Cigarette smoking induces changes in airway epithelial expression of genes associated with monogenic lung disorders

American Journal of Respiratory and Critical Care Medicine

Volumn 193, Issue 2, 2016, Pages 215-217

  Tilley, Ann E ^a   Staudt, Michelle R ^a   Salit, Jacqueline ^a   Van De Graaf, Benjamin ^a   Strulovici Barel, Yael ^a   Kaner, Robert J ^a   Vincent, Thomas ^a   Agosto Perez, Francisco ^a   Mezey, Jason G ^a,b   Raby, Benjamin A ^c   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Cornell University ^*  (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MUCIN 5B;

ARMC4 GENE; BMRP2 GENE; BRONCHIECTASIS; CHST14 GENE; CILIARY DYSKINESIA; COL1A1 GENE; COL5A1 GENE; COL5A2 GENE; CONTROLLED STUDY; CUTIS LAXA; DNAAF2 GENE; DNAH5 GENE; DOWN REGULATION; EFEMP2 GENE; EHLERS DANLOS SYNDROME; ELMOD2 GENE; FBLN5 GENE; FKBP14 GENE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; HEATR2 GENE; HUMAN; HYPER IGE SYNDROME; HYPOVENTILATION; LETTER; LOEY DIETZ SYNDROME; LUNG DISEASE; LUNG EMPHYSEMA; LUNG FIBROSIS; LYMPHANGIOLEIOMYOMATOSIS; MARFAN SYNDROME; MONOGENIC DISORDER; OCULAR ALBINISM; OFD1 GENE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; PULMONARY VASCULAR DISEASE; RESPIRATORY EPITHELIUM; RNA SEQUENCE; SERPINA1 GENE; SMAD3 GENE; SMOKING; TGFBR2 GENE; TNXB GENE; TOTAL LUNG CAPACITY; UPREGULATION; ADVERSE EFFECTS; BREATHING; DRUG EFFECTS; GENETICS; MUTATION; PATHOPHYSIOLOGY; PHENOTYPE;

GENE EXPRESSION; HUMANS; LUNG DISEASES; MUTATION; PHENOTYPE; RESPIRATION; SMOKING;

EID: 85012935652     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/RCCM.201412-2290LE     Document Type: Letter

References (13)

1. Crystal RG, Brantly ML, Hubbard RC, Curiel DT, States DJ, Holmes MD; Clinical Consequences and Strategies for Therapy. The alpha 1-antitrypsin gene and its mutations: clinical consequences and strategies for therapy Chest 1989;95:196-208.
2. Alberts WM. Eosinophilic interstitial lung disease. Curr Opin Pulm Med 2004;10:419-424.
3. Donabedian H, Gallin JI. The hyperimmunoglobulin E recurrent-infection (Job's) syndrome: a review of the NIH experience and the literature. Medicine (Baltimore) 1983;62:195-208.
4. Kitaichi M, Nishimura K, Itoh H, Izumi T. Pulmonary lymphangioleiomyomatosis a report of 46 patients including a clinicopathologic study of prognostic factors. Am J Respir Crit Care Med 1995;151: 527-533.
5. Pierson DM, Ionescu D, Qing G, Yonan AM, Parkinson K, Colby TC, Leslie K. Pulmonary fibrosis in Hermansky-Pudlak syndrome: a case report and review. Respiration 2006;73:382-395.
6. Stämpfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 2009;9:377-384.
7. Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol 2014;76:493-513.
8. Gadek JE, Fells GA, Crystal RG. Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans. Science 1979;206:1315-1316.
9. Raju SV, Jackson PL, Courville CA, McNicholas CM, Sloane PA, Sabbatini G, Tidwell S, Tang LP, Liu B, Fortenberry JA, et al. Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am J Respir Crit Care Med 2013;188: 1321-1330.
10. Raby BA, Toledo D, Yonker LM, Henske E, Kinane TB. A multidisciplinary approach to the evaluation and care of patients with inherited lung disease [abstract]. Am J Respir Crit Care Med 2014;189:A2774.
11. Harvey BG, Heguy A, Leopold PL, Carolan BJ, Ferris B, Crystal RG. Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med (Berl) 2007;85:39-53.
12. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, et al; Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532-555.
13. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, et al.; COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011;364:897-906.