Sepsis in Haiti: Prevalence, treatment, and outcomes in a Port-au-Prince referral hospital

Journal of Critical Care

Volumn 38, Issue , 2017, Pages 35-40

  Papali, Alfred ^a   Verceles, Avelino C ^a   Augustin, Marc E ^b   Colas, L Nathalie ^b   Jean Francois, Carl H ^b   Patel, Devang M ^a   Todd, Nevins W ^a   McCurdy, Michael T ^a   West, T Eoin ^c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b St Luke Family Hospital   (Haïti)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Critical care; Global health; Haiti; Intensive care; Resource limited; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; CHLOROQUINE; CIPROFLOXACIN; COTRIMOXAZOLE; INFUSION FLUID; METRONIDAZOLE; OXYGEN;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN DISEASE; COHORT ANALYSIS; COMMUNITY HOSPITAL; DESCRIPTIVE RESEARCH; DISEASE SEVERITY; FECES ANALYSIS; FEMALE; FLUID RESUSCITATION; HAITIAN; HOSPITAL MORTALITY; HUMAN; HYPOXEMIA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; RETROSPECTIVE STUDY; SEPSIS; FLUID THERAPY; HAITI; INTENSIVE CARE; MIDDLE AGED; MORTALITY; ODDS RATIO; OUTCOME ASSESSMENT; PATIENT REFERRAL; STATISTICS AND NUMERICAL DATA;

ADULT; AGED; CRITICAL CARE; FEMALE; FLUID THERAPY; HAITI; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; OUTCOME ASSESSMENT (HEALTH CARE); PREVALENCE; REFERRAL AND CONSULTATION; RETROSPECTIVE STUDIES; SEPSIS;

EID: 85013678323     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2016.09.031     Document Type: Article

References (23)

1. [1] Adhikari, N.K., Fowler, R.A., Bhagwanjee, S., Rubenfeld, G.D., Critical care and the global burden of critical illness in adults. Lancet 376:9749 (2010), 1339–1346.
2. [2] Vincent, J.-L., Marshall, J.C., Ñamendys-Silva, S.A., François, B., Martin-Loeches, I., Lipman, J., et al. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med 2:5 (2014), 380–386.
3. [3] Rhodes, A., Phillips, G., Beale, R., Cecconi, M., Chiche, J.D., De Backer, D., et al. The Surviving Sepsis Campaign bundles and outcome: results from the international multicentre prevalence study on sepsis (the IMPreSS study). Intensive Care Med 41:9 (2015), 1620–1628.
4. [4] Dellinger, R.P., Levy, M.M., Rhodes, A., Annane, D., Gerlach, H., Opal, S.M., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:2 (2013), 580–637.
5. [5] IMAI district clinician manual: hospital care for adolescents and adults: guidelines for the management of illnesses with limited-resources. 2012, World Health Organization, Geneva.
6. [6] Jacob, S.T., Banura, P., Baeten, J.M., Moore, C.C., Meya, D., Nakiyingi, L., et al. The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study. Crit Care Med 40:7 (2012), 2050–2058.
7. [7] Maitland, K., Kiguli, S., Opoka, R.O., Engoru, C., Olupot-Olupot, P., Akech, S.O., et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:26 (2011), 2483–2495.
8. [8] Andrews, B., Muchemwa, L., Kelly, P., Lakhi, S., Heimburger, D.C., Bernard, G.R., Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med 42:11 (2014), 2315–2324.
9. [9] World Health Organization, World health statistics 2012 part III: global health indicators. 2012, World Health Organization.
10. [10] Vincent, J.-L., Opal, S.M., Marshall, J.C., Tracey, K.J., Sepsis definitions: time for change. Lancet 381:9868 (2013), 774–775.
11. [11] Wang, H.E., Shapiro, N.I., Angus, D.C., Yealy, D.M., National estimates of severe sepsis in United States emergency departments. Crit Care Med 35:8 (2007), 1928–1936.
12. [12] Jacob, S.T., Moore, C.C., Banura, P., Pinkerton, R., Meya, D., Opendi, P., et al. Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population. PLoS One, 4(11), 2009, e7782 http://dx.doi.org/10.1371/journal.pone.0007782.
13. [13] Chimese, S.M., Andrews, B., Lakhi, S., The etiology and outcome of adult patients presenting with sepsis to the university teaching hospital, Lusaka, Zambia. Med J Zambia 39:3 (2012), 19–22.
14. [14] Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:19 (2001), 1368–1377.
15. [15] Yealy, D.M., Kellum, J.A., Huang, D.T., Barnato, A.E., Weissfeld, L.A., Pike, F., et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:18 (2014), 1683–1693.
16. [16] Peake, S.L., Delaney, A., Bailey, M., Bellomo, R., Cameron, P.A., Cooper, D.J., et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med, 371(16), 2014.
17. [17] Mouncey, P.R., Osborn, T.M., Power, G.S., Harrison, D.A., Sadique, M.Z., Grieve, R.D., et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:14 (2015), 1301–1311.
18. [18] Murthy, S., Leligdowicz, A., Adhikari, N., Intensive care unit capacity in low-income countries: a systematic review. PLoS One, 10(1), 2015, e0116949 http://dx.doi.org/10.1371/journal.pone.0116949.
19. [19] Papali, A., McCurdy, M.T., Calvello, E.J.B., A “three delays” model for severe sepsis in resource-limited countries. J Crit Care 30:4 (2015), 861.e9–861.e14 http://dx.doi.org/10.1016/j.jcrc.2015.04.003.
20. [20] World Health Organization, Antimicrobial resistance: global report on surveillance. 2014, World Health Organization.
21. [21] Von Fricken, M.E., Weppelmann, T.A., Hosford, J.D., Existe, A., Okech, B.A., Malaria treatment policies and drug efficacy in Haiti from 1955-2012. J Pharm Policy Pract, 11(6), 2013, 10 http://dx.doi.org/10.1186/2052-3211-6-10.
22. [22] Ndyomugyenyi, R., Magnussen, P., Clarke, S., Diagnosis and treatment of malaria in peripheral health facilities in Uganda: findings from an area of low transmission in South-Western Uganda. Malar J, 6, 2007, 39.
23. [23] Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:8 (2016), 801–810.