Should all patients with sepsis receive anticoagulation? Yes

Intensive Care Medicine

Volumn 43, Issue 3, 2017, Pages 452-454

  Meziani, Ferhat ^a,b   Gando, Satoshi ^c   Vincent, Jean Louis ^d  

^a HÔPITAL CIVIL   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; ANTITHROMBIN; BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 10A; DROTRECOGIN; HEPARIN; HEPARIN ANTAGONIST; PROTEIN C; PROTEINASE; THROMBIN; THROMBOMODULIN; TISSUE FACTOR PATHWAY INHIBITOR; FIBRINOLYTIC AGENT;

ANTICOAGULANT THERAPY; ANTIINFLAMMATORY ACTIVITY; CELL PROTECTION; EDITORIAL; HOST RESISTANCE; HUMAN; INTERNATIONAL NORMALIZED RATIO; META ANALYSIS (TOPIC); MICROCIRCULATION; MORTALITY; NONHUMAN; OPTIMAL DRUG DOSE; PHASE 2 CLINICAL TRIAL (TOPIC); SEPSIS; SEPTIC SHOCK; TREATMENT DURATION; BLOOD CLOTTING; CLINICAL TRIAL (TOPIC); DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFECT; FIBRINOLYTIC THERAPY; PRACTICE GUIDELINE;

ANTICOAGULANTS; BLOOD COAGULATION; CLINICAL TRIALS AS TOPIC; DISSEMINATED INTRAVASCULAR COAGULATION; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; PRACTICE GUIDELINES AS TOPIC; SHOCK, SEPTIC; THROMBOLYTIC THERAPY; THROMBOMODULIN;

EID: 85012308656     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-016-4621-z     Document Type: Editorial

References (17)

1. Gando S, Meziani F, Levi M (2016) What’s new in the diagnostic criteria of disseminated intravascular coagulation? Intensive Care Med 42(6):1062–1064
2. Fourrier F (2012) Severe sepsis, coagulation, and fibrinolysis: dead end or one way? Crit Care Med 40:2704–2708
3. Engelmann B, Massberg S (2013) Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol 13:34–45
4. Levi M (2015) Recombinant soluble thrombomodulin: coagulation takes another chance to reduce sepsis mortality. J Thromb Haemost 13:505–507
5. Fourrier F, Jourdain M, Tournois A, Caron C, Goudemand J, Chopin C (1995) Coagulation inhibitor substitution during sepsis. Intensive Care Med 21(Suppl 2):S264–S268
6. Wang C, Chi C, Guo L, Wang X, Guo L, Sun J, Sun B, Liu S, Chang X, Li E (2014) Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis. Crit Care 18(5):563
7. Gando S, Saitoh D, Ishikura H, Ueyama M, Otomo Y, Oda S, Kushimoto S, Tanjoh K, Mayumi T, Ikeda T, Iba T, Eguchi Y, Okamoto K, Ogura H, Koseki K, Sakamoto Y, Takayama Y, Shirai K, Takasu O, Inoue Y, Mashiko K, Tsubota T, Endo S, Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Study Group for the JDICAT (2013) A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Crit Care 17(6):R297
8. Yamakawa K, Aihara M, Ogura H, Yuhara H, Hamasaki T, Shimazu T (2015) Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis. J Thromb Haemost 13(4):508–519
9. Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, Light B, Spapen H, Stone J, Seibert A, Peckelsen C, De Deyne C, Postier R, Pettila V, Artigas A, Percell SR, Shu V, Zwingelstein C, Tobias J, Poole L, Stolzenbach JC, Creasey AA, Group OTS (2003) Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290:238–247
10. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD, PROWESS-SHOCK Study Group (2012) Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366(22):2055–2064
11. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:580–637
12. Umemura Y, Yamakawa K (2016) Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials. J Thromb Haemost 14(3):518–530
13. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344(10):699–709
14. Dhainaut JF, Yan SB, Joyce DE, Pettila V, Basson B, Brandt JT, Sundin DP, Levi M (2004) Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost 2(11):1924–1933
15. Iba T, Di Nisio M, Thachil J, Wada H, Asakura H, Sato K, Kitamura N, Saitoh D (2016) Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. Crit Care 20:287
16. Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, Fareed J, Talwar D, Tsuruta K, Gorelick KJ, Osawa Y, Kaul I (2013) A randomized, double-blind, placebo-controlled, phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 41:2069–2079
17. Delabranche X, Quenot J, Lavigne T, Mercier E, François B, Severac F, Grunebaum L, Mehdi M, Zobairi F, Toti F, Meziani F, Boisramé-Helms J, Clinical Research in Intensive Care and Sepsis Network (2016) Early detection of disseminated intravascular coagulation during septic shock: a multicentre prospective study. Crit Care Med 44:e930–e939