Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

Clinical Science

Volumn 130, Issue 14, 2016, Pages 1221-1236

  Pivetta, Eliana ^a   Wassermann, Bruna ^a   Del Bel Belluz, Lisa ^a,b   Danussi, Carla ^a,c   Modica, Teresa Maria Elisa ^a   Maiorani, Orlando ^a   Bosisio, Giulia ^a   Boccardo, Francesco ^d   Canzonieri, Vincenzo ^a   Colombatti, Alfonso ^a   Spessotto, Paola ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

EMILIN1; Extracellular matrix; Human lymphoedematous tissue; Neutrophil elastase; Secondary lymphoedema; Sivelestat

Indexed keywords

CELL PROTEIN; EMILIN1; LEUKOCYTE ELASTASE; REGULATOR PROTEIN; SIVELESTAT; UNCLASSIFIED DRUG; ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN; LEUKOCYTE ELASTASE INHIBITOR; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CELL JUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LYMPH NODE; LYMPH VESSEL; LYMPH VESSEL ENDOTHELIUM; LYMPHEDEMA; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; TAIL LYMPHOEDEMA; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; HUMANS; LYMPHATIC VESSELS; LYMPHEDEMA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; PROTEINASE INHIBITORY PROTEINS, SECRETORY;

EID: 85014098043     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160064     Document Type: Article

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