메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages 25-39

A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project

Author keywords

Cancer cachexia; Dietary supplements; Guidelines; Micronutrients; Minerals; Systematic review; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ARGININE; ASCORBIC ACID; BETA HYDROXY BETA METHYLBUTYRATE; BUTYRIC ACID DERIVATIVE; CARNITINE; GLUTAMINE; ICOSAPENTAENOIC ACID; MAGNESIUM; MINERAL; OMEGA 3 FATTY ACID; PROTEIN; UNCLASSIFIED DRUG; VITAMIN; VITAMIN D;

EID: 85013901621     PISSN: 21905991     EISSN: 21906009     Source Type: Journal    
DOI: 10.1002/jcsm.12127     Document Type: Review
Times cited : (95)

References (43)
  • 1
    • 84863645802 scopus 로고    scopus 로고
    • Clinical practice guidelines on cancer cachexia in advanced cancer patients [Internet]
    • [cited 2016 Apr 23]. Available from
    • Radbruch L, Elsner F, Trottenberg P, Strasser F, Baracos V, Fearon K. Clinical practice guidelines on cancer cachexia in advanced cancer patients [Internet]. Eur Palliat Care Res Collab 2010 [cited 2016 Apr 23]. Available from: http://www.epcrc.org/guidelines.php?p=cachexia
    • (2010) Eur Palliat Care Res Collab
    • Radbruch, L.1    Elsner, F.2    Trottenberg, P.3    Strasser, F.4    Baracos, V.5    Fearon, K.6
  • 2
    • 84861813698 scopus 로고    scopus 로고
    • A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project
    • Ries A, Trottenberg P, Elsner F, Stiel S, Haugen D, Kaasa S, et al. A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project. Palliat Med 2012;26:294–304.
    • (2012) Palliat Med , vol.26 , pp. 294-304
    • Ries, A.1    Trottenberg, P.2    Elsner, F.3    Stiel, S.4    Haugen, D.5    Kaasa, S.6
  • 3
    • 0021919255 scopus 로고
    • Micronutrient requirements of cancer patients
    • Hoffman FA. Micronutrient requirements of cancer patients. Cancer 1985;55:295–300.
    • (1985) Cancer , vol.55 , pp. 295-300
    • Hoffman, F.A.1
  • 4
    • 79955778950 scopus 로고    scopus 로고
    • Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case-control study on bladder cancer risk
    • Brinkman MT, Buntinx F, Kellen E, Dagnelie PC, Van Dongen MCJM, Muls E, et al. Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case-control study on bladder cancer risk. Cancer Causes Control CCC 2011;22:469–478.
    • (2011) Cancer Causes Control CCC , vol.22 , pp. 469-478
    • Brinkman, M.T.1    Buntinx, F.2    Kellen, E.3    Dagnelie, P.C.4    Van Dongen, M.C.J.M.5    Muls, E.6
  • 6
    • 84903468367 scopus 로고    scopus 로고
    • Dietary treatment of weight loss in patients with advanced cancer and cachexia: a systematic literature review
    • Balstad TR, Solheim TS, Strasser F, Kaasa S, Bye A. Dietary treatment of weight loss in patients with advanced cancer and cachexia: a systematic literature review. Crit Rev Oncol Hematol 2014;91:210–221.
    • (2014) Crit Rev Oncol Hematol , vol.91 , pp. 210-221
    • Balstad, T.R.1    Solheim, T.S.2    Strasser, F.3    Kaasa, S.4    Bye, A.5
  • 8
    • 85013993123 scopus 로고    scopus 로고
    • [Internet]. [cited 2015 Aug 6]; Available from
    • World Cancer Research Fund and American Institute for Cancer Research. Cancer Surviv [Internet]. [cited 2015 Aug 6]; Available from: http://www.dietandcancerreport.org/cancer_prevention_recommendations/recommendation_cancer_survivors.php
    • Cancer Surviv
  • 9
    • 33845457114 scopus 로고    scopus 로고
    • Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices
    • Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B, et al. Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 2006;56:323–353.
    • (2006) CA Cancer J Clin , vol.56 , pp. 323-353
    • Doyle, C.1    Kushi, L.H.2    Byers, T.3    Courneya, K.S.4    Demark-Wahnefried, W.5    Grant, B.6
  • 11
    • 31044449173 scopus 로고    scopus 로고
    • Self-reported quality of life in users and nonusers of dietary supplements in cancer
    • Lis CG, Cambron JA, Grutsch JF, Granick J, Gupta D. Self-reported quality of life in users and nonusers of dietary supplements in cancer. Support Care Cancer 2006;14:193–199.
    • (2006) Support Care Cancer , vol.14 , pp. 193-199
    • Lis, C.G.1    Cambron, J.A.2    Grutsch, J.F.3    Granick, J.4    Gupta, D.5
  • 13
    • 19444362507 scopus 로고    scopus 로고
    • Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system
    • Atkins D, Briss PA, Eccles M, Flottorp S, Guyatt GH, Harbour RT, et al. Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res 2005;5:25.
    • (2005) BMC Health Serv Res , vol.5 , pp. 25
    • Atkins, D.1    Briss, P.A.2    Eccles, M.3    Flottorp, S.4    Guyatt, G.H.5    Harbour, R.T.6
  • 14
    • 77649106713 scopus 로고    scopus 로고
    • Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia
    • Mantovani G, Macciò A, Madeddu C, Serpe R, Massa E, Dessì M, et al. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Oncologist 2010;15:200–211.
    • (2010) Oncologist , vol.15 , pp. 200-211
    • Mantovani, G.1    Macciò, A.2    Madeddu, C.3    Serpe, R.4    Massa, E.5    Dessì, M.6
  • 15
    • 84866181433 scopus 로고    scopus 로고
    • L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial
    • Kraft M, Kraft K, Gärtner S, Mayerle J, Simon P, Weber E, et al. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial. Nutr J 2012;11:52.
    • (2012) Nutr J , vol.11 , pp. 52
    • Kraft, M.1    Kraft, K.2    Gärtner, S.3    Mayerle, J.4    Simon, P.5    Weber, E.6
  • 17
    • 0022576094 scopus 로고
    • Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial
    • Willox JC, McAllister EJ, Sangster G, Kaye SB. Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial. Br J Cancer 1986;54:19–23.
    • (1986) Br J Cancer , vol.54 , pp. 19-23
    • Willox, J.C.1    McAllister, E.J.2    Sangster, G.3    Kaye, S.B.4
  • 18
    • 0033992260 scopus 로고    scopus 로고
    • Treatment of vitamin D deficiency in patients with metastatic prostate cancer may improve bone pain and muscle strength
    • Van Veldhuizen PJ, Taylor SA, Williamson S, Drees BM. Treatment of vitamin D deficiency in patients with metastatic prostate cancer may improve bone pain and muscle strength. J Urol 2000;163:187–190.
    • (2000) J Urol , vol.163 , pp. 187-190
    • Van Veldhuizen, P.J.1    Taylor, S.A.2    Williamson, S.3    Drees, B.M.4
  • 19
    • 33847110692 scopus 로고    scopus 로고
    • Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration
    • Yeom CH, Jung GC, Song KJ. Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration. J Korean Med Sci 2007;22:7–11.
    • (2007) J Korean Med Sci , vol.22 , pp. 7-11
    • Yeom, C.H.1    Jung, G.C.2    Song, K.J.3
  • 20
    • 0031975234 scopus 로고    scopus 로고
    • Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial
    • Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer 1998;82:395–402.
    • (1998) Cancer , vol.82 , pp. 395-402
    • Gogos, C.A.1    Ginopoulos, P.2    Salsa, B.3    Apostolidou, E.4    Zoumbos, N.C.5    Kalfarentzos, F.6
  • 21
    • 0036227772 scopus 로고    scopus 로고
    • Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine
    • May PE, Barber A, D'Olimpio JT, Hourihane A, Abumrad NN. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am J Surg 2002;183:471–479.
    • (2002) Am J Surg , vol.183 , pp. 471-479
    • May, P.E.1    Barber, A.2    D'Olimpio, J.T.3    Hourihane, A.4    Abumrad, N.N.5
  • 22
    • 51649122773 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122)
    • Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, et al. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Support Care Cancer 2008;16:1179–1188.
    • (2008) Support Care Cancer , vol.16 , pp. 1179-1188
    • Berk, L.1    James, J.2    Schwartz, A.3    Hug, E.4    Mahadevan, A.5    Samuels, M.6
  • 23
    • 33744748305 scopus 로고    scopus 로고
    • A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress
    • Mantovani G, Macciò A, Madeddu C, Gramignano G, Lusso MR, Serpe R, et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomark Prev 2006;15:1030–1034.
    • (2006) Cancer Epidemiol Biomark Prev , vol.15 , pp. 1030-1034
    • Mantovani, G.1    Macciò, A.2    Madeddu, C.3    Gramignano, G.4    Lusso, M.R.5    Serpe, R.6
  • 24
    • 0024501575 scopus 로고
    • Branched chain amino acids as the protein component of parenteral nutrition in cancer cachexia
    • Hunter DC, Weintraub M, Blackburn GL, Bistrian BR. Branched chain amino acids as the protein component of parenteral nutrition in cancer cachexia. Br J Surg 1989;76:149–153.
    • (1989) Br J Surg , vol.76 , pp. 149-153
    • Hunter, D.C.1    Weintraub, M.2    Blackburn, G.L.3    Bistrian, B.R.4
  • 25
    • 0022602879 scopus 로고
    • Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia: A prospective randomized crossover trial
    • Tayek JA, Bistrian BR, Hehir DJ, Martin R, Moldawer LL, Blackburn GL. Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia: A prospective randomized crossover trial. Cancer 1986;58:147–157.
    • (1986) Cancer , vol.58 , pp. 147-157
    • Tayek, J.A.1    Bistrian, B.R.2    Hehir, D.J.3    Martin, R.4    Moldawer, L.L.5    Blackburn, G.L.6
  • 26
    • 84879094001 scopus 로고    scopus 로고
    • Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia
    • Yeh K-Y, Wang H-M, Chang JW-C, Huang J-S, Lai C-H, Lan Y-J, et al. Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:41–48.
    • (2013) Oral Surg Oral Med Oral Pathol Oral Radiol , vol.116 , pp. 41-48
    • Yeh, K.-Y.1    Wang, H.-M.2    Chang, J.W.-C.3    Huang, J.-S.4    Lai, C.-H.5    Lan, Y.-J.6
  • 27
    • 0036083262 scopus 로고    scopus 로고
    • A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer
    • Gianotti L, Braga M, Nespoli L, Radaelli G, Beneduce A, Di Carlo V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology 2002;122:1763–1770.
    • (2002) Gastroenterology , vol.122 , pp. 1763-1770
    • Gianotti, L.1    Braga, M.2    Nespoli, L.3    Radaelli, G.4    Beneduce, A.5    Di Carlo, V.6
  • 29
    • 84913702080 scopus 로고
    • Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery
    • Stehle P, Zander J, Mertes N, Albers S, Puchstein C, Lawin P, et al. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet Lond Engl 1989;1:231–233.
    • (1989) Lancet Lond Engl , vol.1 , pp. 231-233
    • Stehle, P.1    Zander, J.2    Mertes, N.3    Albers, S.4    Puchstein, C.5    Lawin, P.6
  • 30
    • 0035143939 scopus 로고    scopus 로고
    • Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients
    • van Bokhorst-De Van Der Schueren MA, Quak JJ, von Blomberg-van der Flier BM, Kuik DJ, Langendoen SI, Snow GB, et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr 2001;73:323–332.
    • (2001) Am J Clin Nutr , vol.73 , pp. 323-332
    • van Bokhorst-De Van Der Schueren, M.A.1    Quak, J.J.2    von Blomberg-van der Flier, B.M.3    Kuik, D.J.4    Langendoen, S.I.5    Snow, G.B.6
  • 31
    • 0024988290 scopus 로고
    • Branched-chain amino acid-supplemented nutritional support after gastrectomy for gastric cancer with special reference to plasma amino acid profiles
    • Yamanaka H, Kanemaki T, Tsuji M, Kise Y, Hatano T, Hioki K, et al. Branched-chain amino acid-supplemented nutritional support after gastrectomy for gastric cancer with special reference to plasma amino acid profiles. Nutr Burbank Los Angel Cty Calif 1990;6:241–245.
    • (1990) Nutr Burbank Los Angel Cty Calif , vol.6 , pp. 241-245
    • Yamanaka, H.1    Kanemaki, T.2    Tsuji, M.3    Kise, Y.4    Hatano, T.5    Hioki, K.6
  • 32
    • 78149246871 scopus 로고    scopus 로고
    • Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival
    • Buijs N, van B van der Schueren MA, Langius JA, Leemans CR, Kuik DJ, Vermeulen MA, et al. Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival. Am J Clin Nutr 2010;92:1151–1156.
    • (2010) Am J Clin Nutr , vol.92 , pp. 1151-1156
    • Buijs, N.1    van B van der Schueren, M.A.2    Langius, J.A.3    Leemans, C.R.4    Kuik, D.J.5    Vermeulen, M.A.6
  • 33
    • 84958048098 scopus 로고    scopus 로고
    • Effects of standard and/or glutamine dipeptide and/or omega-3 fatty acid-supplemented parenteral nutrition on neutrophil functions, interleukin-8 level and length of stay- A double blind, controlled, randomised study
    • Aliyazicioglu T, Cantürk NZ, Simsek T, Kolayli F, Çekmen M. Effects of standard and/or glutamine dipeptide and/or omega-3 fatty acid-supplemented parenteral nutrition on neutrophil functions, interleukin-8 level and length of stay- A double blind, controlled, randomised study. East Afr Med J 2013;90:59–66.
    • (2013) East Afr Med J , vol.90 , pp. 59-66
    • Aliyazicioglu, T.1    Cantürk, N.Z.2    Simsek, T.3    Kolayli, F.4    Çekmen, M.5
  • 34
    • 0036160008 scopus 로고    scopus 로고
    • Nutritional approach in malnourished surgical patients: a prospective randomized study
    • Braga M, Gianotti L, Nespoli L, Radaelli G, Di Carlo V. Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg 2002;137:174–180.
    • (2002) Arch Surg , vol.137 , pp. 174-180
    • Braga, M.1    Gianotti, L.2    Nespoli, L.3    Radaelli, G.4    Di Carlo, V.5
  • 35
    • 84878532970 scopus 로고    scopus 로고
    • A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients
    • de Luis DA, Izaola O, Cuellar L, Terroba MC, de la Fuente B, Cabezas G. A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients. Eur Rev Med Pharmacol Sci 2013;17:1090–1094.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 1090-1094
    • de Luis, D.A.1    Izaola, O.2    Cuellar, L.3    Terroba, M.C.4    de la Fuente, B.5    Cabezas, G.6
  • 36
    • 34247565529 scopus 로고    scopus 로고
    • Nutritional and lifestyle correlates of the cancer-protective hormone melatonin
    • Dopfel RP, Schulmeister K, Schernhammer ES. Nutritional and lifestyle correlates of the cancer-protective hormone melatonin. Cancer Detect Prev 2007;31:140–148.
    • (2007) Cancer Detect Prev , vol.31 , pp. 140-148
    • Dopfel, R.P.1    Schulmeister, K.2    Schernhammer, E.S.3
  • 37
    • 0023131388 scopus 로고
    • Body composition in malignant disease
    • MacFie J, Burkinshaw L. Body composition in malignant disease. Metabolism 1987;36:290–294.
    • (1987) Metabolism , vol.36 , pp. 290-294
    • MacFie, J.1    Burkinshaw, L.2
  • 39
    • 33845349279 scopus 로고    scopus 로고
    • Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study
    • Cruciani RA, Dvorkin E, Homel P, Malamud S, Culliney B, Lapin J, et al. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. J Pain Symptom Manage 2006;32:551–559.
    • (2006) J Pain Symptom Manage , vol.32 , pp. 551-559
    • Cruciani, R.A.1    Dvorkin, E.2    Homel, P.3    Malamud, S.4    Culliney, B.5    Lapin, J.6
  • 40
    • 1642375575 scopus 로고    scopus 로고
    • Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters
    • Rathmacher JA, Nissen S, Panton L, Clark RH, Eubanks May P, Barber AE, et al. Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J Parenter Enteral Nutr 2004;28:65–75.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , pp. 65-75
    • Rathmacher, J.A.1    Nissen, S.2    Panton, L.3    Clark, R.H.4    Eubanks May, P.5    Barber, A.E.6
  • 43
    • 84949106857 scopus 로고    scopus 로고
    • Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015
    • von Haehling S, Morley JE, Coats AJS, Anker SD. Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015. J Cachexia Sarcopenia Muscle 2015;6:315–316.
    • (2015) J Cachexia Sarcopenia Muscle , vol.6 , pp. 315-316
    • von Haehling, S.1    Morley, J.E.2    Coats, A.J.S.3    Anker, S.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.