Effectiveness of screening colonoscopy to prevent colorectal cancer among medicare beneficiaries aged 70 to 79 years: A prospective observational study

Annals of Internal Medicine

Volumn 166, Issue 1, 2017, Pages 18-26

  García Albéniz, Xabier ^a   Hsu, John ^b   Bretthauer, Michael ^c   Hernán, Miguel A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CANCER RISK; CANCER SCREENING; CLINICAL EFFECTIVENESS; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICARE; OBSERVATIONAL STUDY; PATIENT SAFETY; PREVENTIVE HEALTH SERVICE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; UNITED STATES; ADVERSE EFFECTS; COLORECTAL NEOPLASMS; EARLY CANCER DIAGNOSIS; INCIDENCE; MASS SCREENING;

AGED; COLONOSCOPY; COLORECTAL NEOPLASMS; EARLY DETECTION OF CANCER; FEMALE; HUMANS; INCIDENCE; MALE; MASS SCREENING; MEDICARE; PROSPECTIVE STUDIES; UNITED STATES;

EID: 85013783170     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M16-0758     Document Type: Article

References (50)

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5-29. [PMID: 25559415] doi:10.3322/caac.21254
2. Lieberman DA, Rex DK, Winawer SJ, Giardiello FM, Johnson DA, Levin TR; United States Multi-Society Task Force on Colorectal Cancer. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2012;143:844-57. [PMID: 22763141] doi:10.1053/j.gastro.2012.06.001
3. Quintero E, Castells A, Bujanda L, Cubiella J, Salas D, Lanas Á, et al; COLONPREV Study Investigators. Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. N Engl J Med. 2012;366:697-706. [PMID: 22356323] doi:10.1056/NEJMoa 1108895
4. Kaminski MF, Bretthauer M, Zauber AG, Kuipers EJ, Adami HO, van Ballegooijen M, et al. The NordICC Study: rationale and design of a randomized trial on colonoscopy screening for colorectal cancer. Endoscopy. 2012;44:695-702. [PMID: 22723185] doi:10.1055/s-0032-1306895
5. Colonoscopy versus fecal immunochemical test in reducing mortality from colorectal cancer (CONFIRM). ClinicalTrials.gov:NCT01239082. Accessed at https://clinicaltrials.gov/ct2/show/NCT01239082 on 3 June 2015.
6. Shaukat A, Mongin SJ, Geisser MS, Lederle FA, Bond JH, Mandel JS, et al. Long-term mortality after screening for colorectal cancer. N Engl J Med. 2013;369:1106-14. [PMID: 24047060] doi:10.1056/NEJMoa1300720
7. Scholefield JH, Moss SM, Mangham CM, Whynes DK, Hardcastle JD. Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up. Gut. 2012;61:1036-40. [PMID: 22052062] doi:10.1136/gutjnl-2011-300774
8. Kronborg O, Jøgensen OD, Fenger C, Rasmussen M. Randomized study of biennial screening with a faecal occult blood test: results after nine screening rounds. Scand J Gastroenterol. 2004;39: 846-51. [PMID: 15513382]
9. Faivre J, Dancourt V, Lejeune C, Tazi MA, Lamour J, Gerard D, et al. Reduction in colorectal cancer mortality by fecal occult blood screening in a French controlled study. Gastroenterology. 2004;126: 1674-80. [PMID: 15188160]
10. Lindholm E, Brevinge H, Haglind E. Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. Br J Surg. 2008;95:1029-36. [PMID: 18563785] doi:10.1002/bjs.6136
11. Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, et al; UK Flexible Sigmoidoscopy Trial Investigators. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet. 2010;375:1624-33. [PMID: 20430429] doi:10.1016/S0140-6736(10)60551-X
12. Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M, et al; SCORE Working Group. Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial-SCORE. J Natl Cancer Inst. 2011;103:1310-22. [PMID: 21852264] doi:10.1093/jnci/djr284
13. Hoff G, Grotmol T, Skovlund E, Bretthauer M; Norwegian Colorectal Cancer Prevention Study Group. Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial. BMJ. 2009;338:b1846. [PMID: 19483252] doi:10.1136/bmj.b1846
14. Holme Ø, Løerg M, Kalager M, Bretthauer M, Hernán MA, Aas E, et al. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial. JAMA. 2014; 312:606-15. [PMID: 25117129] doi:10.1001/jama.2014.8266
15. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, et al; PLCO Project Team. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012;366:2345-57. [PMID: 22612596] doi:10.1056/NEJMoa1114635
16. Holme Ø, Bretthauer M, Fretheim A, Odgaard-Jensen J, Hoff G. Flexible sigmoidoscopy versus faecal occult blood testing for colorectal cancer screening in asymptomatic individuals. Cochrane Database Syst Rev. 2013:CD009259. [PMID: 24085634] doi:10.1002/14651858.CD009259.pub2
17. Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW Jr, García FA, et al; US Preventive Services Task Force. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA. 2016;315:2564-75. [PMID:27304597] doi:10.1001/jama.2016.5989
18. Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM; American College of Gastroenterology. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009;104:739-50. [PMID: 19240699] doi:10.1038/ajg.2009.104
19. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Colorectal cancer screening version 1. 2015. Accessed at www.nccn.org/professionals/physician-gls/PDF/colorectal-screening.pdf on 30 November 2015.
20. Gagne JJ, Glynn RJ, Avorn J, Levin R, Schneeweiss S. A combined comorbidity score predicted mortality in elderly patients better than existing scores. J Clin Epidemiol. 2011;64:749-59. [PMID: 21208778] doi:10.1016/j.jclinepi.2010.10.004
21. Warren JL, Klabunde CN, Mariotto AB, Meekins A, Topor M, Brown ML, et al. Adverse events after outpatient colonoscopy in the Medicare population. Ann Intern Med. 2009;150:849-57. [PMID: 19528563]
22. Warren JL, Klabunde CN, Schrag D, Bach PB, Riley GF. Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care. 2002; 40:3-18. [PMID: 12187163]
23. Goodwin JS, Singh A, Reddy N, Riall TS, Kuo YF. Overuse of screening colonoscopy in the Medicare population. Arch Intern Med. 2011;171:1335-43. [PMID: 21555653] doi:10.1001/archinternmed.2011.212
24. Ackermann RT, Williams B, Nguyen HQ, Berke EM, Maciejewski ML, LoGerfo JP. Healthcare cost differences with participation in a community-based group physical activity benefit for medicare managed care health plan members. J Am Geriatr Soc. 2008;56:1459-65. [PMID: 18637982] doi:10.1111/j.1532-5415.2008.01804.x
25. Hernán MA, Robins JM. Using big data to emulate a target trial when a randomized trial is not available. Am J Epidemiol. 2016;183: 758-64. [PMID: 26994063] doi:10.1093/aje/kwv254
26. Danaei G, Rodríguez LA, Cantero OF, Logan R, Hernán MA. Observational data for comparative effectiveness research: an emulation of randomised trials of statins and primary prevention of coronary heart disease. Stat Methods Med Res. 2013;22:70-96. [PMID: 22016461] doi:10.1177/0962280211403603
27. Hernán M, Robins J, Garcia-Rodriguez L. Discussion on "Statistical Issues in the Women's Health Initiative." Biometrics. 2005;61:922-30.
28. Hernán MA, Alonso A, Logan R, Grodstein F, Michels KB, Willett WC, et al. Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology. 2008;19:766-79. [PMID: 18854702] doi:10.1097/EDE.0b013e3181875e61
29. Stampfer MJ. ITT for observational data: worst of both worlds? [Editorial]. Epidemiology. 2008;19:783-4. [PMID: 18813017] doi:10.1097/EDE.0b013e318188442e
30. Hernán MA, Sauer BC, Hernández-Díaz S, Platt R, Shrier I. Specifying a target trial prevents immortal time bias and other selfinflicted injuries in observational analyses. J Clin Epidemiol. 2016. [PMID: 27237061] doi:10.1016/j.jclinepi.2016.04.014
31. Thompson WA Jr. On the treatment of grouped observations in life studies. Biometrics. 1977;33:463-70. [PMID: 911970]
32. D'Agostino RB, Lee ML, Belanger AJ, Cupples LA, Anderson K, Kannel WB. Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study. Stat Med. 1990;9:1501-15. [PMID: 2281238]
33. Hernán MA. The hazards of hazard ratios. Epidemiology. 2010; 21:13-5. [PMID: 20010207] doi:10.1097/EDE.0b013e3181c1ea43
34. U.S. Department of Health and Human Services. Healthy People 2020 objectives. Objective C-16. Accessed at www.healthypeople.gov/2020/topicsobjectives2020/objectiveslist.aspx?topicId=5 on 23 December 2015.
35. Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, et al. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med. 2013;369:1095-105. [PMID: 24047059] doi:10.1056/NEJMoa1301969
36. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150:1-8. [PMID: 19075198]
37. Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M. Protection from colorectal cancer after colonoscopy: a populationbased, case-control study. Ann Intern Med. 2011;154:22-30. [PMID: 21200035] doi:10.7326/0003-4819-154-1-201101040-00004
38. Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ. 2014;348:g2467. [PMID: 24922745] doi:10.1136/bmj.g2467
39. Kahi CJ, Myers LJ, Slaven JE, Haggstrom D, Pohl H, Robertson DJ, et al. Lower endoscopy reduces colorectal cancer incidence in older individuals. Gastroenterology. 2014;146:718-25. [PMID: 24316263] doi:10.1053/j.gastro.2013.11.050
40. Stock D, Paszat LF, Rabeneck L. Colorectal cancer mortality reduction is associated with having at least 1 colonoscopy within the previous 10 years among a population-wide cohort of screening age. Gastrointest Endosc. 2016;84:133-41. [PMID: 26769406] doi:10.1016/j.gie.2015.12.035
41. Shieh Y, Eklund M, Sawaya GF, Black WC, Kramer BS, Esserman LJ. Population-based screening for cancer: hope and hype. Nat Rev Clin Oncol. 2016. [PMID: 27071351] doi:10.1038/nrclinonc.2016.50
42. Esserman LJ, Thompson IM, Reid B, Nelson P, Ransohoff DF, Welch HG, et al. Addressing overdiagnosis and overtreatment in cancer: a prescription for change. Lancet Oncol. 2014;15:e234-42. [PMID: 24807866] doi:10.1016/S1470-2045(13)70598-9
43. Doubeni CA, Weinmann S, Adams K, Kamineni A, Buist DS, Ash AS, et al. Screening colonoscopy and risk for incident late-stage colorectal cancer diagnosis in average-risk adults: a nested casecontrol study. Ann Intern Med. 2013;158:312-20. [PMID: 23460054] doi:10.7326/0003-4819-158-5-201303050-00003
44. Brenner H, Chang-Claude J, Jansen L, Knebel P, Stock C, Hoffmeister M. Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy. Gastroenterology. 2014;146:709-17. [PMID: 24012982] doi:10.1053/j.gastro.2013.09.001
45. Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328:1365-71. [PMID: 8474513]
46. Ding P, VanderWeele TJ. Sensitivity analysis without assumptions. Epidemiology. 2016;27:368-77. [PMID: 26841057] doi:10.1097/EDE.0000000000000457
47. Bretthauer M, Kaminski MF, Løerg M, Zauber AG, Regula J, Kuipers EJ, et al; Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group. Population-based colonoscopy screening for colorectal cancer: a randomized clinical trial. JAMA Intern Med. 2016;176:894-902. [PMID: 27214731] doi:10.1001/jamainternmed.2016.0960
48. Bokemeyer B, Bock H, Hüppe D, Düffelmeyer M, Rambow A, Tacke W, et al. Screening colonoscopy for colorectal cancer prevention: results from a German online registry on 269000 cases. Eur J Gastroenterol Hepatol. 2009;21:650-5. [PMID: 19445041]
49. Stoop EM, de Haan MC, de Wijkerslooth TR, Bossuyt PM, van Ballegooijen M, Nio CY, et al. Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet Oncol. 2012;13:55-64. [PMID: 22088831] doi:10.1016/S1470-2045(11)70283-2
50. Pox CP, Altenhofen L, Brenner H, Theilmeier A, Von Stillfried D, Schmiegel W. Efficacy of a nationwide screening colonoscopy program for colorectal cancer. Gastroenterology. 2012;142:1460-7. [PMID: 22446606] doi:10.1053/j.gastro.2012.03.022