Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Organic Process Research and Development

Volumn 21, Issue 2, 2017, Pages 195-199

  Hugentobler, Katharina G ^a   Rasparini, Marcello ^b   Thompson, Lisa A ^c   Jolley, Katherine E ^c   Blacker, A John ^c   Turner, Nicholas J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b a company of the Mofin Alce Group   (Italy)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

batch reactor; enzyme catalysis; flow chemistry; Thermomyces lanuginosus lipase; ticagrelor

Indexed keywords

BATCH REACTORS; ESTERS;

BATCH OPERATION; BUILDING BLOCKES; ENZYME CATALYSIS; FLOW CHEMISTRY; FLOW PROCESS; LIPASE-CATALYZED RESOLUTION; THERMOMYCES LANUGINOSUS LIPASE; TICAGRELOR;

CATALYSIS;

EID: 85013158095     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/acs.oprd.6b00346     Document Type: Article

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