Mortality outcomes in patients transfused with fresher versus older red blood cells: a meta-analysis

Vox Sanguinis

Volumn 112, Issue 3, 2017, Pages 268-278

  Chai Adisaksopha, C ^a   Alexander, P E ^a   Guyatt, G ^a   Crowther, M A ^a   Heddle, N M ^a,b,c   Devereaux, P J ^a,d   Ellis, M ^e   Roxby, D ^f   Sessler, D I ^g   Eikelboom, J W ^a,d,h  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c CANADIAN BLOOD SERVICES   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e TEL AVIV UNIVERSITY   (Israel)

^f FLINDERS MEDICAL CENTRE   (Australia)

^g LERNER RESEARCH INSTITUTE   (United States)

^h MCMASTER UNIVERSITY   (Canada)

Author keywords

blood processing; clinical trial; red cell component; transfusion therapy

Indexed keywords

ARTICLE; COMPARATIVE STUDY; ERYTHROCYTE TRANSFUSION; HOSPITAL MORTALITY; HOSPITAL PATIENT; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; ADVERSE EFFECTS; BLOOD STORAGE; CAUSE OF DEATH; CYTOLOGY; ERYTHROCYTE; FACTUAL DATABASE; METABOLISM; RISK; TIME FACTOR;

BLOOD PRESERVATION; CAUSE OF DEATH; DATABASES, FACTUAL; ERYTHROCYTE TRANSFUSION; ERYTHROCYTES; HOSPITAL MORTALITY; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; TIME FACTORS;

EID: 85013422867     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12495     Document Type: Article

References (48)

1. Hess JR, Biomedical Excellence For Safer Transfusion C: Scientific problems in the regulation of red blood cell products. Transfusion 2012; 52:1827–1835
2. Takei T, Amin NA, Schmid G, et al.: Progress in global blood safety for HIV. J Acquir Immune Defic Syndr 2009; 52(Suppl 2):S127–S131
3. Zimring JC: Fresh versus old blood: are there differences and do they matter? Hematology Am Soc Hematol Educ Program 2013; 2013:651–655
4. Stapley R, Owusu BY, Brandon A, et al.: Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity. Biochem J 2012; 446:499–508
5. D'Alessandro A, Liumbruno G, Grazzini G, et al.: Red blood cell storage: the story so far. Blood Transfus 2010; 8:82–88
6. Hess JR: Red cell changes during storage. Transfus Apher Sci 2010; 43:51–59
7. Khan SY, Kelher MR, Heal JM, et al.: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood 2006; 108:2455–2462
8. Kucukakin B, Kocak V, Lykkesfeldt J, et al.: Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components. Scand J Clin Lab Invest 2011; 71:299–303
9. Pettila V, Westbrook AJ, Nichol AD, et al.: Age of red blood cells and mortality in the critically ill. Crit Care 2011; 15:R116
10. Robinson SD, Janssen C, Fretz EB, et al.: Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention. Am Heart J 2010; 159:876–881
11. Van. Straten AH, Soliman Hamad MA, Martens EJ, et al.: Effect of storage time of transfused plasma on early and late mortality after coronary artery bypass grafting. J Thorac Cardiovasc Surg 2011; 141:238–243 e1–2
12. Weinberg JA, McGwin G Jr, Vandromme MJ, et al.: Duration of red cell storage influences mortality after trauma. J Trauma 2010; 69:1427–1431; discussion 31–32
13. Edgren G, Kamper-Jorgensen M, Eloranta S, et al.: Duration of red blood cell storage and survival of transfused patients (CME). Transfusion 2010; 50:1185–1195
14. Eikelboom JW, Cook RJ, Liu Y, et al.: Duration of red cell storage before transfusion and in-hospital mortality. Am Heart J 2010; 159:737–43 e1
15. Middelburg RA, van de Watering LM, Briet E, et al.: Storage time of red blood cells and mortality of transfusion recipients. Transfus Med Rev 2013; 27:36–43
16. Wang D, Sun J, Solomon SB, et al.: Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 2012; 52:1184–1195
17. van de Watering L, Biomedical Excellence for Safer Transfusion C: Pitfalls in the current published observational literature on the effects of red blood cell storage. Transfusion 2011; 51:1847–1854
18. Fergusson DA, Hebert P, Hogan DL, et al.: Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. JAMA 2012; 308:1443–1451
19. Hebert PC, Chin-Yee I, Fergusson D, et al.: A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg 2005; 100:1433–1438, table of contents
20. Lacroix J, Hebert PC, Fergusson DA, et al.: Age of transfused blood in critically ill adults. N Engl J Med 2015; 372:1410–1418
21. Bennett-Guerrero E, Stafford-Smith M, Waweru PM, et al.: A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion 2009; 49:1375–1383
22. Kor DJ, Kashyap R, Weiskopf RB, et al.: Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 2012; 185:842–850
23. Schulman CI, Nathe K, Brown M, et al.: Impact of age of transfused blood in the trauma patient. J Trauma 2002; 52:1224–1225
24. Steiner ME, Ness PM, Assmann SF, et al.: Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med 2015; 372:1419–1429
25. Strauss RG, Burmeister LF, Johnson K, et al.: AS-1 red cells for neonatal transfusions: a randomized trial assessing donor exposure and safety. Transfusion 1996; 36:873–878
26. Aubron C, Syres G, Nichol A, et al.: A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients. Transfusion 2012; 52:1196–1202
27. Dhabangi A, Mworozi E, Lubega IR, et al.: The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial. Malar J 2013; 12:55
28. Fernandes da Cunha DH, Nunes Dos Santos AM, Kopelman BI, et al.: Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants. Transfus Med 2005; 15:467–473
29. Heddle NM, Cook RJ, Arnold DM, et al.: The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. Transfusion 2012; 52:1203–1212
30. Alexander PE, Barty R, Fei Y, et al.: Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis. Blood 2016; 127:400–410
31. Heddle NM, Cook RJ, Arnold DM, et al.: Effect of short-term vs. long-term blood storage on mortality after transfusion. N Engl J Med 2016; 375:1937–1945
32. Liberati A, Altman DG, Tetzlaff J, et al.: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009; 339:b2700
33. Higgins JP, Altman DG, Gotzsche PC, et al.: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343:d5928
34. Higgins JP, Altman DG: Assessing risk of bias in included studies; in Higgins JP, Green S (eds): Cochrane Handbook for Systematic Reviews of Interventions. Chichester, The Cochrane Collaboration, 2008:187-241
35. Guyatt G, Busse J: Methods commentary: risk of bias in randomized trials 1. 2000. https://distillercer.com/resources/methodological-resources/risk-of-bias-commentary/ [Last accessed 1 October 2016]
36. Deeks JJ, Altman DG, Bradburn MJ: Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis; in Egger M, Smith GD, Altman DG (eds): Systematic Reviews in Health Care: meta-analysis in context. London, BMJ Publishing Group, 2001: 285–321
37. Deeks JJ, Higgins JP, Altman DG, et al.: Analysing data and undertaking meta-analysis; in Higgins JP (ed.): Cochrane Handbook for systematic Reviews of Interventions. Chichester, The Cochrane Collaboration 2008: 243–296
38. Sterne JA, Egger M: Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 2001; 54:1046–1055
39. Egger M, Davey Smith G, Schneider M, et al.: Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629–634
40. Peters JL, Sutton AJ, Jones DR, et al.: Comparison of two methods to detect publication bias in meta-analysis. JAMA 2006; 295:676–680
41. Guyatt GH, Oxman AD, Vist GE, et al.: GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924–926
42. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, et al.: Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the TOTAL randomized clinical trial. JAMA 2015; 314:2514–2523
43. Sterne JA, Egger M, Moher D, et al.: Addressing Reporting biases; in Higgins JP (ed.): Cochrane Handbook for systematic Reviews of Interventions. Chichester, The Cochrane Collaboration, 2008:297–333
44. Remy KE, Sun J, Wang D, et al.: Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis. Vox Sang 2016; 111:43–54
45. Acker JP, Hansen AL, Kurach JD, et al.: A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing. Transfusion 2014; 54:2534–2543
46. Radwanski K, Cognasse F, Garraud O, et al.: Comparison of apheresis and 24 h RT held red cell concentrates by measurement of storage lesion parameters and neutrophil activating factors during 42-day storage. Transfus Apher Sci 2013; 48:169
47. Heddle NM, Arnold DM, Acker JP, et al.: Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study. Lancet Haematol 2016; 3:e246–e254
48. Carson JL, Guyatt G, Heddle NM, et al.: Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 2016; 316:2025–2035