The effectiveness and safety of dual antiplatelet therapy in ischemic cerebrovascular disease with intracranial and extracranial arteriostenosis in Chinese patients

Medicine (United States)

Volumn 96, Issue 1, 2017, Pages

  Zuo, Feng Tong ^a   Liu, Hui ^a   Wu, Hui Jun ^a   Su, Na ^b   Liu, Jie Qiong ^a   Dong, Ai Qin ^a  

^a CANGZHOU CENTRAL HOSPITAL   (China)

^b Cangzhou Peace Hospital   (China)

Author keywords

Aspirin; Clopidogrel sulfate; Intracranial arteriostenosis; Ischemic cerebrovascular disease; Stroke

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

ADULT; ARTERY OCCLUSION; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR MORTALITY; CHINESE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DUAL ANTIPLATELET THERAPY; EPISTAXIS; EXTRACRANIAL ARTERIOSTENOSIS; FEMALE; GASTROINTESTINAL HEMORRHAGE; GINGIVA BLEEDING; HUMAN; INTRACRANIAL ARTERIOSTENOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SECONDARY PREVENTION; SUBCUTANEOUS HEMORRHAGE; TRANSIENT ISCHEMIC ATTACK; ANALOGS AND DERIVATIVES; ARTERIAL OCCLUSIVE DISEASES; CHEMICALLY INDUCED; CHINA; COMBINATION DRUG THERAPY; COMPLICATION; DOSE RESPONSE; HEMORRHAGE; INTRACRANIAL ARTERIAL DISEASES; MIDDLE AGED; PROCEDURES; STROKE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ARTERIAL OCCLUSIVE DISEASES; ASPIRIN; CHINA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HEMORRHAGE; HUMANS; INTRACRANIAL ARTERIAL DISEASES; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; SECONDARY PREVENTION; STROKE; SURVIVAL ANALYSIS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 85013113423     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000005497     Document Type: Article

References (32)

1. Heron M. Deaths leading causes for 2007. Natl Vital Stat Rep 2011; 59:836-45.
2. Zhao D, Liu J, Wang W, et al. Epidemiological transition of stroke in China twenty-one-year observational study from the Sino-MONICABeijing Project. Stroke 2008;39:1668-74.
3. Ovbiagele B, Cruz-Flores S, Lynn MJ, et al. Early stroke risk after transient ischemic attack among individuals with symptomatic intracranial artery stenosis. Arch Neurol 2008;65:733-7.
4. Kasner SE, Chimowitz MI, Lynn MJ, et al. Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation 2006;113:555-63.
5. Wityk R, Lehman D, Klag M, et al. Race and sex differences in the distribution of cerebral atherosclerosis. Stroke 1996;27:1974-80.
6. Feldmann E, Daneault N, Kwan E, et al. Chinese-white differences in the distribution of occlusive cerebrovascular disease. Neurology 1990;40: 1540-1540.
7. Wong LK. Global burden of intracranial atherosclerosis. Int J Stroke 2006;1:158-9.
8. Sacco RL, Kargman D, Gu Q, et al. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction the Northern Manhattan Stroke study. Stroke 1995;26:14-20.
9. Group EIBSFailure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. N Engl J Med 1985;313:1191-200.
10. Hopkins LN, Budny JL. Complications of intracranial bypass for vertebrobasilar insufficiency. J Neurosurg 1989;70:207-11.
11. Collaboration ATCollaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
12. Committee CS. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348: 1329-39.
13. Geeganage CM. Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials. Stroke 2012;43: 1058-66.
14. Wong KL. Is the measurement of cerebral microembolic signals a good surrogate marker for evaluating the efficacy of antiplatelet agents in the prevention of stroke? Eur Neurol 2005;53:132-9.
15. Markus HS. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation 2005;111: 2233-40.
16. Wong KS, Chen C, Fu J, et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, openlabel, blinded-endpoint trial. Lancet Neurol 2010;9:489-97.
17. Bhatt DL, Fox KA, Hacke W, et al. CHARISMA InvestigatorsClopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006;354:1706-17.
18. Benavente OR, Hart RG, Mcclure LA, et al. SPS3 InvestigatorsEffects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med 2012;367:817-25.
19. Yang QD, Niu Q, Zhou YH, et al. Incidence of cerebral hemorrhage in the Changsha community. Cerebrovasc Dis 2004;17:303-13.
20. Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004;364:331-7.
21. Kennedy J, Hill MD, Ryckborst KJ, et al. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007;6:961-9.
22. Asano T, Kobayashi Y, Fukushima K, et al. Safety and efficacy of lowdose clopidogrel in Japanese patients undergoing coronary stenting preliminary 30-day clinical outcome. Circ J 2008;72:1707-8.
23. Halkes PH, van Gijn J, Kappelle LJ, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 2006;367:1665-73.
24. Meyer DM, Albright KC, Allison TA, et al. LOAD: a pilot study of the safety of loading of aspirin and clopidogrel in acute ischemic stroke and transient ischemic attack. J Stroke Cerebrovasc Dis 2008;17:26-9.
25. Rahme RJ, Aoun SG, Batjer HH, et al. SAMMPRIS: end of intracranial stenting for atherosclerosis or back to the drawing board? Neurosurgery 2011;69:N16-8.
26. Kasner SE, Lynn MJ, Chimowitz MI, et al. Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID. Neurology 2006;67:1275-8.
27. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11-9.
28. Markus HS, Droste DW, Kaps M. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection. Circulation 2005;111:2233-40. 2005.
29. Wu CM, McLaughlin K, Lorenzetti DL, et al. Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis. Arch Intern Med 2007;167:2417-22.
30. Wang X, Lin WH, Zhao YD, et al. The effectiveness of dual antiplatelet treatment in acute ischemic stroke patients with intracranial arterial stenosis: a subgroup analysis of CLAIR study. Int J Stroke 2013;8:663-8.
31. Sacco RL, Diener HC, Yusuf S, et al. PRoFESS Study GroupAspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med 2008;359:1238-51.
32. Savi P, Pereillo JM, Uzabiaga MF, et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost 2000;84:891-6.