Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury

Biomaterials

Volumn 123, Issue , 2017, Pages 63-76

  Slotkin, Jonathan R ^a   Pritchard, Christopher D ^b   Luque, Brian ^c   Ye, Janice ^c   Layer, Richard T ^c   Lawrence, Mathew S ^d   O'Shea, Timothy M ^b,e   Roy, Roland R ^f   Zhong, Hui ^f   Vollenweider, Isabel ^g   Edgerton, V Reggie ^f   Courtine, Grégoire ^g   Woodard, Eric J ^h   Langer, Robert ^b,e  

^a GEISINGER MEDICAL CENTER   (United States)

^b Massachusetts Institute of Technology   (United States)

^c InVivo Therapeutics Corporation   (United States)

^d RxGen Inc   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g EPFL   (Switzerland)

^h NEW ENGLAND BAPTIST HOSPITAL   (United States)

Author keywords

Functional improvement; Polymeric scaffolds; Primates; Spinal cord injury; Tissue engineering; Tissue remodeling

Indexed keywords

AMINO ACIDS; ANIMALS; BIOCOMPATIBILITY; BLOCK COPOLYMERS; ENZYME INHIBITION; MAMMALS; PATIENT REHABILITATION; POLYMERS; PROTEINS; RECOVERY; SAFETY ENGINEERING; TISSUE; TISSUE ENGINEERING;

FUNCTIONAL IMPROVEMENTS; POLYMERIC SCAFFOLD; PRIMATES; SPINAL CORD INJURIES (SCI); TISSUE REMODELING;

SCAFFOLDS (BIOLOGY);

GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOLIC ACID; POLYLYSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIODEGRADABILITY; CHLOROCEBUS SABAEUS; CONTROLLED STUDY; ELECTROMYOGRAPHY; FUNCTIONAL ASSESSMENT; KINEMATICS; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MUSCLE CONTRACTION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; TISSUE ENGINEERING; TISSUE SCAFFOLD; ANIMAL; BIODEGRADABLE IMPLANT; CHLOROCEBUS AETHIOPS; CONVALESCENCE; DEVICE FAILURE ANALYSIS; DEVICES; EQUIPMENT DESIGN; HUMAN; NEUROLOGIC GAIT DISORDER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD REGENERATION; TISSUE REGENERATION;

ABSORBABLE IMPLANTS; ANIMALS; CERCOPITHECUS AETHIOPS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GAIT DISORDERS, NEUROLOGIC; GUIDED TISSUE REGENERATION; HUMANS; MALE; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; SPINAL CORD REGENERATION; TISSUE SCAFFOLDS;

EID: 85012307080     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2017.01.024     Document Type: Article

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