Brain function in children with untreated epilepsy: Relationship to biomarkers of brain damage

Journal of Pediatric Epilepsy

Volumn 2, Issue 2, 2013, Pages 115-124

  Hamed, Sherifa A ^a   Eltayeb, Azza A ^a   Mohamad, Hanan O ^b   Moussa, Ehab M M ^a  

^a ASSIUT UNIVERSITY   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

Author keywords

Children; Cognition; Idiopathic epilepsy; Intelligence; Neuron specific enolase; S100 protein

Indexed keywords

EID: 85013590702     PISSN: 2146457X     EISSN: 21464588     Source Type: Journal    
DOI: 10.3233/PEP-13050     Document Type: Article

References (54)

1. Ottman R. Progress in the genetics of the partial epilepsies. Epilepsia 2001;42 Suppl 5: 24-30.
2. Haerer AF, Anderson DW, Schoenberg BS. Prevalence and clinical features of epilepsy in a biracial United States population. Epilepsia 1986;27(1): 66-75.
3. Jernigan TL, Trauner DA, Hesselink JR, Tallal PA. Maturation of human cerebrum observed in vivo during adolescence. Brain 1991;114(Pt 5): 2037-49.
4. Jørgensen OS, Dwyer B, Wasterlain CG. Synaptic proteins after electroconvulsive seizures in immature rats. J Neurochem 1980;35(5): 1235-7.
5. Metz-Lutz MN, Kleitz C, de Saint Martin A, Massa R, Hirsch E, Marescaux C. Cognitive development in benign focal epilepsies of childhood. Dev Neurosci 1999;21(3-5): 182-90.
6. Cavazzuti GB, Nalin A. Psychobehavioral disturbance in epileptic children. Child’s Nerv Syst 1990;6(8): 430-3.
7. Henkin Y, Sadeh M, Kivity S, Shabtai E, Kishon-Rabin L, Gadoth N. Cognitive function in idiopathic generalized epilepsy of childhood. Dev Med Child Neurol 2005;47(2): 126-32.
8. Høie B, Mykletun A, Sommerfelt K, Bjørnaes H, Skeidsvoll H, Waaler PE. Seizure-related factors and non-verbal intelligence in children with epilepsy. A population-based study from Western Norway. Seizure 2005;14(4): 223-31.
9. Parrish J, Geary E, Jones J, Seth R, Hermann B, Seidenberg M. Executive functioning in childhood epilepsy: parentreport and cognitive assessment. Dev Med Child Neurol 2007;49(6): 412-6.
10. Bhise VV, Burack GD, Mandelbaum DE. Baseline cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy. Dev Med Child Neurol 2010;52(1): 22-6.
11. Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain 2008;131(Pt 9): 2243-63.
12. Luat AF, Asano E, Juhász C, Chandana SR, Shah A, Sood S, et al. Relationship between brain glucose metabolism positron emission tomography (PET) and electroencephalography (EEG) in children with continuous spike-andwave activity during slow-wave sleep. J Child Neurol 2005;20(8): 682-90.
13. Fuerst D, Shah J, Shah A, Watson C. Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study. Ann Neurol 2003;53(3): 413-6.
14. Hamed SA. The aspects and mechanisms of cognitive alterations in epilepsy: the role of antiepileptic medications. CNS Neurosci Ther 2009;15(2): 134-56.
15. Klein B, Levin BE, Duchowny MS, Llabre MM. Cognitive outcome of children with epilepsy and malformations of cortical development. Neurology 2000;55(2): 230-5.
16. Helmstaedter C, Kurthen M, Lux S, Reuber M, Elger CE. Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy. Ann Neurol 2003;54(4): 425-32.
17. Meador KJ. Cognitive outcomes and predictive factors in epilepsy. Neurology 2002;58(8 Suppl 5): S21-S6.
18. Albuerne M, Mammola CL, Naves FJ, Levanti B, Germanà G, Vega JA. Immunohistochemical localization of S100 proteins in dorsal root, sympathetic and enteric ganglia of several mammalian species, including man. J Peripher Nerv Syst 1998;3(4): 243-53.
19. Berger RP, Adelson PD, Pierce MC, Dulani T, Cassidy LD, Kochanek PM. Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg 2005; 103(1 Suppl): 61-8.
20. Liu L, Zheng CX, Peng SF, Zhou HY, Su ZY, He L, et al. Evaluation of urinary S100B protein level and lactate/ creatinine ratio for early diagnosis and prognostic prediction of neonatal hypoxic-ischemic encephalopathy. Neonatology 2010;97(1): 41-4.
21. Hamed SA, Hamed EA, Zakary MM. Oxidative stress and S-100B protein in children with bacterial meningitis. BMC Neurol 2009;9(1): 51.
22. Hamed SA, Hamed EA, Abdella MM. Septic encephalopathy: relationship to serum and cerebrospinal fluid levels of adhesion molecules, lipid peroxides and S-100B protein. Neuropediatrics 2009;40(2): 66-72.
23. Rabinowicz AL, Correale J, Boutros RB, Couldwell WT, Henderson CW, DeGiorgio CM. Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring. Epilepsia 1996;37(2): 122-5.
24. Steinhoff BJ, Tumani H, Otto M, Mursch K, Wiltfang J, Herrendorf G, et al. Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy. Epilepsy Res 1999;36(1): 75-82.
25. Pugliese M, Geloso MC, Carrasco JL, Mascort J, Michetti F, Mahy N. Canine cognitive deficit correlates with diffuse plaque maturation and S100beta (-) astrocytosis but not with insulin cerebrospinal fluid level. Acta Neuropathol 2006;111(6): 519-28.
26. Kallioinen MJ, Heikkinen ER, Nyström S. Histopathological and immunohistochemical changes in neurosurgically resected epileptic foci. Acta Neurochir (Wien) 1987;89(3-4): 122-9.
27. Palmio J, Peltola J, Vuorinen P, Laine S, Suhonen J, Keränen T. Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizures. J Neurol Sci 2001;183(1): 27-31.
28. Lu C, Li J, Sun W, Feng L, Li L, Liu A, et al. Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: a case-control study. Neurosci Lett 2010;484(2): 139-42.
29. Leutmezer F, Wagner O, Baumgartner C. Serum s-100 protein is not a suitable seizure marker in temporal lobe epilepsy. Epilepsia 2002;43(10): 1172-4.
30. Paus E, Nustad K. Immunoradiometric assay for alpha gamma- and gamma gamma-enolase (neuron-specific enolase), with use of monoclonal antibodies and magnetizable polymer particles. Clin Chem 1989;35(10): 2034-8.
31. Gonçalves CA, Leite MC, Nardin P. Biological and methodological features of the measurement of S100B, a putative marker of brain injury. Clin Biochem 2008;41(10-11): 755-63.
32. Melika LK. Wechsler adult intelligence scale-revised manual: Arabic examiner’s handbook. 1st ed. Cairo: Dar Egyptian Books House; 1996.
33. Wechsler D. Wechsler intelligence scale for children. 3rd ed. San Antonio, TX: Psychological Corporation Harcourt Brace Jovanovich; 1991.
34. Melika LK. The Stanford. Binet intelligence scale. Arabic examiner’s handbook. 4th ed. Cairo: Dar El Maref Publishing; 1998.
35. Thorndike RL, Hagen EP, Sattler JM. The Stanford-binet intelligence scale. Technicalmanual. 4th ed. Chicago: Riverside; 1986.
36. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1981;22(4): 489-501.
37. Hamed SA, Hamed EA, Kandil MR, El-Shereef HK, Abdellah MM, Omar H. Serum thyroid hormone balance and lipid profile in patients with epilepsy. Epilepsy Res 2005;66(1-3): 173-83.
38. Noachtar S, Binnie C, Ebersole J, Mauguiere F, Sakamoto A, Westmoreland B. A glossary of terms most commonly used by clinical electroencephalographers and proposals for the report for the EEG findings. In: Deuschl G, Eisen A, editors. Recommendation for the practice of clinical neurophysiology: guidelines of the international Federation of clinical neurophysiology (EEG Suppl. 52). 1st ed. Amsterdam, New York: Elsevier Science, 1999; p. 21-44.
39. Sloviter RS. Status epilepticus-induced neuronal injury and network reorganization. Epilepsia 1999;40 Suppl 1: S34-9.
40. Bengzon J, Kokaia Z, Elmér E, Nanobashvili A, Kokaia M, Lindvall O. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc Natl Acad Sci U S A 1997;94(19): 10432-7.
41. Cavazos JE, Das I, Sutula TP. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci 1994;14(5 Pt 2): 3106-21.
42. Kotloski R, Lynch M, Lauersdorf S, Sutula T. Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits. Prog Brain Res 2002;135: 95-110.
43. Titze K, Koch S, Helge H, Lehmkuhl U, Rauh H, Steinhausen HC. Prenatal and family risks of children born to mothers with epilepsy: effects on cognitive development. Dev Med Child Neurol 2008;50(2): 117-22.
44. Tanabe T, Suzuki S, Hara K, Shimakawa S, Wakamiya E, Tamai H. Cerebrospinal fluid and serum neuron-specific enolase levels after febrile seizures. Epilepsia 2001;42(4): 504-7.
45. de Oliveira DL, Fischer A, Jorge RS, da Silva MC, Leite M, Gonçalves CA, et al. Effects of early-lifeLiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein. Epilepsia 2008;49(5): 842-52.
46. Reid IC, Stewart CA. Seizures, memory and synaptic plasticity. Seizure 1997;6(5): 351-9.
47. Zhang G, Raol YH, Hsu FC, Coulter DA, Brooks-Kayal AR. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience 2004;125(2): 299-303.
48. Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol 2003;53(6): 711-7.
49. Patel M, Li QY. Age dependence of seizure-induced oxidative stress. Neuroscience 2003;118(2): 431-7.
50. Rizzi M, Perego C, Aliprandi M, Richichi C, Ravizza T, Colella D, et al. Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. Neurobiol Dis 2003;14(3): 494-503.
51. Sommer B, Köhler M, Sprengel R, Seeburg PH. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 1991;67(1): 11-9.
52. Tandon P, Yang Y, Das K, Holmes GL, Stafstrom CE. Neuroprotective effects of brain-derived neurotrophic factor in seizures during development. Neuroscience 1999;91(1): 293-303.
53. Stafstrom CE, Chronopoulos A, Thurber S, Thompson JL, Holmes GL. Age-dependent cognitive and behavioral deficits after kainic acid seizures. Epilepsia 1993;34(3): 420-32.
54. Lynch M, Sayin U, Bownds J, Janumpalli S, Sutula T. Long-term consequences of early postnatal seizures on hippocampal learning and plasticity. Eur J Neurosci 2000;12(7): 2252-64.