High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia

Respirology

Volumn 22, Issue 5, 2017, Pages 1000-1006

  Vestjens, Stefan M T ^a   Spoorenberg, Simone M C ^a   Rijkers, Ger T ^a,b   Grutters, Jan C ^a,c   Ten Berg, Jurriën M ^a   Noordzij, Peter G ^a   van de Garde, Ewoudt M W ^a   Bos, Willem Jan W ^a   Biesma, Douwe H ^a   Endeman, Henrik ^e   Hardeman, Hans ^f   Heijligenberg, Rik ^g   Meijvis, Sabine C A ^c   Remmelts, Hilde H ^c   van Velzen Blad, Heleen ^a  

^a Paul)   (Netherlands)

^b University College Roosevelt   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^f Zuwe Hofpoort   (Netherlands)

^g Gelderse Vallei Hospital   (Netherlands)

Author keywords

biomarkers; cardiovascular system; mortality; pneumonia; troponin T

Indexed keywords

ANTITHROMBOCYTIC AGENT; DEXAMETHASONE; PLACEBO; TROPONIN T; BIOLOGICAL MARKER; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; CONTROLLED STUDY; FEMALE; HOSPITAL MORTALITY; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PNEUMONIA SEVERITY INDEX; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SMOKING; BLOOD; COMMUNITY ACQUIRED INFECTION; DOUBLE BLIND PROCEDURE; HOSPITALIZATION; MIDDLE AGED; OUTCOME ASSESSMENT; PNEUMONIA; PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL;

AGED; BIOMARKERS; COMMUNITY-ACQUIRED INFECTIONS; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; GLUCOCORTICOIDS; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PNEUMONIA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TROPONIN T;

EID: 85013443474     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12996     Document Type: Article

References (30)

1. Mortensen EM, Kapoor WN, Chang C-CH, Fine MJ. Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia. Clin. Infect. Dis. 2003; 37: 1617–24.
2. Waterer GW, Kessler LA, Wunderink RG. Medium-term survival after hospitalization with community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 2004; 169: 910–4.
3. Bruns AHW, Oosterheert JJ, Cucciolillo MC, El Moussaoui R, Groenwold RHH, Prins JM, Hoepelman AIM. Cause-specific long-term mortality rates in patients recovered from community-acquired pneumonia as compared with the general Dutch population. Clin. Microbiol. Infect. 2011; 17: 763–8.
4. Adamuz J, Viasus D, Jiménez-Martínez E, Isla P, Garcia-Vidal C, Dorca J, Carratalà J. Incidence, timing and risk factors associated with 1-year mortality after hospitalization for community-acquired pneumonia. J. Infect. 2014; 68: 534–41.
5. Corrales-Medina VF, Suh KN, Rose G, Chirinos JA, Doucette S, Cameron DW, Fergusson DA. Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies. PLoS Med. 2011; 8: e1001048.
6. Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy D, Musher DM. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore) 2009; 88: 154–9.
7. Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. J. Thromb. Haemost. 2003; 1: 1897–905.
8. von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ. Res. 2007; 100: 27–40.
9. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify low-risk patients with community-acquired pneumonia. N. Engl. J. Med. 1997; 336: 243–50.
10. Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 2003; 58: 377–82.
11. Alan M, Grolimund E, Kutz A, Christ-Crain M, Thomann R, Falconnier C, Hoess C, Henzen C, Zimmerli W, Mueller B et al.; ProHOSP Study Group. Clinical risk scores and blood biomarkers as predictors of long-term outcome in patients with community-acquired pneumonia: a 6-year prospective follow-up study. J. Intern. Med. 2015; 278: 174–84.
12. Krüger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T; German Competence Network for the Study of Community Acquired Pneumonia (CAPNETZ) Study Group. Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: results from the German Competence Network, CAPNETZ. Am. J. Respir. Crit. Care Med. 2010; 182: 1426–34.
13. Chang CL, Mills GD, Karalus NC, Jennings LC, Laing R, Murdoch DR, Chambers ST, Vettise D, Tuffery CM, Hancox RJ. Biomarkers of cardiac dysfunction and mortality from community-acquired pneumonia in adults. PLoS One 2013; 8: e62612.
14. Cangemi R, Casciaro M, Rossi E, Calvieri C, Bucci T, Calabrese CM, Taliani G, Falcone M, Palange P, Bertazzoni G et al.; SIXTUS Study Group; SIXTUS Study Group. Platelet activation is associated with myocardial infarction in patients with pneumonia. J. Am. Coll. Cardiol. 2014; 64: 1917–25.
15. Lim W, Qushmaq I, Devereaux PJ, Heels-Ansdell D, Lauzier F, Ismaila AS, Crowther MA, Cook DJ. Elevated cardiac troponin measurements in critically ill patients. Arch. Intern. Med. 2006; 166: 2446–54.
16. Vasile VC, Chai H-S, Abdeldayem D, Afessa B, Jaffe AS. Elevated cardiac troponin T levels in critically ill patients with sepsis. Am. J. Med. 2013; 126: 1114–21.
17. ver Elst KM, Spapen HD, Nguyen DN, Garbar C, Huyghens LP, Gorus FK. Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin. Chem. 2000; 46: 650–7.
18. Meijvis SCA, Hardeman H, Remmelts HHF, Heijligenberg R, Rijkers GT, van Velzen-Blad H, Voorn GP, van de Garde EMW, Endeman H, Grutters JC et al. Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet 2011; 377: 2023–30.
19. Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin. Chem. 2010; 56: 254–61.
20. Lee YJ, Lee H, Park JS, Kim SJ, Cho Y-J, Yoon HI, Lee JH, Lee C-T, Park JS. Cardiac troponin I as a prognostic factor in critically ill pneumonia patients in the absence of acute coronary syndrome. J. Crit. Care 2015; 30: 390–4.
21. Fine MJ, Singer DE, Hanusa BH, Lave JR, Kapoor WN. Validation of a pneumonia prognostic index using the MedisGroups Comparative Hospital Database. Am. J. Med. 1993; 94: 153–9.
22. Wakabayashi K, Romaguera R, Laynez-Carnicero A, Maluenda G, Ben-Dor I, Sardi G, Gaglia MA, Mahmoudi M, Gonzalez MA, Delhaye C et al. Impact of smoking on acute phase outcomes of myocardial infarction. Coron. Artery Dis. 2011; 22: 217–22.
23. Omland T, de Lemos JA, Sabatine MS, Christophi CA, Rice MM, Jablonski KA, Tjora S, Domanski MJ, Gersh BJ, Rouleau JL et al.; Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) Trial Investigators. A sensitive cardiac troponin T assay in stable coronary artery disease. N. Engl. J. Med. 2009; 361: 2538–47.
24. Everett BM, Brooks MM, Vlachos HEA, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and cardiac events in stable ischemic heart disease and diabetes. N. Engl. J. Med. 2015; 373: 610–20.
25. Sibelius U, Grandel U, Buerke M, Mueller D, Kiss L, Kraemer HJ, Braun-Dullaeus R, Haberbosch W, Seeger W, Grimminger F. Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. Circulation 2000; 101: 78–85.
26. Mahajan VS, Jarolim P. How to interpret elevated cardiac troponin levels. Circulation 2011; 124: 2350–4.
27. Mirsaeidi M, Peyrani P, Aliberti S, Filardo G, Bordon J, Blasi F, Ramirez JA. Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest 2010; 137: 416–20.
28. Amsterdam EA, Wenger NK; American College of Cardiology; American Heart Association. The 2014 American College of Cardiology ACC/American Heart Association guideline for the management of patients with non-ST-elevation acute coronary syndromes: ten contemporary recommendations to aid clinicians in optimizing patient outcomes. Clin. Cardiol. 2015; 38: 121–3.
29. Feldman C, Anderson R. Community-acquired pneumonia: pathogenesis of acute cardiac events and potential adjunctive therapies. Chest 2015; 148: 523–32.
30. Oz F, Gul S, Kaya MG, Yazici M, Bulut I, Elitok A, Ersin G, Abakay O, Akkoyun CD, Oncul A et al. Does aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trial. Coron. Artery Dis. 2013; 24: 231–7.