What is a NICE-SUGAR for patients in the intensive care unit?

Mayo Clinic Proceedings

Volumn 84, Issue 5, 2009, Pages 400-402

  Bellomo, Rinaldo ^a,b   Egi, Moritoki ^c  

^a AUSTIN HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c OKAYAMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ALGORITHM; EDITORIAL; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT;

EID: 66149176934     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/84.5.400     Document Type: Editorial

References (39)

1. Bellomo R, Egi M. Glycemic control in the intensive care unit: why we should wait for NICE-SUGAR [editorial]. Mayo Clin Proc. 2005;80(12):1546-1548. (Pubitemid 41747054)
2. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359-1367.
3. Wittenberg MD, Gattas DJ, Ryan A, Totaro R. Introduction of intensive glycaemic control into a neurosurgical intensive care unit: a retrospective cohort study. Crit Care Resusc. 2008;10(3):203-208.
4. Mitchell I, Knight E, Gissane J, et al; Australian and New Zealand Intensive Care Society Clinical Trials Group. A phase II randomised controlled trial of intensive insulin therapy in general intensive care patients. Crit Care Resusc. 2006;8(4):289-293.
5. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients [published correction appears in Mayo Clin Proc. 2005;80(8):1101]. Mayo Clin Proc. 2004;79(8):992-1000.
6. Dan A, Jacques TC, O'Leary MJ. Enteral nutrition versus glucose-based or lipid-based parenteral nutrition and tight glycaemic control in critically ill patients. Crit Care Resusc. 2006;8(4):283-288.
7. Orford NR. Intensive insulin therapy in septic shock. Crit Care Resusc. 2006;8(3):230-234.
8. Shaw GM, Chase JG, Wong J, et al. Rethinking glycaemic control in critical illness - from concept to clinical practice change. Crit Care Resusc. 2006;8(2):90-99.
9. Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 2004 Mar 30;109(12):1497-1502. Epub 2004 Mar 8. (Pubitemid 38420177)
10. Orford N, Stow P, Green D, Corke C. Safety and feasibility of an insulin adjustment protocol to maintain blood glucose concentrations within a narrow range in critically ill patients in an Australian level III adult intensive care unit. Crit Care Resusc. 2004;6(2):92-98.
11. Price GC, Stevenson K, Walsh TS. Evaluation of a continuous glucose monitor in an unselected general intensive care population. Crit Care Resusc. 2008;10(3):209-216.
12. Bilotta F, Caramia R, Cernak I, et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care. 2008;9(2):159-166.
13. Implement effective glucose control: establish a glycemic control policy in your ICU. Institute for Healthcare Improvement (IHI) Web site. http:// www.ihi.org/IHI/Topics/CriticalCare/IntensiveCare/Changes/IndividualChanges /EstablishaGlycemicControlPolicyinYourICU.htm. Accessed April 1, 2009.
14. Egi M, Bellomo R, Stachowski E, et al. Intensive insulin therapy in postoperative intensive care unit patients: a decision analysis. Am J Respir Crit Care Med. 2006 Feb 15;173(4):407-413. Epub 2005 Oct 20. (Pubitemid 43228328)
15. Bagshaw SM, Bellomo R. The need to reform our assessment of evidence from clinical trials: a commentary. Philos Ethics Humanit Med. 2008 Sep 30;3:23.
16. Shaw GM, Chase JG, Wong J, et al. Rethinking glycaemic control in critical illness - from concept to clinical practice change. Crit Care Resusc. 2006;8(2):90-99.
17. van den Berghe G, Wilmer A, Milants I, et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes. 2006;55(11):3151-3159.
18. van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449-461. (Pubitemid 43200296)
19. Glucontrol study: comparing the effects of two glucose control regimens by insulin in intensive care unit patients. National Institutes of Health ClinicalTrials.gov Web site. http://clinicaltrials.gov/ct/gui/show/NCT00107601. Updated June 26, 2008. Accessed April 1, 2009.
20. Brunkhorst FM, Engel C, Bloos F, et al; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125-139.
21. Arabi YM, Dabbagh OC, Tamim HM, et al. Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med. 2008;36(12):3190-3197.
22. Wiener RS, Wiener DC, Larson RJ. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis [published correction appears in JAMA. 2009;300(8):936]. JAMA. 2008;300(8):933-944.
23. van den Berghe G, Wilmer A, Bouillon R. Insulin and pentastarch for severe sepsis [letter]. N Engl J Med. 2008;358(19):2073.
24. Oddo M, Schmidt JM, Carrera E, et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36(12):3233-3238.
25. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105(2):244-252. (Pubitemid 44148168)
26. Egi M, Bellomo R, Stachowski E, French CJ, Hart G, Stow P. Circadian rhythm of blood glucose values in critically ill patients. Crit Care Med. 2007;35(2):416-421. (Pubitemid 46148530)
27. Egi M, Bellomo R, Stachowski E, et al. Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med. 2008;36(8):2249-2255.
28. NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26; 360(13):1283-1297. Epub 2009 Mar 24.
29. Inzucchi SE, Siegel MD. Glucose control in the ICU - how tight is too tight [editorial]? N Engl J Med. 2009 mar 26;360(13):1346-1349. Epub 2009 Mar 24.
30. Keller-Wood ME, Shinsako J, Dallman MF. Inhibition of the adrenocorticotropin and corticosteroid responses to hypoglycemia after prior stress. Endocrinology. 1983;113(2):491-496.
31. Herlein JA, Morgan DA, Phillips BG, Haynes WG, Sivitz WI. Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses. Endocrinology. 2006 Jun;147(6):2781-2788. Epub 2006 Mar 9.
32. Diéguez G, Fernández N, García JL, García-Villalón AL, Monge L, Gomez B. Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats. Eur J Pharmacol. 1997;330(2-3):185-193. (Pubitemid 27296721)
33. Dagogo-Jack SE, Craft S, Cryer PE. Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus: recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest. 1993;91(3):819-828. (Pubitemid 23095255)
34. Mitrakou A, Fanelli C, Veneman T, et al. Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med. 1993;329(12):834-839. (Pubitemid 23267210)
35. Oddo M, Schmidt JM, Carrera E, et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36(12):3233-3238.
36. Lanier WL, Pasternak JJ. Refining perioperative glucose management in patients experiencing, or at risk for, ischemic brain injury [editorial]. Anesthesiology. 2009;110(3):456-458.
37. Finfer S, Bellomo R. Why publish statistical analysis plans? Crit Care Resusc. 2009;11(1):5-6.
38. Finfer S, Cass A, Gallagher M, Lee J, Su S. Bellomo R; RENAL Study Investigators. The RENAL (Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy) study: statistical analysis plan. Crit Care Resusc. 2009;11(1):58-65.
39. Finfer S, Heritier S; NICE Study Management Committee and SUGAR Study Executive Committee. The NICE-SUGAR (Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation) study: statistical analysis plan. Crit Care Resusc. 2009;11(1):46-57.