Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis

Open Biology

Volumn 6, Issue 3, 2016, Pages

  Hathaway, Lucy J ^a   Grandgirard, Denis ^a   Valente, Luca G ^a   Täuber, Martin G ^a   Leib, Stephen L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Capsule; Meningitis; Serotype; Streptococcus pneumoniae

Indexed keywords

CYTOKINE;

ANIMAL; BACTERIAL CAPSULE; BRAIN; CEREBROSPINAL FLUID; DISEASE MODEL; GENETICS; IMMUNOLOGY; MICROBIOLOGY; NASOPHARYNX; NEWBORN; PATHOLOGY; PNEUMOCOCCAL MENINGITIS; RAT; SEROTYPE; SEVERITY OF ILLNESS INDEX; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANIMALS, NEWBORN; BACTERIAL CAPSULES; BRAIN; CYTOKINES; DISEASE MODELS, ANIMAL; MENINGITIS, PNEUMOCOCCAL; NASOPHARYNX; RATS; SEROGROUP; SEVERITY OF ILLNESS INDEX; STREPTOCOCCUS PNEUMONIAE;

EID: 85013076892     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.150269     Document Type: Article

References (31)

1. O'Brien K et al. 2009 Burdern of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374, 893-902. (doi:10.1016/S0140-6736(09)61204-6)
2. Grimwood K, Anderson V, Bond L, Catroppa C, Hore R, Keir E, Nolan T, Roberton D. 1995 Adverse outcomes of bacterial meningitis in school-age survivors. Pediatrics 95, 646-656.
3. Bellac C, Coimbra R, Christen S, Leib S. 2010 Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis. J. Neuropathol. Exp. Neurol. 69, 1096-1104. (doi:10.1097/NEN.0b013e3181f7e7e9)
4. Koedel U, Scheld W, Pfister H-W. 2002 Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect. Dis. 2, 721-736. (doi:10.1016/S1473-3099(02)00450-4)
5. Thigpen M et al. 2011 Bacterial meningitis in the United States, 1998-2007. N. Engl. J. Med. 364, 2016-2025. (doi:10.1056/NEJMoa1005384)
6. Bentley S et al. 2006 Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes. PLoS Genet. 2, e31. (doi:10.1371/journal.pgen.0020031)
7. Brueggemann A, Peto T, Crook D, Butler J, Kristinsson K, Spratt B. 2004 Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children. J. Infect. Dis. 190, 1203-1211. (doi:10.1086/423820)
8. Kronenberg A, Zucs P, Droz S, Muhlemann K. 2006 Distribution and invasiveness of Streptococcus pneumoniae serotypes in Switzerland, a country with low antibiotic selection pressure, from 2001 to 2004. J. Clin. Microbiol. 44, 2032-2038. (doi:10.1128/JCM.00275-06)
9. Weinberger D, Trzcinski K, Lu Y, Bogaert D, Brandes A, Galagan J, Anderson P, Malley R, Lipsitch M. 2009 Pneumococcal capsular polysaccharide structure predicts serotype prevalence. PLoS Pathog. 5, e1000476. (doi:10.1371/journal.ppat.1000476)
10. Jansen A, Rodenburg G, Ende A, Alphen L, Veenhoven R, Spanjaard L, Sanders E, Hak E. 2009 Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics and outcome. Clin. Infect. Dis. 49, e23-e29. (doi:10.1086/600045)
11. Sjöström K, Spindler C, Ortqvist A, Kalin M, Sandgren A, Kühlmann-Berenzon S, Henriques-Normark B. 2006 Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen. Clin. Infect. Dis. 42, 451-459. (doi:10.1086/499242)
12. Täuber M, Burroughs M, Niemöller U, Kuster H, Borschberg U, Tuomanen E. 1991 Differences of pathophysiology in experimental meningitis caused by three strains of Streptococcus pneumoniae. J. Infect. Dis. 163, 806-811. (doi:10.1093/infdis/163.4.806)
13. Tuomanen E, Tomasz A, Hengstler B, Zak O. 1985 The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis. J. Infect. Dis. 151, 535-540. (doi:10.1093/infdis/151.3.535)
14. Ribes S, Taberner F, Cabellos C, Tubau F, Ardanuy C, Gerber J, Linares J, Nau R, Gudiol F. 2008 Contribution of capsular and clonal types and β-lactam resistance to the severity of experimental pneumococcal meningitis. Microb. Infect. 10, 129-134. (doi:10.1016/j.micinf.2007.10.014)
15. Hathaway L et al. 2012 Capsule type of Streptococcus pneumoniae determines growth phenotype. PLoS Pathog. 8, e1002574. (doi:10.1371/journal.ppat.1002574)
16. Sanchez C, Hinojosa C, Shivshankar P, Hyams C, Camberlein E, Brown J, Orihuela C. 2011 Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PLoS ONE 6, e26587. (doi:10.1371/journal.pone.0026587)
17. Hu F et al. 2012 In vivo capsular switch in Streptococcus pneumoniae: analysis by whole genome sequencing. PLoS ONE 7, e47983. (doi:10.1371/journal.pone.0047983)
18. Sabharwal V, Stevenson A, Figueira M, Orthopoulos G, Trzcinski K, Pelton S. 2014 Capsular switching as a strategy to increase pneumococcal viruence in experimental otitis media model. Microb. Infect. 16, 292-299. (doi:10.1016/j.micinf.2013.12.002)
19. Muhlemann K, Matter H, Tauber M, Bodmer T. 2003 Nationwide surveillance of nasopharyngeal Streptococcus pneumoniae isolates from children with respiratory infection, Switzerland, 1998-1999. J. Infect. Dis. 187, 589-596. (doi:10.1086/367994)
20. Sung C, Li H, Claverys J, Morrison D. 2001 An rpsL cassette, Janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl. Environ. Microbiol. 67, 5190-5196. (doi:10.1128/AEM.67.11.5190-5196.2001)
21. Trzcinski K, Thompson C, Lipsitch M. 2003 Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4. Appl. Environ. Microbiol. 69, 7364-7370. (doi:10.1128/AEM.69.12.7364-7370.2003)
22. Liechti F, Grandgirard D, Leppert D, Leib S. 2014 Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infect. Immun. 82, 1710-1718. (doi:10.1128/IAI.00073-14)
23. Liechti F, Grandgirard D, Leib S. 2015 The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. Neuroscience 297, 89-94. (doi:10.1016/j.neuroscience.2015.03.056)
24. Perdomo-Celis F, Torres M, Ostos H, Gutierrez-Achury J, Molano V, Duran L, Gonzalez G, Narvaez C. 2015 Patterns of local and systemic cytokines in bacterial meningitis and its relation with severity and longterm sequelae. Biomark. Insights 10, 125-131.
25. Grandgirard D, Gaumann R, Coulibaly B, Dangy J-P, Sie A, Junghanss T, Schudel H, Pluschke G, Leib S. 2013 The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis. Mediat. Inflamm. 2013, 312476. (doi:10.1155/2013/312476)
26. Too L, Ball H, McGregor I, Hunt N. 2014 The proinflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain Behav. Immun. 40, 252-268. (doi:10.1016/j.bbi.2014.02.020)
27. Pettini E, Fiorino F, Cuppone A, Iannelli F, Medaglini D, Pozzi G. 2015 Interferon-gamma from brain leukocytes enhances meningitis by type 4 Streptococcus pneumoniae. Front. Microbiol. 6, 1340. (doi:10.3389/fmicb.2015.01340)
28. Hanage W, Kaijalainen T, Saukkoriipi A, Rickcord J, Spratt B. 2006 A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus. J. Clin. Microbiol. 44, 743-749. (doi:10.1128/JCM.44.3.743-749.2006)
29. Dalia A, Weiser J. 2011 Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody. Cell Host Microb. 10, 486-496. (doi:10.1016/j.chom.2011.09.009)
30. Varvio S, Auranen K, Arjas E, Makela P. 2009 Evolution of the capsular regulatory genes in Strepocococcus pneumoniae. J. Infect. Dis. 200, 1144-1151. (doi:10.1086/605651)
31. Geno K, Gilbert G, Song J, Skovsted I, Klugman K, Jones C, Konradsen H, Nahm M. 2015 Pneumococcal capsules and their types: past, present and future. Clin. Microbiol. Rev. 28, 871-899. (doi:10.1128/CMR.00024-15)