메뉴 건너뛰기




Volumn 8, Issue JAN, 2017, Pages

Hsp65-producing Lactococcus lactis prevents inflammatory intestinal disease in mice by IL-10- and TLR2-dependent pathways

Author keywords

Colitis; DSS; Hsp; IL 10; Lactococcus lactis; TLR2

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; XYLOSE; ZYMOSAN;

EID: 85012183969     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00030     Document Type: Article
Times cited : (40)

References (66)
  • 1
    • 84859808080 scopus 로고    scopus 로고
    • Oral tolerance to food protein
    • Pabst O, Mowat AM. Oral tolerance to food protein. Mucosal Immunol (2012) 5(3):232-9. doi: 10.1038/mi.2012.4
    • (2012) Mucosal Immunol , vol.5 , Issue.3 , pp. 232-239
    • Pabst, O.1    Mowat, A.M.2
  • 3
    • 84859390119 scopus 로고    scopus 로고
    • Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    • Bilate AM, Lafaille JJ. Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol (2012) 30:733-58. doi:10.1146/annurev-immunol-020711-075043
    • (2012) Annu Rev Immunol , vol.30 , pp. 733-758
    • Bilate, A.M.1    Lafaille, J.J.2
  • 4
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 474(7351):298-306. doi:10.1038/nature10208
    • (2011) Nature , vol.474 , Issue.7351 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 5
    • 0030830553 scopus 로고    scopus 로고
    • Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases
    • Sartor RB. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol (1997) 92(12 Suppl):5S-11S.
    • (1997) Am J Gastroenterol , vol.92 , Issue.12 , pp. 5S-11S
    • Sartor, R.B.1
  • 6
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med (2002) 347(6):417-29. doi:10.1056/NEJMra020831
    • (2002) N Engl J Med , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 7
    • 84903118680 scopus 로고    scopus 로고
    • Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases
    • Sobczak M, Fabisiak A, Murawska N, Wesolowska E, Wierzbicka P, Wlazlowski M, et al. Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases. Pharmacol Rep (2014) 66(5):766-75. doi:10.1016/j.pharep.2014.04.005
    • (2014) Pharmacol Rep , vol.66 , Issue.5 , pp. 766-775
    • Sobczak, M.1    Fabisiak, A.2    Murawska, N.3    Wesolowska, E.4    Wierzbicka, P.5    Wlazlowski, M.6
  • 8
    • 84880152461 scopus 로고    scopus 로고
    • Host-recognition of pathogens and commensals in the mammalian intestine
    • Rossi O, van Baarlen P, Wells JM. Host-recognition of pathogens and commensals in the mammalian intestine. Curr Top Microbiol Immunol (2013) 358:291-321. doi:10.1007/82_2011_191
    • (2013) Curr Top Microbiol Immunol , vol.358 , pp. 291-321
    • Rossi, O.1    van Baarlen, P.2    Wells, J.M.3
  • 9
    • 84902601983 scopus 로고    scopus 로고
    • Microbiota activation and regulation of innate and adaptive immunity
    • Alexander KL, Targan SR, Elson CO III. Microbiota activation and regulation of innate and adaptive immunity. Immunol Rev (2014) 260(1):206-20. doi:10.1111/imr.12180
    • (2014) Immunol Rev , vol.260 , Issue.1 , pp. 206-220
    • Alexander, K.L.1    Targan, S.R.2    Elson, C.O.3
  • 10
    • 0029609870 scopus 로고
    • Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD)
    • MacDonald TT. Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD). Clin Exp Immunol (1995) 102(3):445-7. doi:10.1111/j.1365-2249.1995.tb03835.x
    • (1995) Clin Exp Immunol , vol.102 , Issue.3 , pp. 445-447
    • MacDonald, T.T.1
  • 11
    • 84902657697 scopus 로고    scopus 로고
    • Inflammatory bowel disease as a model for translating the microbiome
    • Huttenhower C, Kostic AD, Xavier RJ. Inflammatory bowel disease as a model for translating the microbiome. Immunity (2014) 40(6):843-54. doi:10.1016/j.immuni.2014.05.013
    • (2014) Immunity , vol.40 , Issue.6 , pp. 843-854
    • Huttenhower, C.1    Kostic, A.D.2    Xavier, R.J.3
  • 12
    • 0842346315 scopus 로고    scopus 로고
    • Interactions of commensal gut microbes with subsets of B-and T-cells in the murine host
    • Jiang HQ, Thurnheer MC, Zuercher AW, Boiko NV, Bos NA, Cebra JJ. Interactions of commensal gut microbes with subsets of B-and T-cells in the murine host. Vaccine (2004) 22(7):805-11. doi:10.1016/j.vaccine.2003.11.022
    • (2004) Vaccine , vol.22 , Issue.7 , pp. 805-811
    • Jiang, H.Q.1    Thurnheer, M.C.2    Zuercher, A.W.3    Boiko, N.V.4    Bos, N.A.5    Cebra, J.J.6
  • 13
    • 84903275253 scopus 로고    scopus 로고
    • Inflammatory bowel disease: clinical aspects and treatments
    • Fakhoury M, Negrulj R, Mooranian A, Al-Salami H. Inflammatory bowel disease: clinical aspects and treatments. J Inflamm Res (2014) 7:113-20. doi:10.2147/JIR.S65979
    • (2014) J Inflamm Res , vol.7 , pp. 113-120
    • Fakhoury, M.1    Negrulj, R.2    Mooranian, A.3    Al-Salami, H.4
  • 14
    • 0033066588 scopus 로고    scopus 로고
    • Oral tolerance: mechanisms and therapeutic applications
    • Faria AM, Weiner HL. Oral tolerance: mechanisms and therapeutic applications. Adv Immunol (1999) 73:153-264. doi:10.1016/S0065-2776(08)60787-7
    • (1999) Adv Immunol , vol.73 , pp. 153-264
    • Faria, A.M.1    Weiner, H.L.2
  • 15
    • 0024151897 scopus 로고
    • The heat-shock proteins
    • Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet (1988) 22:631-77. doi:10.1146/annurev.ge.22.120188.003215
    • (1988) Annu Rev Genet , vol.22 , pp. 631-677
    • Lindquist, S.1    Craig, E.A.2
  • 16
    • 15944368140 scopus 로고    scopus 로고
    • Protein folding assisted by chaperones
    • Borges JC, Ramos CH. Protein folding assisted by chaperones. Protein Pept Lett (2005) 12(3):257-61. doi:10.2174/0929866053587165
    • (2005) Protein Pept Lett , vol.12 , Issue.3 , pp. 257-261
    • Borges, J.C.1    Ramos, C.H.2
  • 17
    • 0037007283 scopus 로고    scopus 로고
    • Molecular chaperones - cellular machines for protein folding
    • Walter S, Buchner J. Molecular chaperones - cellular machines for protein folding. Angew Chem Int Ed Engl (2002) 41(7):1098-113. doi:10.1002/1521-3773(20020402)41:7[1098::AID-ANIE1098]3.0.CO;2-9
    • (2002) Angew Chem Int Ed Engl , vol.41 , Issue.7 , pp. 1098-1113
    • Walter, S.1    Buchner, J.2
  • 18
    • 0043205830 scopus 로고    scopus 로고
    • T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors
    • Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O. T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors. FASEB J (2003) 17(11):1567-9. doi:10.1096/fj.02-1139fje
    • (2003) FASEB J , vol.17 , Issue.11 , pp. 1567-1569
    • Zanin-Zhorov, A.1    Nussbaum, G.2    Franitza, S.3    Cohen, I.R.4    Lider, O.5
  • 19
    • 35548988445 scopus 로고    scopus 로고
    • Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases
    • Van Eden W, Wick G, Albani S, Cohen I. Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases. Ann N Y Acad Sci (2007) 1113:217-37. doi:10.1196/annals.1391.020
    • (2007) Ann N Y Acad Sci , vol.1113 , pp. 217-237
    • Van Eden, W.1    Wick, G.2    Albani, S.3    Cohen, I.4
  • 20
    • 0026490037 scopus 로고
    • Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis
    • Stevens TR, Winrow VR, Blake DR, Rampton DS. Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis. Clin Exp Immunol (1992) 90:271-4. doi:10.1111/j.1365-2249.1992.tb07941.x
    • (1992) Clin Exp Immunol , vol.90 , pp. 271-274
    • Stevens, T.R.1    Winrow, V.R.2    Blake, D.R.3    Rampton, D.S.4
  • 21
    • 77951238010 scopus 로고    scopus 로고
    • Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease
    • Puga Yung GL, Fidler M, Albani E, Spermon N, Teklenburg G, Newbury R, et al. Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease. PLoS One (2009) 4(11):e7714. doi:10.1371/journal.pone.0007714
    • (2009) PLoS One , vol.4 , Issue.11
    • Puga Yung, G.L.1    Fidler, M.2    Albani, E.3    Spermon, N.4    Teklenburg, G.5    Newbury, R.6
  • 22
    • 0026033502 scopus 로고
    • Autoimmunity, microbial immunity and the immunological homunculus
    • Cohen IR, Young DB. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today (1991) 12(4):105-10. doi:10.1016/0167-5699(91)90093-9
    • (1991) Immunol Today , vol.12 , Issue.4 , pp. 105-110
    • Cohen, I.R.1    Young, D.B.2
  • 23
    • 17144417382 scopus 로고    scopus 로고
    • Heat-shock proteins induce T-cell regulation of chronic inflammation
    • van Eden W, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol (2005) 5(4):318-30. doi:10.1038/nri1593
    • (2005) Nat Rev Immunol , vol.5 , Issue.4 , pp. 318-330
    • van Eden, W.1    van der Zee, R.2    Prakken, B.3
  • 24
    • 84874080279 scopus 로고    scopus 로고
    • HSP60: issues and insights on its therapeutic use as an immunoregulatory agent
    • Coelho V, Faria AM. HSP60: issues and insights on its therapeutic use as an immunoregulatory agent. Front Immunol (2011) 2:97. doi:10.3389/fimmu.2011.00097
    • (2011) Front Immunol , vol.2 , pp. 97
    • Coelho, V.1    Faria, A.M.2
  • 25
    • 33745817772 scopus 로고    scopus 로고
    • Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling
    • Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest (2006) 116(7):2022-32. doi:10.1172/JCI28423
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 2022-2032
    • Zanin-Zhorov, A.1    Cahalon, L.2    Tal, G.3    Margalit, R.4    Lider, O.5    Cohen, I.R.6
  • 26
    • 58449116889 scopus 로고    scopus 로고
    • IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis
    • Wieten L, Berlo SE, Ten Brink CB, van Kooten PJ, Singh M, van der Zee R, et al. IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis. PLoS One (2009) 4(1):e4186. doi:10.1371/journal.pone.0004186
    • (2009) PLoS One , vol.4 , Issue.1
    • Wieten, L.1    Berlo, S.E.2    Ten Brink, C.B.3    van Kooten, P.J.4    Singh, M.5    van der Zee, R.6
  • 27
    • 0032940596 scopus 로고    scopus 로고
    • The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse
    • Ablamunits V, Elias D, Cohen IR. The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse. Clin Exp Immunol (1999) 115(2):260-7. doi:10.1046/j.1365-2249.1999.00802.x
    • (1999) Clin Exp Immunol , vol.115 , Issue.2 , pp. 260-267
    • Ablamunits, V.1    Elias, D.2    Cohen, I.R.3
  • 29
    • 0037167684 scopus 로고    scopus 로고
    • Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice
    • Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation (2002) 106(13):1708-15. doi:10.1161/01.CIR.0000029750.99462.30
    • (2002) Circulation , vol.106 , Issue.13 , pp. 1708-1715
    • Maron, R.1    Sukhova, G.2    Faria, A.M.3    Hoffmann, E.4    Mach, F.5    Libby, P.6
  • 30
    • 84873703883 scopus 로고    scopus 로고
    • Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells
    • Rezende RM, Oliveira RP, Medeiros SR, Gomes-Santos AC, Alves AC, Loli FG, et al. Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. J Autoimmun (2013) 40:45-57. doi:10.1016/j.jaut.2012.07.012
    • (2013) J Autoimmun , vol.40 , pp. 45-57
    • Rezende, R.M.1    Oliveira, R.P.2    Medeiros, S.R.3    Gomes-Santos, A.C.4    Alves, A.C.5    Loli, F.G.6
  • 33
    • 33845662118 scopus 로고    scopus 로고
    • Oral tolerance: therapeutic implications for autoimmune diseases
    • Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol (2006) 13(2-4):143-57. doi:10.1080/17402520600876804
    • (2006) Clin Dev Immunol , vol.13 , Issue.2-4 , pp. 143-157
    • Faria, A.M.1    Weiner, H.L.2
  • 35
    • 0037346154 scopus 로고    scopus 로고
    • Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis
    • Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL. Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun (2003) 20(2):135-45. doi:10.1016/S0896-8411(02)00112-9
    • (2003) J Autoimmun , vol.20 , Issue.2 , pp. 135-145
    • Faria, A.M.1    Maron, R.2    Ficker, S.M.3    Slavin, A.J.4    Spahn, T.5    Weiner, H.L.6
  • 36
    • 84929953820 scopus 로고    scopus 로고
    • Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects
    • Oliveira RP, Santiago AF, Ficker SM, Gomes-Santos AC, Faria AM. Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects. J Immunol Methods (2015) 421:36-43. doi:10.1016/j.jim.2015.02.005
    • (2015) J Immunol Methods , vol.421 , pp. 36-43
    • Oliveira, R.P.1    Santiago, A.F.2    Ficker, S.M.3    Gomes-Santos, A.C.4    Faria, A.M.5
  • 37
    • 84930477291 scopus 로고    scopus 로고
    • Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65-kDa heat shock protein in Lactococcus lactis
    • de Azevedo MS, Rocha CS, Electo N, Pontes DS, Molfetta JB, Gonçalves ED, et al. Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65-kDa heat shock protein in Lactococcus lactis. Genet Mol Res (2012) 11(2):1146-57. doi:10.4238/2012.April.27.14
    • (2012) Genet Mol Res , vol.11 , Issue.2 , pp. 1146-1157
    • de Azevedo, M.S.1    Rocha, C.S.2    Electo, N.3    Pontes, D.S.4    Molfetta, J.B.5    Gonçalves, E.D.6
  • 38
    • 84914169012 scopus 로고    scopus 로고
    • From field to fermentation: the origins of Lactococcus lactis and its domestication to the dairy environment
    • Cavanagh D, Fitzgerald GF, McAuliffe O. From field to fermentation: the origins of Lactococcus lactis and its domestication to the dairy environment. Food Microbiol (2015) 47:45-61. doi:10.1016/j.fm.2014.11.001
    • (2015) Food Microbiol , vol.47 , pp. 45-61
    • Cavanagh, D.1    Fitzgerald, G.F.2    McAuliffe, O.3
  • 39
    • 84896716554 scopus 로고    scopus 로고
    • Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance
    • Mercadante AC, Perobelli SM, Alves AP, Gonçalves-Silva T, Mello W, Gomes-Santos AC, et al. Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance. J Immunol (2014) 192(4):1928-37. doi:10.4049/jimmunol.1301034
    • (2014) J Immunol , vol.192 , Issue.4 , pp. 1928-1937
    • Mercadante, A.C.1    Perobelli, S.M.2    Alves, A.P.3    Gonçalves-Silva, T.4    Mello, W.5    Gomes-Santos, A.C.6
  • 40
    • 0034714188 scopus 로고    scopus 로고
    • Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
    • Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science (2000) 289(5483):1352-5. doi:10.1126/science.289.5483.1352
    • (2000) Science , vol.289 , Issue.5483 , pp. 1352-1355
    • Steidler, L.1    Hans, W.2    Schotte, L.3    Neirynck, S.4    Obermeier, F.5    Falk, W.6
  • 41
    • 77249133143 scopus 로고    scopus 로고
    • Orally administered L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis
    • Vandenbroucke K, de Haard H, Beirnaert E, Dreier T, Lauwereys M, Huyck L, et al. Orally administered L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis. Mucosal Immunol (2010) 3(1):49-56. doi:10.1038/mi.2009.116
    • (2010) Mucosal Immunol , vol.3 , Issue.1 , pp. 49-56
    • Vandenbroucke, K.1    de Haard, H.2    Beirnaert, E.3    Dreier, T.4    Lauwereys, M.5    Huyck, L.6
  • 42
    • 34547542844 scopus 로고    scopus 로고
    • Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein
    • Foligne B, Dessein R, Marceau M, Poiret S, Chamaillard M, Pot B, et al. Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein. Gastroenterology (2007) 133(3):862-74. doi:10.1053/j.gastro.2007.06.018
    • (2007) Gastroenterology , vol.133 , Issue.3 , pp. 862-874
    • Foligne, B.1    Dessein, R.2    Marceau, M.3    Poiret, S.4    Chamaillard, M.5    Pot, B.6
  • 43
    • 84930477291 scopus 로고    scopus 로고
    • Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65 kDa heat shock protein in Lactococcus lactis
    • de Azevedo MS, Electo N, Pontes DS, Machado JBM, Gonçalves EDC, Azevedo V, et al. Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65 kDa heat shock protein in Lactococcus lactis. Genet Mol Res (2012) 11(2):1146-50. doi:10.4238/2012.April.27.14
    • (2012) Genet Mol Res , vol.11 , Issue.2 , pp. 1146-1150
    • de Azevedo, M.S.1    Electo, N.2    Pontes, D.S.3    Machado, J.B.M.4    Gonçalves, E.D.C.5    Azevedo, V.6
  • 44
    • 80051590424 scopus 로고    scopus 로고
    • Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems
    • Pontes DS, de Azevedo MS, Chatel JM, Langella P, Azevedo V, Miyoshi A. Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems. Protein Expr Purif (2011) 79(2):165-75. doi:10.1016/j.pep.2011.06.005
    • (2011) Protein Expr Purif , vol.79 , Issue.2 , pp. 165-175
    • Pontes, D.S.1    de Azevedo, M.S.2    Chatel, J.M.3    Langella, P.4    Azevedo, V.5    Miyoshi, A.6
  • 45
    • 0027275654 scopus 로고
    • Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin
    • Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergran DJ. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci (1993) 38(9):1722-34. doi:10.1007/BF01303184
    • (1993) Dig Dis Sci , vol.38 , Issue.9 , pp. 1722-1734
    • Murthy, S.N.1    Cooper, H.S.2    Shim, H.3    Shah, R.S.4    Ibrahim, S.A.5    Sedergran, D.J.6
  • 47
    • 0019479358 scopus 로고
    • Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine
    • Davies MD, Parrott DM. Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. Gut (1981) 22(6):481-8. doi:10.1136/gut.22.6.481
    • (1981) Gut , vol.22 , Issue.6 , pp. 481-488
    • Davies, M.D.1    Parrott, D.M.2
  • 48
    • 84858195802 scopus 로고    scopus 로고
    • New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa
    • Gomes-Santos AC, Moreira TG, Castro-Junior AB, Horta BC, Lemos L, Cruz DN, et al. New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa. Clin Dev Immunol (2012) 2012:560817. doi:10.1155/2012/560817
    • (2012) Clin Dev Immunol , vol.2012
    • Gomes-Santos, A.C.1    Moreira, T.G.2    Castro-Junior, A.B.3    Horta, B.C.4    Lemos, L.5    Cruz, D.N.6
  • 49
    • 84883673597 scopus 로고    scopus 로고
    • Multi-faceted functions of secretory IgA at mucosal surfaces
    • Corthésy B. Multi-faceted functions of secretory IgA at mucosal surfaces. Front Immunol (2013) 4:185. doi:10.3389/fimmu.2013.00185
    • (2013) Front Immunol , vol.4 , pp. 185
    • Corthésy, B.1
  • 50
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 75(2):263-74. doi:10.1016/0092-8674(93)80068-P
    • (1993) Cell , vol.75 , Issue.2 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 51
  • 52
    • 40849136114 scopus 로고    scopus 로고
    • Heat shock protein derivatives for delivery of antigens to antigen presenting cells
    • Nishikawa M, Takemoto S, Takakura Y. Heat shock protein derivatives for delivery of antigens to antigen presenting cells. Int J Pharm (2008) 354(1-2):23-7. doi:10.1016/j.ijpharm.2007.09.030
    • (2008) Int J Pharm , vol.354 , Issue.1-2 , pp. 23-27
    • Nishikawa, M.1    Takemoto, S.2    Takakura, Y.3
  • 53
    • 84895773130 scopus 로고    scopus 로고
    • Heat shock factor 2 levels are associated with the severity of ulcerative colitis
    • Miao J, Niu J, Wang K, Xiao Y, Du Y, Zhou L, et al. Heat shock factor 2 levels are associated with the severity of ulcerative colitis. PLoS One (2014) 9(2):e88822. doi:10.1371/journal.pone.0088822
    • (2014) PLoS One , vol.9 , Issue.2
    • Miao, J.1    Niu, J.2    Wang, K.3    Xiao, Y.4    Du, Y.5    Zhou, L.6
  • 54
    • 77956291693 scopus 로고    scopus 로고
    • Do heat shock proteins play any role in gut inflammation?
    • Ciancio MJ, Chang EB. Do heat shock proteins play any role in gut inflammation? Inflamm Bowel Dis (2008) 14(Suppl 2):S102-3. doi:10.1002/ibd.20697
    • (2008) Inflamm Bowel Dis , vol.14 , pp. S102-S103
    • Ciancio, M.J.1    Chang, E.B.2
  • 55
    • 0033884351 scopus 로고    scopus 로고
    • Involvement of luminal bacteria, heat shock protein 60, macrophages and gammadelta T cells in dextran sulfate sodium-induced colitis in rats
    • Leung FW, Heng MC, Allen S, Seno K, Leung JW, Heng MK. Involvement of luminal bacteria, heat shock protein 60, macrophages and gammadelta T cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci (2000) 45(7):1472-9. doi:10.1023/A:1005545128954
    • (2000) Dig Dis Sci , vol.45 , Issue.7 , pp. 1472-1479
    • Leung, F.W.1    Heng, M.C.2    Allen, S.3    Seno, K.4    Leung, J.W.5    Heng, M.K.6
  • 56
    • 0034808748 scopus 로고    scopus 로고
    • Colon epithelial cellular protein induces oral tolerance in the experimental model of colitis by trinitrobenzene sulfonic acid
    • Dasgupta A, Ramaswamy K, Giraldo J, Taniguchi M, Amenta PS, Das KM. Colon epithelial cellular protein induces oral tolerance in the experimental model of colitis by trinitrobenzene sulfonic acid. J Lab Clin Med (2001) 138(4):257-69. doi:10.1067/mlc.2001.118221
    • (2001) J Lab Clin Med , vol.138 , Issue.4 , pp. 257-269
    • Dasgupta, A.1    Ramaswamy, K.2    Giraldo, J.3    Taniguchi, M.4    Amenta, P.S.5    Das, K.M.6
  • 57
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology (2007) 132(4):1359-74. doi:10.1053/j.gastro.2007.02.056
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 58
    • 33747114270 scopus 로고    scopus 로고
    • Role of toll-like receptors in spontaneous commensal-dependent colitis
    • Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 25(2):319-29. doi:10.1016/j.immuni.2006.06.010
    • (2006) Immunity , vol.25 , Issue.2 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 59
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of toll-like receptors
    • Tsan MF, Gao B. Endogenous ligands of toll-like receptors. J Leukoc Biol (2004) 76(3):514-9. doi:10.1189/jlb.0304127
    • (2004) J Leukoc Biol , vol.76 , Issue.3 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 60
    • 84905050462 scopus 로고    scopus 로고
    • Assembly and localization of toll-like receptor signalling complexes
    • Gay NJ, Symmons MF, Gangloff M, Bryant CE. Assembly and localization of toll-like receptor signalling complexes. Nat Rev Immunol (2014) 14(8):546-58. doi:10.1038/nri3713
    • (2014) Nat Rev Immunol , vol.14 , Issue.8 , pp. 546-558
    • Gay, N.J.1    Symmons, M.F.2    Gangloff, M.3    Bryant, C.E.4
  • 61
    • 84881157196 scopus 로고    scopus 로고
    • Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPβ and C/EBPd
    • Borges TJ, Lopes RL, Pinho NG, Machado FD, Souza AP, Bonorino C. Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPβ and C/EBPd. Int J Hyperthermia (2013) 29(5):455-63. doi:10.3109/02656736.2013.798037
    • (2013) Int J Hyperthermia , vol.29 , Issue.5 , pp. 455-463
    • Borges, T.J.1    Lopes, R.L.2    Pinho, N.G.3    Machado, F.D.4    Souza, A.P.5    Bonorino, C.6
  • 62
    • 0038205797 scopus 로고    scopus 로고
    • Direct binding of toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A
    • Sato M, Sano H, Iwaki D, Kudo K, Konishi M, Takahashi H, et al. Direct binding of toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol (2003) 171(1):417-25. doi:10.4049/jimmunol.171.1.417
    • (2003) J Immunol , vol.171 , Issue.1 , pp. 417-425
    • Sato, M.1    Sano, H.2    Iwaki, D.3    Kudo, K.4    Konishi, M.5    Takahashi, H.6
  • 63
    • 79960990849 scopus 로고    scopus 로고
    • Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?
    • Shields AM, Panayi GS, Corrigall VM. Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis? Clin Exp Immunol (2011) 165:292-300. doi:10.1111/j.1365-2249.2011.04433.x
    • (2011) Clin Exp Immunol , vol.165 , pp. 292-300
    • Shields, A.M.1    Panayi, G.S.2    Corrigall, V.M.3
  • 64
    • 34447109876 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro
    • Motta A, Schmitz C, Rodrigues L, Ribeiro F, Teixeira C, Detanico T, et al. Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro. Immunology (2007) 121(4):462-72. doi:10.1111/j.1365-2567.2007.02564.x
    • (2007) Immunology , vol.121 , Issue.4 , pp. 462-472
    • Motta, A.1    Schmitz, C.2    Rodrigues, L.3    Ribeiro, F.4    Teixeira, C.5    Detanico, T.6
  • 65
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • de Kleer IM, Wedderburn LR, Taams LS, Patel A, Varsani H, Klein M, et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol (2004) 172(10):6435-43. doi:10.4049/jimmunol.172.10.6435
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 6435-6443
    • de Kleer, I.M.1    Wedderburn, L.R.2    Taams, L.S.3    Patel, A.4    Varsani, H.5    Klein, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.