Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Morris, Jill K ^a   Vidoni, Eric D ^a   Johnson, David K ^b   Van Sciver, Angela ^a   Mahnken, Jonathan D ^c   Honea, Robyn A ^a   Wilkins, Heather M ^a   Brooks, William M ^a   Billinger, Sandra A ^a   Swerdlow, Russell H ^a   Burns, Jeffrey M ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEROBIC EXERCISE; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN SIZE; CARDIORESPIRATORY FITNESS; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORNELL SCALE FOR DEPRESSION IN DEMENTIA; CORRELATIONAL STUDY; DEPRESSION; DISABILITY ASSESSMENT FOR DEMENTIA; EXECUTIVE FUNCTION; FEMALE; FOOT PAIN; FUNCTIONAL STATUS; FUNCTIONAL STATUS ASSESSMENT; HEART ARRHYTHMIA; HIP PAIN; HIPPOCAMPUS; HUMAN; KNEE PAIN; LEG PAIN; LOW BACK PAIN; MALE; MEMORY; NUCLEAR MAGNETIC RESONANCE IMAGING; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; THORAX PAIN; TREATMENT DURATION; ADVERSE EFFECTS; EXERCISE; KINESIOTHERAPY; PROCEDURES; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CARDIORESPIRATORY FITNESS; EXECUTIVE FUNCTION; EXERCISE; EXERCISE THERAPY; FEMALE; HUMANS; MALE; MEMORY; PILOT PROJECTS;

EID: 85012170408     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0170547     Document Type: Article

References (53)

1. Alzheimer's Association. 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 2015 Mar; 11(3):332-84. PMID: 25984581
2. Daviglus ML, Bell CC, Berrettini W, Bowen PE, Connolly ES Jr., Cox NJ, et al. National Institutes of Health State-of-the-Science Conference statement: preventing alzheimer disease and cognitive decline. Ann Intern Med. 2010 Aug 3; 153(3):176-81. doi: 10.7326/0003-4819-153-3-201008030-00260 PMID: 20547888
3. Nichol K, Deeny SP, Seif J, Camaclang K, Cotman CW. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement. 2009 Jul; 5(4):287-94. doi: 10.1016/j.jalz.2009. 02.006 PMID: 19560099
4. van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999; 96(23):13427-31. PMID: 10557337
5. Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist. 2012 Feb; 18(1):82-97. doi: 10.1177/1073858410397054 PMID: 21531985
6. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5638-43. doi: 10.1073/pnas.0611721104 PMID: 17374720
7. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5568-72. PMID: 1695380
8. Isaacs KR, Anderson BJ, Alcantara AA, Black JE, Greenough WT. Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J Cereb Blood Flow Metabol Society Of Cerebral Blood Flow And Metabolism. 1992; 12(1):110-9.
9. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease. J Neurosci. 2005; 25(17):4217-21. doi: 10.1523/JNEUROSCI. 0496-05.2005 PMID: 15858047
10. Wu CW, Chang YT, Yu L, Chen HI, Jen CJ, Wu SY, et al. Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. J Appl Physiol (1985). 2008 Nov; 105(5):1585-94.
11. Burns JM, Cronk BB, Anderson HS, Donnelly JE, Thomas GP, Harsha A, et al. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology. 2008 Jul 15; 71(3):210-6. doi: 10.1212/01. wnl.0000317094.86209.cb PMID: 18625967
12. Vidoni ED, Honea RA, Billinger SA, Swerdlow RH, Burns JM. Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years. Neurobiol Aging. 2012 Aug; 33(8):1624-32. doi: 10. 1016/j.neurobiolaging.2011.03.016 PMID: 21531480
13. Tolppanen AM, Solomon A, Kulmala J, Kareholt I, Ngandu T, Rusanen M, et al. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimers Dement. 2015 Apr; 11 (4):434-43 e6. doi: 10.1016/j.jalz.2014.01.008 PMID: 24721528
14. Jedrziewski MK, Ewbank DC, Wang H, Trojanowski JQ. Exercise and cognition: results from the National Long Term Care Survey. Alzheimers Dement. 2010 Nov; 6(6):448-55. doi: 10.1016/j.jalz. 2010.02.004 PMID: 21044775
15. Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, et al. Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study. Neurology. 2010 Oct 19; 75 (16):1415-22. doi: 10.1212/WNL.0b013e3181f88359 PMID: 20944075
16. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, et al. Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older. Ann Intern Med. 2006 Jan;2006; 144(2):73-81. PMID: 16418406
17. Weuve J, Kang JH, Manson JE, Breteler MMB, Ware JH, Grodstein F. Physical Activity, Including Walking, and Cognitive Function in Older Women. JAMA 2004; 292(12):1454-61. doi: 10.1001/jama.292.12. 1454 PMID: 15383516
18. Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, et al. Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition. J Int Neuropschol Soc. 2015 Nov; 21(10):841-50.
19. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol. 2010 Jan; 67(1):71-9. doi: 10. 1001/archneurol.2009.307 PMID: 20065132
20. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008 Sep 3; 300(9):1027-37. doi: 10.1001/jama.300.9.1027 PMID: 18768414
21. Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003 Oct 15; 290(15):2015-22. doi: 10.1001/jama.290.15.2015 PMID: 14559955
22. van Uffelen JG, Chinapaw MJ, van Mechelen W, Hopman-Rock M. Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. Br J Sports Med. 2008 May; 42(5):344-51. doi: 10.1136/bjsm.2007.044735 PMID: 18308888
23. Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2015; 4:CD006489.
24. Paillard T, Rolland Y, de Souto Barreto P. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review. J Clin Neurol. 2015 Jul; 11(3):212-9. doi: 10.3988/jcn.2015.11.3.212 PMID: 26174783
25. Vidoni ED, Van Sciver A, Johnson DK, He J, Honea R, Haines B, et al. A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease. Contemp Clin Trials. 2012 Aug 7; 33 (6):1105-16. doi: 10.1016/j.cct.2012.08.002 PMID: 22903151
26. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):270-9. doi: 10.1016/j.jalz.2011.03.008 PMID: 21514249
27. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr., Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):263-9. doi: 10.1016/j.jalz.2011.03.005 PMID: 21514250
28. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993 November 1, 1993; 43(11):2412-4.
29. Topolski TD, LoGerfo J, Patrick DL, Williams B, Walwick J, Patrick MB. The Rapid Assessment of Physical Activity (RAPA) among older adults. Prev Chronic Dis. 2006 Oct; 3(4):A118. PMID: 16978493
30. Kryscio RJ. Secondary prevention trials in Alzheimer disease: the challenge of identifying a meaningful end point. JAMA Neurol. 2014 Aug 1; 71(8):947-9. doi: 10.1001/jamaneurol.2014.1120 PMID: 24886838
31. Johnson DK, Storandt M, Morris JC, Langford ZD, Galvin JE. Cognitive profiles in dementia: Alzheimer disease vs nondemented aging. Neurology. 2008 Nov 25; 71(22):1783-9. doi: 10.1212/01.wnl. 0000335972.35970.70 PMID: 19029518
32. Harry A, Crowe SF. Is the Boston Naming Test still fit for purpose? Clinical Neuropsychol. 2014; 28 (3):486-504.
33. Shirk SD, Mitchell MB, Shaughnessy LW, Sherman JC, Locascio JJ, Weintraub S, et al. A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery. Alzheimer Res Ther. 2011; 3(6):32.
34. Vidoni ED, Johnson DK, Morris JK, Van Sciver A, Greer CS, Billinger SA, et al. Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial. PloS One. 2015; 10 (7):e0131647. doi: 10.1371/journal.pone.0131647 PMID: 26158265
35. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell Scale for Depression in Dementia. Biol Psychiatr. 1988 Feb 1; 23(3):271-84.
36. Feldman H, Sauter A, Donald A, Gelinas I, Gauthier S, Torfs K, et al. The disability assessment for dementia scale: a 12-month study of functional ability in mild to moderate severity Alzheimer disease. Alzheimer Dis Assoc Disord. 2001 Apr-Jun; 15(2):89-95. PMID: 11391090
37. Billinger SA, Vidoni ED, Honea RA, Burns JM. Cardiorespiratory response to exercise testing in individuals with Alzheimer's disease. Arch Phys Med Rehabil. 2011 Dec; 92(12):2000-5. doi: 10.1016/j.apmr. 2011.07.194 PMID: 22133248
38. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of Different Doses of Physical Activity on Cardiorespiratory Fitness Among Sedentary, Overweight or Obese Postmenopausal Women With Elevated Blood Pressure: A Randomized Controlled Trial. JAMA. 2007; May 16; 297(19):2081-91. doi: 10.1001/jama.297.19.2081 PMID: 17507344
39. Fleg JL, Morrell C. H., Bos A. G., et al. Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults. Circulation. 2005; 112(5):674-82. doi: 10.1161/CIRCULATIONAHA.105.545459 PMID: 16043637
40. American Thoracic S. ATS statement: guidelines for the six-minute walk test. Am jJ Resp Crit Care Med. 2002; 166 111-7.
41. Reuter M, Schmansky NJ, Rosas HD, Fischl B. Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage. 2012 Jul 16; 61(4):1402-18. doi: 10.1016/j.neuroimage.2012.02. 084 PMID: 22430496
42. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, et al. Ageing, fitness and neurocognitive function. Nature. 1999 Jul 29; 400(6743):418-9. doi: 10.1038/22682 PMID: 10440369
43. Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E, Cohen NJ, et al. Cardiovascular fitness, cortical plasticity, and aging. Proc Nat Acad Sci U S A. 2004; 101(9):3316-21.
44. Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med. 2010 Jan 25; 170(2):170-8. doi: 10.1001/archinternmed.2009.494 PMID: 20101012
45. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3017-22. doi: 10.1073/pnas.1015950108 PMID: 21282661
46. ten Brinke LF, Bolandzadeh N, Nagamatsu LS, Hsu CL, Davis JC, Miran-Khan K, et al. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. Br J Sports Med. 2015 Feb; 49(4):248-54. doi: 10.1136/bjsports-2013-093184 PMID: 24711660
47. Tappen RM, Roach KE, Applegate EB, Stowell P. Effect of a combined walking and conversation intervention on functional mobility of nursing home residents with Alzheimer disease. Alzheimer Dis Assoc Disord. 2000 Oct-Dec; 14(4):196-201. PMID: 11186596
48. Team RC. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2013.
49. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, et al. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3985-90. doi: 10.1073/pnas.1105829109 PMID: 22343285
50. Billinger SA, Vidoni ED, Morris JK, Thyfault JP, Burns JM. Exercise Test Performance Reveals Support of the Cardiorespiratory Fitness Hypothesis. J Aging Phys Act. 2016 Oct 5:1-17.
51. Hayes SM, Hayes JP, Cadden M, Verfaellie M. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Fron Agingeurosci. 2013; 5:31.
52. Gaugler JE, Kane RL, Kane RA, Clay T, Newcomer R. Caregiving and institutionalization of cognitively impaired older people: utilizing dynamic predictors of change. Gerontologist. 2003 Apr; 43(2):219-29. PMID: 12677079
53. Bossers WJ, van der Woude LH, Boersma F, Hortobagyi T, Scherder EJ, van Heuvelen MJ. Comparison of Effect of Two Exercise Programs on Activities of Daily Living in Individuals with Dementia: A 9-Week Randomized, Controlled Trial. J Am Geriatr Soc. 2016 Jun; 64(6):1258-66. doi: 10.1111/jgs. 14160 PMID: 27321604