Molecular markers of metastasis in breast cancer: Current understanding and prospects for novel diagnosis and prevention

Expert Reviews in Molecular Medicine

Volumn 3, Issue 22, 2001, Pages 1-14

  Braun, Stephan ^a   Harbeck, Nadia ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85012441028     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399401003520     Document Type: Article

References (69)

1. Black, R.J. et al. (1997) Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990. Eur J Cancer 33, 1075–1107, PubMed ID: 98022056
2. Pantel, K. (1996) Detection of minimal disease in patients with solid tumors. J Hematother 5, 359–367, PubMed ID: 97031805
3. Fidler, I.J. and Radinsky, R. (1990) Genetic control of cancer metastasis. J Natl Cancer Inst 82, 166–168, PubMed ID: 90112466
4. Liotta, L.A., Steeg, P.S. and Stetler-Stevenson, W.G. (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64, 327–336, PubMed ID: 91105850
5. Schlimok, G. et al. (1987) Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17–1A monoclonal antibodies. Proc Natl Acad Sci U S A 84, 8672–8676, PubMed ID: 88068651
6. Mansi, J.L. et al. (1987) Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases. Br Med J (Clin Res Ed) 295, 1093–1096, PubMed ID: 88078977
7. Ridell, B. and Landys, K. (1979) Incidence and histopathology of metastases of mammary carcinoma in biopsies from the posterior iliac crest. Cancer 44, 1782–1788, PubMed ID: 80044603
8. Redding, W.H. et al. (1983) Detection of micrometastases in patients with primary breast cancer. Lancet 2, 1271–1274, PubMed ID: 84066777
9. Schlimok, G. et al. (1990) Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization, and prognostic significance. J Clin Oncol 8, 831–837, PubMed ID: 90237837
10. Pantel, K. et al. (1994) Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. J Hematother 3, 165–173, PubMed ID: 95128653
11. Taylor-Papadimitriou, J. et al. (1985) Monoclonal antibodies to epithelial membrane antigen and human milk fat globule mucin define epitopes expressed on other molecules. Lancet 1, 458, PubMed ID: 85136524
12. Heyderman, E. and Macartney, J.C. (1985) Epithelial membrane antigen and lymphoid cells. Lancet 1, 109
13. Delsol, G. et al. (1984) Human lymphoid cells express epithelial membrane antigen. Implications for diagnosis of human neoplasms. Lancet 2, 1124–1129, PubMed ID: 85059810
14. Cordell, J.L. et al. (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32, 219–229, PubMed ID: 84112646
15. Braun, S. et al. (2001) Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. J Clin Oncol 19, 1468–1475, PubMed ID: 21142879
16. Gerber, B. et al. (2001) Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol 19, 960–971, PubMed ID: 21104152
17. Braun, S. et al. (2000) Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 342, 525–533, PubMed ID: 20132301
18. Mansi, J.L. et al. (1999) Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 354, 197–202, PubMed ID: 99347669
19. Landys, K. et al. (1998) Prognostic value of bone marrow biopsy in operable breast cancer patients at the time of initial diagnosis: Results of a 20-year median follow-up. Breast Cancer Res Treat 49, 27–33, PubMed ID: 98357981
20. Diel, I.J. et al. (1996) Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst 88, 1652–1658, PubMed ID: 97085469
21. Harbeck, N. et al. (1994) Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up. Br J Cancer 69, 566–571, PubMed ID: 94168969
22. Schlimok, G. et al. (1992) Prognostic significance of disseminated tumor cells detected in bone marrow of patients with breast and colorectal cancer: a multivariate analysis. Proc Am Soc Clin Oncol 11, 102 (Abstract)
23. Cote, R.J. et al. (1991) Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 9, 1749–1756, PubMed ID: 92014147
24. Untch, M. et al. (1999) Detection of cytokeratin 18-positive cells in bone marrow of breast cancer patients: no prediction of bad outcome. Proc Am Soc Clin Oncol 18, 639a (Abstract 2472)
25. Gogas, H. et al. (1997) Can the presence of micrometastases in primary breast cancer predict outcome? Long term (median 12.5 yrs) follow-up. Proc Am Soc Clin Oncol 16, 153a (Abstract 537)
26. Funke, I. et al. (1996) Comparative analyses of bone marrow micrometastases in breast and gastric cancer. Int J Cancer 65, 755–761, PubMed ID: 96200258
27. Singletary, S.E. et al. (1991) Detection of micrometastatic tumor cells in bone marrow of breast carcinoma patients. J Surg Oncol 47, 32–36, PubMed ID: 91218415
28. Courtemanche, D.J. et al. (1991) Monoclonal antibody LICR-LON-M8 does not predict the outcome of operable breast cancer. Can J Surg 34, 21–26, PubMed ID: 91145821
29. Mathieu, M.C. et al. (1990) Immunohistochemical staining of bone marrow biopsies for detection of occult metastasis in breast cancer. Breast Cancer Res Treat 15, 21–26, PubMed ID: 90227255
30. Salvadori, B. et al. (1990) Use of monoclonal antibody MBr1 to detect micrometastases in bone marrow specimens of breast cancer patients. Eur J Cancer 26, 865–867, PubMed ID: 91026317
31. Kirk, S.J. et al. (1990) The prognostic significance of marrow micrometastases in women with early breast cancer. Eur J Surg Oncol 16, 481–485, PubMed ID: 91071461
32. Porro, G. et al. (1988) Monoclonal antibody detection of carcinoma cells in bone marrow biopsy specimens from breast cancer patients. Cancer 61, 2407–2411, PubMed ID: 88210216
33. Osborne, M.P. and Rosen, P.P. (1994) Detection and management of bone marrow micrometastases in breast cancer. Oncology (Huntingt) 8, 25–31; discussion 35–26, 39–42, PubMed ID: 95033953
34. Brugger, W. et al. (1999) Expression of MUC-1 epitopes on normal bone marrow: implications for the detection of micrometastatic tumor cells. J Clin Oncol 17, 1535–1544, PubMed ID: 99265710
35. Braun, S. et al. (1998) Re: Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J Natl Cancer Inst 90, 1099–1101, PubMed ID: 98336003
36. Doglioni, C. et al. (1990) Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study. Virchows Arch A Pathol Anat Histopathol 416, 479–490, PubMed ID: 90246710
37. Mueller, P. et al. (1998) Low frequency epithelial cells in bone marrow aspirates from prostate carcinoma patients are cytogenetically aberrant. Cancer 83, 538–546, PubMed ID: 98352857
38. Klein, C.A. et al. (1999) Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc Natl Acad Sci U S A 96, 4494–4499, PubMed ID: 99218308
39. Zippelius, A. et al. (1997) Limitations of reverse- transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow. J Clin Oncol 15, 2701–2708, PubMed ID: 97358747
40. de Graaf, H. et al. (1997) Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein gene EGP-2. Int J Cancer 72, 191–196, PubMed ID: 97355761
41. Krismann, M. et al. (1995) Low specificity of cytokeratin 19 reverse transcriptase-polymerase chain reaction analyses for detection of hematogenous lung cancer dissemination. J Clin Oncol 13, 2769–2775, PubMed ID: 96067236
42. Schoenfeld, A. et al. (1994) Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction. Cancer Res 54, 2986–2990, PubMed ID: 94243819
43. Traweek, S.T., Liu, J. and Battifora, H. (1993) Keratin gene expression in non-epithelial tissues. Detection with polymerase chain reaction. Am J Pathol 142, 1111–1118, PubMed ID: 93235940
44. Bostick, P.J. et al. (1998) Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients. J Clin Oncol 16, 2632–2640, PubMed ID: 98368411
45. Gerhard, M. et al. (1994) Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 12, 725–729, PubMed ID: 94201788
46. Slade, M.J. et al. (1999) Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. J Clin Oncol 17, 870–879, PubMed ID: 99168836
47. Bauer, K.D. et al. (2000) Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging. Clin Cancer Res 6, 3552–3559, PubMed ID: 20452372
48. Kamby, C. et al. (1987) The presence of tumor cells in bone marrow at the time of first recurrence of breast cancer. Cancer 60, 1306–1312, PubMed ID: 87301246
49. Berger, U. et al. (1988) The relationship between micrometastases in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis. Am J Clin Pathol 90, 1–6, PubMed ID: 88267166
50. Cote, R.J. et al. (1988) Monoclonal antibodies detect occult breast carcinoma metastases in the bone marrow of patients with early stage disease. Am J Surg Pathol 12, 333–340, PubMed ID: 88207695
51. Molino, A. et al. (1997) Bone marrow micrometastases in 109 breast cancer patients: correlations with clinical and pathological features and prognosis. Breast Cancer Res Treat 42, 23–30, PubMed ID: 97205799
52. Mansi, J.L. et al. (1991) Bone marrow micrometastases in primary breast cancer: prognostic significance after 6 years' follow-up. Eur J Cancer 27, 1552–1555, PubMed ID: 92144222
53. Funke, I. and Schraut, W. (1998) Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. J Clin Oncol 16, 557–566, PubMed ID: 98129243
54. Hayes, D.F. et al. (1996) Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 88, 1456–1466, PubMed ID: 96438660
55. Braun, S. et al. (2000) Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 18, 80–86, PubMed ID: 20090975
56. Hempel, D. et al. (1997) Adoptive immunotherapy with monoclonal antibody 17–1A to reduce minimal residual disease in breast cancer patients after high-dose chemotherapy. Blood 90, 379B (Abstract 4454)
57. Hohaus, S. et al. (1996) Persistence of isolated tumor cells in patients with breast cancer after sequential high-dose therapy with peripheral blood stem cell transplantation. Blood 88, 128A (Abstract 501)
58. Schlimok, G. et al. (1995) Reduction of metastatic carcinoma cells in bone marrow by intravenously administered monoclonal antibody: towards a novel surrogate test to monitor adjuvant therapies of solid tumours. Eur J Cancer 31A, 1799–1803, PubMed ID: 96138100
59. Scholz, D. et al. (1991) Biological activity in the human system of isotype variants of oligosaccharide-Y-specific murine monoclonal antibodies. Cancer Immunol Immunother 33, 153–157, PubMed ID: 91256204
60. Braun, S. et al. (1999) Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res 5, 3999–4004, PubMed ID: 20096192
61. Braun, S. et al. (1999) Tumor-antigen heterogeneity of disseminated breast cancer cells: implications for immunotherapy of minimal residual disease. Int J Cancer 84, 1–5, PubMed ID: 99140722
62. Baselga, J. et al. (1996) Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 14, 737–744, PubMed ID: 96186197
63. Slamon, J.D. et al. (1998) Addition of HerceptinTM (humanized anti-HER2 antibody) to first-line chemotherapy for HER2 overexpressing metastatic bresast cancer markedly increases anti-cancer activity: a randomized, multinational controlled phase III trial. Proc Am Soc Clin Oncol 17, 98 (Abstract 377)
64. Jain, R.K. (1990) Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res 50, 814s-819s, PubMed ID: 90124272
65. Riethmuller, G. and Johnson, J.P. (1992) Monoclonal antibodies in the detection and therapy of micrometastatic epithelial cancers. Curr Opin Immunol 4, 647–655, PubMed ID: 93039805
66. Otte, M. et al. (2000) Immunomagnetic enrichment of disseminated tumor cells from bone marrow of carcinoma patients. Proc Am Assoc Cancer Res 41, 687 (Abstract 2475)
67. Braun, S. and Pantel, K. (1996) Biological characteristics of micrometastatic carcinoma cells. In Attempts to Understand Metastasis Formation (213/I) (Günthert, U. and Berchmeier, W., eds), pp. 163–177, Springer, Berlin - New York - Tokyo
68. Pantel, K. et al. (1993) Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst 85, 1419–1424, PubMed ID: 93353545
69. Pantel, K. et al. (1995) Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines. J Natl Cancer Inst 87, 1162–1168, PubMed ID: 95404634