Tight glycemic control in critically Ill children

New England Journal of Medicine

Volumn 376, Issue 8, 2017, Pages 729-741

  Agus, M S D ^a   Wypij, D ^a   Hirshberg, E L ^b   Srinivasan, V ^c,d   Faustino, E V ^e   Luckett, P M ^f   Alexander, J L ^a   Asaro, L A ^a   Curley, M A Q ^c,d   Steil, G M ^a   Nadkarni, V M ^c,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; BLOOD GLUCOSE MONITORING; CHILD; CHILD CARE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; EARLY TERMINATION OF CLINICAL TRIAL; EMBRYO; FEMALE; GLYCEMIC CONTROL; HEALTHCARE ASSOCIATED INFECTION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INFANT; INTENSIVE CARE UNIT; INTENTION TO TREAT ANALYSIS; MALE; MORTALITY; MULTICENTER STUDY (TOPIC); MULTIPLE ORGAN FAILURE; NEWBORN; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL (TOPIC); REFERENCE VALUE; RISK BENEFIT ANALYSIS; SCHOOL CHILD; TREATMENT OUTCOME; ANALYSIS; CARDIOVASCULAR SURGERY; CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; GLUCOSE BLOOD LEVEL; HOSPITAL MORTALITY; LENGTH OF STAY; MULTICENTER STUDY; PEDIATRIC INTENSIVE CARE UNIT; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL;

ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE BLOOD LEVEL; INSULIN;

ADOLESCENT; BLOOD GLUCOSE; CARDIOVASCULAR SURGICAL PROCEDURES; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; GLUCOSE; HOSPITAL MORTALITY; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFANT; INFANT, NEWBORN; INSULIN; INTENSIVE CARE UNITS, PEDIATRIC; INTENTION TO TREAT ANALYSIS; LENGTH OF STAY; MALE; POSTOPERATIVE PERIOD;

EID: 85013984919     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1612348     Document Type: Article

References (38)

1. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-67.
2. The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 1283-97.
3. The NICE-SUGAR Study Investigators. Hypoglycemia and risk of death in critically ill patients. N Engl J Med 2012; 367: 1108-18.
4. Preiser JC, Devos P, Ruiz-Santana S, et al. A prospective randomised multicentre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med 2009; 35: 1738- 48.
5. Vlasselaers D, Milants I, Desmet L, et al. Intensive insulin therapy for patients in paediatric intensive care: A prospective, randomised controlled study. Lancet 2009; 373: 547-56.
6. Macrae D, Grieve R, Allen E, et al. A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med 2014; 370: 107-18.
7. Agus MSD, Steil GM, Wypij D, et al. Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med 2012; 367: 1208-19.
8. Jeschke MG, Kulp GA, Kraft R, et al. Intensive insulin therapy in severely burned pediatric patients: A prospective randomized trial. Am J Respir Crit Care Med 2010; 182: 351-9.
9. Faustino EV, Apkon M. Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146: 30-4.
10. Faustino EVS, Bogue CW. Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med 2010; 11: 690-8.
11. Hirshberg E, Larsen G, Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatr Crit Care Med 2008; 9: 361-6.
12. Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni V. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5: 329-36.
13. Hirshberg EL, Sward KA, Faustino EVS, et al. Clinical equipoise regarding glycemic control: A survey of pediatric intensivist perceptions. Pediatr Crit Care Med 2013; 14: 123-9.
14. Ruttimann UE, Pollack MM. Variability in duration of stay in pediatric intensive care units: A multiinstitutional study. J Pediatr 1996; 128: 35-44.
15. Slater A, Shann F, Pearson G. PIM2: A revised version of the Paediatric Index of Mortality. Intensive Care Med 2003; 29: 278-85.
16. Agus MS, Hirshberg E, Srinivasan V, et al. Design and rationale of Heart and Lung Failure-Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children. Contemp Clin Trials 2016 December 30 (Epub ahead of print).
17. Steil GM, Deiss D, Shih J, Buckingham B, Weinzimer S, Agus MSD. Intensive care unit insulin delivery algorithms: why so many? How to choose? J Diabetes Sci Technol 2009; 3: 125-40.
18. Piper HG, Alexander JL, Shukla A, et al. Real-Time continuous glucose monitoring in pediatric patients during and after cardiac surgery. Pediatrics 2006; 118: 1176-84.
19. Gaies MG, Langer M, Alexander J, et al. Design and rationale of safe pediatric euglycemia after cardiac surgery: A randomized controlled trial of tight glycemic control after pediatric cardiac surgery. Pediatr Crit Care Med 2013; 14: 148-56.
20. Steil GM, Langer M, Jaeger K, Alexander J, Gaies M, Agus MS. Value of continuous glucose monitoring for minimizing severe hypoglycemia during tight glycemic control. Pediatr Crit Care Med 2011; 12: 643-8.
21. Bellomo R, Egi M. What is a NICESUGAR for patients in the intensive care unit? Mayo Clin Proc 2009; 84: 400-2.
22. Van den Berghe G, Schetz M, Vlasselaers D, et al. Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target? J Clin Endocrinol Metab 2009; 94: 3163-70.
23. Bier DM, Leake RD, Haymond MW, et al. Measurement of "true" glucose production rates in infancy and childhood with 6, 6-dideuteroglucose. Diabetes 1977; 11: 1016-23.
24. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125-39.
25. Arabi YM, Dabbagh OC, Tamim HM, et al. Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients. Crit Care Med 2008; 36: 3190-7.
26. De La Rosa GDC, Donado JH, Restrepo AH, et al. Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: A randomised clinical trial. Crit Care 2008; 12: R120.
27. Leteurtre S, Martinot A, Duhamel A, et al. Validation of the Paediatric Logistic Organ Dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362: 192-7.
28. CDC/NHSN surveillance definitions for specific types of infections. January 2017 (http://www.cdc.gov/nhsn/pdfs/pscmanual/17pscnosinfdef-current.pdf).
29. Draper E, Fleming T, McKinney P, Parslow R, Thiru K, Willshaw A. National report of the Paediatric Intensive Care Audit Network: January 2004-December 2006. Universities of Leeds and Leicester, 2007 (http://www.picanet.org.uk/Audit/Annual-Reporting/Annual-Report-Archive/PICANet-National-Report-2007.pdf).
30. Ashley A, Draper E, Fleming T, et al. National report of the Paediatric Intensive Care Audit Network: January 2006-December 2008. Universities of Leeds and Leicester, 2008 (http://www.picanet.org.uk/Audit/Annual-Reporting/Annual-Report-Archive/PICANet-National-Report-2009.pdf).
31. Pollack MM, Patel KM, Ruttimann UE. PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24: 743-52.
32. Gennari FJ. Hypokalemia. N Engl J Med 1998; 339: 451-8.
33. Gaies MG, Gurney JG, Yen AH, et al. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010; 11: 234-8.
34. Jacobi J, Bircher N, Krinsley J, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med 2012; 40: 3251-76.
35. Moghissi ES, Korytkowski MT, Di- Nardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009; 32: 1119-31.
36. Qaseem A, Chou R, Humphrey LL, Shekelle P. Inpatient glycemic control: best practice advice from the Clinical Guidelines Committee of the American College of Physicians. Am J Med Qual 2014; 29: 95-8.
37. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: A systematic review and metaanalysis. Chest 2010; 137: 544-51.
38. Fivez T, Kerklaan D, Mesotten D, et al. Early versus late parenteral nutrition in critically ill children. N Engl J Med 2016; 374: 1111-22.