sanchez, Isvett Josefina ^a   Ramos Valdivia, Ana Carmela ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Hamelia; Monoterpenoid indole and oxindole alkaloids; Uncaria

Indexed keywords

ALKALOID; APIGETRIN; BETULIN; CATECHIN; CHLOROGENIC ACID; CORYNANTHEINE; CYCLITOL; EPHEDRINE; FLAVONOID; HIRSUTINE; INDOLE ALKALOID; ISOMITRAPHYLLINE; ISOPTEROPODINE; ISORHYNCHOPHYLLINE; MALVIDIN CHLORIDE; MITRAPHYLLINE; NARIRUTIN; OLEANOLIC ACID; OXINDOLE ALKALOID; PLANT EXTRACT; PTEROPODINE; RHYNCHOPHYLLINE; ROSMARINIC ACID; RUTOSIDE; TRITERPENOID; UNCARIA EXTRACT; UNCARIA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; YOHIMBINE;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; HAMELIA; HUMAN; IMMUNOSTIMULATION; NONHUMAN; PATENT; PLANT BIOTECHNOLOGY; PLANT GENE; PLANT METABOLISM; PRIORITY JOURNAL; RUBIACEAE; SECONDARY METABOLISM; UNCARIA; VARIETAS;

EID: 85014565263     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-017-9498-0     Document Type: Article

References (191)

1. Ahn SY, Ban JG, Choi HI et al (2003) Usage as HCV NS3/NS4 protease inhibitor of 5-membered fused aromatic heterocyclic compound. KR Patent 100392292B1
2. Alexandrov N, Brover V, Feldmann K (2014) Nucleic acid sequences encoding strictosidine synthase. US Patent 8710201B2
3. Ali-Sayed M, Jantan I, Vijayaraghavan K et al (2016) Betulinic acid: recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy. Chem Biol Drug Res 87:517–536
4. Anderson E, Jiang X, Liu X et al (2015) Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring. US Patent 9090574B2
5. Awano I, Takihara T, Araki Y et al (2013) Carbonated beverage packed in container and manufacturing method therefor. JP Patent 5311357B1
6. Babish JG, Howell T, Pacioretty L (2003) Combinations of diterpene triepoxide lactones and diterpene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2. US Patent 6629835B2
7. Bai K, Guo Y, Zheng Y (2012) Ursolic acid derivative chemically modified by polyethylene glycol and preparation method of ursolic acid derivative. CN Patent 102329362B
8. Bednarczyk-Cwynar B, Zaprutko L, Atamanyuk D et al (2014) New O-acylated oximes of oleanolic acid derivatives and process for the preparation of acylated oximes derivatives of oleanolic acid. PL Patent 217864B1
9. Beindorff C, Cain FW, Pierce JH et al (2006) Blends of ursolic acid/oleanolic acid. DE Patent 60114708B1
10. Berry DW (2014) Compositions and methods for treatment of mammalian skin. US Patent 8652534B2
11. Berry DW (2016a) Topical treatment of radiation dermatitis using Hamelia patens. US Patent 9345736B2
12. Berry DW (2016b) Topical treatment of keratotic lesions using Hamelia patens. US Patent 9345737B2
13. Bobrowski PJ (2004) Methods and preparations of extracts of Uncaria species with reduced alkaloid content. US Patent 6797286B2
14. Bomshteyn AL, Rathnam P, Saxena BB (2005) Betulinol derivatives. US Patent 6890533B2
15. Bremer BA (2009) A review of molecular phylogenetic studies of Rubiaceae 1. Ann Mo Bot Gard 96:4–26
16. Brenner C (1998) Intellectual property rights and technology transfer in developing country agriculture: rhetoric and reality. Working paper 133, OECD, Paris, pp 1–53
17. Cain FW, Stam W, Schmid U et al. (2008) Use of compositions comprising oleanic acid and ursolic acid for the preparation of a medicament for the treatment of hypersensitivity and hyperreactivity. E Patent 1694320B1
18. Castillo GM, Snow AD (2010) Composition and methods for treating Alzheimer’s disease and other amyloidosis. US Patent 7754250B2
19. Castillo G, Choi PY, Nguyen B et al (2013) Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants. CA Patent 2427661C
20. Cepanee I, Knezevic Z (2015) Probiotic formulation with apigenin and peppermint extract, HR Patent K20130487B3
21. Chang TS, Ding HY (2015) Method of manufacturing 6-hydroxyapigenin by biotransformation. TW Patent I507527B
22. Chen R (2016) Preparation method of shrimp shell cold noodles. CN Patent 10341760B
23. Chen Y, Zhu Y, Zhu Y (2012) Uncaria extract and application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy. CN Patent 101791342B,
24. Chen Q, Liu J, Fu M et al (2013) Method for synthesizing betulinic acid by catalyzing botulin with laccase. CN Patent 102226213B
25. Chen D, Li X, Ji X et al (2014) Method for preparing chlorogenic acid by freezing, concentrating and crystallizing. CN Patent 102476997B
26. Cheng K, Liang H, Su C et al (2015) Oleanolic acid-pyrimide conjugate as well as preparation method and application thereof. CN103864882B
27. Cheng K, Liang H, Su C et al (2016) Oleanolic acid-uridine conjugate as well as preparation method and application thereof. CN103864881B
28. Chien M, Hausler A, van Leersum H (2012) Taste modifiers comprising a chlorogenic acid. US Patent 8197875B2
29. Choi IW, Park YK, Kim YS et al (2013) Composition for preventing and treating alcoholic liver disease comprising flavonoid. KR Patent 101268325B1
30. Chun HK, Park TH, Choung DH et al (2014a) Ursolic acid having anti-bacterial activity against causative bacteria of porcine respiratory disease complex and uses thereof. KR Patent 101478110B1
31. Chun HK, Park TH, Choung DH (2014b) Oleanolic acid having antibacterial activity against causative bacteria of porcine respiratory disease complex and uses thereof. KR Patent 101478109B1
32. Cook-Deegan R, Niehaus A (2014) After myriad: genetic testing in the wake of recent Supreme Court decisions about gene patents. Curr Genet Med Rep 2:223–241
33. Crespy V, Castiel I, Bel-Rhlid R et al (2016) Biological effects of compositions of rosmarinic acid. US Patent 9314490B2
34. Croat TB (1978) Flora of Barro Colorado Island. Standford University Press, USA, pp 809–810
35. Du Z, Tao Y (2015) Natural drug composition for curing rheumatism bone diseases and preparation method thereof. CN 104096221B
36. Duan D, Ren J, Yang Z et al (2011) Uncaria alkaloid monomer as well as preparation method and application thereof. CN Patent 101798306B
37. Duke JA (2002) Handbook of medicinal herbs, 2nd edn, CRC Press LLC, USA p 615-616
38. Eidenberger T (2013) Stabilized anthocyanin compositions. US8449927B2
39. El Khatib N, El Kettany S (2015) Plant composition for the treatment or prevention of viral blood-borne diseases caused by the human immunodeficiency virus (HIV) or hepatitis C. E Patent 2416794B1
40. Elias TS, Pooler MR (2004) The identity of the African firebush (Hamelia) in the ornamental nursery trade. HortoScience 39:1224–1226
41. European Medicines Agency (2015) Assessment report on Uncaria tomentosa (Wild. ex Schult.) DC., cortex. Committee on Herbal Medicinal Product, United Kingdom, pp 1-78
42. Fan Q (2015) Pressure reduction milk tea and preparation method thereof. CN Patent 103385301B
43. Flores-Sanchez IJ, Ortega-Lopez M-HM et al (2002) Biosynthesis of sterols and triterpenes in cell suspension cultures of U. tomentosa. Plant Cell Physiol 43:1502–1509
44. Flores-Sanchez IJ, Paniagua-Vega D, Vera-Reyes I et al (2016) Alkaloid biosynthesis and metabolic profiling responses to jasmonic acid elicitation in Hamelia patens by NMR-based metabolomics. Metabolomics 12:66
45. Forsyth WGC, Simmonds NW (1954) A survey of the anthocyanins of some tropical plants. Proc R Soc Lond B Biol Sci 142:549–564
46. Gao X, Dong X, Liu Z et al (2011) Capsule containing hooked Uncaria and Gastrodia. CN Patent 101411852B
47. Gao Y, Li Z, Wang C et al (2016) Folic acid-polyamide polyamidoamine (PAMAM)-ursolic acid nanodrug with tumor targeting and preparation method of drug. CN Patent 103990145B
48. Geisler K, Hughes RK, Sainsbury F et al (2013) Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proc Natl Acad Sci USA 110:E3360–E3367
49. Giampapa VC (2015a) Supplement composition for supporting DNA repair and method of use. US Patent 8968801B1
50. Giampapa VC (2015b) Dietary supplement system for multifunctional anti-aging management and method of use. US Patent 8974839B2
51. Glinski J, Branly KL (2002) Pentacyclic triterpenes. US Patent 6433010B2
52. Goldman D (2013) Estrous cycle monitoring by color response. US Patent 8420398B2
53. Graus YMF, Smit HF, Osterhaus ADME, Hageman RJJ (2007) Chlorogenic acid and analog thereof for immune system stimulation. US Patent 7288271B2
54. Gribble GW, Honda T, Sporn MB et al (2016) Therapeutic compounds and methods of use. US Patent 9278913B2
55. Hashimoto A (2013) Method for producing highly active POA. JP Patent 5334508B2
56. Hatinguais P, Cousse H, Vilain P (1983) Derivatives of tetrahydroalstonine, their preparation and their application as medicaments. E Patent 0017525B1
57. Hayashi S, Yoshida A, Kametaka S et al (1988) Composition for oral cavity application. JP Patent S6326083B2
58. Hayes E, Zolotoy A (2010) Compositions to reduce blood glucose levels and treat diabetes. E Patent 1996176B1
59. He Y, Nan M, Zhao Q et al (2012) Amino acid derivatives of rotundic acid and application of derivatives in preparation of antitumor medicines. CN Patent 102391352B
60. Hefferon K (2010) Plant biotechnology patents; applications in agriculture and medicine. Recent Pat Biotechnol 4:136–152
61. Hefferon K (2015a) Agricultural biotechnology. In: Rapley R, Whitehouse D (eds) Molecular biology and biotechnology, 6th edn. The Royal Society of Chemistry, Cambridge, pp 483–507
62. Hefferon KL (2015b) Nutritionally enhanced food crops; progress and perspectives. Int J Mol Sci 16:3895–3914
63. Heitzman ME, Neto CC, Winiarz E et al (2005) Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry 66:5–29
64. Herrera JL, Perez BEG, Lopez MLD et al (2013) Vaccine adjuvant composition based on ursolic acid. MX2012006516A
65. Heuer MA, Clement K (2011) Compositions and methods for increasing adipose metabolism, lipolysis or lipolytic metabolism via thermogenesis. US Patent 7955624B2
66. Huang H, Zhong R, Jia X et al (2012) Uncaria-containing composition with anti-aging function. CN Patent 102078507B
67. Huang L, Li J, Ye H et al (2012b) Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta 236:1571–1581
68. Huang W, Li J, Zhou F (2012) Uncaria sustained-release tablet and preparation method thereof. CN Patent 101862304B
69. Huang W, Li J, Zhou F (2015) Uncaria slow release capsule preparation and preparation method. CN Patent 101869556B
70. Huang W, Ma J, Zhou F (2016) Method for preparing Eucommia ulmoides step-down oral presentation. CN Patent 103610795B
71. Jia Q, Zhao Y (2015) Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention or treatment of oral diseases and conditions. US Patent 8945518B2
72. Jiang R (2016) Powder for treating convulsion. CN Patent 103446458B
73. Jiang BH, Fang J (2013) Apigenin for chemoprevention, and chemotherapy combined with therapeutic reagents. US Patent 8377918B2
74. Jiang X, Bender CF, Visnick M (2016a) C13-hydroxy derivatives of oleanolic acid and methods of use thereof. US Patent 9278912B2
75. Jiang X, Liu X, Greiner J et al (2016b) Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives. US Patent 9249089B2
76. Kaiser S, Verza SG, Moraes RC (2013) Cat’s claw oxindole alkaloid isomerization induced by common extraction methods. Quim Nova 36:808–814
77. Kano Y, Wu C, Ma B et al (2013) Method for extracting alkaloid valid parts from hooked Uncaria leaf, with hooked stem branch or full grass and uses thereof. CN Patent 101342259B
78. Kawabata J, Mizuhata K, Sato E et al (2003) 6-hydroxyflavonoids as α-glucosidase inhibitors from Marjoram (Origanum majorana) leaves. Biosci Biotechnol Biochem 67:445–447
79. Keplinger K, Wagner H, Kreutzkamp B (1990) Oxindole alkaloids having properties stimulating the immunologic system and preparation containing the same. US Patent 4940725A
80. Keplinger D, Keplinger K, Laus G (2001) Process for isomerization of spirocyclic compounds with β-aminocarboxyl and/or β-aminocarbonyl systems. E Patent 0741727B1
81. Keplinger K, Laus G, Wurm M (2010) Method and substances for releasing a growth factor from endothelial cells, growth factor released in accordance with said method and use of same. E Patent 0989856B1
82. Kim BC, Jo EJ, Kim SJ (2015a) A novel composition for suppressing metastasis of cancer. KR Patent 101505175B1
83. Kim YH, Kim HC, Nam KH et al (2015b) An insecticide comprising ursolic acid. KR Patent 101542843B1
84. Klopotenko LL (2014) Ointment containing encapsulated triterpenic acid or derivatives thereof. RU Patent 2519133C1
85. Krasutsky PA, Carlson RM, Karim R (2004) Triterpenes having antibacterial activity. US Patent 6689767B2
86. Laurent D, Pauilac S, Chinain M et al (2015) Use of rosmarinic acid and the derivatives thereof to treat ciguatera. US Patent 9060985B2
87. Laus G (2004) Advances in chemistry and bioactivity of the genus Uncaria. Phytother Res 18:259–274
88. Lee JJ, Takei M, Akemi U et al (2010) Dendritic cells matured by uncarinic acid C, compositions for immunotheraphy containing the dendritic cells, and methods for preparing mature dendritic cells using uncarinic acid C. KR Patent 100954887B1
89. Lee LT, Chang SF, Kuo ZK et al (2016) Pharmaceutical composition and method for preventing or treating hepatitis C. US Patent 9289443B2
90. Li J (2015) Tryptophan hydroxylase-1 inhibitor ursolic acid derivatives as well as preparation method and application thereof. CN Patent 103936814B
91. Li Y (2016) Novel technology for preparing apigenin from by one-step method. CN Patent 103819438B
92. Li X, Li Y, Lu X et al (2013) Preparation method of ursolic acid as immunologic adjuvant vaccine and use. CN103251944A
93. Li C, Zhang G, Zhou X (2015) Method for producing β-amyrin with Saccharomyces cerevisiae engineering bacterium. CN Patent 103509726B
94. Liao Y (2004) Complex fertilizer for killing insect and bacteria and its production method. CN Patent 1182083C
95. Lines TC (2013) Method for treating addiction using quercetin-containing compositions. US Patent 8507548B2
96. Liu Y, Liu D, Xie X et al (2014) Piperazine derivative of oleanolic acid, preparation method and application of piperazine derivative. CN 102875630B
97. Lv Y (2014) Liver-clearing and lung-nourishing health-care tea. CN 103392886B
98. Manns U, Bremer B (2010) Towards a better understanding of intertribal relationships and stable tribal delimitations within Cinchonoideae s.s. (Rubiaceae). Mol Phylogenet Evol 56:21–39
99. Martinez JA, Durand E, Viamontes AJ et al (1996) Alkaloids of Hamelia patens growing in Cuba. Rev Cubana Quim 8:75–79
100. Martins D, Nunez CV (2015) Secondary metabolites from Rubiaceae species. Molecules 20:13422–13495
101. Maslov LI, Borodulin VV (2015) Agent and method of treating diabetes mellitus. RU patent 2545765C1
102. Mermelstein H, Marchese FP (2005) Composition and method for treatment of vaginal dryness. US Patent 6893648B2
103. Minami K, Taniwaki S, Katsumata A (2016) Rutin-rich extract and method of making same. US Patent 9308216B2
104. Mo Z, Weng J (2012) Use of hirsutine in preparing anti-addictive drug. CN Patent 101972251B
105. Mo Z, Weng J, Cai H et al (2012) Drug for preventing and curing dependence of amphetamine and opiate drugs. CN Patent 102008577B
106. Monagas JM, Sanchez FP, Quintanilla JEL et al (2014) Phenolic extracts from Uncaria tomentosa L. (cat’s claw) containing procyanidins, propelargonidins and flavonolignans, method for the production thereof. WO2014096488A1
107. Nair MG, Jayaprakasam B, Olson LK et al (2011) Insulin secretion by anthocyanins and anthocyanidins. CA Patent 2573510C
108. Olalde JAR (2008a) Arthritis phyto-nutraceutical synergistic composition. US Patent 7416748B2
109. Olalde JAR (2008b) Multiple sclerosis synergistic phyto-nutraceutical composition. US Patent 7390512B2
110. Onoue S, Yamada S, Chan HK (2014) Nanodrugs: pharmacokinetics and safety. Int J Nanomedicine 9:1025–1037
111. Osbourn A, Qi X (2014) Enzymes involved in triterpene synthesis. US Patent 8647875B2
112. Osbourn AE, Haralampidis K, Bryan GT (2011) An isolated plant gene encoding a β-amyrin synthase. CA Patent 2392435C
113. Parisi C, Rodriguez-Cerezo E, Thangaraj H (2013) Analysing patent landscapes in plant biotechnology and new plant breeding techniques. Transgenic Res 22:15–29
114. Pero RW (2004) Method of preparation and pharmaceutical composition of an Uncaria water-soluble extract. E Patent 1096943B1
115. Pero RW (2013) Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxyl alkyl ester. US Patent 8372449B2
116. Perrier E, Rival D, Lamy V (2014) Method for testing a substance which is potentially active in the field of lipolysis and its mainly cosmetic use. US Patent 8741359B2
117. Poignant JC (1979) Pharmaceutical compositions containing tetrahydroalstonine and method for treating circulation disorders. DE Patent 2439523C2
118. Polanco MA (2015) Hamelia plant named ‘Grelmsiz’. US Patent PP26247P2
119. Qi W, Yue SJ, Sun JH et al (2014) Alkaloids from the hook-bearing branch of Uncaria rhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death. J Asian Nat Prod Res 16:876–883
120. Qu G, Tian J, Jian W (2010) Application of rosmarinic acid in the preparation of medicines for treating or preventing liver fibrosis and kidney fibrosis. CN Patent 101095668B
121. Qui Y (2015a) Uncaria planting method. CN105027932A
122. Qui Y (2015b) Uncaria shearing machine. CN105171862A
123. Qui Y (2015c) Uncaria cutter. CN105034047A
124. Renard L, Massalyai DM, Merillon JM (2016) Anti-inflammatory composition comprising malvidin-3-O-β-glucoside and a propolis extract. US Patent 9308231B2
125. Reyes-Chilpa R, Rivera J, Oropeza M et al (2004) Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium. Biol Pharm Bull 27:1617–1620
126. Ridsdale CE (1978) A revision of Mitragyna and Uncaria (Rubiaceae). Blumea 24:43–100
127. Rios MY, Aguilar-Guadarrama AB (2006) Alcaloides indolicos, terpenos, esteroles y flavonoides de las hojas de Hamelia patens Jacquin (Rubiaceae). Rev Cubana Plant Med 11:1–5
128. Robbrecht E (1988) Tropical woody Rubiaceae. Oper Bot Belg 1:599–602
129. Roewer N, Broscheit J (2016) Anthocyanidin complex. E Patent 2831122B1
130. Rong F, Xu R, Xie F et al (2015) Oleanolic acid amidate derivatives, preparation methods and uses thereof. US Patent 8987502B2
131. Ronquillo FA, Melgar MF, Carrillo JE et al (1988) Especies vegetales de uso actual y potencial en alimentación y medicina de las zonas semiáridas del nororiente de Guatemala. Cuadernos DIGI 159:7–88
132. Salbury Jr FR, Scorpinato KD, King SB (2013) Chemotherapeutic for inducing an MSH2-dependent apoptotic pathway. US Patent 8486957B2
133. Saxena BB, Rathnam P (2011) Betulinol derivatives as anti-HIV agents. US Patent 8008280B2
134. Saxena BB, Rathnam P (2012) Betulinol derivatives as anti-cancer agents. US Patent 8088757B2
135. Schutz J (2016) Methods of treating polycystic ovarian syndrome using chlorogenic acid and inositol. US Patent 9259410B2
136. Shao J, Xiang L, Yang X et al (2016) Applications of ursolic acid derivatives in preparation of drug for preventing and treating tumor metastasis. CN Patent 103933048B
137. Slimestad R (2005) Product. US Patent 6967032B2
138. Snow AD, Castillo GM, Choi PY et al (2011) Proanthocyanidins for the treatment of amyloid and α-synuclein diseases. CA Patent 2441099C
139. Stöckigt J, Barleben L, Panjikar S (2008) 3D-structure and function of strictosidine synthase—the key enzyme of monoterpenoid indole alkaloid biosynthesis. Plant Physiol Biochem 46:340–355
140. Su F (2012) Medicament for preventing and treating ischemic cerebrovascular diseases. CN Patent 102049010B
141. Suarez AI, Diaz B, Tillet S et al (2008) Leishmanicidal activity of alkaloids from Hamelia patens. Ciencia 16:148–155
142. Sugiyama M, Kasamutsu S (2015) Apigenin-containing composition. US Patent 9056209B2
143. Sugiyama Y, Yamawaki K, Kubo Y (2015) Process for production of purified chlorogenic acid-containing pharmaceutical preparation. E Patent 2592064B1
144. Sun Y, Yu H, Zhang Y (2012) Uncaria abalone sour soup for treating trigeminal neuralgia. CN Patent 102091239B
145. Taal L (2012) Botanical extract composition. E Patent 1720561B1
146. Tang J, Liu M, Zhou S et al (2012) Process for extracting rhynchophylline monomers from Uncaria rhynchophylla. CN Patent 102093359B
147. Tang J, Shen Y, Liu S et al (2014) Liver-targeted magnetic resonance imaging contrast agent based on oleanolic acid and preparation method thereof. CN Patent 102895678B
148. The Plant List (2016) Version 1.1. Published on the internet. http://www.theplantlist.org/. Accessed 4 May 2016
149. Thimmappa R, Geisler K, Louveau T et al (2014) Triterpene biosynthesis in plants. Ann Rev Plant Biol 65:225–257
150. Tong X (2015) Traditional Chinese medicine composition for preventing and treating obese type 2 diabetes combined dyslipidemia. CN Patent 103417950B
151. Trentini AMM (2015) Hydroalcoholic extract of Uncaria tomentosa for the treatment of herpes virus infection. E Patent 1786446B1
152. Vajdy M, Padrah S (2015) Adjuvant compositions and method of use. US Patent 9180184B2
153. Velazquez T, Ornelas JF (2010) Pollen consumption by flower mites in three hummingbird-pollinated plant species. Exp Appl Acarol 50:97–105
154. Villarreal F, Yamazake KG, Taub PR et al (2014) Adverse cardiac remodeling. US Patent 8648059B2
155. Wang X, Hai C (2015a) Medicinal composition, and its application in preparation of medicines for treating obesity, insulin resistance and diabetes. CN Patent 103585161B
156. Wang X, Hai C (2015b) Medicinal composition and its application in preparation of liver cancer treatment medicines. CN Patent 103585158B
157. Wang H, Wang X (2014) Plaster for treating lumbar disc herniation. CN Patent 102824484B
158. Wang B, Guo Z, Ye Z et al (2008) Chinese preparation for treating enteritis ulcer colitis and preparation method thereof. US Patent 7354570B2
159. Wang H, Niu B, Yan H et al (2015a) Apigenin polylactic sustained release microsphere and preparation method thereof. CN Patent 103585113B
160. Wang S, He J, Li T et al (2015b) Application of Uncaria active alkaloid to preparation of prostatic medicament. CN105012441A
161. Wei S, Ma X, Pan L et al (2015) Rapid propagation method of Uncaria macrophylla Wall. CN105028202A
162. Whitehead SR, Poveda K (2011) Herbivore-induced changes in fruit-frugivore interactions. J Ecol 99:964–969
163. Wu X (2015) Five-vegetable blood pressure-reducing sweet rice flour and production method thereof. CN Patent 103461802B
164. Xiao W, Wang Z, Meng Z et al (2015) Vincoside lactam preparation method. CN Patent 102786568B
165. Xu R, Rong F, Lai H (2015) 2-substituted oleanolic acid derivative, method preparing for same, and application thereof. US Patent 9156801B2
166. Xue Z, Qi X, Sun J et al (2014) Optimized triterpenoid synthase coding gene and application thereof. CN Patent 103088042B
167. Yamaji H (2013) Method of identifying the species of plant belonging to the genus Uncaria. CN Patent 101772579B
168. Yamaki K, Sano T, Hori K et al (2005) External skin care application. US Patent 6878378B1
169. Yan X (2012) Novel pharmaceutical use of kaempferol. CN Patent 101889999B
170. Yan X, Wang Y, Ding W et al (2013) A method for producing betulinic acid. CA Patent 2705902C
171. Yan S, Wang Y, Bao H et al (2015) Traditional Chinese medicine for treating thyroid associated ophthalmopathy in acute stage. CN Patent 103446543B
172. Yang X, Zhou J, Yu Z et al (2011) Method for extracting and preparing ursolic acid from Uncaria. CN Patent 101643492B
173. Yang Q, Huo K, Zhang C et al (2015) Method for shortening seedling raising time limit of Uncaria rhynchophylla seeds. CN104996138A
174. Yao T, Zhu Y, Zhu Y (2010) Gambir plant extract and its use in preparation of target organ protective medicine. CN Patent 1939453B
175. Yao J, Li Y, Zhou J (2016) Preparation of amphiphilic ursolic acid-polysaccharide coupled substance and application thereof in treating tumors. CN Patent 103705939B
176. Yoon YH (2015) Ursolic acid derivative and methods for preparing same. US Patent 9120839B2
177. Zachwieja JJ, Pirner MA, Smith JE (2015) Methods of reducing blood lactate concentration. US Patent 9198453B2
178. Zeng C, Huang Y, Chen Q (2015) HPLC method for distinguishing different varieties of Uncaria. CN Patent 103869010B
179. Zhang L (2015) Stem and hook separation device for Uncaria. CN Patent 204134889U
180. Zhang J, Zhao H, Zheng L (2014) Oleanolic acid oxime ester derivative, preparation method and application thereof. CN Patent 102690315B
181. Zhang Q, Zhao JJ, Xu J et al (2015) Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. J Ethnopharmacol 173:48–80
182. Zhang J, Zhang L, Huang W (2016a) Preparation method of medicinal chlorogenic acid. CN Patent 104496815B
183. Zhang K, He Ping, Zhao S et al (2016b) Novel use of ursolic acid derivative. CN 103877097B
184. Zhao L (2014) Medicine composition containing apigenin, apigenin derivant and Bc1-2 inhibitor and application thereof in preparation of medicines capable of treating cancer. CN Patent 102441168B
185. Zhao Y, Jia Q (2013) Flavonoid composition for treating oral diseases. CN Patent 101083981B
186. Zhao Q, He Y, Nan M et al (2012) Rotundic acid derivative and synthesis method thereof as well as application of rotundic acid derivative in preparing medicament for preventing and curing cardiovascular disease. CN Patent 102140126B
187. Zhao S, Wu P, Zhang K et al (2016) Chemically modified ursolic acid and its preparation method and use. CN Patent 104045678B
188. Zhou Y, Zhou S, Mo Z et al (2016) Application of rhynchophylline in preparation of drug with anxiolytic effect and antidepressant effect. CN Patent 103446140B
189. Zhu Y, Wu L, Zhu Y (2011a) Application of hirsutine in preparing medicament for treating myocardial damage. CN Patent 101683338B
190. Zhu Y, Wu L, Zhu Y (2011b) Application of corynantheine in preparing medicament for treating heart disease induced by myocardial damage. CN Patent 101683337B
191. Zou H, Zhu H, Stöckigt J et al (2014) Strictosidine-like alkaloids as well as preparation method and application thereof. CN Patent 102532218B